• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2363-2367
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• 2014

The association between the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene C609T polymorphism (rs1800566) and gastric cancer has been widely evaluated, but a definitive answer is so far lacking. We first conducted a case-control study to assess this association in a large Han Chinese population, and then performed a meta-analysis to further address this issue. Although our case-control association study indicated no significant difference in the genotype and allele distributions of C609T polymorphism between gastric cancer patients and controls, in the meta analysis involving 4,000 subjects, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95%CI) for odds ratio (OR)=1.20-1.79) in individuals with the T allele. The tendency was similar to the homozygote (OR=1.81, 95%CI: 1.16-2.84), dominant models (OR=1.41, 95%CI: 1.12-1.79), as well as recessive model (OR=1.58, 95%CI: 1.06-2.35). Stratified analysis by study design demonstrated stronger associations in population-based than in hospital-based studies. And ethnicity-based analysis demonstrated a significant association in Asians. We conclude that the NQO1 gene C609T polymorphism increases the risk for gastric cancer, especially in Asian populations.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4915-4921
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• 2012

Published data on any association between the CYP2E1 RsaI/PstI (c1/c2) polymorphism and liver cancer risk among east Asians are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of the relationship. A literature search of Pubmed, Embase, Web of science and CBM databases from inception through July 2012 was conducted. Twelve case-control studies were included with a total of 1,552 liver cancer cases and 1,763 healthy controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association under five genetic models. When all the eligible studies were pooled into the meta-analysis, the results showed that the c2 allele and the c2 carrier (c2/c2 + c2/c1) of RsaI/PstI polymorphism were associated with decreased risk of liver cancer among east Asians (c2 vs. c1: OR = 0.75, 95%CI: 0.59-0.95, P = 0.016; c2/c2 + c2/c1 vs. c1/c1: OR = 0.76, 95%CI: 0.58-1.00, P = 0.050). In the stratified analysis by country, significant associations were observed between RsaI/PstI polymorphism and decreased risk of liver cancer among the Chinese population (c2 vs. c1: OR = 0.70, 95%CI: 0.54-0.91, P = 0.007; c2/c2 + c2/c1 vs. c1/c1: OR = 0.72, 95%CI: 0.54-0.95, P = 0.020), but not among Japanese and Korean populations. Results from the current meta-analysis indicates that the c2 allele of CYP2E1 RsaI/PstI (c1/c2) polymorphism may be a protective factor for HCC among east Asians, especially among China populations.

• 보건교육건강증진학회지
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• 제21권2호
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• pp.147-165
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• 2004

Injury is a leading cause of death in the children and adolescent populations. In particular, more than 80％ of unintentional injury was related to risk-taking behaviors involved in diverse accidents around school and home. Therefore, educational approaches should be provided for children and adolescent populations, and schools are the essential and appropriate sites to conduct safety education. This study was conducted to identify injury prevalence and safety education at schools among middle and high school students in Korea. About 1,034 middle and high students in 28 schools participated in a self-administered survey. The target schools were selected from the stratified random sampling method throughout schools of seven metropolitan cities in Korea. The questionnaires were delivered to the vice-principals by ground mailing service and the vice-principals administered survey data collection. The questionnaire asked about safety education provided in schools, injury experience in the last year, needs for injury prevention class in school, and demographics. All survey responses were entered into SPSS worksheet. Multivariate analysis of variance (MANOVA) and descriptive discriminant analysis (DDA) were used in statistical analysis with SPSS software 11.1. Multivariate analysis of variance was conducted as a preliminary analysis of DDA. According to the result of multivariate analysis of variance, gender (man), grade (poor), living with both parents, and displaying injury prevention messages on school news board were significantly different between the injured student group and the uninjured student group (p＝ .00). These four factors also had significant effects on students' injury experience in DDA, although correlation of the four factors with injury experience was weak overall based on their canonical function coefficients. All structure coefficients of the four factors were greater than .30, which means the four factors have discriminant effects on injury prevalence. The sizes of the discriminant effects, in order, were largly from gender, grade, living with both parents, and safety message display on school news boards.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4683-4688
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• 2012

