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http://dx.doi.org/10.7314/APJCP.2014.15.7.3021

Lack of Association of the MDR1 C3435T Polymorphism with Susceptibility to Gastric Cancer and Peptic Ulcer: a Systemic Review and Meta-analysis  

Wu, Dan-Dan (Department of Gastroenterology, Renmin Hospital of Wuhan University)
Zhang, Ji-Xiang (Department of Gastroenterology, Renmin Hospital of Wuhan University)
Li, Jiao (Department of Gastroenterology, Renmin Hospital of Wuhan University)
Dong, Wei-Guo (Department of Gastroenterology, Renmin Hospital of Wuhan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.7, 2014 , pp. 3021-3027 More about this Journal
Abstract
Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.
Keywords
Gastric cancer; peptic ulcer; gastric ulcer; duodenal ulcer; MDR1; polymorphism; meta-analysis;
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1 Yuan H, Li X, Wu J, et al (2008). Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance. Curr Med Chem, 15, 470-6.   DOI   ScienceOn
2 Tahara T, Arisawa T, Shibata T, et al (2007). Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population. J Gastroenterol Hepatol, 22, 1678-82.   DOI   ScienceOn
3 Wang ZM, Wang T, Bian JN (2013). Association between MDR1 C3435T polymorphism and risk of breast cancer. Gene, 532, 94-9.   DOI   ScienceOn
4 Wu H, Xu C, Chen G, et al (2013). XRCC1 polymorphism and prognosis of platinum-based chemotherapy in gastric and colorectal cancer: a meta-analysis. J Gastroenterol Hepatol. [Epub ahead of print]
5 Zhang D, Wang C, Zhou Z (2013). Meta-Analysis of ABCB1 3435C>T Polymorphism and Colorectal Cancer. Pak J Med Sci, 29, 1269-74.
6 Zintzaras E, Ioannidis JP (2005). Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol, 28, 123-37.   DOI   ScienceOn
7 Zou TH, Wang ZH, Fang JY (2013). Positive association between Toll-like receptor 4 gene +896A/G polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis. Tumour Biol, 34, 2441-50.   DOI   ScienceOn
8 Oliveira J, Felipe AV, Chang PY, et al (2012). Association between the C3435T single-nucleotide polymorphism of multidrug resistance 1 gene and risk of gastric cancer. Mol Med Rep, 6, 395-8.   DOI
9 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
10 Markova S, Nakamura T, Sakaeda T, et al (2006). Genotype-dependent down-regulation of gene expression and function of MDR1 in human peripheral blood mononuclear cells under acute inflammation. Drug Metab Pharmacokinet, 21, 194-200.   DOI   ScienceOn
11 Mizutani T, Masuda M, Nakai E, et al (2008). Genuine functions of P-glycoprotein (ABCB1). Curr Drug Metab, 9, 167-74.   DOI   ScienceOn
12 Piao Y, Liu Z, Ding Z, et al (2013). EGF +61A>G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis. Gene, 519, 26-33.   DOI   ScienceOn
13 Sabahi Z, Salek R, Heravi RE, et al (2010). Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. Indian J Cancer, 47, 317-21.   DOI   ScienceOn
14 Song B, Duan ZY, Zhong YH, et al (2013). Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk. Asian Pac J Cancer Prev, 14, 6649-51.   과학기술학회마을   DOI   ScienceOn
15 Sugimoto M, Furuta T, Shirai N, et al (2008). MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese. Life Sci, 83, 301-4.   DOI   ScienceOn
16 Sung JJ, Kuipers EJ, El-Serag HB (2009). Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther, 29, 938-46.   DOI   ScienceOn
17 Tahara T, Shibata T, Yamashita H, et al (2011). Influence of MDR1 polymorphism on H. pylori-related chronic gastritis. Dig Dis Sci, 56, 103-8.   DOI
18 Jemal A, Bray F, Center MM, et al (2011). Global Cancer Statistics. CA Cancer J Clin, 61, 69-90.   DOI
19 Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58.   DOI   ScienceOn
20 Hoffmeyer S, Burk O, von Richter O, et al (2000). Functional polymorphisms of the human multidrug resistance gene multiple sequence variations and correlation of one allele with p-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA, 97, 3473-8.   DOI   ScienceOn
21 Johnstone RW, Ruefli AA, Smyth MJ (2000). Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci, 25, 1-6.   DOI   ScienceOn
22 Larsen UL, Hyldahl OL, Olesen L, et al (2007). Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Scand J Clin Lab Invest, 67, 123-34.   DOI   ScienceOn
23 Lauren P (1965). The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand, 64, 31-49.   DOI
24 Li X, Qu L, Zhong Y, et al (2013). Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis. J Cancer Res Clin Oncol, 139, 1433-47.   DOI   ScienceOn
25 Liu Y, Li L, Qi H, et al (2013). Survivin 231G.C polymorphism and gastrointestinal tract cancer risk: a meta-analysis. PLoS One, 8, 54081.   DOI
26 Lozano R, Naghavi M, Foreman K, et al (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380, 2095-128.   DOI   ScienceOn
27 Breier A, Barancik M, Sulova Z, et al (2005). P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy. Curr Cancer Drug Targets, 5, 457-68.   DOI   ScienceOn
28 Annese V, Valvano MR, Palmieri O, et al (2006). Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. World J Gastroenterol, 12, 3636-44.   DOI
29 Basiri Z, Safaralizadeh R, Bonyadi MJ, et al (2014). Helicobacter pylori vacA d1 genotype predicts risk of gastric adenocarcinoma and peptic ulcers in Northwestern Iran. Asian Pac J Cancer Prev, 15, 1575-9.   DOI   ScienceOn
30 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI   ScienceOn
31 Chang H, Rha SY, Jeung HC, et al (2010). Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy. Oncol Rep, 23, 271-8.
32 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI   ScienceOn
33 Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI   ScienceOn
34 Ho GT, Moodie FM, Satsangi J (2003). Multidrug resistance 1 gene (p-glycoprotein 170): an important determinant in gastrointestinal disease? Gut, 52, 759-66.   DOI