• 한국음향학회지
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• 제23권2호
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• pp.162-172
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• 2004

본 연구에서는 산출실험을 통해 발화속도와 한국어의 분절음의 지속시간 및 포만트 특성과의 관계와 모음의 지속시간과 포만트 간의 상관관계를 살펴보았다. 빠른 발화일수록 음절 및 자음과 모음의 지속시간은 짧게 나타났으며 대부분의 화자에서 폐쇄음의 폐쇄구간 대 기식구간의 비율이나 한 음절 내의 모음 대 자음 지속시간의 비율은 발화속도의 영향을 받지 않는 반면 일부 화자들은 발화속도의 영향을 받는 것으로 나타났다. 발화속도의 영향을 받는 화자들에서 폐쇄음의 경우 폐쇄구간이 기식구간보다 영향을 더 받으며 음절의 경우 모음이 자음보다 더 영향을 받는 것으로 나타났다. 발화속도와 모음의 포만트값과의 관계 분석 결과 발화속도가 모음약화에 영향을 미치는 정도가 화자간에 차이를 보였으며 이는 화자마다 모음의 포만트값 구현에 관하여 다른 발화기재를 이용하고 있다는 것을 간접적으로 시사해주는 것이라고 할 수 있다. 즉, 발화속도의 증가에 따라 조음기관의 움직임의 속도를 증가시키는 화자가 있는 반면 발화속도의 변화에 관계없이 일정한 속도를 유지하는 화자가 있다는 것을 의미한다.

• 동의신경정신과학회지
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• 제17권1호
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• pp.59-78
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• 2006

Objective : This research investigates the effect of the CMT and SCMT on Alzheimer's disease. Methods : The effects of the CMT and SCMT on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA; (5) the infarction area of the hippocampus in Alzheimer's disease mice induced with CT105 & ${\beta}A$ were investigated Rresults : 1. The CMT and SCMT suppressed the expression of APP, AChE mRNA in PC-12 cells treated with CT-105 2. The CMT and SCMT suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and SCMT group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency 4. The CMT and SCMT suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA in the mice with Alzheimer's disease induced by ${\beta}A$. 5. The CMT and SCMT reduced the infarction area of hippocampus with Alzheimer's disease induced by ${\beta}A$. Conclusions : These results suggest that the CMT and SCMT may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CMT and SCMT for Alzheimer's disease is suggested for future research.

• Asian-Australasian Journal of Animal Sciences
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• 제17권1호
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• pp.33-38
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• 2004

This study was aimed at testing the gene expression of antioxidant enzymes and apoptosis genes for in vitro culture in porcine embryos produced by in vitro maturation/in vitro fertilization (IVM/IVF). Pocine preimplantation embryos obtainted from IVM/IVF can be successfully culture in vitro, but they are delayed or stop to develop at specific developmental stage. Many factors such as reactive oxygen species and apoptosis in an IVM/IVF system followed by in vitro culture influence the rate of production of viable blastocysts. Porcine embryos derived from IVM/IVF were cultured in the atmosphere of 5% $CO_2$ and 20% $O_2$ at $38.5^{\circ}C$ in NCSU23 medium. The patterns of gene expression for antioxidant enzymes and apoptosis genes during in vitro culture in pocine IVM/IVF embryos were examined by the modified semi-quantitative single cell reverse transcriptase-polymerase chain reaction (RT-PCR). Porcine embryos produced by in vitro procedures were expressed mRNAs for CuZn-SOD, GAPDH and GPX, whereas transcripts for Mn-SOD and catalase were not detected at any developmental stages. Expression of caspase-3 mRNA was detected at 2 cell, 8 cell 16 cell and blastocyst, but p53 mRNA was not detected at any stages. The fas transcripts was only detected in blastocyst stage. These results suggest that various antioxidant enzymes and apoptosis genes play crucial roles in vitro culture of porcine IVM/IVF embryos.

