• Journal of Ginseng Research
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• v.47 no.4
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• pp.543-551
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• 2023

Background: Panax ginseng Meyer is a representative Chinese herbal medicine with antioxidant and anti-inflammatory activity. 20(S)-Protopanaxadiol (PPD) has been isolated from ginseng and shown to have promising pharmacological activities. However, effects of PDD on pulmonary fibrosis (PF) have not been reported. We hypothesize that PDD may reverse inflammation-induced PF and be a novel therapeutic strategy. Methods: Adult male C57BL/6 mice were used to establish a model of PF induced by bleomycin (BLM). The pulmonary index was measured, and histological and immunohistochemical examinations were made. Cell cultures of mouse alveolar epithelial cells were analyzed with Western blotting, coimmunoprecipitation, immunofluorescence, immunohistochemistry, siRNA transfection, cellular thermal shift assay and qRT-PCR. Results: The survival rate of PPD-treated mice was higher than that of untreated BLM-challenged mice. Expression of fibrotic hallmarks, including α-SMA, TGF-β1 and collagen I, was reduced by PPD treatment, indicating attenuation of PF. Mice exposed to BLM had higher STING levels in lung tissue, and this was reduced by phosphorylated AMPK after activation by PPD. The role of phosphorylated AMPK in suppressing STING was confirmed in TGF-b1-incubated cells. Both in vivo and in vitro analyses indicated that PPD treatment attenuated BLM-induced PF by modulating the AMPK/STING signaling pathway. Conclusion: PPD ameliorated BLM-induced PF by multi-target regulation. The current study may help develop new therapeutic strategies for preventing PF.

• The Korean Journal of Emergency Medical Services
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• v.17 no.1
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• pp.63-78
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• 2013

Purpose : This study aimed to improve quality of prehospital emergency care for the insect bite patients by figuring out its current situations and problems. Methods : This study was conducted to 219 insect bite patients who were transferred to the hospital by 119 ambulance in D-City from July 1, 2009 to June 30, 2011. This study was a descriptive study by 119 run sheets. A total of 171 emergency medical technicians(EMTs) working in D-city and C-province completed the questionnaire. All of data were analyzed by SPSS 18.0. Results : Among the 219 patients, bee sting accounted for 62.6% and wasp sting accounted for 20.1%. Some patients complained of dizziness, headache, dyspnea, and disturbance of consciousness. The 119 EMTs initially treated the patients with oxygen supply to 57 patients (31.1%). Knowledge toward insect bite was statistically significant (p=.000) between advanced EMTs and basic EMTs. The obstacle to the prehospital care, many EMTs answered that the obstacle was due to the lack of 119 EMTs. Conclusion : It is necessary to differentiate the patients' symptoms and provide the better prehospital emergency care to verify the exact symptoms and signs.

• Journal of Yeungnam Medical Science
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• v.33 no.2
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• pp.134-137
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• 2016

Bee sting causes mild symptoms such as urticaria and localized pain, and severe symptoms including anaphylaxis, cardiovascular collapse, and death. We reported on a patient with arterial thrombotic occlusion and severe ischemia in the lower limb after multiple bee stings. The patient was stung 5 times and complained of pallor, pain, and coldness in the left toe, and did not have dorsalis pedis pulsation. Computed tomography angiography showed multiple thrombotic occlusion of the anterior and posterial tibial artery below the knee. Local thrombolytic therapy using urokinase was administered and the occluded arteries were successfully recanalized.

• The Korean Journal of Soil Zoology
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• v.9 no.1_2
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• pp.12-15
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• 2004

Five isolates of Belonolaimus longicaudatus collected from different geographical locations and hosts in southeastern United Stated were tested to determine their host specificity and reproductive compatibility. Both the Georgia and Lake Alfred isolates reproduced well on cotton, bermudagrass, and citrus. On the other hand, the North Carolina and Gainesville isolates reproduced poorly on all crops. The Hastings isolate reproduced well on cotton and potato. The Lake Alfred and Hastings isolates showed greater host specificity to their original host of citrus and potato, respectively. Except for the Hastings isolate, all isolates reproduced poorly on potato, which clearly differentiated the Hastings isolate from others (P>0.05). Hybridization test presented reproductive compatibility among five different isolates of B. longicaudatus by generating F$_1$ offspring. The Gainesville males showed comparatively poor ability to fertilize other females and generated a lower number of offspring. In contrast, the North Carolina males were attracted by all the other isolates of sting nematode, and produced the highest number of juveniles.

