• Journal of Veterinary Science
• /
• 제22권5호
• /
• pp.47.1-47.10
• /
• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Nuclear Engineering and Technology
• /
• 제53권12호
• /
• pp.3879-3891
• /
• 2021

A heat pipe residual heat removal system is proposed to be incorporated into the reactor driven subcritical (RDS) facility, which has been proposed by MIT Nuclear Reactor Laboratory for testing and demonstrating the Fluoride-salt-cooled High-temperature Reactor (FHR). It aims to reduce the risk of the system operation after the shutdown of the facility. One of the main components of the system is an air-cooled heat pipe heat exchanger. The alkali-metal high-temperature heat pipe was designed to meet the operation temperature and residual heat removal requirement of the facility. The heat pipe model developed in the previous work was adopted to simulate the designed heat pipe and assess the heat transport capability. 3D numerical simulation of the subcritical facility active zone was performed by the commercial CFD software STAR CCM + to investigate the operation characteristics of this proposed system. The thermal resistance network of the heat pipe was built and incorporated into the CFD model. The nominal condition, partial loss of air flow accident and partial heat pipe failure accident were simulated and analyzed. The results show that the residual heat removal system can provide sufficient cooling of the subcritical facility with a remarkable safety margin. The heat pipe can work under the recommended operation temperature range and the heat flux is below all thermal limits. The facility peak temperature is also lower than the safety limits.

• Geomechanics and Engineering
• /
• 제28권5호
• /
• pp.521-529
• /
• 2022

This research work deals with the development of air pluviation method for preparing uniform sand specimens for conducting large scale laboratory testing. Simulating real field conditions and to get reliable results, air pluviation method is highly desirable. This paper presents a special technique called air pluviation or sand raining technique for achieving uniform relative density. The apparatus is accompanied by a hopper, shutters with different orifice sizes and numbers and set of sieves. Before using this apparatus, calibration curves are drawn for relative density against different height of fall (H) and shutter sizes. From these calibration curves, corresponding to the desired relative density of 60%, the shutter size of 13mm and height of fall of 457.2 mm, are selected and maintained throughout the pluviation process. The density obtained from the mobile pluviator is then verified using the Dynamic Cone Penetrometer (DCP) test where the soil is poured in the box using defined shutter size and fall height. The results obtained from the DCP test are averaged as 60±0.5 which was desirable. The mobile pluviator used in this research is also capable of obtaining relative densities up to 90%. The instrument is validated using experimental and numerical approach. In numerical study, Plaxis 3D software is used in which the soil mass is defined by 10-Node tetrahedral elements and 6-Node plate is used to simulate plate behavior in the validation phase. The results obtained from numerical approach were compared with that of experimental one which showed very close correlation.

• Wind and Structures
• /
• 제34권2호
• /
• pp.185-197
• /
• 2022

This study aimed to analyze the wind-induced mechanical energy (WME) of a proposed super high-rise and long-span transmission tower-line system (SHLTTS), which, in 2021, is the tallest tower-line system with the longest span. Anew index - the WME, accounting for the wind-induced vibration behavior of the whole system rather than the local part, was first proposed. The occurrence of the maximum WME for a transmission tower, with or without conductors, under synoptic winds, was analyzed, and the corresponding formulae were derived based on stochastic vibration theory. Some calculation data, such as the drag coefficient, dynamic parameters, windshielding areas, mass, calculation point coordinates, mode shape and influence function, derived from wind tunnel testing on reducedscale models and finite element software were used in calculating the maximum WME of the transmission tower under three cases. Then, the influence of conductors, wind speed, gradient wind height and wind yaw angle on WME components and the energy transfer relationship between substructures (transmission tower and conductor) were analyzed. The study showed that the presence of conductors increases the WME of transmission towers and changes the proportion of the mean component (MC), background component (BC) and resonant component (RC) for WME; The RC of WME is more susceptible to the wind speed change. Affected by the gradient wind height, the WME components decrease. With the RC decreasing the fastest and the MC decreasing the slowest; The WME reaches the its maximum value at the wind yaw angle of 30°. Due to the influence of three factors, namely: the long span of the conductors, the gradient wind height and the complex geometrical profile, it is important that the tower-line coupling effect, the potential for fatigue damage and the most unfavorable wind yaw angle should be given particular attention in the wind-resistant design of SHLTTSs

