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Comparison of Inodilator Effect of Higenamine, YS49, YS51, Tetrahydroisoquinoline Analogs, and Dobutamine in the Rat

  • Chong, Won-Seog;Lee, Young-Soo;Kang, Young-Jin;Lee, Duck-Hyung;Ryu, Jae-Chun;Yun-Choi, Hye-Sook;Chang, Ki-Churl
    • The Korean Journal of Physiology and Pharmacology
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    • v.2 no.3
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    • pp.323-330
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    • 1998
  • Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series of THI, using rats' isolated atria and aorta. In addition, a $[^3H]$ prazosin displacement binding study with THI compounds was performed, using rat brain homogenates to investigate whether these probes have ?${\alpha}$-adrenoceptor affinity. We also compared the vascular relaxation potency of these probes with dobutamine. YS 49, YS 51, higenamine and dobutamine, concentration-dependently, relaxed endothelium-denuded rat thoracic aorta precontracted with phenylephrine (PE, 0.1 ${\mu}M$) in which $pEC_{50}$ were $5.56{\pm}0.32$ and $5.55{\pm}0.21$, $5.99{\pm}1.16$ and $5.57{\pm}0.34$, respectively. These probes except higenamine also relaxed KCl (65.4 mM)-contracted aorta. In isolated rat atria, all THIs and dobutamine increased heart rate and contractile force. In the presence of propranolol, the concentration response curves of YS 49 and YS 51 shifted to the right and resulted in $pA_2$ values of $8.07{\pm}0.84$ and $7.93{\pm}0.11$, respectively. The slope of each compound was not deviated from unity, indicating that these chemicals are highly competitive at the cardiac ?${\beta}-adrenoceptors$. YS 49, YS 51, and higenamine showed ?${\alpha)-adrenoceptor$ affinity in rat brain, in which the dissociation constant $(K_i)$ was 2.75, 2.81, and 1.02 ${\mu}M$, respectively. It is concluded, therefore, that THI alkaloids have weak affinity to ${\alpha)_1-adrenoceptor$ in rat aorta and brain, respectively, while these probes show relatively high affinity for cardiac ${\beta}-adrenoceptors$. Thus, these chemicals may be useful in the treatment of congestive heart failure.

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Building a Log Framework for Personalization Based on a Java Open Source (JAVA 오픈소스 기반의 개인화를 지원하는 Log Framework 구축)

  • Sin, Choongsub;Park, Seog
    • KIISE Transactions on Computing Practices
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    • v.21 no.8
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    • pp.524-530
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    • 2015
  • A log is for text monitoring and perceiving the issues of a system during the development and operation of a program. Based on the log, system developers and operators can trace the cause of an issue. In the development phase, it is relatively simple for a log to be traced while there are only a small number of personnel uses of a system such as developers and testers. However, it is the difficult to trace a log when many people can use the system in the operation phase. In major cases, because a log cannot be tracked, even tracing is dropped. This study proposed a simplified tracing of a log during the system operation. Thus, the purpose is to create a log on the run time based on an ID/IP, using features provided by the Logback. It saves an ID/IP of the tracking user on a DB, and loads the user's ID/IP onto the memory to trace once WAS starts running. Before the online service operates, an Interceptor is executed to decide whether to load a log file, and then it generates the service requested by a certain user in a separate log file. The load is insignificant since the arithmetic operation occurs in a JVM, although every service must pass through the Interceptor to be executed.

