• BMB Reports
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• v.55 no.3
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• pp.148-153
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• 2022

Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents. In this study, we investigated whether PEMFs influence the anti-cancer effects of etoposide in MCF-7 cells and determined the signal pathways affected by PEMFs. We observed that co-treatment with etoposide and PEMFs led to a decrease in viable cells compared with cells solely treated with etoposide. PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. PEMF also increased the etoposide-induced activation of DNA damage-related molecules. In addition, the reactive oxygen species (ROS) level was slightly elevated during etoposide treatment and significantly increased during co-treatment with etoposide and PEMF. Moreover, treatment with ROS scavenger restored the PEMF-induced decrease in cell viability in etoposide-treated MCF-7 cells. These results combined indicate that PEMFs enhance etoposide-induced cell death by increasing ROS induction-DNA damage-caspase-dependent apoptosis.

• The Journal of Information Systems
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• v.6 no.2
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• pp.85-105
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• 1997

The objective of this research is to construct and build a software platform to enable collaboration among enterprise headquarters, product designers, software engineers, manufacturing plants, and suppliers which are locate at different remote locations via internet. In specific, agent technology is adopted as a software vehicle to automate demand and supply process in the internet environment. Agents are programs that act on behalf of their human users to perform laborious tasks such as information locating, accessing, filtering, integrating, adapting and resolving inconsistencies. Global competion is forcing the present day industry to produce high quality product more fast and inexpensively. In Korea, most labor-intensive industries have moved to China and other Asian countries for cost reduction. The need for fast information exchange has increased among the remote locations for the cooperation and coordination. In this research, a virtual global purchasing and ordering system will be constructured that distributes production schedule among remote places, acts as a bridge between the headquarters and manufacturing plants, distributes tasks and collates different solutions between demand and supply using agent. The external communication protocol takes HTML format, internal message handling requires SGML for document exchange, and KQML for agent implementation. The expected benefits will be : reduced cost of real-time information exchange, realization of global manufacturing environment, the maximum utilization of internet for the enterprise data exchange.

• The Transactions of the Korea Information Processing Society
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• v.6 no.9
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• pp.2493-2503
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• 1999

The TMN that appears to operate the various communication networks generally and efficiently is developed under the different platform environment such as the different hardware and the different operating system. One of the main problems is that all the agents of the TMN system must be duplicated and maintain the software and the data blocks that perform the identical function. Therefore, the multi-platform cannot be supported in the development of the TMN agent. In order to overcome these problems, the Farming methodology that is based on the Farmer model has been suggested. With the Farming methodology, the software and the data components which are duplicated and stored in each distributed object are saved in the platform independent class repository (PICR) by converting into the format of the independent componentware in the platform, so that the componentwares that are essential for the execution can be loaded and used statically or dynamically from PICR as described in the framework of each distributed object. The distributed TMN agent of the personal communication network is designed and developed by using the Farmer model.

• Journal of KIISE:Computing Practices and Letters
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• v.5 no.6
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• pp.727-737
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• 1999

프로세스 중심 소프트웨어 개발 환경(PSEE : Process-centered Software Engineering Environment)은 소프트웨어 개발자를 위한 여러가지 정보의 제공과 타스크의 수행, 소프트웨어 개발 도구의 수행 및 제어, 필수적인 규칙이나 업무의 수행등과 같은 다양한 행위를 제공하는 프로세스 모형의 수행을 통하여 소프트웨어 개발 행위를 지원한다. SEED(Software Engineering Environment for Development)는 효율적인 소프트웨어 개발과 프로세스 모형의 수행을 제어하기 위해 ETRI에서 개발된 PSEE이다.본 논문에서는 SEED에서 프로세스 모형을 설계하기 위해 사용되는 SimFlex 프로세스 프로그래밍 언어와, 수행지원시스템인 SEED Engine의 구현에 대하여 기술한다. SimFlex는 간단한 언어 구조를 가진 프로세스 프로그래밍 언어이며, 적절한 적합화를 통하여 다른 PSEE에서 사용될 수 있다. SimFlex 컴파일러는 SimFlex에 의해 기술된 프로세스 모형을 분석하고, 모형의 오류를 검사하며, SEED Engine에 의해 참조되는 중간 프로세스 모형을 생성한다. 중간 프로세스 모형을 사용하여 SEED Engine은 외부 모니터링 도구와 연관하여 사용자를 위한 유용한 정보뿐만 아니라 SimFlex에 의해 기술된 프로세스 모형의 자동적인 수행을 제공한다. SimFlex 언어와 수행지원 시스템의 지원을 통하여 소프트웨어 프로세스를 모형화하는데 드는 비용과 시간을 줄일 수 있으며, 편리하게 프로젝트를 관리하여 양질의 소프트웨어 생산물을 도출할 수 있다. Abstract Process-centered Software Engineering Environments(PSEEs) support software development activities through the enaction of process models, providing a variety of activities such as supply of various information for software developers, automation of routine tasks, invocation and control of software development tools, and enforcement of mandatory rules and practices. The SEED(Software Engineering Environment for Development) system is a PSEE which was developed for effective software process development and controlling the enactment of process models by ETRI.In this paper, we describe the implementation of the SimFlex process programming language used to design process models in SEED, and its runtime support system called by SEED Engine. SimFlex is a software process programming language to describe process models with simple language constructs, and it could be embedded into other PSEEs through appropriate customization. The SimFlex compiler analyzes process models described by SimFlex, check errors in the models, and produce intermediate process models referenced by the SEED Engine. Using the intermediate process models, the SEED Engine provides automatic enactment of the process models described by SimFlex as well as useful information for agents linked to the external monitoring tool. With the help of the SimFlex language and its runtime support system, we can reduce cost and time in modeling software processes and perform convenient project management, producing well-qualified software products.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.12
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• pp.959-968
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• 2020