• Journal of East-West Nursing Research
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• v.3 no.1
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• pp.17-26
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• 1998

The purposes of this study were to identify the contents, frequency of use, and the rationales of folk remedies frequently used for first aid at home for stomachache, vomiting, strain, food poisoning, vaginal bleeding, or wounds of snake or dog bite, or bee sting. As the method of the study, data were collected by conducting a questionnaire of 185 persons, who filled it out or who were interviewed from May to August in 1998. The collected data was analyzed by using frequency and the rationales for the contents of the folk remedies were described base on literatures. The results were as follows,. 1. The folk remedies for stomachache in frequency order were 'warming the abdomen', 'rubbing the abdomen with a hand', or 'pricking a finger to bleed', which have the rationals. 2. The folk remedies for vomiting in frequency order are 'drinking water of watery radish' and 'pricking a finger to bleed', which have the rationales. 3. The folk remedies for strain in frequency order are 'soaking the affected area into cold water or applying an ice pack' and 'after soaking jasmine in water, making a dough with flour, and then attaching it on the affected area', which have the rationales, Additionally, although the frequencies are low, 'drinking brewed Achyranthis Radix' and 'applying brewed leaves and stalks of Sambuci Cortex' have the rationales. 4. The folk remedies for food poisoning in frequency order are 'drinking black beans and licorice brewed together' and 'eating mung beans', which have the scientific grounds. 5. The folk remedies for bloody discharge in frequency order are 'drinking brewed lotus root' and 'eating boiled chicken stuffed with root of bell-flower'. However, 'drinking brewed Thujae orientalis Folium' has the rationales. 6. The folk remedy for snake bite wounds that has the scientific grounds is 'sucking blood by a person without hurt in the mouth'. However, quite a lot of people apply alum or soy paste, which has no rationales. 7. The folk remedies for the bee sting in frequency order are 'after removing the sting, applying soy paste or sauce' and 'applying saliva'. No rationales for 'applying saliva' have been found. 8. The folk remedy for the dog bite wound that has the rationales is 'applying juice of leaves or stalks of Xanthii Fructus'. However, 85% of surveyed people use remedies that have no scientific grounds, such as 'applying burnt dog hair mixed with (sesame) oil' and 'applying soy paste or sauce'. Various materials are used in folk remedies for first aid treatment as shown above. Some of the folk remedies have the rationales since their medicinal actions have been found. However, the medicinal actions of the majority have not been found, but only known that they are effective, Especially for the materials except botanical drugs, they are used without knowing the effects since their components and pharmacognosies have not been described in any literature. The results of this research may be used for materials to educate the surveyed people or to consult them. Accordingly, the folk remedies that have the rationales are required to continue to study to find out the effects.

• 한국전산유체공학회:학술대회논문집
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• 1995.10a
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• pp.213-218
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• 1995

마하수 4일때 초음속 풍동의 벽면과 모델지지부의 간섭에 관해 연구하였다. 특히 모델지지부 주위에서의 충격파 형성과 sting, strut 그리고 second throat에서의 반사 충격파의 상호 작용에 연구의 촛점을 두었다. 수치 기법은 내재적 플럭스 차분 분할기법 (implicit flux-difference splitting technique)을 사용하였다. 2차원과 3차원 유동해석 결과로부터 모델지지부 후류의 유동에 미치는 diffuser 출구 경계조건의 영향을 알아보았다.

