• 한국추진공학회지
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• 제24권5호
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• pp.56-64
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• 2020

29.7% 축소 NASA 표준 연구 모형에 대하여 소형 저속 풍동에서 시험을 수행하였다. 풍동시험 모형은 NASA Langley 연구소와 AIAA 항력추정 워크숍 위원회의 지침에 따라 알루미늄으로 제작하였다. 풍동의 능력 한계 등으로 상대적으로 낮은 레이놀즈수인 0.3 × 10⁶ 에서 정적 힘과 모멘트를 측정하였다. 세 가지 타입(핀 스팅, 블레이드 스팅, 벨리 스팅) 모형지지부에 대하여 피칭모멘트를 비교하였다. 보정된 벨리 스팅과 핀 스팅에 의한 피칭모멘트 보정량은 비슷하였으며 블레이드 스팅에 의한 피칭모멘트 값이 가장 적었다.

• Journal of Acupuncture Research
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• 제26권1호
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• pp.135-151
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• 2009

Objectives : To survey concept, meaning, and problems of beekeeper's bee sting therapy by reviewing and summarizing outline, indications, and clinical cases of 'Research on Bee Sting Therapy' described in Monthly Yangbonggye. Methods : As a narrative review, literature researches were carried out based on 'Research on Bee Sting Therapy' in Monthly Yangbonggye in the aspects of outline, indications, and clinical cases. In the concrete, outline was just summarized and described, and indications were categorized by recent version of international statistical classification of diseases and related health problems(ICD) of WHO(World health organization), and clinical cases were collected and summarized from the viewpoint of acupoints and methods of therapy. Results : 1. Bee sting therapy is to inject venom into skin by stimulating affected lesions or acupoints on meridian with sting of bee alive for therapeutic purposes. It can be divided into two classes(direct stimulation(直針法) and indirect stimulation(拔針法)) by the differences of methods, and is different from bee venom acupuncture therapy in the aspects of the way of extraction and injection. 2. In this material, bee sting therapy has 83 indications classified into 17 of 22 chapters of ICD. Among clinical cases, cases on neoplasm, goitre, lump, and haemorrhoids by direct stimulation were especially outstanding. 3. The therapeutic acupoints selected in bee sting therapy are mainly Ashi points(阿是穴), and partly acupoints on meridian(經穴), Extra points(經外奇穴), and New points(新穴) with careful consideration of patients' condition. Conclusions : Although bee sting therapy has more or less controversial points of diagnosis, treatment, and management of side effects, it is thought that the accumulated and inherited experiences from old times can be used as meaningful material by further experimental and clinical researches.

• Fisheries and Aquatic Sciences
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• 제21권3호
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• pp.5.1-5.8
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• 2018

Stimulator of interferon gene (STING) is induced by various inflammatory agents, such as lipopolysaccharide and microbial pathogens, including virus and bacteria. In this study, we obtained a full-length cDNA of a STING homolog from olive flounder using rapid amplification of cDNA ends PCR technique. The full-length cDNA of Paralichthys olivaceus STING (PoSTING) was 1442 bp in length and contained a 1209-bp open reading frame that translated into 402 amino acids. The theoretical molecular mass of the predicted protein sequence was 45.09 kDa. In the PoSTING protein, three transmembrane domains and the STING superfamily domain were identified as characteristic features. Quantitative real-time PCR revealed that PoSTING expressed in all the tissues analyzed, but showed the highest level in the spleen. Temporal expression analysis examined the significantly upregulated expression of PoSTING mRNA after viral hemorrhagic septicemia virus (VHSV) stimulation. In contrast, no significant changes in the PoSTING expression were detected in Edwardsiella tarda-challenged group compared to the un-injected control. The expression of P. olivaceus type I interferon (PoIFN-I) was also highly upregulated upon VHSV challenge. These results suggest that STING might be involved in the essential immune defense against viral infection together with the activation of IFN-I in olive flounder.

• BMB Reports
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• 제52권5호
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• pp.336-341
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• 2019

The cGAS-STING pathway plays an important role in pathogen-induced activation of the innate immune response. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) found predominantly in the synovial fluid of osteoarthritis (OA) patients increases the expression of catabolic factors via the toll-like receptor-2 (TLR-2) signaling pathway. In this study, we investigated whether 29-kDa FN-f induces inflammatory responses via the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon gene (STING) pathway in human primary chondrocytes. The levels of cGAS and STING were elevated in OA cartilage compared with normal cartilage. Long-term treatment of chondrocytes with 29-kDa FN-f activated the cGAS/STING pathway together with the increased level of gamma-H2AX, a marker of DNA breaks. In addition, the expression of pro-inflammatory cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF/CSF-2), granulocyte colony-stimulating factor (G-CSF/CSF-3), and type I interferon ($IFN-{\alpha}$), was increased more than 100-fold in 29-kDa FN-f-treated chondrocytes. However, knockdown of cGAS and STING suppressed 29-kDa FN-f-induced expression of GM-CSF, G-CSF, and $IFN-{\alpha}$ together with the decreased activation of TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and inhibitor protein ${\kappa}B{\alpha}$ ($I{\kappa}B{\alpha}$). Furthermore, NOD2 or TLR-2 knockdown suppressed the expression of GM-CSF, G-CSF, and $IFN-{\alpha}$ as well as decreased the activation of the cGAS/STING pathway in 29-kDa FN-f-treated chondrocytes. These data demonstrate that the cGAS/STING/TBK1/IRF3 pathway plays a critical role in 29-kDa FN-f-induced expression of pro-inflammatory cytokines.

