• 대한기계학회논문집
• /
• 제16권4호
• /
• pp.649-657
• /
• 1992

본 연구에서는 스테핑 모터의 토크특성과 전동시스템의 미스얼라인 먼트에 의 한 플리편심을 고려하여 스페핑 모터 구동 타이밍벨트 전동시스템의 전동오차에 관한 이론 및 실험적 연구를 수행하고, 전동오차 감소를 위한 설계 개선 기초자료를 얻고자 한다.

• 생명과학회지
• /
• 제14권1호
• /
• pp.131-140
• /
• 2004

T7박테리오파지 gp4는 dTTP 가수분해에너지를 이용하여 DNA복제시 이중 나선 DNA를 단일가닥 DNA로 풀어내는 나선효소(helicase)이다. T7 나선효소의 활성형의 4차구조는 한가운데 구멍을 지닌 육량체 고리모양이다. 단일가닥 DNA는 나선효소가 $5'\rightarrow3'$방향으로 이동할 때 육량체 고리의 구멍으로 빠져나간다. 이러한 DNA의 이중나선 풀어헤침을 빠른 효소반응속도 측정법을 이용하여 정량적으로 측정하였으며, 그 결과 단일가닥 DNA 산물들이 생성되기 전에 지연상태(lag phase)가 존재함을 관찰하였다. 이러한 지연상태를 나선효소에 의한 이중나선 DNA의 풀어헤침이 속도론적 단계과정(kinetic stepping)을 거친다는 모델로써 분석하였다. 예상대로 이중나선의 길이가 클수록 지연상태의 지속시간이 늘어났다. $\tau7$ 나선효소가 이중나선 DNA를 풀어내는 과정에서 넣어준 trap DNA는 풀어내는 이중나선 DNA의 양을 변화시키지 못하여서, $\tau7$ 나선효소가 매우 큰 공정성을 지닌 효소임을 알 수 있었다. 이러한 속도론적 data를 global fitting법을 써서 kinetic stepping 모델에 적용한 결과 매 단계(step)마다 10∼l개의 염기쌍이 풀려지고 1초당 3.7번의 step이 일어난다는 것을 알 수 있었다. DNA 풀어헤침과 dTTP가수분해의 메커니즘과 이들의 연계성은 $4∼37^{\circ}C$사이의 온도범위에서 영향을 받지 않았다. 이상을 종합할 때, T7나선효소의 이중나선 DNA의 풀어헤침 시 나타나는 속도론적 단계과정은 DNA복제 시 이용되는 나선효소의 내재적 속성임을 알 수 있다.

• Korean Journal of Acupuncture
• /
• 제21권4호
• /
• pp.69-82
• /
• 2004

Objectives : In the present study, the effect of electroacupuncture (EA) applied to hand yang meridian on the ankle sprain model was examined. Methods & Results : A common source of persistent pain in humans is the lateral ankle sprain. To model this condition, the rat's right ankle was bent repeatedly, overextending lateral ligaments, for 4 min under halothane anesthesia. The rat subsequently showed swelling of the ankle and a reduced stepping force of the affected limb for the next several days. The reduced stepping force of the limb was presumably due to a painful ankle. EA was applied to the several acupuncture point on the contralateral forelimb for 30 min under gaseous anesthesia. After the termination of EA, behavioral tests measuring stepping force were periodically conducted during the next 4 h. EA applied to SI-6 point produced a significant improvement of stepping force of the sprained foot lasting for at least 2 h. However, neigher LI-4 point nor TE-3 point produced any significant increase of weight bearing force. The improvement of stepping pressure was interpreted as an analgesic effect. The analgesic effect was specific to the acupuncture point since the analgesic effect on the ankle sprain pain model could not be mimicked by EA applied to a nearby point, LI-4 or TE-3. The analgesic effect of EA applied to SI-6 was more powerful when EA was applied by low-frequency and high-intensity stimulation. In addition, this effect need to be stimulated more than 15 min. Conclusions : These data suggest that EA produces a potent analgesic effect on the ankle sprain pain model in the rat. This analgesic effect is produced by applying EA to a Tae-Yang meridian at opposite side from the painful area in a stimulus point-specific way.

• 한국한의학연구원논문집
• /
• 제12권3호통권18호
• /
• pp.49-58
• /
• 2006

Although the usage of acupuncture for pain has increased in recent years, the mechanisms of acupuncture analgesia (AA) remain unclear. The lack of suitable experimental animal models for persistent pain, which show clear AA, has been the major stumbling block in the investigation of the physiological mechanisms of AA. In the present study, we test AA in two knee arthritis models induced by injection of CFA or carrageenan as persistent pain models. After induction of arthritis, the rat subsequently showed a reduced stepping force of the affected limb for the next several days. Electroacupuncture (EA) was applied to an acupuncture point each on the contralateral forelimb for 30 minutes under gaseous anesthesia. After the termination of EA, behavioral tests measuring stepping force were periodically conducted during the next several hours. EA produced a significant improvement of stepping force of the foot lasting for at least 2 hours when applied to LR2 in CFA model, and applied to ST36 in carrageenan model, but both points did not produce any significant effects in each other model. Further experiments showed that intraperitoneal pretreatment of naltrexone, a non-selective opioid antagonist, did not reduced the EA-induced improvement of stepping force in both of two models. These data suggest that EA produce analgesic effect in knee arthritic pain and the analgesic effect is specific to the acupuncture point depending on painful conditions.