Aim: To investigate the association of transforming growth factor-beta 1 (TGF-${\beta}1$) C-509T polymorphism and susceptibility to cancer by means of meta-analysis. Methods: An extensive search was performed to identify eligible case-control studies investigating such a link. The strength of the association between TGF-${\beta}1$ C-509T polymorphism and cancer risk was assessed by pooled odds ratios (ORs) and 95%confidence intervals (95%CIs) in fixed or random effects models. Results: 55 published case-control studies with a total number of 21,639 cases and 28,460 controls were included. Overall, there was no association between TGF-${\beta}1$ C-509T and cancer risk in all genetic comparison models (TT vs. CC: OR=1.01, 95%CI=0.89-1.15; T vs. C: OR=1.01, 95%CI=0.94-1.07). However, a stratified analysis by cancer type indicated -509 T allele was significantly associated with decreased risk of colorectal cancer (CRC) (TT vs. CT/CC: OR=0.85, 95%CI=0.76-0.95), especially for Caucasians (TT vs. CT/CC: OR=0.83, 95%CI=0.71-0.98) and for population-based studies (TT vs. CT/CC: OR=0.78, 95%CI=0.68-0.89). Conclusion: This meta-analysis suggested that TGF-${\beta}1$ C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8451-8454
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• 2014

Objectives: Epidemiological studies have shown that molecular mechanisms underlying the development of lung cancers differ between smokers and unsmokers. Aberrant promoter methylation in some tumor suppressor genes is frequent in lung tumors from smokers but rare in those from non-smokers. Recently, many studies have investigated the association between cigarette smoking and RASSF1A gene promoter hypermethylation in lung cancer patients, but a unanimous conclusion could not be reached. We therefore performed this meta-analysis to derive a more precise estimation of any association. Study Design: An electronic search of PubMed and Chinese Biomedicine databases was conducted to select studies. A total of 19 case-control studies were chosen, and odds ratios (ORs) with confidence intervals (CIs) were used to assess the strength of associations. Results: The case-control studies covered 2, 287 lung cancer patients: 63.4%(1449) of the patients were smokers, 36.6% (838) were unsmokers. The overall results suggested that smokers with lung cancer had a 1.297-fold (95% CI: 1.066~1.580, p=0.010, p=0.087) higher risk for RASSF1A gene hypermethylation than the non-smokers. In the stratified analysis, an increased risk of RASSF1A gene hypermethylation in smokers than in non-smokers was found in Asian (OR=1.481, 95%CI: 1.179~1.861, p=0.001, p=0.186). Conclusions: This meta-analysis supports the idea that RASSF1A gene hypermethylation is associated with cigarette smoking-induced lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4563-4566
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• 2014

Background: To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China. Materials and Methods: A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs. Results: In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis. The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. Conclusions: These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.

• 디지털융복합연구
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• 제15권11호
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• pp.611-620
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• 2017

이 연구의 목적은 휘트니스센터 지도자의 감정노동과 직무소진 및 직무만족의 관계를 규명하는 것이다. 이를 위해 인천지역 소재 휘트니스센터에서 근무하고 있는 지도자를 모집단으로 설정, 편의표본추출법을 이용하여 총 323명의 자료를 실제 분석에 사용하였다. 분석방법은 빈도분석, 확인적 요인분석, 신뢰도 검증, 구조방정식모형 분석을 실시하였다. 이를 통해 얻어진 결론은 다음과 같다. 이 연구는 휘트니스센터 지도자의 감정노동과 직무소진 및 직무만족의 관계를 실증적으로 구명하는데 목적이 있다. 이에 본 연구결과와 논의를 통해 다음과 같은 결론을 도출하였다. 첫째, 휘트니스센터 지도자의 감정노동 중 내면행위는 직무소진에 부정적인 영향을 미치는 것으로 나타났다. 둘째, 휘트니스센터 지도자의 감정노동 중 표면행위는 직무소진에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 휘트니스센터 지도자의 직무소진은 직무만족에 부정적인 영향을 미치는 것으로 나타났다. 넷째, 휘트니스센터 지도자의 감정노동 중 내면행위는 직무만족에 긍정적인 영향을 미치는 것으로 나타났다. 다섯째, 휘트니스센터 지도자의 감정노동 중 표면행위는 직무만족에 부정적인 영향을 미치지 않는 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4599-4608
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• 2016

