• 청정기술
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• 제20권3호
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• pp.226-231
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• 2014

본 연구는 미세 몰드 기술을 이용하여 산세기 자극에 따라 모양이 변화하는 야누스 입자를 제조하는 방법에 관한 것이다. 야누스 입자는 산세기(pH) 응답형 단량체인 acrylic acid (AA)를 사용하여 친수성 부분을 제조하고, trimethylolpropane triacylate (TMPTA)를 사용하여 소수성 부분을 제조하였다. 제조된 야누스 입자는 산세기 변화에 따라서 친수성 부분의 팽윤이 유도되며 결과적으로 자극 응답성을 가짐을 증명 하였다. 자극 응답성 정도는 산세기의 범위 또는 AA의 조성을 다양화 함으로써 제어가 가능하다. 더 나아가 야누스 입자의 양쪽 부분이 반대 전하를 띄는 특성을 부여하기 위해 AA와 2-(dimethylamino)ethyl methacrylate (DAEMA)를 사용하여 양극성 야누스 입자를 제조하였다. 양극성 야누스 입자는 동일한 산세기 조건에서 서로 다른 팽윤율을 갖게 되며 비대칭적 형상을 띄게 된다. 결론적으로, 본 연구에서는 야누스 입자의 친수성 부분에 산세기 응답형 단량체를 사용함으로써, 산세기 자극에 의해 가역적으로 모양 변형이 가능한 야누스 입자를 제조하였다. 본 연구를 통해 제조된 자극 응답형 야누스 입자는 향후 바이오 센서나 검출 기구 등에 활용 될 것으로 기대한다.

• 생명과학회지
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• 제29권8호
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• pp.922-940
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• 2019

비만은 에너지 섭취와 소비의 불균형으로 인해 유발되는 비정상적인 지방 축적으로, 근래에 다양한 만성질환을 초래하는 주요 국제 보건 문제로 부상하였다. 이러한 이유로, 비만 문제에 대한 여러 해결책들이 제시되고 있다. 에너지를 저장하며 내분비 작용을 하는 백색 지방과 달리 열을 생성하여 에너지를 발산하는 두 종류의 지방조직인 갈색 지방과 베이지색 지방이 성인에 존재하며 외부 자극에 의해 유도될 수 있다는 것이 밝혀진 이래로, 이들은 비만 치료의 유망한 표적으로서 각광받고 있다. 이러한 외부 자극 중, 인간 장관계에서 인간과 공존하는 장내 미생물총은 다양한 대사 작용에 참여하며, 이를 조절하는 것이 여러 대사 질환의 치료에 유력한 작용을 할 것으로 보인다. 따라서, 다양한 연구에서 항비만 치료가 장내 미생물 환경 전환이나 갈색 지방 조직 활성화에 미치는 영향에 초점을 맞추고 있다. 본 총설에서는 비만과 체중 증가, 대사 질환을 해소하는 것으로 알려진 자극과, 장내 미생물총의 변화나 갈색지방의 활성화를 야기하는 자극과, 이 자극들과 장내 미생물총의 조작, 지방조직의 갈색화 사이에서 알려져 있거나 있을 수 있는 상관관계를 중점적으로 다루고자 한다.

• 감성과학
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• 제25권3호
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• pp.47-62
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• 2022

이전 정서연구에서는 다양한 정서유발자극을 이용한 정서 차원 연구들을 통해 쾌불쾌 차원(valence)과 각성 차원(arousal)이란 두 가지의 핵심정서(core affect) 차원을 밝혔다. 최근 등장한 ASMR은 심리적 안정감, 편안함 등의 정서를 유발하는데, 이런 새로운 자극 또한 핵심정서차원에 위치하는지, 사람들에게 일으키는 정서표상은 어떤 양상을 보이는지 확인하고자 하였다. 본 연구는 3가지 정서유형(부정, 중립, 긍정)으로 구분한 ASMR 영상을 자극으로 사용하였다. 연구1에서는 청각 ASMR, 연구2에서는 청각 및 시청각 ASMR을 자극으로 사용하였고, 각 자극마다 10가지의 형용사에 대해 5점 리커트 척도로 정서경험을 보고받았다. 자료수집 이후 다차원척도법과 분류분석을 실시하였다. 다차원척도법 결과, 청각 및 시청각 ASMR 모두 핵심정서차원인 쾌불쾌 차원에서 잘 구분되었다. 분류분석 결과, 동일한 감각양상 및 서로 다른 감각양상의 ASMR에 대한 참가자 개인의 정서표상 구분과 참가자들간 정서표상 구분이 잘 이뤄졌다. 종합적으로 본 연구는 다른 정서유발자극들과 같이 ASMR 또한 핵심정서차원에 위치한다는 것을 시사한다는 점에서 기존의 Russell(1980)의 핵심정서차원 이론을 지지한다. 또한, 감각양상에 상관없이 ASMR에 대한 참가자 개인의 정서표상이 예측가능하며, 참가자들의 정서표상이 일관적이라는 점을 시사한다.

