• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2001년도 Korean Environmental Mutagen Society
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• pp.174-174
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• 2001

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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• pp.130-130
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• 2001

The commercially available paclitaxel product, Taxol$\circledR$ is currently formulated in a vehicle containing approximately a 1:1 v/v mixture of polyoxyethylated castor oil (Cremophor EL) and ethanol. Cremophor EL, a commonly used surfactant for lipophilic compounds, has been associated with many issues, such as adverse effects particularly following rapid administration, stability with the possibility for drug precipitation upon dilution, and filtering requirements.(omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.287.3-288
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• 2002

Previously. we reported a novel polymeric micellar solubilizeI'. Aceporol 330. that showed relatively low toxic effects when it was compared with that of Cremophor EL which is currently being used for paclitaxel. In this study. we have developed a new micellar solubilizeI, Aceporol 460. that has 3-4 times higher loding capacity for paclitaxel than Aceporol 330. The single-dose and the repeated-dose toxicity of Aceporol 460 were evaluated in ICR mice. (omitted)

• Journal of Pharmaceutical Investigation
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• 제29권3호
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• pp.185-191
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• 1999

The polymeric films containing drug and various excipients were fabricated using aqueous-based $Eudragit^{\circledR}$ RS 30D dispersions. The diffusional behaviors and mechanism of the fabricated polymeric film were investigated using Keshary-Chien diffusion cell. The melatonin was used as a model drug. The diffusion behaviors of drug through the fabricated polymeric films were highly dependent on drug concentration in donor part, polymer contents and drug concentration, and the types of plasticizers and solubilizers. The fabricated polymeric films containing excipients and solubilizers could be applied for the controlled release of poorly water-soluble drug and for the preparation of drug-containing latex films for topical or oral drug delivery.

• 한국버섯학회지
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• 제11권2호
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• pp.53-62
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• 2013

A total of 35 phosphate solubilizing bacterial strains were isolated from waste mushroom bed of Agaricus bisporus in Buyeo-Gun, Chungnam and screened for the production of indole acetic acid (IAA). The best IAA producing strain was identified as Pantoea rodasii using 16S rRNA analysis. In addition to the IAA production, this strain could act as an efficient phosphate solubilizer (1100 ${\mu}g$ $ml^{-1}$ after 5 days of incubation) also. The selected strain was cultured under different conditions in order to assess the optimum conditions for maximum IAA production. The nutrient broth (NB) medium was recorded as the best medium, where the maximum IAA production (229 ${\mu}g$ $ml^{-1}$) was recorded at the start of stationary phase (12 hours after inoculation) of the bacteria growth. The performance of the strain was found to be maximum at the temperature of $30^{\circ}C$ followed by $25^{\circ}C$. IAA production was found to be increased with increasing tryptophan concentration (from 0.1 to 0.6%), however beyond this limit, a slight reduction in IAA production was observed. The strains' ability to produce IAA was further confirmed by extraction of crude IAA and subsequent TLC analysis. A specific spot from the extracted IAA preparation was found corresponding with the standard spot of IAA with same $R_f$ value. The results of HPLC analysis conducted in identifying and quantifying the IAA production more precisely, are in agreement with the results of the assessment done with colorimetric method. As revealed by the results of the pot experiment, the isolated strain could significantly enhance the growth (as measured by shoot and root growth) of mung bean plants compared to that of non-inoculated plants. Therefore it can be concluded that the present strain, Pantoea rodasii has great potential to be used as bio-inoculants.

• 한국응용과학기술학회지
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• 제14권1호
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• pp.45-52
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• 1997

It is the problem point of stability for this study to produce cosmetics and to occur in the circulation process, and specially in a case of alcoholic toilet water the precipitation materials to float on content materials has study on the solubility of perfume, and it has practiced in order to examine the problem point whether the raw materials of plastic vessel is or not harmful in content materials. In testing result, A study on stability of alcoholic toilet water is above all the precipitation materials which floats in content materials, and It is appeared by combination ratio to the raw materials of perfume, ethanol, solubilizer and refining water etcs, and in second the alkali degree which has gushed out of glass vessel can understand the thing that the change of PH is largely increased following to the passage of time, and in third the harmful component of content materials out of raw material in plastics vessel must certainly consider a stability and a safety in quality control of products.

