• Molecules and Cells
• /
• v.44 no.1
• /
• pp.13-25
• /
• 2021

Apoptosis and compensatory proliferation, two intertwined cellular processes essential for both development and adult homeostasis, are often initiated by the mis-regulation of centrosomal proteins, damaged DNA, and defects in mitosis. Fly Anastral spindle 3 (Ana3) is a member of the pericentriolar matrix proteins and known as a key component of centriolar cohesion and basal body formation. We report here that ana3m19 is a suppressor of lethality induced by the overexpression of Sol narae (Sona), a metalloprotease in a disintegrin and metalloprotease with thrombospondin motif (ADAMTS) family. ana3m19 has a nonsense mutation that truncates the highly conserved carboxyl terminal region containing multiple Armadillo repeats. Lethality induced by Sona overexpression was completely rescued by knockdown of Ana3, and the small and malformed wing and hinge phenotype induced by the knockdown of Ana3 was also normalized by Sona overexpression, establishing a mutually positive genetic interaction between ana3 and sona. p35 inhibited apoptosis and rescued the small wing and hinge phenotype induced by knockdown of ana3. Furthermore, overexpression of Ana3 increased the survival rate of irradiated flies and reduced the number of dying cells, demonstrating that Ana3 actively promotes cell survival. Knockdown of Ana3 decreased the levels of both intra- and extracellular Sona in wing discs, while overexpression of Ana3 in S2 cells dramatically increased the levels of both cytoplasmic and exosomal Sona due to the stabilization of Sona in the lysosomal degradation pathway. We propose that one of the main functions of Ana3 is to stabilize Sona for cell survival and proliferation.

• Journal of Electrical Engineering and Technology
• /
• v.13 no.3
• /
• pp.1337-1345
• /
• 2018

The reliability of power transmission and distribution depends up on the consistency of insulation in the high voltage power transformer. In recent times, considering the drawbacks of conventional mineral oils such as poor biodegradability and poor fire safety level, several research works are being carried out on natural ester based nanofluids. Earlier research works show that sunflower oil has similar dielectric characteristics compared with mineral oil. BIOTEMP oil which is now commercially available in the market for transformers is based on sunflower oil. Addition of nanofillers in the base oil improves the dielectric characteristics of liquid insulation. Only few results are available in the literature about the insulation characteristics of nano modified natural esters. Hence understanding the influence of addition of nanofillers in the dielectric properties of sunflower oil and collecting the database is important. Considering these facts, present work contributes to investigate the important characteristics such as partial discharge, lightning impulse, breakdown strength, tandelta, volume resistivity, viscosity and thermal characteristics of $SiO_2$ nano modified sunflower oil with different wt% concentration of nano filler material varied from 0.01wt% to 0.1wt%. From the obtained results, nano modified sunflower oil shows better performance than virgin sunflower oil and hence it may be a suitable candidate for power transformer applications.

• International Journal of Computer Science & Network Security
• /
• v.21 no.6
• /
• pp.11-16
• /
• 2021

At the present time, the number of accidents has enlarged speedily and in country like India per day there are about 204 accidents occurred. Accidents of two-wheeler compose a foremost segment of every accident and it can be true for the reason that two-wheelers like bikes not able to produce as many as security measurements normally incorporated in cars, truks and bus etc. General main rootcost of the two-wheeler accidents happen only when people community not remember to wearing a device helmet and during the driving time feels like sleep condition, alcohol disbursement, many of the drivers doesn't know heavy vehicles like Loory and buses approaching into very closer to their two wheelers, contravention of two wheelers in traffic rules and regulations. Let's overcome the above situations; our important objective is to develop an intelligent system device that can successfully facilitate in avoidance of every kind of problems. Suppose any of the above stated situations occurs, at that moment how system device identify and represents the commanders and community, and finally the stated situation be able to taken care of straight away without any further delay. A smart intelligent helmet system is a defending head covering used by rider for making bike riding safer than earlier. This is finished by incorporating sophisticated features like detecting the usage of helmet by the rider, connected Bluetooth module in helmet. In order to maintain the temperature inside the helmet device we need to include CPU fan module inside the device. RF based helmet prevents road accidents and identify whether people community is not using a component helmet or used. Main responsibility of the system is to detect accidents by vibration sensors, accelerometers and also with the help of modules global positioning system and global system for mobile commnicaiton module. A wireless communication device used to discover the accident area site location and likewise notifying the two-wheeler drived people's relatives and short message text information passed to the positioned hospitals.

• Structural Engineering and Mechanics
• /
• v.90 no.2
• /
• pp.143-157
• /
• 2024

Cold-formed steel (CFS) I sections are increasingly being used as load-bearing components in building constructions, and such I sections frequently incorporate web holes to facilitate service installation. The economical and structural advantages of these elements have prompted many researchers to investigate the behavior of such structures. Despite numerous studies on the buckling stability of castellated beams, there is a notable absence of experimental investigation into oval castellated beams with stiffeners. This study examines the local buckling of cold-formed steel castellated I-beams stiffened with oval constellations through experimental and numerical analysis. Four specimens are fabricated with and without stiffeners, including parallel, perpendicular, and intersecting types attached to the web portion of the beam, along with cross stiffeners for the oval-shaped openings at the beam ends. Additionally, a numerical model is developed to predict the behavior of castellated beams with oval openings up to failure, considering both material and geometric nonlinearities. Codal analysis is performed using the North American specification for cold-formed steel AISI S-100 and the Australian/New Zealand design code AS/NZS 4600. The anticipated outcomes from numerical analysis, experimental research, and codal analysis are compared and presented. It will be more helpful to the preliminary designers.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.10 no.3
• /
• pp.61-68
• /
• 1973

