• Journal of Environmental Health Sciences
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• v.24 no.2
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• pp.80-87
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• 1998

To evaluate the effects on health by exposure to low dose organic solvents, the author analyzed the air concentration of mixed organic solvents (toluene, xylene, butylacetate) at worker's breathing zone during painting, some laboratory findings of blood (WBC, RBC, Hb, Hct, SGOT, SGPT, TC, TG, HDL-C, LDL-C, IgG, IgM, IgA and IgE) and urine (hippuric acid, urinary protein, urobilinogen), surveyed the subjective symptoms those were obtained from 35 male workers exposed to mixed organic solvents, and 25 male workers not exposed to organic solvents who worked in car repair workshops in Taejon area from December 1, 1995, to February 29, 1996. The results were as follows: 1. The mean concentration of urinary hippuric acid of car painting worker group (organic solvent exposure group) was 0.76$\pm$ 0.21 g/l, which is significantly higher than that of non-exposed group. 2. In hematologic findings, the values of RBC, TC, LDL-C, IgG and IgE in the exposure group were significantly lower than those of the nonexposed group, but SGOT and SGPT in the exposure group were significantly higher than those of the non-exposed group. 3. Urinary hippuric acid levels showed positively correlated with toluene, urobilinogen and HDL-C levels, but those were negatively correlated with RBC, LDL-C, IgM levels. 4. Rates of the subjective symptoms such as "dizziness", "appetite loss", "weight loss", "palpitation", "chest tightness", "sore throat and eye discomfort", "tingling sense and acrodynia", "illusion or hallucination" and "decreaased motor power" were significantly higher in the exposure group than those of the non-exposed group.

• Asian Oncology Nursing
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• v.2 no.1
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• pp.72-82
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• 2002

Purpose : To observe changes in side effects and fatigue of the cancer patients receiving radiation therapy on the head/neck and the chest over a period from the start to the end of the therapy, and to analyze correlation between side effects and fatigue. Method : Twenty seven patients receiving radiation therapy 5 days per week for longer than 6 weeks participated in the present study. Fatigue was measured for when healthy, before-, and after-therapy. Side effects was surveyed by structured questionnaire on the last day of each therapy. Result : The results of this study were as follows. 1. Major side effects of the head/neck patients were skin irritation, change of taste, sore throat and xerostomia, while the chest patients experienced fatigue, skin irritation, anorexia, difficulty swallowing and cough increased with therapy. 2. Although fatigue was significantly changed for when healthy and before-therapy (F=60.25, p <.05) and also for before- and after-therapy, no statistical significance was demonstrated in fatigue of both the chest head/neck patients (p> .05). 3. Fatigue and side effects showed high correlation form the 4-th week with after the therapy Conclusion : The present results could be of great use to develop systematic intervention technique, leading to practical help for patients, since side effects and fatigue change to a large degree depending on the disease and the timing and technique of the therapy.

• The Journal of Pediatrics of Korean Medicine
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• v.17 no.2
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• pp.27-35
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• 2003

Objective : About 5% of children suffer from convulsive disease before they grow up. Among the convulsive disease, epilepsy means the chronic and relapsed nervous disorder. The etiologic factors of epilepsy are very various. But about 75% of cases are idiopathic, in other words, we cannot find the origin of the disease. Method : We report on 8-year-old male patient with idiopathic epilepsy. We treated him with Hyoungbangdojeok-San and acupuncture. Results : After treatments, the symptoms(convulsion, cough, sputum, constipation, and sore throat) are improved. Conclusion : We had good effects in oriental medical treatment on Idiopathic Epilepsy. And the more study about this disease is needed.

• Korean Journal of Pharmacognosy
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• v.33 no.1 s.128
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• pp.29-34
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• 2002

Albizzia julibrissin belonging to the family Leguminosae has been used for the treatment of contusion, sore throat, amnesia, and insomnia in Oriental traditional medicine. The water extract of A. julibrissin induced apoptosis in Jurkat T-acute lymphoblastic leukemia (ALL) cells as measured by cell morphology. The capability of this herb medicine to induce apoptosis was associated with proteolytic cleavage of specific target protein such as beta-catenin protein suggesting the possible involvement of caspases. The purpose of the present study is also to investigate the effect of A. julibrissin on cell cycle progression. Our results showed that GI checkpoint related gene products (cyclin D1, cyclin dependent kinase 4, retinoblastoma, E2F1) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by A. julibrissin may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.285-288
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• 2004

This study was designed to report the clinical effects of Hyunhwang-haedok-tang on patients who have suffered from acute tonsillitis. Patients complained of fever, sore throat, swallowing difficulty, headache, cough. We give a diagnosis of acute tonsillitis. Therefore, we treated patients with oriental medicine, especially Hyunhwang-haedok-tang, and found that those symptoms and signs were improved by VAS, which is visual analogue scale. Through this study, Hyunhwang-haedok-tang on patients who have suffered from acute tonsillitis, proved to be effective.

