• Molecules and Cells
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• v.19 no.1
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• pp.137-142
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• 2005

We showed recently that ginsenosides inhibit the activity of various types of ion channel. Here we have investigated the role of the carbohydrate component of ginsenoside $Rg_3$ in the inhibition of $Na^+$ channels. The channels were expressed in Xenopus oocytes by injecting cRNAs encoding rat brain Nav1.2 ${\alpha}$ and ${\beta}1$ subunits, and analyzed by the two-electrode voltage clamp technique. Treatment with $Rg_3$ reversibly inhibited the inward $Na^+$ peak current ($I_{Na}$) with an $IC_{50}$ of $32.2{\pm}4.5{\mu}M$, and the inhibition was voltage-dependent. To examine the role of the sugar moiety, we prepared a straight chain form of the second glucose and a conjugate of this glucose with 3-(4-hydroxyphenyl) propionic acid hydrazide (HPPH). Neither derivative inhibited $I_{Na}$. Treatment with the carbohydrate portion of ginsenoside $Rg_3$, sophorose [${\beta}-D-glucopyranosyl$ ($1{\rightarrow}2$)-${\beta}-glucopyranoside$], or the aglycone (protopanaxadiol), on their own or in combination had no effect on $I_{Na}$. These observations indicate that the carbohydrate portion of ginsenoside $Rg_3$ plays an important role in its effect on the $Na^+$ channel.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.23 no.3
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• pp.218-222
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• 2014

A 3D printer was used to fabricate a micro-TAS system for biomedical applications. A polymeric medical device fabrication based on a 3D printer can be performed at atmospheric conditions. A CAD- and CAM-based system is a flexible method to design medical components, and a 3D printer is a suitable device to perform this task. In this research, a 100-micron-wide fluidic channel was fabricated with a high-aspect ratio. A cross-sectional SEM image confirmed its possible usage in a micro-reactor using 3D printers. CNC-machined samples were compared to 3D printer-fabricated samples, and the advantages and disadvantages were discussed. Based on the SEM images, the surface roughness of the 3D printed reactor was not affected by wet or dry conditions due to its manufacturing principle. An aspect ratio of 5 to 1 was achievable with 100-${\mu}$ m-wide fluid channels. No melting was found, and the shape of channels was straight enough to be used for micro reactors.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.9
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• pp.2223-2236
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• 1995

0The fields of turbomachinery and electrical generators provide many examples of flow through rotating internal passages. At the practicing Reynolds number, most of the flow motion is three dimensional and highly turbulent. The proper understanding for the characteristics of these turbulent flow is necessary for the design of thermo-fluid machinery of a good efficiency. The flow characteristics in the rotating duct with curvature are very complex in practice due to the curvature and rotational effect of the duct. The understanding of the effect of the curvature on the structure and rotational effect of the duct. The understanding of the effect of the curvature on the structure of turbulence in the curved passage and the characteristics of the flow in a rotating radial straight channel have been well studied separately by many workers. But the combined effects of curvature and rotation on the flow have not been well understood inspite of the importance of the phenomena in the practical design process. In this study, the characteristics of a developing turbulent flow in a square sectioned 90.deg. bend rotating at a constant angular velocity are measured by using hot-wire anemometer to seize the rotational effects on the flow characteristics. As the results of this study, centrifugal forces associated with the curvature of the bend and Coriolis forces and centripetal forces associated with the rotational affect directly both the mean motion and the turbulent fluctuations.

• Journal of The Korean Society of Agricultural Engineers
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• v.47 no.2
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• pp.15-21
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• 2005

This study is to trace the change of stream shape using the past series of aerial photographs, and to compare the land use changes of riparian area along the stream. For the Gyeongan national stream, aerial photographs of 1966, 1981 and 2000 were selected and ortho-photographs were made with interior orientation and exterior orientation, respectively. Apparent changes of the stream were found that the consolidated reaches of stream by levee construction became straight together with widening of their stream widths. Especially the stream width of inlet part of Paldang lake widened almost twice because of the rise of water level by dam construction in 1974. The land use of riparian areas of three selected years were classified into six categories (water, forest, agricultural land, urban area, road, sandbar) by digitizing method. The forest and agricultural lands decreased and urban area increased as the stream maintenance had been performed.

• Design & Manufacturing
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• v.1 no.1
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• pp.27-32
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• 2007

In the optical application demand for high quality lens is increasing. Plastics lenses are demanded more than glass lenses for large size lenses as well as micro-size lenses. It is difficult to apply typical straight cooling channels of injection mold to lens molding due to its non-uniform temperature distribution. In this study, we manufactured molds for plastic lenses with the conventional cooling channels and conformal cooling channels produced by the DMLS process. We evaluated cooling performance for the 2 molds by injection molding experiment. Also, uniformity of the temperature distribution was tested by infrared camera and temperature monitoring. We confirmed that the cooling performance and temperature uniformity with the conformal cooling channels is much improved from the ones with the conventional. The cooling time with the conformal cooling channels was reduced 30% compared with the conventional cooling channels.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.3
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• pp.249-253
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• 2014

