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http://dx.doi.org/10.7314/APJCP.2014.15.11.4563

Cyclooxygenase-2 Promoter 765C Increase of Digestive Tract Cancer Risk in the Chinese Population: a Meta-analysis  

Xu, Yan-Song (Department of Emergency, First Affiliated Hospital, Guangxi Medical University)
Zhao, Bo (Department of General Surgery, First Affiliated Hospital, Guangxi Medical University)
Long, Chen-Yan (Department of General Surgery, Center Hospital)
Li, Hui (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University)
Lu, Xing (Department of Emergency, First Affiliated Hospital, Guangxi Medical University)
Liu, Gang (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University)
Tang, Xiao-Zhun (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University)
Tang, Wei-Zhong (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.11, 2014 , pp. 4563-4566 More about this Journal
Abstract
Background: To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China. Materials and Methods: A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs. Results: In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis. The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. Conclusions: These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.
Keywords
Digestive tract cancer; cyclooxygenase-2; polymorphism; meta-analysis;
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Times Cited By KSCI : 2  (Citation Analysis)
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