Behaviors of Ionic Conductivity with Temperature for High-Temperature PEMFC Containing Room Temperature ionic Liquids Under Non-humidified Condition (상온 이온액을 이용한 고온 무수 PEMFC용 고정화 액막의 온도에 따른 이온전도도 거동)

  • Kim, Beom-Sik;Byun, Yong-Hoon;Park, You-In;Lee, Sang-Hak;Lee, Jung-Min;Koo, Kee-Kahb
    • Membrane Journal
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    • v.16 no.4
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    • pp.268-275
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    • 2006
  • Novel SILEMs were prepared by multi-stage phase separation process combined by the low temperature phase separation (LTPS) and the high temperature phase separation (HTPS) using room temperature ionic liquids (RTILs) which have a high ionic conductivity. PVDF and imidazolium series ionic liquids were used as membrane material and electrolyte, respectively. To study the ion conducting properties, the SILEMs were tested using LCR meter at temperature controlled from 30 to $130^{\circ}C$. Under humid conditions, with increasing temperature from 30 to $100^{\circ}C$, the ion conductivity of the cast $Nafion^{(R)}$ membrane increased linearly, but then started to decrease after $100^{\circ}C$. However, in the case of the SILEMs, with increasing operating temperature, the ion conductivity increased. Also, the ion conductivity behaviors of the SILEMs were almost same, regardless of humidity. The ion conductivity of the SILEMs was $2.7{\times}10^{-3}S/cm$ and increased almost linearly up to $2.2{\times}10^{-2}S/cm$ with increasing temperature to $130^{\circ}C$. The effects of an inorganic filler on the physical properties of the SILEMs were studied using the $SiO_2$. The addition of $SiO_2$ could improve the mechanical strength of the SILEMs, though the ionic conductivity was decreased slightly.

Technical Trend on the Recycling Technologies for Stripping Process Waste Solution by the Patent and Paper Analysis (특허(特許)와 논문(論文)으로 본 스트리핑 공정폐액(工程廢液) 재활용(再活用) 기술(技術) 동향(動向))

  • Lee, Ho-Kyung;Lee, In-Gyoo;Park, Myung-Jun;Koo, Kee-Kahb;Cho, Young-Ju;Cho, Bong-Gyoo
    • Resources Recycling
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    • v.22 no.4
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    • pp.81-90
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    • 2013
  • Since the 1990s, the rapid development of information and communication industry, the demand for semiconductor and LCD continues to increase. Therefore in the formation of fine circuit patterns, which are the cores of sensitizer and the most expensive thinner and stripper liquor used to remove photoresist and its dilution, the amount in demand are dramatically increasing, emerging need for recycling of waste thinner and stripper liquor. Recently, recycling technologies of stripping process waste solution has been widely studied by economic aspects and environmental aspects, in terms of efficiency of the stripping process. In this study, analyzed paper and patent for recycling technologies of waste solution from stripping process. The range of search was limited in the open patents of USA (US), European Union (EP), Japan (JP), Korea (KR) and SCI journals from 1981 to 2010. Patents and journals were collected using key-words searching and filtered by filtering criteria. The trends of the patents and journals was analyzed by the years, countries, companies, and technologies.

Museum Politics: A Study of Orientalism as Represented in the National Museum of Indonesia (박물관의 정치학: 인도네시아 국립박물관에 표상된 오리엔탈리즘 연구)