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제11권9호
• /
• pp.371-380
• /
• 2022

합성곱 신경망은 이미지와 같은 격자 형태로 배열된 데이터를 다루는데 널리 사용되고 있는 신경망이다. 일반적인 합성곱 신경망은 합성곱층과 완전연결층으로 구성되며 각 층은 비선형활성함수를 포함하고 있다. 본 논문은 합성곱 신경망의 성능을 향상시키기 위해 결합된 파라메트릭 활성함수를 제안한다. 결합된 파라메트릭 활성함수는 활성함수의 크기와 위치를 변환시키는 파라미터를 적용한 파라메트릭 활성함수들을 여러 번 더하여 만들어진다. 여러 개의 크기, 위치를 변환하는 파라미터에 따라 다양한 비선형간격을 만들 수 있으며, 파라미터는 주어진 입력데이터에 의해 계산된 손실함수를 최소화하는 방향으로 학습할 수 있다. 결합된 파라메트릭 활성함수를 사용한 합성곱 신경망의 성능을 MNIST, Fashion MNIST, CIFAR10 그리고 CIFAR100 분류문제에 대해 실험한 결과, 다른 활성함수들보다 우수한 성능을 가짐을 확인하였다.

• Computers and Concrete
• /
• 제29권 6호
• /
• pp.407-418
• /
• 2022

This paper numerically investigates the effect of changes in the mechanical properties (displacement, strain, and stress) of the ultra-high-performance concrete (UHPC) without rebar and the reinforced concrete (RC) using steel re-bars. This reinforced concrete is mostly used in the concrete bridge decks. A mixture of sand, gravel, cement, water, steel fiber, superplasticizer, and micro silica was used to fabricate UHPC specimens. The extended finite element method as used in the ABAQUS software is applied for considering the mechanical properties of UHPC, RC, and ordinary concrete specimens. To calibrate the ABAQUS, some experimental tests have been carried out in the laboratory to measure the direct tensile strength of UHPC by the compressive-to-tensile load converting (CTLC) device. This device contains a concrete specimen and is mounted on a universal tensile testing apparatus. In the experiments, three types of mixed concrete were used for UHPC specimens. The tensile strength of these specimens ranges from 9.24 to 11.4 MPa, which is relatively high compared with ordinary concrete specimens, which have a tensile strength ranging from 2 to 5 MPa. In the experimental tests, the UHPC specimen of size 150×60×190 mm with a central hole of 75 mm (in diameter)×60 mm (in thickness) was specially made in the laboratory, and its direct tensile strength was measured by the CTLC device. However, the numerical simulation results for the tensile strength and failure mechanism of the UHPC were very close to those measured experimentally. From comparing the numerical and experimental results obtained in this study, it has been concluded that UHPC can be effectively used for bridge decks.

• 한국정보통신학회논문지
• /
• 제26권2호
• /
• pp.230-238
• /
• 2022

사물인터넷은 통신 기능이 없는 사물에 통신 기능을 추가하여 사물의 정보를 원격에서 수집 및 사물의 기능을 제어하는 통신기술이다. 이를 위해 Wi-Fi, 3GPP, 블루투스 등 다양한 통신기술이 사용 가능하며 NB-IoT와 LoRa(Long Range)는 사물인터넷 개념에 특화된 통신기술이다. LoRa는 장거리, 저전력, 저속 통신을 지원하는 통신기술로 원거리의 사물에서 생성되는 정보를 수집하고 장비를 제어하기에 적합하다. 이러한 특징 때문에 많은 응용 분야에서 활용되고 있으며 다양한 성능 향상 연구가 진행 중이다. 본 논문은 더욱더 넓은 응용 분야에서 활용하기 위한 초장거리 LoRa 통신 모듈을 제안하고자 한다. 초장거리 LoRa 통신 모듈을 개발하기 위해 하드웨어, 펌웨어 및 테스트를 위한 응용 소프트웨어를 설계 및 구현한다. 구현된 장비는 실제 환경에서 테스트를 통해 성능을 검증하여 활용도를 확인하겠다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제11권11호
• /
• pp.473-478
• /
• 2022

