• Nuclear Engineering and Technology
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• 제48권3호
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• pp.635-641
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• 2016

Because of prohibitive data storage requirements in large-scale simulations, the memory problem is an obstacle for Monte Carlo (MC) codes in accomplishing pin-wise three-dimensional (3D) full-core calculations, particularly for whole-core depletion analyses. Various kinds of data are evaluated and quantificational total memory requirements are analyzed based on the Reactor Monte Carlo (RMC) code, showing that tally data, material data, and isotope densities in depletion are three major parts of memory storage. The domain decomposition method is investigated as a means of saving memory, by dividing spatial geometry into domains that are simulated separately by parallel processors. For the validity of particle tracking during transport simulations, particles need to be communicated between domains. In consideration of efficiency, an asynchronous particle communication algorithm is designed and implemented. Furthermore, we couple the domain decomposition method with MC burnup process, under a strategy of utilizing consistent domain partition in both transport and depletion modules. A numerical test of 3D full-core burnup calculations is carried out, indicating that the RMC code, with the domain decomposition method, is capable of pin-wise full-core burnup calculations with millions of depletion regions.

• 대한약침학회지
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• 제20권1호
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• pp.10-17
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• 2017

Objectives: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. Methods: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8.0 mg/kg, Intraperitoneally, i.p.) and TMT + BA (40, 80 and 160 mg/kg, i.p.)-administrated rats. BA was used daily for 21 days. To evaluate the cognitive improving of BA, we performed the Morris water maze test. Moreover, to investigate the neuroprotective effect of BA, we determined the acetylcholinesterase (AchE) activity, the malondialdehyde (MDA) level as a marker of lipid peroxidation, and the glutathione (GSH) content in the cerebral cortex. Results: Treatment with TMT impaired learning and memory, and treatment with BA at a dose of 160 mg/kg produced a significant improvement in learning and memory abilities in the water maze tasks. Consistent with behavioral data, the activity of AChE was significantly increased in the TMT-injected rats compared to the control group (P < 0.01) whereas all groups treated with BA presented a more significant inhibitory effect against AChE than the TMT-injected animals. In addition, TMT reduced the GSH content and increased the MDA level in the cerebral cortex as compared to the control group) P < 0.01). On the other hand, treatment with BA at 160 mg/kg slightly increased the GSH content and reduced the MDA level in comparison to the TMT-administered group (P < 0.01). Conclusion: The above results suggest that the effect of BA in improving the cognitive function may be mediated through its antioxidant activity.

• 한국실내디자인학회논문집
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• 제25권2호
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• pp.41-49
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• 2016

The purpose of this study is to analyze the change and to compare to the difference of 'selective elements' and 'space-memory' focusing on the theory, 'selective attention' through the survey results. In this study, In this study, the lighting is considered a important factor in the change of 'selective elements'. this survey is to find the selective elements of participants and to measure the spatial sensitivity of respondents through 'self- test'. The analysis in this study is conducted by descriptive statistics, t-test and one way ANOVA by SPSS program 22. The results of this study are as following; Firstly, 'attention-element' could be classified with 4 types, 'shape', 'material', 'contrast' and 'combination'. 'shape' could divide into 'structure' and' furniture and object'. In case of 'material', it could section with 'pattern' and 'color'. Secondly, through the results of study, 'attention-element' is different each space during the day in detail. But we could know that 'shape' is the important element of the 'attention-elements' during the day through comparison of this result. That means users consider this as a important factor when they evaluate the space. Therefore, it is effective way designers to consider 'shape' as the first element when they want to conduct the special sensitivity of users in the space through planning. On the other hand, what selective elements of users are different by the lighting situation should be acknowledged by designers. And they should think the kinds of selective elements are more various when lighting turns on than turns off.. Thirdly, through the results such as the meaningful difference of space-memory of users according to the change of 'attention-elements', designers should judge about which kind of feeling of users to the space do you want lead in the design process. For the effective feedback between spaces and users to induce the same emotion of users, designers need to consider the unified design and the individual design both. Also, we will regard the differences in the users' emotion to the space according to the lighting situation when we design the space.

• Nutrition Research and Practice
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• 제9권5호
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• pp.480-488
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• 2015

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide ($A{\beta}$) and oxidative stress in the brain are the most common causes of AD. MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an $A{\beta}_{25-35}$-injected AD mouse model. CA was administered at an oral dose of 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress. RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the $A{\beta}_{25-35}$-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the $A{\beta}_{25-35}$-injected control group. In particular, CA 50 mg/kg/day showed the stronger protective effect from cognitive impairment than CA 10 mg/kg/day. CONCLUSIONS: The present results suggest that CA improves $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

• Fisheries and Aquatic Sciences
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• 제25권8호
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• pp.450-461
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• 2022

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2'-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (MoCA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

• 한국공간정보시스템학회 논문지
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• 제6권2호
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• pp.63-75
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• 2004

본 논문은 웹 환경에서 다양한 유형의 공간정보 서버들 간의 상호운영성 및 확장성을 보장하고, 유무선 네트워크 환경에서 활용 가능한 공간정보 웹 서비스 프레임워크를 제안하고 있다. 이러한 공간정보와 관련된 웹 환경의 구축은 대부분 OGC에 의하여 연구되고 표준사양들이 발표되어 왔다. 이에 본 공간정보 웹 서비스 프레임워크는 OGC의 WMS, WFS, WCS, WRS 표준사양과 W3C의 웹 서비스 사양을 수용함으로써 상호운영성 및 확장성을 보장하도록 구성되었다. 또한 본 프레임워크는 효율적인 공간정보 웹 서비스를 위하여 대용량 공간정보지원, GML 지원, 공간 서비스지원, 무선 네트워크 환경지원의 요구사항들을 만족하도록 구성되었다. 이러한 공간정보 웹 서비스 프레임워크는 공간정보 서버그룹, 공간정보 중개자, 웹 기반 클라이언트로 구성되었으며, 공간정보 서버그룹은 다양한 서비스를 위하여 GIS, SIIS, ITS, GNSS, Telematics 서버들로 구성될 수 있다. 특히, 본 논문은 공간정보 서버그룹을 위하여 무선 네트워크 환경에서 대용량 GML 서비스를 지원할 수 있는 메인 메모리 기반 GIS 서버(MMG 서버)를 제안하고 있으며, 끝으로 공간정보 서버의 프로토타입 구현과 성능 실험을 통하여 본 연구결과의 가용성을 검증하고 있다.