  • Song, Seung-Won
    • The Southeast Asian review
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    • v.21 no.1
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    • pp.137-184
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    • 2011
  • This article is aimed at understanding the political narratives represented in the National Museum of Indonesia. Starting initially as a colonial museum, the National Museum of Indonesia functioned as a useful tool for the Dutch colonial force to fuel its imaginations of the colonial territory and the people within it. The Dutch used the cultural display to advertize its benevolent colonial rule. All the while, the museum also inevitably reflected orientalism on the people and the culture of the colony. The republic of Indonesia inherited the colonial museum's practices and its display patterns. The business surrounding the museum also played a key role in the newly-born nation-state laying out a future for its redefined territory and people. Thus, what the colonial force imagined for the colonial territory through the study of museum displays was rather directly transferred to the republic without serious consideration of the decolonization process. Four main characteristics have been seen in the museum displays. The first is an emphasis on the glorious Hindu-Buddha history, from which numerous temples, statues, and jewelry have been found. Secondly, the Islamic period, which spanned between the Hindu-Buddha times to the colonial era, has almost completely been eliminated from the display. Third, the colonial era has been depicted as the time of Europe's exportation of scientific tools and adaption of sophisticated living patterns. Fourth, the images of ethnic groups were represented as being stagnant without reflecting any challenges and responses that these groups had faced throughout history. Looking at these display patterns, it can be concluded that all the dynamic internal developments and anti-colonial resistance that took place during the Islamic and Colonial Era have simply not been represented in the museum display. These display patterns do not reflect the real history or culture of the archipelago. Two considerations are thought to have influenced the neglecting of social realities in the display. The first of which is the Dutch's and Republic's apprehension over the possible political upheaval by the Islamic forces. Yet, more fundamentally, cultural displays themselves are distinct from historical education in that the former pays more attention to business ideas with an aim to attract tourists rather than to project objective historical knowledge. Thus, in cultural displays, objects which work to stimulate fantasies and spur curiosity on archipelagic culture tend to be selected and emphasized. In this process, historical objectivity is sometimes considered less vital. Cultural displays are set up to create more appealing narratives for viewers. Therefore, if a narrative loses its luster, it will be replaced by another flashy and newly-resurrected memory. This fact reveals that museums, as transmitters of historical knowledge, have a certain degree of limitation in playing their role.

Competition and Diversity: Perspective of the Objectives of Broadcasting-related Laws (경쟁과 다양성: 방송관련법의 목적의 관점)

  • Hong, Dae-Sik
    • Journal of Legislation Research
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    • no.44
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    • pp.63-101
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    • 2013
  • This article firstly explores into the concepts, components, and pictures of institutional realization of competition and diversity respectively on the premise that competition and diversity comprise the primary objectives to be pursued by the broadcasting-related laws which provide the concrete measures of media policy, and argues that while the competition objective has differentiation factors, there are also particularities in the diversity value in the broadcasting-related laws as sector-specific competition laws. Then assuming that special competition rules including structural regulatory measures particularly in the broadcasting market are required in order to realize values of competition and diversity harmoniously, this article suggests the following improvement directions for regulations aimed at protection of competition and diversity in the broadcasting-related laws. The first one is with the improvement method for regulations aimed at protection of competition. Regulation on share of audience as an ex ante regulation of status and regulation on prohibited activities as an ex post regulation of conduct may play important roles in substituting the causative regulation while seeking for diversity value. For this purpose, it is needed to develop a concrete method that incorporates diversity-related factors as consideration factors in the standard for determining illegality of prohibited activities by inference to methods of determining illegality in the competition law. The second one is with the improvement method for regulations aimed at protection of diversity. This could be considered from three viewpoints that are the setting of regulatory objectives, the identification of alternative regulatory measures, and the choice of regulatory measures and levels suitable for regulatory objectives. From these viewpoints, the regulatory framework should be improved mainly with institutional measures in which diversity value is used for tools of assessment and analysis, not just remaining as mere rhetorical devices, and whether or to what extent to maintain regulations seemingly unreasonable in terms of harmonization with economic objectives such as competition should be discreetly reviewed.

A Study on the Market Efficiency in a Pari-Mutuel Betting Market in Korea (경마 베팅시장의 효율성에 관한 연구)

  • Yu, Woong;Nahm, Jun-woo
    • Review of Culture and Economy
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    • v.20 no.2
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    • pp.149-171
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    • 2017
  • This paper presents empirical findings about the market inefficiency field in the korean horse track. We first use the place betting data instead of the win betting data inevitably depended on by past studies, and discuss the degree of the long shot anomaly and the bettor's risk attitude sequentially in the place betting market. The empirical result of betting simulations using the place winning function in this study reveals persistently higher returns than the expected payoff in korean racetrack betting market. The clear departures from perfect efficiency in horse-racing betting imply that much of the market information is insufficient and less accurate. This market asymmetry aggravates popular speculations exquisitely since people are attracted by the higher odds figures in the racetrack display although those are much uncertain in future. The findings suggest the more objective and credible information of winning possibilities such as the place winning function including the smart information of marginal odds needs to be available to the betting decision of the public, which contributes to reducing the speculative spirit in korean racetrack.