It was found that the rapidly changeable consonant's conlponents of the Korean speech can not be analyzed precisely by the method of frequency analysis, but only by the method of frequency synthesis based on the speech pattern obtained from sona-graph. The following two methods mer mainly: One was to extract the frequency region of Consortarts, and the other was to observe how the mode of the Formant of the Korean Vowel, $\mid$ㅏ$\mid$, following after some consonants. changes both by the articulation manner and by the articulation position.

• Proceedings of the Korea Society of Design Studies Conference
• /
• 2001.10a
• /
• pp.8.2-8
• /
• 2001

• Advances in Energy Research
• /
• v.4 no.4
• /
• pp.275-284
• /
• 2016

In the present work, ZnO nanoparticles (NPs) have been dispersed alone in the same solvent of the active layer for improving performance parameters of the organic solar cells. Different concentrations of the ZnO NPs have been blended inside active layer of the solar cell based on poly(3-hexylthiophene) (P3HT), which forms the hole-transport network, and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM), which forms the electron-transport network. In the present investigations, the ZnO NPs may represent an efficient tool for improving light harvesting through light scattering inside active layer, electron mobility, and electron acceptance strength which tend to improve photocurrent and performance parameters of the investigated solar cell. The fill factor (FF) of the ZnO-doped solar cell increases nearly 14% compared to the non-doped solar cell when the doping is 50%. The present investigations show that ZnO NPs improve power conversion efficiency of the solar cell from 1.23% to 1.64% with increment around 25% that takes place after incorporation of 40% as a volume ratio of the ZnO NPs inside P3HT:PCBM active layer.

• Advances in Computational Design
• /
• v.3 no.1
• /
• pp.71-86
• /
• 2018

Thin-walled cross-sections can be optimized to enhance their resistance and progress their behaviour, leading to more competent and inexpensive structural system. The aim of this study is to afford a methodology that would facilitate progress of optimized cold formed steel (CFS) column section with maximum ultimate strength for practical applications. The proposed sections are designed to comply with the geometrical standards of pre-qualified column standards for CFS structures as well as with the number of industrialized and practical constraints. The stiffening evaluation process of CFS lipped channel columns, a five different cross section are considered. The experimental strength and behaviour of the proposed sections are verified by using the finite element analysis (FEA). A series comprehensive parametric study is carried out covering a wide range of section slenderness and overall slenderness ratio of the CFS column with and without intermediate web stiffeners. The ultimate strength of the sections is determined based on the Direct Strength Specification and other design equation available from the literature for CFS structures. A modified design method is proposed for the DSM specification. The results indicate that the CFS column with complex edge and intermediate web stiffeners provides an ultimate strength which is up to 78% higher than standard optimized shapes with the same amount of cross sectional area.

• Journal of Power Electronics
• /
• v.16 no.1
• /
• pp.205-216
• /
• 2016

The manufacturing sector resorts to automation to increase production and homogeneity of products during mass production, without increasing scarce, expensive, and unreliable manpower. Automation in the form of multiple robotic arms that handle materials in all directions in different stages of the process is proven to be the best way to increase production. This paper thoroughly investigates robotic single-arm movements, that is, 360° vertical rotation, with the help of a brushless DC motor, controlled by a fuzzy proportional-integral-derivative (PID) controller. This paper also deals with the design and performance of the fuzzy-based PID controller used to control vertical movement against the limited scope of conventional PID feedback controller and how the torque of the arm is affected by the fuzzy PID controller in the four quadrants to ensure constant speed and accident-free operation despite the influence of gravitational force. The design was simulated through MATLAB/SIMULINK and integrated with dSPACE DS1104-based hardware to verify the dynamic behaviors of the arm.

• Journal of Electrical Engineering and Technology
• /
• v.11 no.4
• /
• pp.951-960
• /
• 2016

Tower insulators in electric power transmission network play a crucial role in preserving the reliability of the system. Electrical utilities frequently face the problem of flashover of insulators due to pollution deposition on their surface. Several research works based on leakage current (LC) measurement has been already carried out in developing diagnostic techniques for these insulators. Since the LC signal is highly intermittent in nature, estimation of pollution severity based on LC signal measurement over a short period of time will not produce accurate results. Reports on the measurement and analysis of LC signals over a long period of time is scanty. This paper attempts to use Random Forest (RF) classifier, which produces accurate results on large data bases, to analyze the pollution severity of high voltage tower insulators. Leakage current characteristics over a long period of time were measured in the laboratory on porcelain insulator. Pollution experiments were conducted at 11 kV AC voltage. Time domain analysis and wavelet transform technique were used to extract both basic features and histogram features of the LC signal. RF model was trained and tested with a variety of LC signals measured over a lengthy period of time and it is noticed that the proposed RF model based pollution severity classifier is efficient and will be helpful to electrical utilities for real time implementation.