• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.635-641
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• 2016

Because of prohibitive data storage requirements in large-scale simulations, the memory problem is an obstacle for Monte Carlo (MC) codes in accomplishing pin-wise three-dimensional (3D) full-core calculations, particularly for whole-core depletion analyses. Various kinds of data are evaluated and quantificational total memory requirements are analyzed based on the Reactor Monte Carlo (RMC) code, showing that tally data, material data, and isotope densities in depletion are three major parts of memory storage. The domain decomposition method is investigated as a means of saving memory, by dividing spatial geometry into domains that are simulated separately by parallel processors. For the validity of particle tracking during transport simulations, particles need to be communicated between domains. In consideration of efficiency, an asynchronous particle communication algorithm is designed and implemented. Furthermore, we couple the domain decomposition method with MC burnup process, under a strategy of utilizing consistent domain partition in both transport and depletion modules. A numerical test of 3D full-core burnup calculations is carried out, indicating that the RMC code, with the domain decomposition method, is capable of pin-wise full-core burnup calculations with millions of depletion regions.

• Journal of Pharmacopuncture
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• v.20 no.1
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• pp.10-17
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• 2017

Objectives: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. Methods: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8.0 mg/kg, Intraperitoneally, i.p.) and TMT + BA (40, 80 and 160 mg/kg, i.p.)-administrated rats. BA was used daily for 21 days. To evaluate the cognitive improving of BA, we performed the Morris water maze test. Moreover, to investigate the neuroprotective effect of BA, we determined the acetylcholinesterase (AchE) activity, the malondialdehyde (MDA) level as a marker of lipid peroxidation, and the glutathione (GSH) content in the cerebral cortex. Results: Treatment with TMT impaired learning and memory, and treatment with BA at a dose of 160 mg/kg produced a significant improvement in learning and memory abilities in the water maze tasks. Consistent with behavioral data, the activity of AChE was significantly increased in the TMT-injected rats compared to the control group (P < 0.01) whereas all groups treated with BA presented a more significant inhibitory effect against AChE than the TMT-injected animals. In addition, TMT reduced the GSH content and increased the MDA level in the cerebral cortex as compared to the control group) P < 0.01). On the other hand, treatment with BA at 160 mg/kg slightly increased the GSH content and reduced the MDA level in comparison to the TMT-administered group (P < 0.01). Conclusion: The above results suggest that the effect of BA in improving the cognitive function may be mediated through its antioxidant activity.

• Korean Institute of Interior Design Journal
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• v.25 no.2
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• pp.41-49
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• 2016

The purpose of this study is to analyze the change and to compare to the difference of 'selective elements' and 'space-memory' focusing on the theory, 'selective attention' through the survey results. In this study, In this study, the lighting is considered a important factor in the change of 'selective elements'. this survey is to find the selective elements of participants and to measure the spatial sensitivity of respondents through 'self- test'. The analysis in this study is conducted by descriptive statistics, t-test and one way ANOVA by SPSS program 22. The results of this study are as following; Firstly, 'attention-element' could be classified with 4 types, 'shape', 'material', 'contrast' and 'combination'. 'shape' could divide into 'structure' and' furniture and object'. In case of 'material', it could section with 'pattern' and 'color'. Secondly, through the results of study, 'attention-element' is different each space during the day in detail. But we could know that 'shape' is the important element of the 'attention-elements' during the day through comparison of this result. That means users consider this as a important factor when they evaluate the space. Therefore, it is effective way designers to consider 'shape' as the first element when they want to conduct the special sensitivity of users in the space through planning. On the other hand, what selective elements of users are different by the lighting situation should be acknowledged by designers. And they should think the kinds of selective elements are more various when lighting turns on than turns off.. Thirdly, through the results such as the meaningful difference of space-memory of users according to the change of 'attention-elements', designers should judge about which kind of feeling of users to the space do you want lead in the design process. For the effective feedback between spaces and users to induce the same emotion of users, designers need to consider the unified design and the individual design both. Also, we will regard the differences in the users' emotion to the space according to the lighting situation when we design the space.

• Nutrition Research and Practice
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• v.9 no.5
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• pp.480-488
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• 2015

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is characterized by deficits in memory and cognitive functions. The accumulation of amyloid beta peptide ($A{\beta}$) and oxidative stress in the brain are the most common causes of AD. MATERIALS/METHODS: Caffeic acid (CA) is an active phenolic compound that has a variety of pharmacological actions. We studied the protective abilities of CA in an $A{\beta}_{25-35}$-injected AD mouse model. CA was administered at an oral dose of 10 or 50 mg/kg/day for 2 weeks. Behavioral tests including T-maze, object recognition, and Morris water maze were carried out to assess cognitive abilities. In addition, lipid peroxidation and nitric oxide (NO) production in the brain were measured to investigate the protective effect of CA in oxidative stress. RESULTS: In the T-maze and object recognition tests, novel route awareness and novel object recognition were improved by oral administration of CA compared with the $A{\beta}_{25-35}$-injected control group. These results indicate that administration of CA improved spatial cognitive and memory functions. The Morris water maze test showed that memory function was enhanced by administration of CA. In addition, CA inhibited lipid peroxidation and NO formation in the liver, kidney, and brain compared with the $A{\beta}_{25-35}$-injected control group. In particular, CA 50 mg/kg/day showed the stronger protective effect from cognitive impairment than CA 10 mg/kg/day. CONCLUSIONS: The present results suggest that CA improves $A{\beta}_{25-35}$-induced memory deficits and cognitive impairment through inhibition of lipid peroxidation and NO production.