• Asia Marketing Journal
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• 제15권3호
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• pp.159-172
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• 2013

In the present study, we apply the multiple cue probability learning (MCPL) paradigm to examine consumer learning from feedback in repeated trials. This paradigm is useful in investigating consumer learning, especially learning the relationships between the overall quality and attributes. With this paradigm, we can analyze what people learn from repeated trials by using the lens model, i.e., whether it is knowledge or consistency. In addition to introducing this paradigm, we aim to demonstrate that knowledge people gain from repeated trials with feedback is robust enough to weaken one of the most often examined contextual effects, the asymmetric dominance effect. The experiment consists of learning session and a choice task and stimuli are sport rafting boats with motor engines. During the learning session, the participants are shown an option with three attributes and are asked to evaluate its overall quality and type in a number between 0 and 100. Then an expert's evaluation, a number between 0 and 100, is provided as feedback. This trial is repeated fifteen times with different sets of attributes, which comprises one learning session. Depending on the conditions, the participants do one (low) or three (high) learning sessions or do not go through any learning session (no learning). After learning session, the participants then are provided with either a core or an extended choice set to make a choice to examine if learning from feedback would weaken the asymmetric dominance effect. The experiment uses a between-subjects experimental design (2 × 3; core set vs. extended set; no vs. low vs. high learning). The results show that the participants evaluate the overall qualities more accurately with learning. They learn the true trade-off rule between attributes (increase in knowledge) and become more consistent in their evaluations. Regarding the choice task, there is a significant decrease in the percentage of choosing the target option in the extended sets with learning, which clearly demonstrates that learning decreases the magnitude of the asymmetric dominance effect. However, these results are significant only when no learning condition is compared either to low or high learning condition. There is no significant result between low and high learning conditions, which may be due to fatigue or reflect the characteristics of learning curve. The present study introduces the MCPL paradigm in examining consumer learning and demonstrates that learning from feedback increases both knowledge and consistency and weakens the asymmetric dominance effect. The latter result may suggest that the previous demonstrations of the asymmetric dominance effect are somewhat exaggerated. In a single choice setting, people do not have enough information or experience about the stimuli, which may lead them to depend mostly on the contextual structure among options. In the future, more realistic stimuli and real experts' judgments can be used to increase the external validity of study results. In addition, consumers often learn through repeated choices in real consumer settings. Therefore, what consumers learn from feedback in repeated choices would be an interesting topic to investigate.

• 한국의상디자인학회지
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• 제13권2호
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• pp.63-71
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• 2011

The purpose of this study was to analyze children's clothing preference on animated character color. The experimental materials developed for this study were a set of stimulus and response scales. The stimuli were 30 color pictures, in which gender (boy, girl), type of character (Mickey Mouse, Mini Mouse), hue of character (red, yellow, green, blue, purple), and tone of character (vivid, light, dark) were manipulated. The 5-point scale was used to evaluate children's clothing preferences. Data were obtained from 300 boys and 300 girls living in Seoul, Busan, Jinju, and Changwon in April 2010. For data analysis, ANOVA and Duncan-test were used by using SPSS program. Results of this study were as follows. Tone of character had an independent effect on children's clothing preference. Interaction effects of gender and hue of the character were found. Interaction effects of gender and tone of the character were found. Interaction effects of type and tone of the character were found.

