Browse > Article
http://dx.doi.org/10.14405/kjvr.2013.53.3.177

Flurbiprofen toxicity in 2 dogs  

Lee, Ye-Hyun (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Nam, Eui-Hwa (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Park, Seol-Hee (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Song, Chi-Youn (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Lee, Yong-Uk (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Lee, Jong-Myung (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Park, Jung-Hoon (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Hwang, Cheol-Yong (College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
Publication Information
Korean Journal of Veterinary Research / v.53, no.3, 2013 , pp. 177-180 More about this Journal
Abstract
Two dogs were presented with melena, vomiting and depression after accidental swallowing of candy form of Strepsils (flurbiprofen), which is one of non-steroidal anti-inflammatory drugs used in human medicine for controlling a sore throat. These dogs had common signs of anemia induced by gastrointestinal ulceration and hemorrhage with azotemia and leukocytosis. The dogs were treated with blood transfusion, fluid therapy, proton-pump inhibitor, antiemetics, mucus protectant and antibiotic. Although most of clinical signs of two dogs were resolved, azotemic problem with evidence of renal injury have remained.
Keywords
dogs; non-steroidal anti-inflammatory drugs (NSAIDs); Strepsils (flurbiprofen); toxicity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Enberg TB, Braun LD, Kuzma AB. Gastrointestinal perforation in five dogs associated with the administration of meloxicam. J Vet Emerg Crit Car 2006, 16, 34-43.   DOI
2 Brogden RN, Heel RC, Speight TM, Avery GS. Flurbiprofen: a review of its pharmacological properties and therapeutic use in rheumatic diseases. Drugs 1979, 18, 417-438.   DOI   ScienceOn
3 Capell HA, Konetschnik B, Glass RC. Anti-inflammatory analgesic drug responders and non-responders: a clinicopharmacological study of flurbiprofen. Br J Clin Pharmacol 1977, 4, 623-624.   DOI   ScienceOn
4 Carmichael S. Clinical use of non-steroidal anti-inflammatory agents (NSAIDs); The current position. EJCAP 2011, 21, 171-177.
5 Harirforoosh S, Jamali F. Renal adverse effects of nonsteroidal anti-inflammatory drugs. Expert Opin Drug Saf 2009, 8, 669-681.   DOI   ScienceOn
6 Heasman PA, Benn DK, Kelly PJ, Seymour RA, Aitken D. The use of topical flurbiprofen as an adjunct to non-surgical management of periodontal disease. J Clin Periodontol 1993, 20, 457-464.   DOI   ScienceOn
7 Loboz KK, Shenfield GM. Drug combinations and impaired renal function - the 'triple whammy'. Br J Clin Pharmacol 2004, 59, 239-243.
8 Jeffcoat MK, Williams RC, Wechter WJ, Johnson HG, Kaplan ML, Gandrup JS, Goldhaber P. Flurbiprofen treatment of periodontal disease in beagles. J Periodontal Res 1986, 21, 624-633.   DOI
9 Khan SA, McLean MK. Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats. Vet Clin North Am Small Anim Pract 2012, 42, 289-306.   DOI   ScienceOn
10 KuKanich B, Bidgood T, Knesl O. Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs. Vet Anaesth Analg 2012, 39, 69-90.   DOI   ScienceOn
11 Rainsford KD. Profile and mechanisms of gastrointestinal and other side effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Am J Med 1999, 107, 27-35S.
12 Wallace JL. Pathogenesis of NSAID-induced gastroduodenal mucosal injury. Best Pract Res Clin Gastroenterol 2001, 15, 691-703.   DOI   ScienceOn
13 Watson N, Nimmo WS, Christian J, Charlesworth A, Speight J, Miller K. Relief of sore throat with the antiinflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract 2000, 54, 490-496.
14 Whelton, A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med 1999, 106, 13-24S.   DOI   ScienceOn
15 Whittle BJ. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins. Br J Pharmacol 1977, 60, 455-460.   DOI   ScienceOn