• Fisheries and Aquatic Sciences
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• v.25 no.8
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• pp.450-461
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• 2022

A randomized, double-blind, and placebo-controlled clinical study was used to determine the cognitive functions related to working memory (WM) and antioxidant properties of fermented Laminaria japonica (FLJ) on healthy volunteers. Eighty participants were divided into a placebo group (n = 40) and FLJ group (n = 40) that received FLJ (1.5 g/day) for 6 weeks. Memory-related blood indices (brain-derived neurotrophic factor, BDNF; angiotensin-converting enzyme; human growth hormone, HGH; insulin-like growth factor-1, IGF-1) and antioxidant function-related indices (catalase, CAT; malondialdehyde, MDA; 8-oxo-2'-deoxyguanosine, 8-oxo-dG; thiobarbituric acid reactive substances, TBARS) were determined before and after the trial. In addition, standardized cognitive tests were conducted using the Cambridge Neuropsychological Test Automated Batteries. Furthermore, the Korean Wechsler Adult Intelligence Scale (K-WAIS)-IV, and the Korean version of the Montreal Cognitive Assessment (MoCA-K) were used to assess the pre and post intake changes on WM-related properties. According to the results, FLJ significantly increased the level of CAT, BDNF, HGH, and IGF-1. FLJ reduced the level of TBARS, MDA, and 8-oxo-dG in serum. Furthermore, FLJ improved physical activities related to cognitive functions such as K-WAIS-IV, MoCA-K, Paired Associates Learning, and Spatial Working Memory compared to the placebo group. Our results suggest that FLJ is a potential candidate to develop functional materials reflecting its capability to induce antioxidant mechanisms together with WM-related indices.

• Journal of Korea Spatial Information System Society
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• v.6 no.2 s.12
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• pp.63-75
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• 2004

This paper proposes a Web Service framework on both wired and wireless network environment that can be interoperable and extensible among geo-spatial servers. Mostly, OGC has studied and announced international standards which are related to web services on various kinds of geo-spatial data. Therefore, the proposed framework satisfies interoperability and extensibility for geo-spatial servers by adapting WMS, WFS, WCS, and WRS standards of OGC and web services standards of W3C. This framework, also, satisfies requirements of huge volumed data service, GML service, geo-spatial function service, and wireless network service. This framework consists of geo-spatial servers group, geo-spatial broker, and web-based client. The geo-spatial servers group includes GIS, SIIS, ITS, GNSS, and Telematics server for the purpose of providing various kinds of geo-spatial services. Especially, this paper proposes main memory based GIS server(MMG server) that can efficiently serve huge volumed GML data on wireless network environment. Finally, experimental results about the MMG server and prototype implementations of the framework show the effectiveness of this study.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.10
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• pp.82-94
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• 2015

In this paper, we propose hardware prefetch mechanism with an efficient cache replacement policy by giving priority to the trigger block in which a spatial region and producing a spatial region by using the displacement field. It could be taken into account the sequence of the program since a history is based on the trigger block of history record, and it could be quickly prefetching the instructions or data address by adding a stored value to the trigger address and displacement field since a history is stored as a displacement value. Also, we proposed a method of replacing at random by the cache replacement policy from the low priority block when the cache area is full after giving priority to the trigger block. We analyzed using the memory simulator program gem5 and PARSEC benchmark to assess the performance of the hardware prefetcher. As a result, compared to the existing hardware prefecture to generate the spatial region using a bit vector, L1 data cache miss rate was reduced about 44.5% on average and an average of 26.1% of L1 instruction misses occur. In addition, IPC (Instruction Per Cycle) showed an improvement of about 23.7% on average.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.1
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• pp.101-108
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• 2005

Adaptive constant false alarm rate(CFAR) algorithm is used for good detection probability as well as constant false alarm rate in clutter background. Especially, filtering technique adaptive to spatial variation is necessary for improving detection quality in non stationary clutter environment which has spatial correlation and large magnitude deviation. In this paper, we propose a two-dimensional block interpolation(TBI) adaptive CFAR algorithm that calculates the node estimate in the fred two dimensional region and subsequently determines the final estimate for each resolution cell by two-dimensional interpolation. The proposed method is efficient for filtering abnormal ejection by adopting distribution median in fixed region and also has advantage of reducing required memory space by using estimation method which gets final values after calculating the block node values. Through simulations, we show that the proposed method is superior to the traditional adaptive CFAR algorithms which are transversal or recursive in aspect of the detection performance and required memory space.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.1
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• pp.11-20
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• 2012

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.10C
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• pp.1023-1032
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• 2003

Object-based coding, such as MPEG-4, enables various content-based functionalities for multimedia applications. In order to support such functionalities, as well as to improve coding efficiency, each frame of video sequences should be segmented into video objects. In this paper. we propose an effective video object segmentation method using nonlinear multiscale filtering and spatio-temporal information. Proposed method performs a spatial segmentation using a nonlinear multiscale filtering based on the stabilized inverse diffusion equation(SIDE). And, the segmented regions are merged using region adjacency graph(RAG). In this paper, we use a statistical significance test and a time-variant memory as temporal segmentation methods. By combining of extracted spatial and temporal segmentations, we can segment the video objects effectively. Proposed method is more robust to noise than the existing watershed algorithm. Experimental result shows that the proposed method improves a boundary accuracy ratio by 43% on "Akiyo" and by 29% on "Claire" than A. Neri's Method does.