• The KIPS Transactions:PartD
• /
• v.15D no.5
• /
• pp.609-620
• /
• 2008

The service handling the map data in the mobile device including navigation, LBS, Telematics, and etc., becomes various. The size of map data which is stored and managed in the mobile device is growing and reaches in several GB. The conventional navigation system has used the read-only PSF (physical storage format) in order to enhance the performance of system by maximum in the mobile device which has limited resources. So though a little part of the map data is changed the whole data must be updated. In general, it takes several ten minutes to write the 2 GB map data to a flash memory of mobile device. Therefore, we have developed the mobile spatial DBMS (database management system) to solve the problem which is that the partial map data couldn't be updated in the conventional navigation system. And we suggest the policy to guarantee the performance of the navigation system which is implemented using the spatial mobile DBMS and verify this by experiment.

• Journal of Ginseng Research
• /
• v.44 no.3
• /
• pp.442-452
• /
• 2020

Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore the alleviative effect and the underlying molecular mechanism of stem-leaf saponins of Panax notoginseng (SLSP) on the abnormal neuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory induced by SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronal morphological changes were observed by Nissl staining. Autophagosome formation was examined by transmission electron microscopy, immunofluorescent staining, acridine orange staining, and transient transfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin V staining. The expression or activation of autophagy and apoptosis-related proteins were detected by Western blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h, accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampal neurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycin and re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transduction in HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD.

• Journal of Life Science
• /
• v.26 no.4
• /
• pp.475-483
• /
• 2016

The current study was conducted to evaluate beneficial effects of a new formula (CWC-9) using four traditional Oriental medicinal herbs, Cynanchum wilfordii, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, on hippocampal cells and memory function. To examine the neuroprotective effects of a new four-herb extract, cell viability, cytotoxicity, and reactive oxygen species (ROS) assays were performed in HT22 cells and behavioral tests (Morris water maze and passive avoidance retention), Western blot, and immunohistochemistry were performed in a mouse model of focal cerebral ischemia. In HT22 hippocampal cells, pretreatment with CWC-9 resulted in significantly reduced glutamate-induced cell death with suppression of ROS accumulation caused by glutamate. In a mouse model of focal cerebral ischemia, we observed significant improvement of spatial and short-term memory function by treatment with CWC-9. Phosphorylated p38 mitogen-activated protein kinases (MAPK) in hippocampus of ischemic mice were decreased by treatment with CWC-9, but phosphorylated phosphatidylinositol-3 kinase (PI3K) and cAMP response element binding protein (CREB) were significantly enhanced. By immunohistochemical analysis, we confirmed higher expression of phosphorylation of CREB in the hippocampal neurons of CWC-9 treated mice. These results suggest that new multi-herb formula CWC-9 mainly exerted beneficial effects on cognitive function through regulation of neuro-protective signaling pathways associated with CREB.

• Journal of Korea Water Resources Association
• /
• v.53 no.2
• /
• pp.131-140
• /
• 2020

The purpose of this study is to analyze the possibility of future droughts by calculating the Standardized Groundwater level Index(SGI) after predicting groundwater level using Long Short Term Memory (LSTM) model. The groundwater level of the Kumho River basin was predicted for the next three years by using the LSTM model, and it was validated through RMSE after learning with observation data except the last three years. The temporal SGI was calculated by using the prediction data and the observation data. The calculated SGI was interpolated within the study area, and the spatial SGI was calculated as the average value for each catchment using the interpolated SGI. The possibility of spatio-temporal drought was analyzed using calculated spatio-temporal SGI. It is confirmed that there is a spatio-temporal difference in the possibility of drought. Through the improvement of deep learning model and diversification of validation method, it is expected to obtain more reliable prediction results and the expansion of study area can be used to respond to drought nationwide, and furthermore it can provide important information for future water resource management.

• Nutrition Research and Practice
• /
• v.12 no.3
• /
• pp.191-198
• /
• 2018

BACKGROUD/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a mouse model of inflammation-induced memory and cognitive deficit. MATERIALS/METHODS: C57BL/6 mice were injected with lipopolysaccharide (LPS; 2.5 mg/kg, intraperitoneally) and orally administrated G. uralensis, G. glabra, and SW extract (150 mg/kg/day). SW, a new species of licorice in Korea, was combined with G. uralensis and G. glabra. Behavioral tests, including the T-maze, novel object recognition and Morris water maze, were carried out to assess learning and memory. In addition, the expressions of inflammation-related proteins in brain tissue were measured by western blotting. RESULTS: There was a significant decrease in spatial and objective recognition memory in LPS-induced cognitive impairment group, as measured by the T-maze and novel object recognition test; however, the administration of licorice ameliorated these deficits. In addition, licorice-treated groups exhibited improved learning and memory ability in the Morris water maze. Furthermore, LPS-injected mice had up-regulated pro-inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin-6, via activation of toll like receptor 4 (TLR4) and nuclear factor-kappa B ($NF{\kappa}B$) pathways in the brain. However, these were attenuated by following administration of the three licorice varieties. Interestingly, the SW-administered group showed greater inhibition of iNOS and TLR4 when compared with the other licorice varieties. Furthermore, there was a significant increase in the expression of brain-derived neurotrophic factor (BDNF) in the brain of LPS-induced cognitively impaired mice that were administered licorice, with the greatest effect following SW treatment. CONCLUSIONS: The three licorice varieties ameliorated the inflammation-induced cognitive dysfunction by down-regulating inflammatory proteins and up-regulating BDNF. These results suggest that licorice, in particular SW, could be potential therapeutic agents against cognitive impairment.