온라인 저지 시스템 지원하기 위한 표절 검사, 소스코드 분석 및 자동화된 튜터링 기법이 연구되고 있다. 최근 딥러닝 기술 기반의 소스코드 유사도 분석을 통한 표절 감지 기술들이 제안되었으나, 자동화된 튜터링을 지원하기 위한 딥러닝 기반의 연구는 미흡한 실정이다. 따라서 본 논문에서는 자바 바이트코드와 문제정보를 결합하여 학습하고, 학습자가 온라인 저지 시스템에 코드를 제출하기 전에 pass/fail 여부를 예측할 수 있는 GRU 기반의 Input / Output side FiLM 모델을 제안한다. 또한 온라인 저지에 수집되는 데이터의 특성상 비대칭이 발생하기 때문에 밸런스 샘플링 기법을 적용하여 데이터를 균등하게 분포시켜 두 상황을 제안한 모델로 학습하였다. 실험 결과 Input side FiLM 모델이 가장 높은 73.63%의 성능을 보였다. 이를 기반으로 학습자들이 온라인 저지의 평가를 받기 전에 pass/faill 여부를 확인하여 소스코드 개선에 대한 피드백 기능에 적용 가능할 것으로 예상된다.

• International Journal of Computer Science & Network Security
• /
• 제22권5호
• /
• pp.175-181
• /
• 2022

COVID-19 is an acute respiratory syndrome that affects the host's breathing and respiratory system. The novel disease's first case was reported in 2019 and has created a state of emergency in the whole world and declared a global pandemic within months after the first case. The disease created elements of socioeconomic crisis globally. The emergency has made it imperative for professionals to take the necessary measures to make early diagnoses of the disease. The conventional diagnosis for COVID-19 is through Polymerase Chain Reaction (PCR) testing. However, in a lot of rural societies, these tests are not available or take a lot of time to provide results. Hence, we propose a COVID-19 classification system by means of machine learning and transfer learning models. The proposed approach identifies individuals with COVID-19 and distinguishes them from those who are healthy with the help of Deep Visual Embeddings (DVE). Five state-of-the-art models: VGG-19, ResNet50, Inceptionv3, MobileNetv3, and EfficientNetB7, were used in this study along with five different pooling schemes to perform deep feature extraction. In addition, the features are normalized using standard scaling, and 4-fold cross-validation is used to validate the performance over multiple versions of the validation data. The best results of 88.86% UAR, 88.27% Specificity, 89.44% Sensitivity, 88.62% Accuracy, 89.06% Precision, and 87.52% F1-score were obtained using ResNet-50 with Average Pooling and Logistic regression with class weight as the classifier.

• Coupled systems mechanics
• /
• 제11권6호
• /
• pp.557-586
• /
• 2022

In spite of extensive testing of the individual shear wall and the coupling beam (CB), numerical and experimental researches on the seismic behavior of CSW are insufficient. As far as we know, no previous research has investigated the affectations of position of CB regarding to the slab level (SL). So, the investigation aims to enhance an overarching framework to examine the consequence of connection positions between CB and SL. And, three cases have been created. One is composed of the floor slab (FS) at the top of the CB (FSTCB); the second is created with the FS within the panel depth (FSWCB), and the third is employed with the FS at the bottom of the CB (FSLCB). And, FEA is used to demonstrate the consequences of various CB positions with regard to the SL. Furthermore, the main measurements of structure response that have been investigated are deformation, shear, and moment in a coupled beam. Additionally, wall elements are used to simulate CB. In addition, ABAQUS software was used to figure out the strain distribution, shear stress for four stories to further understand the implications of slab position cases on the coupled beam rigidity. Overall, the findings show that the position of the rigid linkage among the CB and the FS can affect the behavior of the structures under seismic loads. For all structural heights (4, 8, 12 stories), the straining actions in FSWCB and FSLCB were less than those in FSTCB. And, the increases in displacement time history response for FSWCB are around 16.1-81.8%, 31.4-34.7%, and 17.5% of FSTCB.