• 대한수학회논문집
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• 제11권3호
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• pp.557-562
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• 1996

We find an equivalent condition of $M_n(R)[x, \delta]$ to be primitive and characterize a special subring P of $M_n(R)$. Also, we find an equivalent condition of $P[x, \delta]$ to be primitive.

• Communications for Statistical Applications and Methods
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• 제19권3호
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• pp.395-403
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• 2012

Process adjustment, also called engineering process control(EPC), is applied to maintain process output close to a target value by manipulating controllable variables, but special causes may still make the process deviate from the target and result in significant costs. Thus, it is important to detect and mediate deviations as early as possible. We propose a one-step detection method, the moving search block(MSB), with which the time and type of a special cause can be identified in short periods. A modified control rule that can entertain the effects of the special cause is proposed. A numerical example is presented to evaluate the performance of the proposed scheme.

• 대한수학회지
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• 제38권3호
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• pp.503-521
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• 2001

A change of Finsler metric L(x,y)longrightarrowL(x,y) is called a Randers change of L, if L(x,y) = L(x,y) +$\rho$(x,y), where $\rho$(x,y) = $\rho$(sub)i(x)y(sup)i is a 1-form on a smooth manifold M(sup)n. Let us consider the special Randers change of Finsler metric LlongrightarrowL = L + $\beta$ by $\beta$. On the basis of this special Randers change, the purpose of the present paper is devoted to studying the conditions for Finsler space F(sup)n which are transformed by a special Randers change of Finsler spaces F(sup)n with ($\alpha$,$\beta$)-metrics of Douglas type to be also of Douglas type, and vice versa.

• 품질경영학회지
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• 제32권2호
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• pp.201-211
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• 2004

Process adjustment is a complimentary tool to process monitoring in process control. Process adjustment directs on maintaining a process output close to a target value by manipulating another controllable variable, by which significant process improvement can be achieved. Therefore, this approach can be applied to the 'Improve' stage of Six Sigma strategy. Though the optimal control rule minimizes process variability in general, it may not properly function when special causes occur in underlying process, resulting in off-target bias and increased variability in the adjusted output process, possibly for long periods. In this paper, we consider a responsive feedback control system and the minimum mean square error control rule. The bias in the adjusted output process is investigated in a general framework, especially focussing on stationary underlying process and the special cause of level shift type. Illustrative examples are employed to illustrate the issues discussed.

• 호남수학학술지
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• 제45권3호
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• pp.491-502
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• 2023

As a generalization of Berwald spaces, we have the ideas of Douglas spaces and Landsberg spaces. S. Bacso defined a weakly-Berwald space as another generalization of Berwald spaces. In 1972, Matsumoto proposed the (α, β) metric, which is a Finsler metric derived from a Riemannian metric α and a differential 1-form β. In this paper, we investigated an important class of (α, β)-metrics of the form $F={\mu}_1\alpha+{\mu}_2\beta+{\mu}_3\frac{\beta^2}{\alpha}$, which is recognized as a special form of the first approximate Matsumoto metric on an n-dimensional manifold, and we obtain the criteria for such metrics to be weakly-Berwald metrics. A Finsler space with a special (α, β)-metric is a weakly Berwald space if and only if B^m_m is a 1-form. We have shown that under certain geometric and algebraic circumstances, it transforms into a weakly Berwald space.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.174.2-175
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• 2000

• 한국문헌정보학회지
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• 제52권2호
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• pp.5-25
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• 2018

본 연구는 공공도서관의 주제전문서비스와 주제전문사서에 대한 문헌정보학과 재학생의 인식에 대한 광범위한 조사연구이다. 전국의 문헌정보학과 학생들을 대상으로 주제전문서비스와 주제전문사서에 대한 인지 수준, 필요성 인식 수준, 주제전문사서의 역량과 현재 학생들의 역량, 주제전문사서의 자격제도 등에 대한 의견을 조사하였다. 그 결과 학생들의 주제전문서비스와 주제전문사서에 대한 이해와 필요성 수준, 주제전문사서로 일하고자 하는 의사, 주제전문사서 역량을 구비하기 위한 추가적인 노력을 기울인 의사가 높은 것으로 나타났다. 주제전문사서의 역량은 학사제도와 문헌정보학의 교과과정을 통해서 구비하고 있지만 아무것도 하지 않는 응답자 비율도 높았다. 주제전문사서 자격제도화 필요성이 있다고 하였고, 주제전문서비스를 하기 위해서는 주제전문성이 가장 중요한데, 현재 학생들은 스스로 주제전문성 부분이 가장 부족하다고 생각하였다. 이 연구의 결과들을 바탕으로 문헌정보학과 재학생들의 현재의 어려움을 개선하고 유능한 주제전문사서로 성장하는데 도움을 줄 수 있는 교육방안 개발에 관심을 두어야 한다고 제언하였다.