• Proceedings of the Korean Information Science Society Conference
• /
• 2004.10b
• /
• pp.73-75
• /
• 2004

최근에 무선 인터넷과 이동 컴퓨팅 기술이 발전하고, 휴대 전화, PDA와 같은 이동 단말기가 보편화됨에 따라 사용자의 위치 정보를 활용하는 위치 기반 서비스(LBS: Location Based Service)가 다양한 분야에서 제공되고 있다. 모바일 환경에서 위치 기반 서비스를 제공하기 위해서는 모바일 장치에서 대용량의 공간 데이타를 신속하게 처리하고 효과적으로 관리하기 위한 공간 MMDBMS(Main Memory Database Management System)가 필요하다. 이에 본 논문에서는 기존의 PC용 MMDBMS인 HSQLDB를 확장하여 모바일 장치에서 공간 데이타를 효율적으로 관리할 수 있는 공간 MMDBMS를 설계 및 구현하였다. 공간 MMDBMS는 OGC의 공간 데이타 모델을 따르며, 공간 데이타 특성에 적합한 압축 기법인 산술 코딩 기법을 제공하고, 모바일 장치에 적합한 MBR 압축 및 해슁 기법을 이용한 공간 인덱스를 지원한다. 그리고, 모바일 장치의 낮은 성능의 프로세서에서 공간 데이타 디스플레이 기능을 제공하고, 모바일 장치와 디스크 기반 GIS인 ZEUS 사이에서 공간 데이타 import/export의 성능 향상을 위한 데이타 캐쉬 기능을 지원한다.

• Proceedings of the IEEK Conference
• /
• 2001.09a
• /
• pp.113-116
• /
• 2001

제로트리 부호화 알고리즘 중 효율적이며 잘 알려진 SPIHT는 높은 메모리 요구로 인해 하드웨어 구현에 큰 어려움을 가지고 있다. 이 논문에서는 저 메모리 사용과 빠른 제로트리 부호화 알고리즘을 제안한다. 메모리를 줄이고 빠른 코딩을 위한 방법으로 다음 3가지를 사용한다. 첫 번째, 리프팅을 이용한 웨이블릿 변환은 기존의 필터뱅크 방식의 변환보다 저 메모리와 계산량의 감소를 가진다. 두 번째, 웨이블릿 변환된 계수들은 블럭으로 나누어져 각각 코딩된다. 여기서 블록은 제로트리 구조가 유지되는 STB(spatial tree-based block)이다. 세 번째, Wheeler 와 Pearlman이 제안한 NLS (no list SPIHT)를 이용한 부호화이다. NLS는 효율성에서 SPIHT와 거의 같으며 작고 고정된 메모리와 빠른 부호화 속도를 보여준다.

• Research in Mathematical Education
• /
• v.9 no.4 s.24
• /
• pp.329-333
• /
• 2005

Based on author's practice of instructing Chinese gifted students to join the Chinese Mathematics Olympic (CMO), the paper adopted test analysis model of the Scholastic Aptitude Test of Mathematics (SAT-M), tested mathematics ability of 212 mathematical gifted students to join the CMO, applied correlation analysis and factor analysis and proposed the mathematics ability structure in Chinese gifted students including comprehensive operation ability, logic thinking ability, abstract generalization ability, spatial imagination ability, memory ability, transfer ability and intuition thinking ability. And it analyzed the expression form of these abilities respectively and gave some suggestion on mathematics teaching about gifted Chinese students.

• International Journal of Contents
• /
• v.11 no.1
• /
• pp.69-72
• /
• 2015

Generally, existing parallel main-memory spatial index structures to avoid the trade-off between query freshness and CPU cost uses light-weight locking techniques. However, still, the lock based methods have some limits such as thrashing which is a well-known problem in lock based methods. In this paper, we propose a distributed index structure for moving objects exploiting the parallelism in multiple machines. The proposed index is a lock free multi-version concurrency technique based on the D-Stream model of Spark Stream. The proposed method exploits the multiversion nature of D-Stream of Spark Streaming.

• Journal of Fisheries and Marine Sciences Education
• /
• v.17 no.1
• /
• pp.76-85
• /
• 2005

GIS (Geographic Information Systems) technology is a necessary function to support location based on service by using GPS in the mobile environment. These mobile systems have basic functional limitations such as a low rate of processing, limited memory capacity, and small screen size. Because of these limitations, most of the mobile systems require development of a reduced digital map to overcome problems with large-volume spatial data. In this paper, we suggest using the reduced digital map format in order to use location based on service in a PDA environment. The processing of the proposed data format consists of map generation, redefinition of layers, creating polygons, and format conversion. The proposed data format reduces the data size by about 98% comparing with DXF format based on the digital map of Busan.