• 제목/요약/키워드: Solid Tumor

검색결과 590건 처리시간 0.033초

다년생 도라지의 항암 및 면역활성 (Antitumor and Immunomodulatory Activities of the P. grandiflorum Cultivated for More Than 20 Years)

  • 김영섭;이병의;김근재;이연태;조규봉;정영철
    • 약학회지
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    • 제42권4호
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    • pp.382-387
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    • 1998
  • Platycodon radix is a dried root of Platycodon grandiflorum (P. grandiflorum) A. DC, a perennial grown on the hills and fields in Korea and Japan, or cultivated in various districts. Recently, P. grandiflorum (Changkil) has been successfully cultivated for more than 20 years and generally has been employed as folk remedy for adult diseases such as hyperlipidemia, hypertension and diabetes. We investigated various biological activities of the extracts from Changkil. When treated in vitro with B16-F1 mouse melanoma cell lines, it showed 100% laminin-binding inhibitory activities at the concentration over 0.125mg/ml. In in vivo test it showed 61.5% reduction of the solid tumor weight transplanted in mice and exhibited anticancer activity of 128% ILS against Sarcoma-180 ascites. It also increased the ratio of positive cells of natural killer cells in lymphocytic composition against Sarcoma-18O ascites and solid tumor transplanted in ICR mice when tests were carried out by FACScan method.

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15세 여아에서 발생한 췌장의 비기능성 신경내분비종양 - 1예 보고 - (Nonfunctioning Neuroendocrine Tumor of the Pancreas in a 15-year-old Girl - a Case Report -)

  • 이경근;박진영
    • Advances in pediatric surgery
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    • 제15권2호
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    • pp.180-185
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    • 2009
  • We report a case of nonfunctioning neuroendocrine tumor of the pancreas in a 15-year-old girl who presented with back pain. On physical examination, there was mild tenderness in the left upper quadrant of the abdomen. The patient had no pancreatic hormone-associated symptoms. An abdominal ultrasonography showed a well-demarcated hypervascular solid mass with calcification in the tail of the pancreas. An abdominal computed tomography scan showed a $6{\times}5cm$ sized well-encapsulated enhancing solid mass with cystic component in the tail of the pancreas. Distal pancreatectomy was performed. Pathology revealed awelldifferentiated nonfunctioning low grade malignant neuroendocrine tumor of the pancreas. The postoperative course was uneventful.

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건비보현항암탕(健脾補腎抗癌湯) 및 건비보현항암탕가미방(健脾補腎抗癌湯加味方)이 고형암 및 면역세포에 미치는 영향 (Effects of Gunbibosinhangam-tang and Gunbibosinhangam-tang-gamibang on Solid Tumor and Immune Cells in Mice)

  • 이선아;고석재;은선혜;이현기;안민섭;권영미;유다영;문구
    • 동의생리병리학회지
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    • 제24권4호
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    • pp.602-609
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    • 2010
  • This study was carried out to investigate the anti-cancer effects of Gunbibosinhangam-tang (GBHT I) and Gunbibosinhangam-tang-gamibang (GBHT II, GBHT III) on solid tumor and immune cells. The animals were divided into 4 groups ; Control, no treatment. GBHT I, treatment with GBHT itself. GBHT II, treatment with GBHT increased the quantity of Hedyotis Diffusae twice. GBHT III, treatment with GBHT increased the quantity of Hedyotis Diffusae four times. We investigated the effects of GBHT on proliferation of solid tumor cells (S-180), thymocytes, splenocytes in vitro in order to examine cytotoxicity for S-180 and immuno-stimulating activities. The experiments that is about solid tumor weight and survival rate in tumor bearing mice were performed also. As compared with the control group, treatments with GBHT II and GBHT III suppressed the proliferation of S-180 effectively. Treatments with all experimental groups accelerated the proliferation of thymocytes and splenocytes significantly. In addition, GBHT III was significantly decreased on solid tumor weight and increased on survival rate in tumor bearing mice. Based upon these results, we suggest that GBHT and GBHT-gamibang have both anti-cancer effects for S-180 and immuno-stimulating activities for thymocytes and splenocytes. Therefore, we conclude that GBHT and Hedyotis Diffusae is useful to treat the patients with cancer.

