• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.415-425
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• 2022

Memory formation in the hippocampus is formed and maintained by circadian clock genes during sleep. Sleep deprivation (SD) can lead to memory impairment and neuroinflammation, and there remains no effective pharmacological treatment for these effects. Myricetin (MYR) is a common natural flavonoid that has various pharmacological activities. In this study, we investigated the effects of MYR on memory impairment, neuroinflammation, and neurotrophic factors in sleep-deprived rats. We analyzed SD-induced cognitive and spatial memory, as well as pro-inflammatory cytokine levels during SD. SD model rats were intraperitoneally injected with 10 and 20 mg/kg/day MYR for 14 days. MYR administration significantly ameliorated SD-induced cognitive and spatial memory deficits; it also attenuated the SD-induced inflammatory response associated with nuclear factor kappa B activation in the hippocampus. In addition, MYR enhanced the mRNA expression of brain-derived neurotropic factor (BDNF) in the hippocampus. Our results showed that MYR improved memory impairment by means of anti-inflammatory activity and appropriate regulation of BDNF expression. Our findings suggest that MYR is a potential functional ingredient that protects cognitive function from SD.

• Journal of Ginseng Research
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• 제46권3호
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• pp.435-443
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• 2022

Background: Post-traumatic stress disorder (PTSD) is a psychiatric disease that develops following exposure to a traumatic event and is a stress-associated mental disorder characterized by an imbalance of neuroinflammation. Korean Red Ginseng (KRG) is the herbal supplement that is known to be involved in a variety of pharmacological activities. We aimed to investigate the effects of KRG on neuroinflammation as a potential mechanism involved in single prolonged stress (SPS) that negatively influences memory formation and consolidation and leads to cognitive and spatial impairment by regulating BDNF signaling, synaptic proteins, and the activation of NF-κB. Methods: We analyzed the cognitive and spatial memory, and inflammatory cytokine levels during the SPS procedure. SPS model rats were injected intraperitoneally with 20, 50, or 100 mg/kg/day KRG for 14 days. Results: KRG administration significantly attenuated the cognitive and spatial memory deficits, as well as the inflammatory reaction in the hippocampus associated with activation of NF-κB in the hippocampus induced by SPS. Moreover, the effects of KRG were equivalent to those exerted by paroxetine. In addition, KRG improved the expression of BDNF mRNA and the synaptic protein PSD-95 in the hippocampus. Taken together, these findings demonstrate that KRG exerts memory-improving actions by regulating anti-inflammatory activities and the NF-κB and neurotrophic pathway. Conclusion: Our findings suggest that KRG is a potential functional ingredient for protecting against memory deficits in mental diseases, such as PTSD.

• 대한한의학회지
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• 제27권4호
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• pp.125-134
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• 2006

During the prenatal period, the development of the individual is influenced by a host of environmental factors. Exposure to noise stress during pregnancy was determined to result in the retardation of growth, a reduction in neurogenesis, and an impairment of spatial learning ability in the rat pups. In the present study, we have attempted to characterize the effects of prenatal treatment with Cnidium officinale Makino on spatial memory and neurogenesis in the hippocampus of rat pups born from maternal rats exposed to noise stress during pregnancy. Prenatal treatment with Cnidium officinale Makino was shown to increase neurogenesis and enhanced spatial learning ability in rat pups born from maternal rats exposed to noise stress. In this study, we have determined that prenatal treatment with Cnidium officinale Makino can stimulate spatial development and neurogenesis in the brain of the fetuses exposed to prenatal stresses.

• ETRI Journal
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• 제44권2호
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• pp.208-219
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• 2022

Crime amount prediction is crucial for optimizing the police patrols' arrangement in each region of a city. First, we analyzed spatiotemporal correlations of the crime data and the relationships between crime and related auxiliary data, including points-of-interest (POI), public service complaints, and demographics. Then, we proposed a crime amount prediction model based on 2D convolution and long short-term memory neural network (2DCONV-LSTM). The proposed model captures the spatiotemporal correlations in the crime data, and the crime-related auxiliary data are used to enhance the regional spatial features. Extensive experiments on real-world datasets are conducted. Results demonstrated that capturing both temporal and spatial correlations in crime data and using auxiliary data to extract regional spatial features improve the prediction performance. In the best case scenario, the proposed model reduces the prediction error by at least 17.8% and 8.2% compared with support vector regression (SVR) and LSTM, respectively. Moreover, excessive auxiliary data reduce model performance because of the presence of redundant information.

• 대한한방소아과학회지
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• 제25권1호
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• pp.40-48
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• 2011

Objectives: The purpose of this study is to evaluate the effect of Gonjadaesungchimjoongbang on spatial learning abilities and memories in ischemic brain injury. Methods: Rats were separated into three groups; (1) Normal, (2) Saline medication after ischemic brain injuries (control), (3) Gonjadaesungchimjoongbang medication after ischemic brain injuries (experiment). Ischemic brain injuries was induced by MCA occlusion and reperfusion. Morris water maze test was conducted for spatial learning and memory tests. Then, the change of BDNF in the hippocampus($7^{th}$, $14^{th}$ day) was examined by immunohistoche- mistry. Results: In Morris water maze test, spatial learning abilities and memory functioning were considerably increased in the experiment group as oppose to control group on $7^{th}$ and $14^{th}$ day(p<0.01). Moreover, immunohistochemistric response of BDNF in the hippocampus indicated that the more increased immune reaction was found in the experiment group as oppose to the control group on $7^{th}$ and $14^{th}$ day. Conclusions: Gonjadaesungchimjoongbang can improve the learning abilities and memories in ischemic brain injury.