• 한국철도학회논문집
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• 제18권4호
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• pp.391-400
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• 2015

본 연구는 철도관광정책 직무만족도 영향요인을 분석하여 철도관광정책 직무만족도에 대한 제언을 제시할 목적으로 철도공사에 근무하는 350명의 직원들을 대상으로 설문조사를 실시하였다. 선행연구를 통하여 직무만족도에 영향을 미치는 것으로 연구된 영향요인과 직무만족도가 철도현업 종사원의 개인적 속성에 의해 어떤 차이가 나타나는지를 검정하며, 대분류 요인(부분목표)과 소분류 요인(세부목표)간에 미치는 영향요인을 분석하였다. 분석결과 국가지원 부분목표는 기반시설 확충과 철도연계관광 효율성 제고 항목과 유의미한 관련이 있으며, 인적자원 확보 부분목표는 인재배출 교육기관의 필요성과 one-stop 인재확보 항목과 유의미한 관련이 있는 것으로 나타났다. 또한 철도 관광 상품개발 부분목표는 관광객의 욕구충족상품 개발과 공동컨소시엄 개발과 유의미한 관련성이 있으며, 고정 관념적 사고의 전환 분분목표는 무사 안일주의사고 탈피와 수요예측전문성 발휘와 유의미한 관련성이 있는 것으로 조사되었다.

• 동의생리병리학회지
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• 제20권6호
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• pp.1658-1663
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• 2006

Panax notoginseng (Buck) F.H chen. root (PNS) is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Korean and Chinses medicine. The pharmacokinetic profiles of the main PNS are still not accurately investigated. Our preliminary aim is to elucidate the pharmacokinetics features of the PNS in rats. Objective of this study is to determine whether PNS affects hepatic microvascular dysfunction elicited by gut ischemia and reperfusion (I/R), since gut I/R causes hepatic microvascular dysfunction, and to investigate the role of nitric oxide (NO). No has been found to be a modulator of the adhesive interactions between platelet and endothelial cells. Male Wistar rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor the number of non-perfused sinusoids (NPS). In another set of experiments, PNS (1 g/kg pre day intragastrically) was administered to rats for 7 days. In some experiments, dexamethasone (ST) (2 mg/kg per day intravenously) was administered. In control rats, gut I/R elicited increases in the number of NPS, and plasma TNF-${\alpha}$ and ALT activities, and these changes were mitigated by the pretreatment with PNS. Pretreatment with an No synthase inhibitor diminished the protective effects of PNS on the increase in NPS and plasma TNF-${\alpha}$ levels, but not its effect on the increase in plasma ALT activities. Pretreatment with PNS increased plasma nitrite/nitrate levels. The responses caused by gut I/R were attenuated by the pretreatment with ST. Pretreatment with an NO synthase inhibitor did not affect the effect of ST. These results suggest that PNS attenuates the gut I/R-induced hepatic microvascular dysfunction and inflammatory responses such as TNF-${\alpha}$ production in the early phase via enhancement of NO production, and sequential hepatocellular damage via its anti-inflammatory effect like corticosteroid effect.

• 수산해양기술연구
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• 제53권3호
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• pp.276-285
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• 2017

The research vessel NARA equipped with an azimuth thruster system was built in 2015. There are few vessels with this propulsion system in Korea. This vessel has two modes such as the normal for maneuvering and the power for investigation, and the other two modes as one axis and two axes on the operating. This type of vessels does not seem to have a clear grasp of the maneuvering character in comparison with the vessel with a conventional propulsion system. So the authors carried out the sea test for the turning, the zigzag and the inclination, and the results are as follows. In turning test, the case of using the two axes mode is much better than the case of using the one axis mode for the elements of turning, such as advance, transfer, tactical diameter and final diameter, but turning hard over the rudder in full speed is very vulnerable to capsize in both modes. In zigzag test, the yaw quicking responsibility index, T is very large excessively, which means a bad counter maneuvering ability, so an operator has to keep in mind that in turning operation. If necessary to avoid collision at head on situation, it may be a more effective method to use the crash astern stop than the turning according to the conditions and circumstances for the shortest stopping distance is very short.