PURPOSE: This study intends to examine the effects of change of anatomical position of the ankle joint in open kinematic chain, an appropriate position for selective muscle training, on vastus lateralis obliques, rectus femoris, vastus medilais obliques, and rectus abdominalis muscle activation and to present an effective method of muscle training for patients and normal people. METHODS: The participants of this study were Korean healthy adult in their 20s. The 8 channel surface electromyography was used to measure muscle activation while the subjects raised their legs under each condition. Under each condition, while the subjects raised the leg to hip joint flexion at $60^{\circ}$ along the arch. RESULTS: The analysis result of muscle activation by each section and position during leg rising. There were significant differences. CONCLUSION: For independent strengthening of each muscle, muscle activation was measured according to leg raising angles and the result differed according to each section and position. If this study result is applied to muscle training for patients who need selective muscle training, more effective muscle strengthening will be made possible.

• Transactions of the Korean hydrogen and new energy society
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• v.24 no.5
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• pp.386-392
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• 2013

Polymer electrolyte membrane (PEM) fuel cell stacks are constructed by stacking several to hundreds of unit cells depending on their power outputs required. Fuel and oxidant are distributed to each cell of a stack through so-called manifolds during its operation. In designing a stack, if the manifold sizes are too small, the fuel and oxidant would be maldistributed among the cells. On the contrary, the volume of the stack would be too large if the manifolds are oversized. In this study, we present a three-dimensional computational fluid dynamics (CFD) model with a geometrically simplified flow-field to optimize the size of the manifolds of a stack. The flow-field of the stack was simplified as a straight channel filled with porous media to reduce the number of computational meshes required for CFD simulations. Using the CFD model, we determined the size of the oxidant manifold of a 30 kW-class PEM fuel cell stack that comprises 99 cells. The stack with the optimal manifold size showed a quite uniform distribution of the cell voltages across the entire cells.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.12
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• pp.1549-1556
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• 2004

We have deigned, fabricated and compared four different types of static chaos microfluid mixers, including the mixers using straight channel flow, microblock-induced alternating whirl flow, microchannel-induced lamination flow, and combined alternating whirl-lamination flow. Among them, the alternating whirl-lamination (AWL-type) mixer, composed of 3-D rotationally arranged microblocks and dividing microchannels fabricated by conventional planar lithography process, is effective to reduce the mixing length over wide flow rate ranges. We characterize the performance of the fabricated mixers, through the flow visualization technique using phenolphthalein solution. We verify that the AWL-type microfluid mixer shows the shortest fluid mixing length of 2.8mm∼5.8mm for the flow rate range of Re=0.26∼26 with the pressure drop lower than 5kPa. Compared to the previous mixers, requiring the mixing lengths of 7∼17mm, the AWL-type microfluid mixer results in the 60% reduction of the mixing lengths. Due to the reduced mixing lengths within reasonable pressure drop ranges, the present micromixers have potentials for use in the miniaturized Micro-Total-Analysis-Systems($\mu$TAS).

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.346-352
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• 2009

The objective of the present work is to improve numerical predictions of unsteady turbulent swirling flows in the draft tubes of hydraulic power plants. We present Large Eddy Simulation (LES) results on a simplified draft tube consisting of a straight conical diffuser. The basis of LES is to solve the large scales of motion, which contain most of the energy, while the small scales are modeled. LES strategy is here preferred to the average equations strategies (RANS models) because it resolves directly the most energetic part of the turbulent flow. LES is now recognized as a powerful tool to simulate real applications in several engineering fields which are more and more frequently found. However, the cost of large-eddy simulations of wall bounded flows is still expensive. Bypass methods are investigated to perform high-Reynolds-number LES at a reasonable cost. In this study, computations at a Reynolds number about 2 $10^5$ are presented. This study presents the result of a new near-wall model for turbulent boundary layer taking into account the streamwise pressure gradient (adverse or favorable). Validations are made based on simple channel flow, without any pressure gradient and on the data base ERCOFTAC. The experiments carried out by Clausen et al. [1] reproduce the essential features of the complex flow and are used to develop and test closure models for such flows.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.85.1-85.1
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• 2011

In this study, Grafoil$^{TM}$ which has comparable electric resistance and chemical stability but is flexible, fragile, and cheap material was adopted as bipolar plates for proton exchange membrane fuel cell(PEMFC) having only one straight line flow channel. Because of its flexibility, pressurizations of cell with various pressures showed different operating characteristics compared to ordinary graphite-used PEMFC. While performances of both cells decreased as these were pressurized, investigation of ohmic and faradaic resistance by electrochemical impedance measurement indicated different tendency of change. Ohmic resistance of graphite-used cell increased with increasing pressure, which is reversed in Grafoil$^{TM}$-used cell. It is speculated that effective chemical reaction area is decreased with increasing pressure in case of graphite-used one, but because of flexible property of Grafoil$^{TM}$, gas diffusion layer in Grafoil$^{TM}$-used cell was well-activated. Different rate of change of faradaic resistances in both cells support this supposition. However, although optimum point of pressurization is found, it is required to investigate other operating conditions because of low performance compared to graphite-used cell.