• 한국항공우주학회지
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• 제30권8호
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• pp.30-36
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• 2002

풍동시험 모형은 모형 지지부 삽입 등으로 실제 비행체와 다른 형상을 갖게 된다. 이러한 형상의 차이는 비행시험과 다른 힘과 모멘트를 발생시키게 되므로 이에 대한 보정은 필수적이다. 이러한 보정에는 cavity 압력 보정, 모형 지지부 간섭 보정 등이 있다. 본 시험에 사용된 모형은 내장밸런스와 함께 벨리 스팅 지지부를 사용하였으며 보정을 위하여 모형지지부 두께변화 방법과 더미 스팅 방법, wire support 방법의 시험결과를 비교하였다. 모형 지지부 두께 변화 방법은 간섭이 거의 없는 것으로 알려진 wire support 방법과 시험결과가 잘 일치하였다.

• 한국항공우주학회지
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• 제49권3호
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• pp.167-174
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• 2021

NASA Common Research Model의 29.7% 축소 모형에 대하여 저속 풍동시험 조건으로 수치해석을 수행하였다. 낮은 레이놀즈수 영역인 0.3×106에서 Belly sting 모형 지지부를 장착한 CRM의 공력계수를 측정하는 시험이 수행되었으며, 수치해석 결과와 비교하였다. 해석의 타당성을 검증하기 위해 선행연구 조건으로 전산해석을 수행하여 비교하였다. Belly sting 모형 지지부 유무에 대한 해석 결과 지지부에 의한 간섭 효과로 동체뿐만 아니라 주날개, 꼬리날개까지 공력에 영향이 있음을 확인하였다.

• 한국항공우주학회지
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• 제48권10호
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• pp.753-763
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• 2020

29.7% 축소 NASA Common Research Model을 벨리 스팅 모형지지부에 장착하여 저속에서 풍동시험을 수행하였다. 다양한 형상의 페어링을 장착한 벨리 스팅 모형지지부에 대하여 공력계수를 측정하는 시험을 수행하였으며 그 결과를 고찰하였다. 벨리 스팅 모형지지부에 장착된 CRM 형상을 이용하여 힘과 모멘트를 측정하였다. 벨리 스팅 페어링 형상 변화에 따른 피칭모멘트로부터 벨리 스팅 간섭 효과를 감소시키는 형상을 찾았다. 전산해석을 통해 벨리 스팅 모형지지부의 간섭과 시험부 페어링의 간섭 감소효과를 확인하였다.

• Molecules and Cells
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• 제38권5호
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• pp.441-451
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• 2015

Recognition of cytosolic DNA initiates a series of innate immune responses by inducing IFN-I production and subsequent triggering JAK1-STAT1 signaling which plays critical roles in the pathogenesis of infection, inflammation and autoimmune diseases through promoting B cell activation and antibody responses. The stimulator of interferon genes protein (STING) has been demonstrated to be a critical hub of type I IFN induction in cytosolic DNA-sensing pathways. However, it still remains unknown whether cytosolic DNA can directly activate the JAK1-STAT1 signaling or not. And the role of STING is also unclear in this response. In the present study, we found that dsDNA directly triggered the JAK1-STAT1 signaling by inducing phosphorylation of the Lyn kinase. Moreover, this response is not dependent on type I IFN receptors. Interestingly, STING could inhibit dsDNA-triggered activation of JAK1-STAT1 signaling by inducing SHP-1 and SHP-2 phosphorylation. In addition, compared with normal B cells, the expression of STING was significantly lower and the phosphorylation level of JAK1 was significantly higher in B cells from MRL/lpr lupus-prone mice, highlighting the close association between STING low-expression and JAK1-STAT1 signaling activation in B cells in autoimmune diseases. Our data provide a molecular insight into the novel role of STING in dsDNA-mediated inflammatory disorders.

• 국방과기술
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• 3호통권145호
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• pp.17-25
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• 1991

Sting Ray는 현대의 첨단기술로 제작된 경어뢰로서, 완전히 디지털 컴퓨터 제어에 의해 작동한다. 항공기에 장착된 유도미사일과 그 기능을 견줄수 있는 최첨단 수중유도무기이며, 수중에서의 음파탐지 및 식별에 수반되는 각종 난관을 극복하였다. 수중에서의 음의 반사 및 굴절효과로 인해 복잡성이 가중된 잡음의 근원과 바닷물의 특성이 수시로 변화되는 상황에서 음향장치 사용을 결정하는 것은 매우 어려운 과제이나, Sting Ray는 이러한 어려운 환경을 극복할수 있도록 설계되었다. 또한 선박, 항공기 또는 헬기등 어디에서 발사되더라도 자율적으로 자체의 전술을 창조하는 Shaped Charge형 탄두는 어떠한 표적에도 치명적 피해를 줄수 있다

• Parasites, Hosts and Diseases
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• 제52권6호
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• pp.681-684
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• 2014

Hymenoptera stings can cause serious injury to humans. We report the clinical findings of 6 cases of Hymenoptera stings. All patients developed painful erythematous papules at the sting sites and had a past history of parasitoid wasp sting. This is the first clinical report of the parasitoid wasp, Cephalonomia gallicola, causing human stings in Korea.