• Journal of Electrochemical Science and Technology
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• 제12권2호
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• pp.279-284
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• 2021

The high theoretical specific capacity of lithium-sulfur (Li-S) batteries makes them a more promising energy storage system than conventional lithium-ion batteries (LIBs). However, the slow kinetics of the electrochemical conversion reaction seriously hinders the utilization of Li-S as an active battery material and has prevented the successful application of Li-S cells. Therefore, exploration of alternatives that can overcome the sluggish electrochemical reaction is necessary to increase the performance of Li-S batteries. In this work, an ionic liquid (IL) is proposed as a functional additive to promote the electrochemical reactivity of the Li-S cell. The sluggish electrochemical reaction is mainly caused by precipitation of low-order polysulfide (l-PS) onto the positive electrode, so the IL is adopted as a solubilizer to remove the precipitated l-PS from the positive electrode to promote additional electron transfer reactions. The ILs effectively dissolve l-PS and greatly improve the electrochemical performance by allowing greater utilization of l-PS, which results in a higher initial specific capacity, together with a moderate retention rate. The results presented here confirmed that the use of an IL as an additive is quite effective at enhancing the overall performance of the Li-S cell and this understanding will enable the construction of highly efficient Li-S batteries.

• 한국미생물·생명공학회지
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• 제40권4호
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• pp.424-429
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• 2012

The intention of this research was to investigate the solubilization of primary sewage sludge using lactic acid bacteria cultured in a glucose and yeast extract medium. Glucose as the carbon source and yeast extract as the source of nitrogen were chosen as an economic medium with the potential for the mass production of lactic acid bacteria. The optimal concentrations of the medium were 3% (w/v) glucose and 2% (w/v) yeast extract. In this study, in order to improve field applications for the solubilization of sludge at sewage treatment plants, a powdered form of lactic acid bacteria was produced. The optimal inoculum of the powder for the maximum efficiency of solubilization was 1% (w/v). In that condition, the SCOD value increased from 8600 (mg/L) at the beginning of experiment to 10290 (mg/L) at 96 h, with the highest solubilization rate (20.6% DDCOD) and 11.2% (SCOD). Also, the TVFAs of the lactic acid bacteria inoculation group were produced more than that of the control group. In particular, acetic acid was produced 5 times more in the experimental group than in the control group. In this research, the potential of lactic acid bacteria in the pretreatment of primary sewage sludge as a solubilizer, and as an energy source producer for microbial fuel cells was revealed.

• 한국응용과학기술학회지
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• 제32권3호
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• pp.461-468
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• 2015

역상 HPLC에 의한 Cetyltrimetyl ammonium chloride(CTM), Stearamidopropyl dimetylamine(SAP), Behentriammonium chloride(BHT), Dihexadeyldimethyl ammonium chloride (DHDDM)의 양이온계면활성제 4종 동시 정량분석 방법을 개발하였다. 분석조건으로 분리관은 Alltech $C_{18}$($250mm{\times}4.6mm$ i.d., $5{\mu}m$)을 사용하였고, 검출기는 ELSD를 사용하였으며, 이동상은 0.2% TFA/Methanol의 기울기 용리에 의해 분석되었다. 이때 검량선의 상관계수($r^2$)는 $130{\sim}1980.5{\mu}g/mL$농도 범위에서 0.997이상 이었고, 검출한계, 정밀성이 우수하였다. 이 방법은 fatty quaternary ammonium salt 4종의 정량분석 가능함을 보여 주었다.

• 한국토양비료학회지
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• 제41권5호
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• pp.342-347
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• 2008

미생물에 의해 분비되는 유기산에 의해 난용성 인산염이 가용화되어 토양 용액 중으로 확산되면 식물 혹은 다른 미생물이 이용할 수 있게 된다. 본 연구는 논 토양을 대상으로 볏짚 퇴비, 석회, 규산 등의 개량제가 토양 인산 가용화균의 생태에 미치는 영향을 조사하였다. 인산가용화 균의 비율이 증가할 수록 토양의 유효인산 함량이 높아지는 경향을 보였다. 논 토양 호기성 세균에 대한 인산가용화 세균의 비율은 석회, 규산 및 퇴비를 함께 시용한 처리구에서 크게 증가하였다. 논 토양에서 분리된 인산가용화 세균은 Aquaspirillum, Arthrobacter, Bacillus, Flavobacterium, Micrococcus, Micromonospora, Pseudomonas속 등이었으나 가장 많이 분리된 균은 Bacillus속이 그 다음으로는 Pseudomonas속이 우점하였다.