• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of the Korean association of regional geographers
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• v.20 no.4
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• pp.393-408
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• 2014

In this study, the spatio-temporal characteristics of summer extreme precipitation events in the Republic of Korea are examined based on the daily precipitation data observed at approximately 360 sites of both Automatic Weather Station (AWS) and Automated Synoptic Observation System (ASOS) networks by the Korea Meteorological Administration for the recent decade(2002~2011). During the summer Changma period(late June~mid July), both the frequency of extreme precipitation events exceeding 80mm of daily precipitation and their decadal maximum values are greatest at most of weather stations. In contrast, during the Changma pause period (late July~early August), these patterns are observed only in the northern regions of Geyeonggi province and western Kangwon province as such patterns are detected around Mt. Sobaek and Mt. Halla as well as in the southern regions of Geyeonggi province and western Kangwon province during the late Changma period (mid August~early September) due to north-south oscillation of the Changma front. Investigation of their regional patterns confirms that not only migration of the Changma front but also topological components in response to the advection of moistures such as elevation and aspect of major mountain ridges are detrimental to spatio-temporal patterns of extreme precipitation events. These results indicate that each local administration needs differentiated strategies to mitigate the potential damages by extreme precipitation events due to the spatiotemporal heterogeneity of their frequency and intensity during each Changma period.

• Korean Journal of Cognitive Science
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• v.20 no.1
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• pp.79-107
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• 2009

Episodic memory, i.e. memorization of information within a spatiotemporal environment, is affected Alzheimer's disease(AD), but its impairment may also be occurred in the normal aging process. The purpose of this study is to analyze and evaluate memory in with Dementia of Alzheimer Type by examining their cognitive skills in episodic memory using the technique. This new method involves assessing the mental images the subject's own past in the mind like projected and movies. Three patients in the early stage of Dementia of Alzheimer Type, one with mild depression, and 2 healthy controls for comparison were asked to retrieve their episodic memory of the previous day, week, month, and a day testing day. The answers were then analyzed with regards to their specific features as emotional state, color, and time order. In the following day, the subjects were tasked to recall again the images they reproduced in the day's test order to observe of memory. Results showed that all 3 patients failed to arrange the retrieved images in time order and their images of the previous day were unclear in color and were stationary like photographs, even when they reproduced the mental images at much quantity as controls. patients could not remember particular events of yesterday, and only recalled the general occurrences of every day life. These results suggest that in the early stage of Dementia of Alzheimer Type, difficulties in the retrieval of recent episodic memory begin to primarily occur, and qualitative impairment happens earlier than quantitative.

• Journal of Korea Water Resources Association
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• v.49 no.4
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• pp.327-333
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• 2016

Due to climate changes accelerated by global warming, South Korea has experienced regional climate variations as well as increasing severities and frequencies of extreme weather. The precipitation in South Korea during the summer season in 2013 was concentrated mainly in the central region; the maximum number of rainy days were recorded in the central region while the southern region had the minimum number of rainy days. As a result, much attention has been paid to the importance of flood control due to damage caused by spatiotemporal intensive rainfalls. In this study, forecast rainfall data was used for rapid responses to prevent disasters during flood seasons. For this purpose, the applicability of numerical weather forecast data was analyzed using the ground observation rainfall and inflow rate. Correlation coefficient, maximum rainfall intensity percent error and total rainfall percent error were used for the quantitative comparison of ground observation rainfall data. In addition, correlation coefficient, Nash-Sutcliffe efficiency coefficient, and standardized RMSE were used for the quantitative comparison of inflow rate. As a result of the simulation, the correlation coefficient up to six hours was 0.7 or higher, indicating a high correlation. Furthermore, the Nash-Sutcliffe efficiency coefficient was positive until six hours, confirming the applicability of forecast rainfall.

• Journal of the Korean Association of Geographic Information Studies
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• v.8 no.1
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• pp.23-39
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• 2005

As developing satellite communication, the tracking range of the moving objects which move in local area is expanded to the whole world. However previous logistics management system is able to monitor freight which transporting in local area using mobile communication system. In this paper, we propose the reefer container management system that manages the location information and other related information such as temperature, humidity of container using the satellite system. The proposed system consists of three parts; data collector, satellite communication manager, reefer container information manager. And the proposed system uses the moving object index for managing the trajectory of container and tracing the location of container or vessel that is transporting the container, and supports various services such as reefer container and vessel tracking, container control and container statistics to logistic companies like shipper and forwarding agent. And the system can be increasing the quality of container transportation service to the shipper, and it makes the efficient management of reefer container to the shipping company.