• Genomics & Informatics
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• 제6권1호
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• pp.44-49
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• 2008

Protein kinase C (PKC) is a family of kinases involved in the transduction of cellular signals that promote lipid hydrolysis. PKC plays a pivotal role in mediating cellular responses to extracellular stimuli involved in proliferation, differentiation and apoptosis. Comparative analysis of the PKC-${\alpha},{\beta},{\varepsilon}$ isozymes of 200 recently sequenced microbial genomes was carried out using variety of bioinformatics tools. Diversity and evolution of PKC was determined by sequence alignment. The ser/thr protein kinases of Streptomyces coelicolor A3 (2), is the only bacteria to show sequence alignment score greater than 30% with all the three PKC isotypes in the sequence alignment. S.coelicolor is the subject of our interest because it is notable for the production of pharmaceutically useful compounds including anti-tumor agents, immunosupressants and over two-thirds of all natural antibiotics currently available. The comparative analysis of three human isotypes of PKC and Serine/threonine protein kinase of S.coelicolor was carried out and possible mechanism of action of PKC was derived. Our analysis indicates that Serine/ threonine protein kinase from S. coelicolor can be a good candidate for potent anti-tumor agent. The presence of three representative isotypes of the PKC super family in this organism helps us to understand the mechanism of PKC from evolutionary perspective.

• 한국염색가공학회지
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• 제22권3호
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• pp.181-186
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• 2010

A thermoresponsive poly(NIPAM-co-dye) labeled with benzopyran-based D-$\pi$-A type dye was prepared by typical radical copolymerization. It can be also constructed a acid/base-induced molecular switch by modulation of intramolecular charge transfer with protonation/deprotonation. The lower critical solution temperature behavior was investigated by means of UV-vis spectroscopy which allows the measurement of the phase transition from $25^{\circ}C$ to $45^{\circ}C$ in aqueous DMSO solution. The morphology of the internal microstructure of the poly(NIPAM-co-dye) hydrogel was observed by scanning electron microscopy. The reversible switch could be obtained by thermal and acid/base stimuli.

• 한국의류학회지
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• 제27권5호
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• pp.475-484
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• 2003

The objectives of this study were to investigate the consumers' general perceptions and attitudes in response to the leaflet fashion advertisements, and to examine how much differently the level of price and the advertisement type affect brand images and consumers' buying intentions. Subjects for this study were 192 female university students in the twenties. Through the pre-test, several casual brands with such various the level of price as high, middle. and low were selected. Stimuli consisted of 8 photographs of the advertisements types which were manipulated according to the price level(highㆍmiddle & low) and the advertisements type(generalㆍleaflet). The results showed that consumers got the information on the fashion products mostly from the advertisements in magazines. It was also found that consumers showed the highest interests on the design and the discount rate of prices in the leaflet fashion advertisements. The price range(highㆍmiddle & low) of casual brands had significantly affected on the brand image and the consumers' buying intention. And the higher the prices of casual brands were, the worse brand images were when products were advertised by fashion leaflets. The advertisements types(generalㆍleaflet) gave some influences only on the brand image. Based on these results, marketing strategies of fashion advertising would be ,suggested.

• 정신신체의학
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• 제3권1호
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• pp.91-97
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• 1995

Pain is a complex symptom consisting of a sensation underlying potenial disease and associated emotional state. Acute pain is a reflex biological response to injury, in contrast, chronic pain consists of pain of a mininum of 6 months duration and associates with physical, emotional past experience, economic resources of the patient, family and society. Moreover, chronic pain is characterized by physiological affective and behavioral responses that are quite different than those of acute pain. The different type of stimuli exciting pain receptor are mechanical, thermal and chemical stimli and chronic pain are concerned with three of all stimli. The major three components of pain central(Analgesia) system in the brain and spinal cord are 'periaqueductal gray area of the mesencephalon', 'the raphe magnus nucleus' and 'pain inhibitory complex located in the dorsal horns of the spinal cord'. But unfortunately, the central biochemical mechanisms of chronic pain are not clearly defined. To proper management of chronic pain, comprehensive urderstanding as a psychosomatic aspect and multidisciplinary therapeuti-team approach must be emphasized.

• Ocean Systems Engineering
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• 제7권1호
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• pp.39-51
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• 2017

Fishes detect various sensory stimuli, which may be used to direct their behavior. Especially, the visual and water flow detection information are critical for locating prey, predators, and school formation. In this study, we examined the specific role of these two different type of stimulation (vision and vibration) during the obstacle avoidance behavior of carp, Cyprinus carpio. When a visual obstacle was presented, the carp efficiently turned and swam away in the opposite direction. In contrast, vibration stimulation of the left or right side with a vibrator did not induce strong turning behavior. The vibrator only regulated the direction of turning when presented in combination with the visual obstacle. Our results provide first evidence on the innate capacity that dynamically coordinates visual and vibration signals in fish and give insights on the novel modulation method of fish behavior without training.