Tourist loyalty is created through good tourism service quality and the availability of tourism products. This study discussed the various attributes of tourism service quality, namely, tour agents, efficient personnel, accessible transportation, and information service quality. Whereas for tourism product availability attributes were varieties of product availability, wide selection of tour agents and tourist products, and wide variety of amenity services. As a general rule, the minimum is to have at least five times as many observations as the number of variables to be analyzed, and the more acceptable sample size would have a 10:1 ratio. A total of 424 questionnaires were returned, with 35 removed due to errors. Finally, 389 questionnaires respondents were used via accidental sampling method through the distribution of questionnaires to foreign tourists at Soekarno Hatta International Airport. In addition, AMOS 7.0 software is used to test models in confirmatory factor analysis (CFA) as well as hypothetical testing using structural equation modeling (SEM). The results showed that all hypotheses were accepted, except for the effect of tourism service quality on tourist loyalty in Indonesia. This research aims to contribute significantly to the existing knowledge of tourism, specifically from a foreign tourist perspective in Indonesia.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.879-884
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• 2004

This paper describes the development of a synthetic multi-agent called KMITL Cadence 2003. KMITL Cadence 2003 is a robotic soccer simulation team consisting of eleven autonomous software agents. Each agent operates in a physical soccer simulation model called Robocup Soccer Server which provides fully distributed and real-time multi-agent system environment. All teammates have to cooperate to achieve the common goal of winning the game. The simulation models many aspects of the football field such as noise in ball movements, noisy sensors, unreliable communication channel between teammates and actuators, limited physical abilities and restricted communication. This paper addresses the algorithm to develop the soccer agents to perform basic actions which are scoring, passing ball and blocking the opponents effectively. The result of this development is satisfactory because the successful scoring attempts is increased from 11.1% to 33.3%, successful passing ball attempts is increased from 22.08% to 63.64%, and also, successful intercepting attempts is increased from 88% to 97.73%.

• Proceedings of the KAIS Fall Conference
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• 2012.05a
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• pp.182-186
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• 2012

human tyrosinase (hTyr) catalyzes first and the rate limiting step in the synthesis of polymerized pigment, melanin which determines skin, hair and eye colors. Mutation of hTyr often brings about decrease of melanin production and further albinism. Meanwhile, a number of cosmetic companies providing skincare products for woman in Asia-Pacific region have tried to develop inhibitors to bright skin color for several decades. In this study, we built a 3D structure by comparative modeling technique based on the crystal structure of tyrosinase from bacillus megaterium as a template to serve structural information of hTyr. According to our model and sequence analysis of type 3 copper protein family proteins, two copper atoms of active site located deep inside are coordinated with six strictly conserved histidine residues coming from four-helix-bundle. Cavity which accommodates substrates was like funnel shape of which entrance was wide and expose to solvent. In addition, protein-substrate and protein-inhibitor complex were modeled with the guide of van der waals surface generated by in house software. Our model suggested that only phenol group or its analogs can fill the binding site near nuclear copper center because inside of binding site has narrow shape relatively. In conclusion, the results of this study may provide helpful information for designing and screening new anti-melanogensis agents.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2002.11a
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• pp.243-246
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• 2002

It is expected that intelligent broadcasting service (IBS) will be able to provide broadcast programs based on user preference and program-associated information (metadata) in order to assist users to easily navigate the program contents being broadcast. So users can access program contents anytime/anywhere in the way they want. In this paper we propose a framework for IBS based on an intelligent software agent platform so called FIPA (Foundation for Intelligent Physical Agents). We use an FIPA implementation. so called FIPA-OS, as a platform for exchanging user preferences and program information as FIPA messages between a server and clients. The user preference is modeled as the User Preference description scheme in MPEG-7 MDS (Multimedia Description Scheme).

• Journal of the Korea Society for Simulation
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• v.12 no.4
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• pp.25-40
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• 2003

With the growing usage of the networks, the world-wide Internet has become the main means to exchange data and carry out transactions. It has also become the main means to attack hosts. To solve the security problems which occur in the network such as Internet, we import software products of network security elements like an IDS (Intrusion Detection System) and a firewall. In this paper, we have designed and constructed the general simulation environment of network security model composed of multiple IDSes and a firewall which coordinate by CNP (Contract Net Protocol) for the effective detection of the intrusion. The CNP, the methodology for efficient integration of computer systems on heterogeneous environment such as distributed systems, is essentially a collection of agents, which cooperate to resolve a problem. Command console in the CNP is a manager who controls the execution of agents or a contractee, who performs intrusion detection. In the network security model, each model of simulation environment is hierarchically designed by DEVS(Discrete Event system Specification) formalism. The purpose of this simulation is that the application of rete pattern-matching algorithm speeds up the inference cycle phases of the intrusion detection expert system and we evaluate the characteristics and performance of CNP architecture with rete pattern-matching algorithm.

• Journal of KIISE:Software and Applications
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• v.31 no.2
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• pp.101-110
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• 2004

In dynamic systems, such as social and economic systems, complex interactions emerge among its members. In that case, their behaviors become adaptive according to Changing environment. In many cases, an individual's behaviors can be modeled by a stimulus-response system in a dynamic environment. In this paper, we use the Iterated Prisoner's Dilemma (IPD) game, which is simple yet capable of dealing with complex problems, to model the dynamic systems. We propose strategic coalition consisting of many agents and simulate their emergence in a co-evolutionary learning environment. Also we introduce the concept of confidence for agents in a coalition and show how such confidences help to improve the generalization ability of the whole coalition. Experimental results are presented to demonstrate that co-evolutionary learning with coalitions and confidence allows better performing strategies that generalize well.