• Journal of the Korean Association of Geographic Information Studies
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• v.7 no.3
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• pp.57-69
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• 2004

This study developed an ecological mapping technique with GIS database using the analyses of existing ecological survey reports and the change detection on the Nakdong river estuary. The data which are used to establish GIS DB include 2 Landsat TM images on Nov. 31, 1984 and May 17, 1997, 1:25,000 topographical maps established by National Geography Institution and various ecological survey reports published by Busan metropolitan city government. The details for producing ecological map are as follows. At first, the current methods of ecomapping efforts and previous ecological surveys of Nakdong river estuary were carefully examined. Secondly, the land cover maps were created from the classified Landsat images of 1984 and 1997 for the spatiotemporal ecosystem analysis. Thirdly, the ecosystem was evaluated by using GIS ecological database based on the criteria of botany, zoology and water quality etc. Each criteria was reclassified into 3 stages which describe the overall quality of ecological condition. At last, the comprehensive ecological map was suggested as a prototype of ecosystem assesment and management tool with the discussion of further study. The findings of this study would be a milestone for preserving and managing the ecosystem.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.4
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• pp.179-188
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• 2014

Social overhead capital (SOC) facilities are being threatened continuously by abnormal climate events that are increasing globally. For disaster response, rapid decision making on evacuation routes and other matters is critical. For this purpose, spatiotemporal information that combine data on disasters and SOC facilities needs to be utilized. This information is separately collected by government agencies and public organizations, and is not managed in an integrated manner. For rapid disaster response, an integrated management of separately collected disaster data and the creation of such information as the safety and damages on SOC facilities are required. To achieve this goal, it is essential to build inventories that integrate all the related information to support decision making indispensable for disaster response. In this study, a development plan for an integrated inventory management system based on the management and connection of inventories to support rapid decision making for disaster response is proposed. This system can collect and standardize data related to disasters and SOC facilities that are being managed separately and provide integrated information in line with the needs of users. The proposed system can be used as a decision making tool for proactive disaster response.

• Journal of the Korean earth science society
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• v.31 no.4
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• pp.322-334
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• 2010

Spatiotemporal characteristics of precipitation in Korea, associated with the weakening of Tropical Cyclones (TCs) around the Korean Peninsula ($32-36^{\circ}N$, $122-132^{\circ}E$) over the last 30 years (1979-2008), were investigated. Weakened TCs are classified as WEC (Weakened to Extratropical Cyclone) and WTD (Weakened to Tropical Depression). In WEC, precipitation was evenly distributed all over the Korean Peninsula and the greater precipitation was recorded in the southern coast. In WTD, the most precipitation was recorded in the southern coast but low precipitation was recorded in the central and inland areas of Korea. The difference of precipitation between WEC and WTD was not statistically significant in Region 2 (Jeollanam-do, Gyeongsangnam-do, southeastern part of Gyeongsangbuk-do, Jeju-do); however, the precipitation resulting from WEC was greater than that resulting from WTD in Region 1 (central area of Korea, Jeollabuk-do, inland of Gyeongsangbuk-do). In WEC, the developed upper-level potential vorticity (PV) and low-level temperature trough shifted to the northwest of TCs approaching Korea. In addition, an upper-level jet stream and strong divergence field were observed to the northeast of the TCs. It was assumed that these meteorological factors had induced baroclinic instability and diabatic process, which created a large precipitation area around the TCs. However, the intense PV, temperature trough, jet stream were not observed in WTD, which created a small precipitation area around the TCs.

• Journal of the Korean Geographical Society
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• v.50 no.1
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• pp.23-36
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• 2015

The temperature change patterns of climatic solar terms and their climatic fitness were analyzed. Harmonic analysis based on thirty-year(1981-2010) time-series data from sixty one weather stations across South Korea showed that the central peaks of the extreme heat had shifted toward start of autumn with increasing mean temperature. The overall climatic fitness of solar terms, such as major heat, frost descent, major snow, and major cold, was low, and it showed significant regional variations. The actual meteorological phenomenon representing each climatic solar term was observed much later than the day of the solar term at most weather stations. The number of observations, where an actual meteorological condition for each climatic solar term was recorded within ${\pm}1$ week from the day of that solar term, ranged only from 7.7% to 40.4% of the entire data. Study results also showed that the climatic fitness of major heat, frost descent, and major snow gradually changed in the east-west direction. Major cold, a solar term with higher climatic fitness, was influenced more strongly by latitude than longitude. Considering geographically uneven magnitude and trends in temperature changes, rearrangement and adjustment of time intervals between the solar terms may help us improve their applicability as realistic indicators of seasonal changes.

• Journal of the Korean Geographical Society
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• v.48 no.4
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• pp.497-508
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• 2013

The objective of this study is to determine the spatiotemporal influences of climatic factors and atmospheric aerosol on phenological cycles of the Korea Peninsular on a regional scale. High temporal-resolution satellite data can overcome limitations of ground-based phenological studies with reasonable spatial resolution. Study results showed that phenological characteristics were similar among evergreen forest, deciduous forest, and grassland, while the inter-annual vegetation index amplitude of mixed forest was differentiated from the other forest types. Forest types with high VI amplitude reached their maximum VI values earlier, but this relationship was not observed within the same forest type. The phase of VI, or the peak time of greenness, was significantly influenced by air temperature. Aerosol optical thickness (AOT) time-series showed strong seasonal and inter-annual variations. Generally, aerosol concentrations were peaked during late spring and early summer. However, inter-annual AOT variations did not have significant relationships with those of VIs. Weak relationships between AOT amplitude and EVI amplitude only indicates that there would be potential impacts of aerosols on vegetation growth in the long run.