Gamma Knife Radiosurgery for Remnant or Recurred Craniopharyngiomas

  • Kwon, Young-Sub;Park, Yong-Sook;Chang, Jong-Hee;Chang, Jin-Woo;Park, Yong-Gou
    • Journal of Korean Neurosurgical Society
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    • 제39권2호
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    • pp.96-101
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    • 2006
  • Objective : The authors assess the long term effectiveness of gamma knife radiosurgery[GKS] for remnant or recurred craniopharyngiomas on tumor control and possibly set proper radiation dose for tumor control with utmost preservation of the adjacent structures. Methods : Sixteen GKS were done in 14 patients with recurred or remnant craniopharyngiomas after surgery. Mean follow up duration was 44.2 months [range $11.3{\sim}123.6\;months$]. Follow up MR imagings were analyzed. Results : Mean tumor volume was $3.6cm^3$ [range $0.6{\sim}18cm^3$] and mean margin dose was 12.2Gy [range $8{\sim}22.4Gy$]. Tumor control was achieved in 87.5% [14 of 16 tumors] which were either solid or cystic in nature. Dose to optic apparatus was mean 7.9Gy and no radiation related complications were observed. Conclusion : GKS seems to be effective treatment modality for craniopharyngiomas regardless of nature of tumor whether it is cystic or solid. Dose of 8 to 8.5Gy may be sufficient to achieve long term tumor control for remnant or recurred craniopharyngiomas.

16세 남아에서 발생한 췌장의 비기능성 악성 신경내분비 종양: 증례 보고 (Non-Functioning, Malignant Pancreatic Neuroendocrine Tumor in a 16-Year-old Boy: A Case Report)

  • 임세웅;이영환;최시성;조현선
    • Investigative Magnetic Resonance Imaging
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    • 제14권2호
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    • pp.145-150
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    • 2010
  • 소아에서 췌장의 악성 종양은 매우 드물게 발생하고 있으며, 특히 악성 신경내분비 종양은 더더욱 드물다. 저자들은 16세 소아 환자에서 발생한 비기능성 악성 신경내분비 종양의 증례를 경험하여 CT와 MRI 소견을 보고하고자 한다. 췌장 두부에서 발생한 고형 종양으로 조영증강 MRI의 문맥기에서 지연기로 갈수록 조영증강이 잘 되고, 주변의 혈관 침습, 총담관 폐색, 림프절병증 등 악성 소견을 동반할 때 췌장의 비기능성 악성 신경내분비 종양을 감별 진단에 포함하여야 한다.

Acacia ferruginea Inhibits Tumor Progression by Regulating Inflammatory Mediators-(TNF-α, iNOS, COX-2, IL-1β, IL-6, IFN-γ, IL-2, GM-CSF) and Pro-Angiogenic Growth Factor-VEGF

  • Sakthivel, Kunnathur Murugesan;Guruvayoorappan, Chandrasekaran
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권6호
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    • pp.3909-3919
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    • 2013
  • The aim of the present investigation was to evaluate the effect of A ferruginea extract on Dalton's lymphoma ascites (DLA) induced tumours in BALB/c mice. Experimental animals received A ferruginea extract (10 mg/kg.b.wt) intraperitoneally for 14 consecutive days after DLA tumor challenge. Treatment with extract significantly increased the life span, total white blood cell (WBC) count and haemoglobin (Hb) content and decreased the level of serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (${\gamma}$-GT) and nitric oxide (NO) in DLA bearing ascites tumor models. In addition, administration of extract significantly decreased the tumour volume and body weight in a DLA bearing solid tumor model. The levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-${\alpha}$), interleukin-1 beta (IL-$1{\beta}$), interleukin-6 (IL-6) and granulocyte monocyte-colony stimulating factor (GM-CSF), as well as pro-angiogenic growth factors such as vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) were elevated in solid tumour controls, but significantly reduced by A ferruginea administration. On the other hand, the extract stimulated the production of interleukin-2 (IL-2) and interferon-gamma (IFN-${\gamma}$) in animals with DLA induced solid tumours. Increase in $CD4^+$ T-cell population suggested strong immunostimulant activity for this extract. GC/MS and LC/MS analysis showed quinone, quinoline, imidazolidine, pyrrolidine, cyclopentenone, thiazole, pyrazole, catechin and coumarin derivatives as major compounds present in the A ferruginea methanolic extract. Thus, the outcome of the present study suggests that A ferruginea extract has immunomodulatory and tumor inhibitory activities and has the potential to be developed as a natural anticancer agent.