• 한국컴퓨터정보학회논문지
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• 제16권10호
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• pp.1-10
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• 2011

NAND 플래시 메모리는 저전력, 저렴한 가격, 그리고 대용량임에도 불구하고 페이지 단위의 쓰기 및 블록 단위의 지우기 연산은 큰 문제점을 가지고 있다. 특히 NAND 플래시 메모리 특성상 덮어쓰기가 불가능하므로 쓰기동작 후 수반되는 지우기 동작은 전체 성능저하의 원인이 된다. 기존의 NAND 플래시 메모리를 위한 SRAM 버퍼는 간단하면서도 NAND 플래시 메모리의 쓰기 동작을 효과적으로 줄여줄 수 있을 뿐 아니라 빠른 접근 시간을 보장 할 수 있다. 본 논문에서는 작은 용량의 SRAM을 이용하여 NAND 플래시 메모리의 가장 큰 오버헤드인 지우기/쓰기 동작을 효과적으로 줄일 수 있는 버퍼 관리 시스템을 제안한다. 제안된 버퍼는 큰 페칭 크기를 가지는 공간적 버퍼와 작은 페칭 크기를 가지는 시간적 버퍼인 완전연관 버퍼로 구성된다. 시간적 버퍼는 공간적 버퍼에서 참조된작은 페칭을 가지며, NAND 플래시 메모리에서 쓰기 및 지우기 수행시 시간적 버퍼내에 존재하는 같은 페이지 혹은 블록에 포함된 페칭 블록을 찾아 동시에 처리한다. 따라서 NAND 플래시 메모리에서 쓰기 및 지우기 동작을 획기적으로 줄였다. 시뮬레이션 결과에 따르면 제안된 NAND 플래시 메모리 버퍼 시스템은 2배 크기의 완전연관 버퍼에 비해 접근 실패율 관점에서는 높았지만, 쓰기 동작과 지우기 동작은 평균적으로 각각 58%, 83% 정도를 줄였으며, 결론적으로 평균 플래시 메모리 접근 시간은 약 84%의 성능 향상을 이루었다.

• 한국수학교육학회지시리즈A:수학교육
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• 제52권1호
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• pp.19-41
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• 2013

What is the foundation of mathematical thinking? Is it logic based symbolic language system? or does it rely more on mental imagery and visuo-spatial abilities? What kind of neural changes happen if someone's mathematical abilities improve through practice? To answer these questions, basic cognitive processes including long term memory, working memory, visuo-spatial perception, number processes are considered through neuropsychological outcomes. Neuronal changes following development and practices are inspected and we can show there are neural networks critical for the mathematical thinking and development: prefrontal-anterior cingulate-parietal network. Through these inquiry, we can infer the answer to our question.

• Journal of Ginseng Research
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• 제20권2호
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• pp.139-148
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• 1996

This study was designed to examine the effects of red ginseng total saponin and extract on spatial working memory in mice using Morris water maze. Two kinds of red ginseng saponin (No. 1 and No. 2) and three kinds of red ginseng extract (No. 1, No. 2 and No. 3) to have different PD/ PT ratio (No. 1=1.24, No.2=1.47 No.3=2.41) were prepared by mixing the different parts of red ginseng In different ratio. In acute administration of total saponin No. 1 or No. 2, escape time to reach to a hidden platform In a fixed location for training trials was significantly decreased as compared with control group and swimming time in the quadrant that had contained the platform was also significantly increased as compared with control group. In acute treatment of extract No. 1 or 1 No. 2, swimming time in the platformless quadrant was increased dose dependently as compared with control group, especially at dose of 200 mg/kg,bw swimming time was significantly Increased. Oral treatment of extract No. 1 (100 mg/kg, bw) for 7 days produced an increase of swimming time In the platformless quadrant but a decrease of swimming time in No.3-treated group (100 mg/kg, bw). These results show that red ginseng may improve spatial discrimination learning and spatial working memory of mice

• 한국광학회:학술대회논문집
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• 한국광학회 1989년도 제4회 파동 및 레이저 학술발표회 4th Conference on Waves and lasers 논문집 - 한국광학회
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• pp.99-102
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• 1989

Optical implementation of adaptive quadratic associative memory for two-dimensional patterns is described by using holographic lenslet arrays and spatial light modulators. Basic experimental results demonstrating its feasibility are reported.

• 한국공간정보시스템학회 논문지
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• 제11권2호
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• pp.79-88
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• 2009

실시간으로 입력되는 스트림을 저장하기 위한 메모리의 크기는 동적으로 변한다. 이 데이터 스트림을 처리하는 연속질의는 저장공간의 크기를 동적으로 관리해야 한다. 이를 위해, 저장되는 현재 데이터양에 따라 즉시 페이지 단위로 메모리를 할당 및 해제하는 기본적인 메모리 관리자가 연구되었다. 그러나 이 방법은 데이터 스트림을 저장하기 위해 메모리의 할당 및 해제를 매우 빈번하게 수행하게 된다. 또한 질의가 메모리가 부족할 때 즉시 페이지를 할당하기 때문에, 특정 지연되는 질의가 대량의 페이지를 점유하는 문제를 발생시킬 수 있다. 메모리관리자에서 발생하는 이와 같은 문제에 초점을 맞추어, 본 연구는 할당 및 해제 빈도수를 감소시키고, 질의 별로 최대한 균등하게 페이지를 분배하는 메모리 관리 기법을 제안한다. 본 기법은 질의의 페이지 이용률을 이용하여 할당 및 해제 빈도수를 크게 감소시키고, 질의의 지연 상태에 따른 메모리의 할당을 통하여 특정 질의의 메모리 독점을 방지할 수 있다.