• Journal of agricultural medicine and community health
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• v.20 no.2
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• pp.169-174
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• 1995

The case was described of a 31 year old female who developed fusiform swelling of the right third finger at the site of puncture by sea urchin spine. We observed a radiopaque linear material suggesting a remnant spine which the size was 2.4 mm in sonography and mammography. We confirmed that it exhibits a urchin spine and distinct caseous necrosis with central calcification. Sea urchins(Echinoidea) are ubiquitous marine creatures that resemble pincushions and are covered by calcareous skeletons surrounded by numerous movable calcium carbonate spines. The sharp spines are brittle and easily detach when touched by the victim. Contact with sea urchin spines produces intense pain, some localized erythema and edema. Inflammation develops in response to retained fragments. Granulomas 1-5 mm in diameter develop rarely 2-12 months after envenomation. In treatment, hot water immersion and thorough wound cleansing are advisable. Analgesics may, be necessary after hot water immersion. Attempts to remove these spines should be performed with good lighting sources, preferably with radiological direction. Chronic granulomas usually require complete excision. Acetone has been suggested for rapid resolution of pain. No antidotes are available.

• Journal of The Korean Society of Clinical Toxicology
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• v.8 no.1
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• pp.30-36
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• 2010

Purpose: The purpose of this study is to analyze the clinical characteristics of anaphylaxis and anaphylactic shock caused by bee venom. Methods: We retrospectively collected the data of the patients who experienced anaphylaxis caused by natural bee sting or acupuncture using bee venom from January 1999 to December 2008. Seventy subjects were divided into the shock and non-shock groups. The clinical characteristics, sources of bee venom, treatments and outcomes were compared between the two groups. Results: The mean age of the subjects was $45.5{\pm}16.3$ years old and the number of males was 44 (62.9%). There were 25 patients in the shock group and 45 in the non-shock group. The age was older (p=0.001) and females (p=0.003) were more frequent in the shock group. Transportation to the hospital via ambulance was more frequent in the shock group (p<0.001). No difference was found in species of bee between the two groups. The cephalic area, including the face, was the most common area of bee venom in both groups. Anaphylaxis caused by bee sting commonly occurred between July and October. Cutaneous and respiratory symptoms were the most frequent symptoms related to anaphylaxis. Cardiovascular and neurologic symptoms were more frequent in the shock group. The amount of intravenously administered fluid and subcutaneous injection of epinephrine were much more in the shock group than that in the non-shock group. Conclusion: Older age was the factors related to anaphylactic shock caused by bee venom. Further validation is needed to evaluate the gender factor associated with shock.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.9
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• pp.27-33
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• 2005

This research presents the influence of the base region modeling on the aerodynamic characteristics of a launch vehicle using CFD. The vicinity of a launch vehicle is divided into four zones, and four computational cases are made using these four zones. The aerodynamic coefficients are predicted for the angle-of-attack of 6 degrees and Mach numbers ranging from 0.4 to 2.86. It was found that modeling of the base region should not be neglected for the prediction of the aerodynamic characteristics of a launch vehicle in subsonic and transonic regions. It was also found that the modeling of the sting support used in the wind tunnel test is necessary to get a better agreement with the experiments.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.58 no.1
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• pp.19-31
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• 2022

Damages by jellyfish are occurring frequently around the world. Among them, accidents caused by jellyfish stings are serious enough to cause death. So we designed a jellyfish blocking net and analyzed its stability to prevent sting caused by jellyfish entering the beach. To this end, the dynamic behavior of the jellyfish blocking net according to the current speed (0.25-1.0 m/s) and the net type (50, 100 and 150 mm) on the upper part of the blocking net was modeled using the mass spring model. As a result of simulations for the model, the horizontal tension (horizontal component of the mooring tension) of the mooring line increased with the decrease in the mesh size on the upper part of the blocking net at all current speeds, but exceeded the holding force at high tides faster than 0.5 m/s and exceeded the holding force at all current speeds at low tide. Therefore, the jellyfish blocking nets showed poor stability overall. The depth of the float line had a little difference according to the upper mesh size and increased lineary proportional to the current speed. However, the float line sank too much to block the incoming jellyfish. These analysis results helped us find ways to improve the stability of the jellyfish blocking net, such as adjusting the length of the mooring line and improving the holding power. Therefore, it is expected that this technology will be applied us various underwater structures to discover the weaknesses of the structures and contribute to increasing the stability in the future.