Conformer with lexicon transducer for Korean end-to-end speech recognition (Lexicon transducer를 적용한 conformer 기반 한국어 end-to-end 음성인식)

  • Son, Hyunsoo;Park, Hosung;Kim, Gyujin;Cho, Eunsoo;Kim, Ji-Hwan
    • The Journal of the Acoustical Society of Korea
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    • v.40 no.5
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    • pp.530-536
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    • 2021
  • Recently, due to the development of deep learning, end-to-end speech recognition, which directly maps graphemes to speech signals, shows good performance. Especially, among the end-to-end models, conformer shows the best performance. However end-to-end models only focuses on the probability of which grapheme will appear at the time. The decoding process uses a greedy search or beam search. This decoding method is easily affected by the final probability output by the model. In addition, the end-to-end models cannot use external pronunciation and language information due to structual problem. Therefore, in this paper conformer with lexicon transducer is proposed. We compare phoneme-based model with lexicon transducer and grapheme-based model with beam search. Test set is consist of words that do not appear in training data. The grapheme-based conformer with beam search shows 3.8 % of CER. The phoneme-based conformer with lexicon transducer shows 3.4 % of CER.

The Internationalization of Korean Software-related New Venture on Resource Based Perspectives - The Bundle of Tangible and Intangible Resources - (자원기반관점에서의 한국 소프트웨어개발 벤처기업의 국제화 - 가시적 자원과 비가시적 자원의 조합을 중심으로 -)

  • Lee, Keun-Hee;Kim, Jung-Po
    • International Area Studies Review
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    • v.13 no.2
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    • pp.393-416
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    • 2009
  • This paper explores the technology resource-based determinants influencing internationalization performance of Korean software-related new ventures. On the ground of the study by Zahra et al.(2003), this paper aims to test empirically in Korea how interaction effects of tangible and intangible technological resources, as firm capability, are related to software new ventures' internationalization performance. The test results shows that intangible technological resource represented by R&D intensity is not significantly related to internationalization performance, but reveals that intangible technological resource represented by strength of technological cooperation network and technological reputation is positively and significantly associated with internationalization performance. Internationalization performance is more significantly and positively associated with the interactions of tangible technological resource and intangible technological resource than those resources respectively. The implication for the findings in the paper is that cutting edge technological capability of software new ventures can be more closely associated with internationalization performance if those resources are fully utilized or leveraged by intangible resources acquired by cooperation with local networks and created through technological reputation of new ventures.

A Study of Policy Conversion in the EU Member States: with Special References to Minimum Income Guarantee (유럽연합의 정책 수렴에 대한 연구: 기초소득 보장을 중심으로)

  • Moon, Jin Young
    • 한국사회정책
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    • v.25 no.1
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    • pp.321-343
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    • 2018
  • This paper aims to apply the convergence theory into the minimum income guarantee which forms the moral foundation of the welfare state. The research question of this paper is if the level of minimum income guarantee among EU member states (EU-15) gradually converging into a certain level. For this purpose, Chapter 2 describes the convergence and diversion of welfare states since the Second World War, and chapter 3 explains the historical development of the EU social policies since the Rome Treaty (1957). Chapter 4, which is the main body of this paper, analyzes if the level of minimum income guarantees of EU member states is converging by the coefficient of variation analysis and regression analysis. However, converging trend of the level of basic income guarantee among EU member states has not been proved. In other words, social policy arena still remains strongly in the realm of national sovereign states, irrespective of growing pressure from the supra-national governing body like the EU. It is in line with the Abram de Swaan's argument that "welfare states is nation states" (1994: 110).