• 한국축산식품학회지
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• 제41권1호
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• pp.16-33
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• 2021

To stop hunger, reducing food losses is a potential movement towards saving food. A large portion of these losses could be avoided and reduced through the improved food chain in many countries. Raising awareness on how and where food losses occur will help recovering foods such as meat by identifying solutions and convincing people to implement those solutions. This, in turn, will lead to private and public efforts to recover meat that might be otherwise wasted. After highlighting the importance of food saving benefits and relevant statistics, this paper explains the possible ways to reduce meat loss and waste in abattoirs and presents a framework for prevention according to the estimates of meat losses in Iran meat supply. The current article answers the questions of where do we have the meat loss in Iran and what approaches are most successful in reducing losses in the meat industry. The national average loss and waste in meat production are about 300,000 metric tonnes (about 15%). Many segments and players are involved with this huge amount of losses in the meat value chain, a large portion of these losses could be avoided and reduced by about 25% through using by-products with the mechanization of design and manufacturing. The production amount of mechanically deboned meat (MDM) is 105,091,000 kg, concluding the major waste (88.33%) of total poultry losses. Ensuring appropriate actions by exploiting the full potential of engaged Iranian associations and institutes is considered to reduce the losses.

• 대한본초학회지
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• 제28권1호
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• pp.9-14
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• 2013

Objectives： Bletillae Rhizoma, the roots of Bletilla striata, is used to restrain the leakage of blood and stop bleeding. It can cure the sores, ulcers, and chapped skin. This study was designed to investigate the collagen metabolism, elastase and tyrosinase activity of Bletillae Rhizoma extract (BR). Methods : The effects of BR on type I procollagen production and collagenase activity in human normal fibroblasts Hs68 after UVB (312 nm) irradiation were measured by ELISA method. The elastase activity, tyrosinase activity, and L-DOPA oxidation after treatment of BR were measured as well. Results : In the present study, the collagen production (type I procollagen) was significantly increased to $15.7{\pm}1.8$ ng/ml at a concentration of BR 100 ${\mu}g/ml$ in UVB damaged Hs68 cells. The increased collagenase activity after UVB damage was significantly recovered to $42.7{\pm}0.7%$, $54.5{\pm}3.5%$, and $38.4{\pm}0.9%$ by BR 10, 30, and 100 ${\mu}g/ml$. The activities of BR 10 mg/ml on tyrosinase activity was significantly reduced to $45.1{\pm}8.4%$ as well. However, there were no significant effects on the elastase activity and the L-DOPA oxidation. Conclusion : BR showed the promoting effects of collagen synthesis and inhibitory effects of collagenase activity in Hs68, human normal fibroblast cells. And these could be thought to have the anti-wrinkle effects and whitening effects in vitro. These results suggest that BR may have potential as an anti-aging ingredient in cosmetic treatment.

• 한국항만경제학회지
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• 제20권1호
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• pp.123-140
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• 2004

With the globalization of economy, there is keen competition among rountries to be a logistics hub and companies are striving to be first in establishing logistics system centering on advantageous sites, especially airport and seaports, to perform supply, production and distribution. Korea competing with Northeast Asia countries is also working out strategies in order to make Korea peninsula a logistics center of Northeast Asia taking advantage of its geographical strength. Gwangyang port has designated as Free Economic Zone together with Pusan and Jinhae, Incheon from October 24th, 2003. However, the introduction of Free Economic Zone in Korea lagged behind other major countries and it has a lot of operational problems. Approximately 600 areas worldwide are designated and operated as a Free Economic Zone and Gwangyang port and its surrounding area has several points to be settled as one of FEZ. First one is its limited functions and related laws. Next is imperfection on development, investment and management system of the hinterland. Lark of promotion activities could be one of the problems. This paper analyzes the above problems and presents various measures to activate Gwangyang Port and Gwangyang Free Economic Zone as follows Benchmarking to promote Gwangyang Free Economic Zone as follows Benchmarking other countries' system, governmental support, introduction & logistics functions, early development of the hinterland, supply of effective one-stop service, investment attraction into the area and diversified promotion & marketing activities.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2005년도 춘계 학술기술논문발표대회 논문집
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• pp.125-131
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• 2005

Recently, to improve condition car park, using surface finishing material for variety color and property epoxy resin, urethane, cement mixed resin mortar or polymeric resin, and so on. However, it is frequent noise and wear out of tier and waterproofing materials, when the car slip or stop in car park, To minimize these cases, It is necessary that reduction of repair cost through performance long term durability of surface finishing material, improvement inside condition such as reduce dirty and car accident and ensurance the expected life of concrete slab in car park. Especially, we have not any tech for quality control, construction tech, production technology for car park surface materials, that's why park slab is not safety and suffer a loss. For this problems, this paper is to test surface finishing materials and as that result, suggest quality standard in the car park.