• Korean Journal of Veterinary Research
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• v.53 no.3
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• pp.177-180
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• 2013

Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.

• Applied Biological Chemistry
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• v.49 no.2
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• pp.125-128
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• 2006

Schizonepeta tenuifolia Briq. are used in folk medicine as common cold, sore throat, headache and skin infection in Korea, China and Japan. To compare the contents of domestic and Chinese Schizonepeta tenuifolia quantitative HPLC analysis was performed using a Luna $C_{18}$ column $(4.6{\times}250\;mm,\;5{\mu}m)$, with 1 ml/min of flow rate of 0.01% formic acid in water : acetonitrile = 50 : 50 under UV 254 nm of detector. Pulegone was detected at retention time of about 17.14 min.

• YAKHAK HOEJI
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• v.45 no.6
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• pp.730-738
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• 2001

Apoptosis is a morphologically and biochemically distinct form of cell death that occurs in many different cell types in a wide variety of organisms. Ajbizzia julibrissin belonging the family Leguminosae has been used for the treatment of contusion, sore throat, amnesia, and insomnia in oriental traditional medicine. This study investigates whether the water extract off julibrissin induce apoptotic cell death in Jurkat T-acute lymphoblastic leukemia (ALL) cells. Jurkat cells were increased inhibitions of cell viability in a concentration-dependent manner by A julibrissin. This herbal medicine also caused apoptosis as measured by cell morphology and DNA fragmentation. The capability oft julibrissin to induce apoptosis was associated with proteolytic cleavage of specific target protein such as poly (ADP-ribose) polymerase (PARP) protein suggesting the possible involvement of caspases. Our result skewed that Bcl-2 and Bax protein levels were not changed in all A julibrissin-treated groups compared to control group. These results suggest that A julibrissin-mediated apoptosis is independent with Bcl-2 related signaling pathway in this cells.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.04a
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• pp.9-9
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• 2018

Arctii Fructus (AF), which contains arctigenin (ARC) as a major constituent, is traditionally used as an anti-inflammatory medicine to treat inflammatory sore throat. Although several studies have proven its anti-inflammatory effects, there have been no reports on its use in inflammation related disorders such as obesity, cancer metastasis, and allergic responses. This study investigated the anti-obesity effect and anti-metastasis effect of AF and ARC. AF and ARC inhibited weight gain by reducing the mass of white adipose tissue in high fat diet (HFD)-induced obese mice. Serum cholesterol levels were also improved by AF and ARC. In in vitro experiments, AF and ARC decreased differentiation of white adipocytes. Furthermore, AF induced differentiation of brown adipocytes, which are able to consume surplus energy through non-shivering thermogenesis. Also, AF and ARC inhibited colon cancer and lung metastasis of colon cancer. They suppressed not only colorectal cancer cell progression by inhibiting cell growth, but also prohibited lung metastasis by regulating epithelial-mesenchymal transition (EMT), migration, and the invasion. These effects were confirmed in an experimental metastasis mouse model. In addition, AF and ARC inhibited mast cell mediated allergic responses. Collectively, our study suggests that AF and ARC might show inhibitory effects on inflammation related diseases, including obesity, cancer, cancer metastasis, and allergic responses.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.256-264
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• 2007

Objective : This study describes a case of urticarial drug eruption assumed to be caused by non-steroidal anti- inflammatory drugs (NSAIDs) treated with oriental medicine and acupuncture. Methods : We studied the case of 20-years-old drug eruption patient. The patient complained of urticaria, angioedema, itching and burning sensation after taking NSAIDs. The indications for NSAIDs prescribed were common cold symptom and sore throat. For diagnosis, blood test and urinalysis were done. For treatment, acupuncture and herbal-medicine treatment were applied. Results : The patient of this report were examined for 13 days. The radiological finding was within normal limits. The WBC, neutrophil, lymphocyte and eosinophil level normalized during admission. After 3 days, itching and wheal reaction of whole body disappeared except facial symptom. The angioedema, itching and wheal reaction in the face was almost improved in the 4th day after discharge. Conclusions : We may expect that the oriental medical therapy improves the urticarial drug eruption caused by NSAIDs.