소세포폐암에서 항암화학요법 중 발생한 치명적 종양용해증후군 1예 (Fatal Tumor Lysis Syndrome During Chemotherapy in Small Cell Lung Cancer)

  • 국은희;김민수;안세한;전세용;윤정호;한민성;김철현;이재철
    • Tuberculosis and Respiratory Diseases
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    • 제64권3호
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    • pp.215-218
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    • 2008
  • 고형암에서의 종양용해증후군은 드물지만 발생하면 높은 사망률을 보이는 치명적인 합병증으로 외국에서는 지금까지 약 50여명의 증례가 보고되어 왔다. 우리 나라에서도 종종 발생한다고 알려져 있지만 실제로 뒷받침 할만한 증례를 찾아 보기가 힘든 실정이었다. 이에 저자들은 소세포폐암에서 항암화학요법 도중 발생한 치명적 종양 용해증후군 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다.

고형 및 유두상 췌장 종양 1례 (A Case of Solid and Papillary Epithelial Neoplasm of the Pancreas)

  • 김종근;이형신;김상용;한지환;이경일;황경태
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제3권2호
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    • pp.217-221
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    • 2000
  • 저자들은 복부종괴가 촉진되고 간헐적 복부 동통을 주소로 내원한 14세 여아에서 복부 컴퓨터 단층 촬영과 조직검사로 고형 및 유두상 종양으로 진단하고 종괴절제술 및 Roux-en-Y 췌장공장문합술(pancreaticojejunostomy)로 치료한 환아 1례를 경험하였기에 보고하는 바이다.

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누에번데기 및 누에애벌레 밀리타리스동충하초(Cordyceps militaris) 열수추출물의 투여가 고형암이 유발된 마우스의 종양성장 억제 및 면역기능에 미치는 영향 (Tumor Growth Inhibitory and Immunomodulatory Activities of Cordyceps Militaris Water Extracts in ICR Mice Bearing Sarcoma-180 Solid Tumor)

  • 이해미;이여진;박태선
    • 한국식품영양과학회지
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    • 제33권1호
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    • pp.59-65
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    • 2004
  • 본 연구에서는 누에번데기 또는 누에애벌레를 기주로 하여 인공 재배된 밀리타리스동충하초의 고형암 성장억제 및 면역조절 기능을 평가하였다. 이를 위해 sarcoma-180 세포주를 겨드랑이에 피하 이식받은 ICR 마우스를 대상으로 밀리타리스동충하초 또는 유효성 분으로 알려진 cordycepin을 10일간 복강투여한 후 고형암 성 장저지능, 면역관련 장기의 무게변화, 비장 내 면역세포수의 변화, 그리고 비장세포에 의한 interleukin-2(IL-2) 생성능을 측정하여 다음과 같은 결론을 얻었다. 겨드랑이에 고형암을 이식받은 마우스에게 50 mg/kg(CMP50) 또는 100 mg/kg(CMP100)의 누에번데기 밀리타리스동충하초 추출물을 10일간 투여한 결과 생리식염수를 투여한 대조군에 비해 3주 후 고형암 성장이 47.3% 및 57.6% 유의하게 억제되었다(p<0.05). 50 mg/kg(CML50) 및 100 mg/kg(CML100)의 누에애벌레 밀리타리스동충하초를 투여받은 경우 35.5% 및 37.1%, 그리고 1 mg/kg 및 2 mg/kg의 cordycepin을 투여받은 군의 경우 26.1%와 29.8%의 고형암 성장 억제효과가 관찰되었다(p<0.05). 고형암을 이식받은 후 누에번데기 또는 누에애벌레 밀리타리스동충하초를 투여받은 마우스는 대조군에 비해 흉선무게가 38∼44% 유의하게 증가하였고(p<0.05), 비장내 CD4+ 및 CD8+ T-세포수, NK-세포수(63∼110% 증가), 그리고 비장세포에 의한 IL-2 생성능(33∼51%증가)이 모두 유의하게 증가하였다(p<0.05). 이상의 결과를 종합해 볼 때, 밀리타리스동충하초 열수추출물은 고형암의 성장을 억제하는 효과가 있으며, 이와 같은 밀리타리스동충하초 추출물의 항암활성은 면역기능 증강효과와 연관이 있을 것으로 생각된다. 아울러 밀리타리스동충하초의 고형암 성장억제 및 면역조절 기능은 cordycepin 단일물질에 비해 더 우수하였다.