• 한국약용작물학회지
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• 제19권3호
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• pp.157-161
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• 2011

Growth characteristics, root yield and ginsenoside contents of 3-year-old ginseng in greenhouse shaded by $30^{\circ}$ sloped-curtain made of aluminum were compared to traditional shade facility in order to develop cultural practice for organic ginseng. Light transmittance ratio in greenhouse with $30^{\circ}$ sloped-curtain shade was distinctly lower than that of traditional shade from sunrise to 9 a.m., while its ratio in greenhouse was higher than traditional shade since 9 a.m. due to the reflection of light. Air temperature of greenhouse was $1.3^{\circ}C$ higher than that of traditional shade on the first ten days of August due to more reflected light. Root yield of greenhouse was 44% higher than that of traditional cultivation because of the inflow of reflected light and the decrease of disease of Alternaria and Anthracnose by blocking rainfall. Dry matter partitioning ratio of rhizome and lateral root were increased in ginseng cultivated at greenhouse due to longer survival time in leaf than traditional cultivation. Total ginsenoside contents cultivated at greenhouse was decreased in the part of taproot, while it was increased in the part of lateral and fine root compare to traditional cultivation. Individual ginsenoside contents between greenhouse and traditional cultivation showed significant difference more frequent in fine root than taproot and lateral root. Total ginsenoside contents including $Rb_1$, $Rb_2$, Rc, Rd, Re, Rf, $Rg_1$, and $Rg_2$ in whole root of 3-year-old ginseng did not showed significant difference by greenhouse and traditional cultivation.

• Journal of Ginseng Research
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• 제45권2호
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• pp.325-333
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• 2021

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. Enhancing hippocampal neurogenesis by promoting proliferation and differentiation of neural stem cells (NSCs) is a promising therapeutic strategy for AD. 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) are small, bioactive compounds found in ginseng that can promote NSC proliferation and neural differentiation in vitro. However, it is currently unknown whether PPD or OA can attenuate cognitive deficits by enhancing hippocampal neurogenesis in vivo in a transgenic APP/PS1 AD mouse model. Here, we administered PPD or OA to APP/PS1 mice and monitored the effects on cognition and hippocampal neurogenesis. Methods: We used the Morris water maze, Y maze, and open field tests to compare the cognitive capacities of treated and untreated APP/PS1 mice. We investigated hippocampal neurogenesis using Nissl staining and BrdU/NeuN double labeling. NSC proliferation was quantified by Sox2 labeling of the hippocampal dentate gyrus. We used western blotting to determine the effects of PPD and OA on Wnt/GSK3β/β-catenin pathway activation in the hippocampus. Results: Both PPD and OA significantly ameliorated the cognitive impairments observed in untreated APP/PS1 mice. Furthermore, PPD and OA significantly promoted hippocampal neurogenesis and NSC proliferation. At the mechanistic level, PPD and OA treatments resulted in Wnt/GSK-3β/β-catenin pathway activation in the hippocampus. Conclusion: PPD and OA ameliorate cognitive deficits in APP/PS1 mice by enhancing hippocampal neurogenesis, achieved by stimulating the Wnt/GSK-3β/β-catenin pathway. As such, PPD and OA are promising novel therapeutic agents for the treatment of AD and other neurodegenerative diseases.

• IMMUNE NETWORK
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• 제24권2호
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• pp.12.1-12.17
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• 2024

Exosomes are double phospholipid membrane vesicles that are synthesized and secreted by a variety of cells, including T cells, B cells, dendritic cells, immune cells, are extracellular vesicles. Recent studies have revealed that exosomes can play a significant role in under both physiological and pathological conditions. They have been implicated in regulation of inflammatory responses, immune response, angiogenesis, tissue repair, and antioxidant activities, particularly in modulating immunity in autoimmune diseases (AIDs). Moreover, variations in the expression of exosome-related substances, such as miRNA and proteins, may not only offer valuable perspectives for the early warning, and prognostic assessment of various AIDs, but may also serve as novel markers for disease diagnosis. This article examines the impact of exosomes on the development of AIDs and explores their potential for therapeutic application.