Background: The x-ray repair cross-complementing group 3 (XRCC3) encodes a protein involved in the homologous recombination repair (HRR) pathway for double-strand DNA repair. Associations of the XRCC3 Thr241Met polymorphism with various cancers have been widely reported. However, published data on links between XRCC3 Thr241Met and gastrointestinal (GI) cancer risk are inconsistent. Objective and Methods: A meta-analysis was conducted to characterize the relationship between XRCC3 Thr241Met polymorphisms and GI cancer risk. Pooled odds ratios (ORs) and 95.0% confidence intervals were assessed using random- or fixed- effect models for 28.0 relevant articles with 30.0 studies containing 7,649.0 cases and 11,123.0 controls. Results: The results of the overall meta-analysis suggested a borderline association between the XRCC3 Thr241Met polymorphism and GI cancer susceptibility (T vs. C: OR=1.18, 9 % CI=1.0-1.4, POR=0.04; TT vs. CT+CC: OR=1.3, 95 % CI=1.0-1.6, POR=0.04). After removing studies not conforming to Hardy-Weinberg equilibrium (HWE), however, this association disappeared (T vs. C: OR=1.00, 95 % CI=0.9-1.1, POR=0.96; TT vs. CT+CC: OR=0.9, 95 % CI=0.8-1.1, POR=0.72). When stratified by ethnicity, source of controls or cancer type, although some associations between XRCC3 Thr241Met polymorphism and GI cancer susceptibility were detected, these associations no longer existed after removing studies not conforming to HWE. Conclusion: Our meta-analysis suggests that the XRCC3 Thr241Met polymorphism is not associated with risk of GI cancer based on current evidence.

• 한국콘텐츠학회논문지
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• 제17권8호
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• pp.186-195
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• 2017

본 연구는 부모의 학대와 청소년의 삶의 만족도와의 관계에서 또래애착, 자아존중감의 매개효과를 검증함을 목적으로 한다. 이를 위하여 층화다단계집락표집에 의해 표본으로 선정된 한국아동 청소년 패널 조사의 초4패널 6차년도 자료 중 중학교 3학년 1,823명의 자료를 분석하였다. 수집된 자료는 SPSS WIN 21.0 프로그램을 이용하였고, 빈도분석, 기술통계량분석, 상관분석, 경로분석, sobel test를 하였다. 분석한 결과는 첫째, 부모의 학대가 청소년의 삶의 만족도에 유의미한 부적영향을 주었다. 둘째, 부모의 학대와 청소년의 삶의 만족도와의 관계에서 또래애착은 부분매개 효과를 나타냈다. 셋째, 부모의 학대와 청소년의 삶의 만족도와의 관계에서 자아존중감은 완전매개 효과를 나타냈다. 이러한 결과를 토대로 하여 또래애착, 자아존중감 향상방안을 제시하였다. 후속 연구자는 청소년의 삶의 만족도를 향상시킬 수 있는 다양한 환경적 요인을 추가하는 연구가 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1345-1349
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• 2014

Although many epidemiologic studies investigated the methylenetetrahydrofolate reductase (MTHFR) polymorphisms and their associations with esophageal cancer, definite conclusions could not be drawn. To clarify the effects of MTHFR polymorphisms on the risk of esophageal cancer, a meta-analysis was here performed in Chinese populations. A total of 16 studies including 3,040 cases and 4,127 controls were involved in this metaanalysis. Overall, significant associations were found between the MTHFR C677T polymorphism and esophageal cancer risk when all studies in Chinese populations were pooled into the meta-analysis (T vs. C, OR = 1.19, 95% CI = 1.06-1.34; TT vs. CC, OR = 1.35, 95% CI = 1.07-1.70; TT+ CT vs. CC, OR = 1.29, 95% CI = 1.08-1.54; TT vs. CC + CT, OR = 1.19, 95% CI = 1.03-1.37). In subgroup analyses stratified by ethnicity and source of controls, the same results were found in Kazakh (TT vs. CC, OR = 1.38, 95% CI = 1.02-1.87; TT + CT vs. CC, OR = 1.50, 95% CI = 1.03-2.18), in not stated populations (T vs. C, OR = 1.24, 95% CI = 1.08-1.42; TT vs. CC, OR = 1.47, 95% CI = 1.10-1.96; TT + CT vs. CC, OR = 1.30, 95% CI = 1.05-1.60; TT vs. CC + CT, OR = 1.32, 95% CI = 1.12-1.56), and in hospital-based studies (T vs. C, OR = 1.34, 95% CI = 1.19-1.51; TT vs. CC, OR = 1.81, 95% CI = 1.37-2.39; TT + CT vs. CC, OR = 1.51, 95% CI = 1.26-1.83; and TT vs. CC + CT, OR = 1.39, 95% CI = 1.13-1.70). In conclusion, this meta-analysis provides evidence that the MTHFR C677T polymorphism contributes to esophageal cancer development in Chinese populations.