• Korean Journal of Acupuncture
• /
• 제22권1호
• /
• pp.7-21
• /
• 2005

Objectives : In the present study, the effect of electroacupuncture (EA) applied to SI6 and won-rak point on the ankle sprain model was examined. A common source of persistent pain in humans is the lateral ankle sprain. Methods : To model this condition, the rat's right ankle was bent repeatedly, overextending lateral ligaments, for 4 min under enflurane anesthesia. The rat subsequently showed swelling of the ankle and a reduced stepping force of the affected limb for the next several days. The reduced stepping force of the limb was presumably due to a painful ankle. EA was applied to the several acupuncture point on the contralateral forelimb for 30 min under gaseous anesthesia. After the termination of EA, behavioral tests measuring stepping force and Paw volume were Periodically conducted during the next 4 h and 18 h respectively. Results : EA applied to $SI_6$ with won-rak point produced more powerful improvement of stepping force of the sprained foot than to $SI_6$ alone lasting for at least 4 h. However, neigher $KI_4$ point nor $BL_{64}$ point produced any significant increase of weight bearing force. The improvement of stepping pressure was interpreted as an analgesic effect. The analgesic effect was specific to the acupuncture point since the analgesic effort on the ankle sprain pain model could not be mimicked by EA applied to $KI_4$ or $BL_{64}$. In addition, EA applied to $SI_6$ with won-rak combination point showed inhibitory effect on the paw edema induced by ankle sprain. Also, COX-2 protein expression increased by ankle sprain were suppressed by the EA stimulation. Conclusion : These data suggest that EA with won-rak combination point produces a more potent analgesic effect on the ankle sprain pain model in the rat and that EA with won-rak combination point induced anti-inflammatory effect through the suppression of COX-2 protein expression.

• 대한기계학회논문집B
• /
• 제23권10호
• /
• pp.1229-1239
• /
• 1999

A computational study on unsteady compressible flows has been performed by adopting a low Reynolds number $k-{\omega}$ turbulence model in conjunction with dual time stepping scheme. An explicit four-stage Runge-Kutta scheme for the Navier-Stokes equations and an approximate factorization scheme for the $k-{\omega}$ turbulence model equations are used. Computational results obtained for blade surface pressure distributions in the process of rotor-stator interaction in a turbine stage are in good agreement with extant experimental data. The effects of the wake from the stator on the boundary-layer transition over the rotor blade surface are discussed by showing that high intensity turbulence of the stator wake induces an early transition.

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• 제13권2호
• /
• pp.100-105
• /
• 2013

In this study, we analyze the balance of quadruped walking robots. For this purpose, a simplified polygonal model of a quadruped walking configuration is considered. A boundary-range-based balance margin is used for determining the system stability of the polygonal walking configuration considered herein. The balance margin enables the estimation of the walking configuration's balance for effective walking. The usefulness of the balance margin is demonstrated through exemplary simulations. Furthermore, balance compensation by means of foot stepping is addressed.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1994년도 하계학술대회 논문집 A
• /
• pp.114-118
• /
• 1994

A comprehensive analytical study of frequency-modulated supply of the dynamic instability in a variable-reluctance stepping motor, is described. It is shown that stability can be achieved by frequency modulation provided that the phase displacement between the modulating signal and the rotor velocity oscillation lies between certain limits. A simplified expression is derived. based on the assumption of high inertia. This model is used to obtain a qualitative understanding of how frequency modulation influences the dynamic stability of the variable-reluctance motor.

• 전기의세계
• /
• 제22권3호
• /
• pp.13-24
• /
• 1973

In this report, as a method to solve the problems on impulse insulation coordination in ribbon core transformer owing to it's BIL stepping up, new design to alter winding distribution of multiple-layer concentric winding to Convex type winding is proposed. The main focus of this method is to settle the weakness of axial direction insulation strength and as a result of theoretical analysis through experiment of model transformers, the following conclusions are obtained; (a) As the electric loadings in a design which increases by strengthenning axial direction insulation endurance in presently avarilable transformers owing to it's BIL stepping up can be restricted in Convex type winding, reasonable design will be suited to the transformer with higher BIL. (b) Convex type winding is a very improved insulation design in respect of insulation coordination because it has shield plate effect to even impulse oscillation. (c) There is a disadvantage to cause leakage flux to increase in Convex type winding, however, the constancy of electric loadings in a design in spite of BIL stepping up restricts the increase of leakage flux to some extent.

• 한국공작기계학회논문집
• /
• 제18권1호
• /
• pp.50-58
• /
• 2009

For precise tracking control of a servo system with nonlinear friction, a robust friction compensation scheme is presented in this paper. The nonlinear friction is difficult to identify the friction parameters exactly through experiments. Friction parameters can be also varied according to contact conditions such as the variation of temperature and lubrication. Thus, in order to overcome these problems and obtain the desired position tracking performance, a robust adaptive back-stepping control scheme with a dual friction observer is developed. In addition, to estimate lumped friction uncertainty due to modeling errors, a DEKF recurrent neural network and adaptive reconstructed error estimator are also developed. The feasibility of the proposed control scheme is verified through the experiment fur a ball-screw system.