• 전자공학회논문지
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• 제52권10호
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• pp.82-94
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• 2015

본 논문에서는 변위 필드를 이용해 히스토리 레코드를 생성하는 방법과 히스토리 레코드의 기준이 되는 트리거 블록에 우선 순위를 부여하여 효율적인 캐시 교체를 가능하게 하는 하드웨어 프리페치 기법을 제안한다. 히스토리 레코드의 트리거 블록을 기준으로 히스토리를 생성하기 때문에 프로그램의 시퀀스를 고려할 수 있으며, 히스토리를 변위 값으로 저장하기 때문에 트리거 주소와 변위필드에 저장된 값을 더해 빠르게 명령어 또는 데이터 주소를 프리페치 할 수 있다. 또한, 트리거 블록에 우선순위를 부여하고 캐시 교체 정책으로 랜덤 교체 방법을 사용해 캐시 공간이 가득 찼을 때 우선순위가 낮은 블록부터 랜덤하게 교체하는 방법을 제안한다. 제안하는 하드웨어 프리페처의 성능을 평가하기 위해 메모리 분석 시뮬레이터인 gem5와 PARSEC 벤치마크 프로그램을 사용하였다. 그 결과 비트벡터를 이용해 공간영역을 생성하는 기존의 하드웨어 프리페처와 비교해 L1 데이터 캐시의 미스율은 평균 약 44.5% 감소하였고 L1 명령어 캐시의 미스율은 평균 약 31% 감소하였다. 또한 IPC (Instruction Per Cycle)는 평균 약 23.7% 향상을 보였다.

• 대한전자공학회논문지SP
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• 제42권1호
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• pp.101-108
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• 2005

적응 CFAR(Constant False Alarm Rate) 알고리즘은 클러터 배경 환경에서 일정한 오경보 율을 유지하면서 탐지확률을 높이기 위해 사용된다. 특히 공간 상관관계, 크기 편차가 큰 비 균일한 클러터 환경에서 탐지성능을 향상시키기 위해서는 공간변화에 적응적인 필터링 기법이 요구된다. 본 논문에서는 클러터 배경추정을 위해 이차원적으로 영역을 구분하여 대표 추정 값을 구하고, 보간(interpolation) 필터를 이용하여 최종 추정 값을 결정하는 이차원 블록 보간(Two-dimensional Block Interpolation : TBI) 적응 CFAR 알고리즘을 제안한다. 제안한 방법은 부분영역의 히스토그램 분포 중앙값을 영역 추정 값으로 선택함으로 불규칙 간섭신호 제거에 효과적이며, 블록 노드 추정 값을 이용하여 각 셀에 대한 최종 추정 값을 얻는 방식을 취함으로 인해 거리 셀 수가 많고, 고도 빔 수가 많은 시스템에서 클러터 필터링에 필요한 메모리 공간을 줄이는데 이점이 있다. 컴퓨터 모의실험을 통해 기존의 트랜스버설(transversal) 방식, 회귀(recursive)방식의 적응 CFAR 알고리즘과 탐지성능, 필요메모리 측면에서 성능을 비교하여 제안한 방법의 우수성을 확인한다.

• 대한물리의학회지
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• 제7권1호
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• pp.11-20
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• 2012

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

• 한국통신학회논문지
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• 제28권10C호
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• pp.1023-1032
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• 2003

MPEG-4와 같은 객체 기반 부호화는 멀티미디어 응용을 위한 다양한 내용 기반 기능들을 제공한다. 압축 효율의 향상과 더불어 이러한 기능들이 지원되도록 하기 위해서는 비디오 데이터의 각 프레임은 비디오 객체로 분할되어야 한다. 본 논문에서는 비선형 다중스케일 필터링과 시공간 정보를 사용한 효과적인 비디오 객체 분할 기법을 제안한다. 제안된 방법은 안정화된 역 확산 방정식(Stabilized Inverse Diffusion Equation : SIDE)에 기반한 비선형 다중스케일 필터링을 사용하여 공간적 분할을 수행한다. 또한 구해진 초기 분할된 영역들은 인접 영역 그래프 (Region Adjacency Graph : RAG)를 사용하여 병합된다. 본 논문에서는 통계적 유의성 검사(Statistical significance test)와 시변 메모리(Time-variant memory)를 시간적 분할 방법으로 사용하며 구해진 공간적 분할과 시간적 분할을 결합하여 최종 객체 영역을 효과적으로 분할한다. 본 논문에서 제안된 공간적 분할 방법은 기존의 형태학적 Watershed 알고리즘에 비해 잡음에 강인한 분할 특성을 나타내었으며 기존의 A. Neri의 방법과 비교하였을 때, 최종 분할된 객체 영역의 정확도 비율이 Akiyo는 43%, Claire는 29% 정도 향상됨을 확인할 수 있었다.