• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.135-141
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• 2012

Purpose: Polymerization of HEMA(2-hydroxyethyl methacrylate) which can be used in the soft contact lens has been performed by using electron beam(EB) irradiation, and examined the best condition for the polymerization. Comparing the physical properties of the contact lenses to the one fabricated by thermal polymerization method, we check the use possibility of the EB irradiation to the fabrication of the soft contact lens. Methods: We investigated the degree of polymerization of the HEMA according to the composition of the monomer, the additive ratio and the dose of electron beam (0~120 kGy). The degree of polymerization was measured depending on the EB dose to research the best synthetic condition under the EB irradiation. The physical properties of the contact lens such as water content(%), oxygen transmissibility(Dk/t) and optical transmittance were analysed by using the FT-IR results with comparing the two different polymerization method (thermal and electron beam polymerization) with same additive ratio. Results: When the dose of electron beam was above 100 kGy, the degree of polymerization of HEMA was above 99% with regardless using cross-linker and initiator. The water content of the lens fabricated by EB method showed 10% higher than the one by the thermal method which was 40%. The lens fabricated by EB method also showed higher oxygen transmissibility(Dk/t) as same with the water content, and showed twice higher value in the lens fabricated by pure HEMA. According to the FT-IR results, hydrophilic property of the lens fabricated by EB method was increased due to increasing the intermolecular hydrogen bonding. It showed above 90% optical transmittance in the visible range of wavelength on the contact lenses fabricated by the both of two different polymerization method. Conclusions: The polymerization of HEMA without cross-linker and initiator was successful above 100 kGy of EB irradiation. Moreover the lens fabricated from the polymer synthesized by pure HEMA with 100 kGy of EB showed the highest water content and oxygen transmissibility. Therefore EB irradiation is another possible method to synthesize the polymer which can be used for the soft contact lens.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.391-401
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• 2011

Purpose: In the present study, the actual management state of trial contact lenses and lens care products in local optical shops was surveyed and analyzed to reduce the risk of lens complication possibly induced by neglecting lens care. Methods: The feeling of contact lens wearers during the wear of trial contact lenses was surveyed. Futhermore, the actual management state of trial contact lenses such as cosmetic lens and RGP lens and lens care products was also investigated by surveying opticians who trade contact lenses in local optical shops. Results: It was found that consumers trusted the sanitary conditions of the lens since trial cosmetic contact lens and RGP lens were cleaned before and after trails by over 98% of opticians in local optical shops. For trial cosmetic lens, cleaning with normal saline, multipurpose solution for soft lens and combination of saline and multipurpose solution were 38.5%, 40.5% and 21%, respectively, before trials. After trials, cosmetic lenses were cleaned with normal saline, multipurpose solution for soft lens and a combination of saline and multipurpose solution were 13%, 75%, and 12%, respectively. On the other hand, cleaning with normal saline, multipurpose solution for RGP lens and combination of saline and multipurpose solution were 28.5%, 38.5% and 33%, respectively, before trying trial RGP lens. After trials, RGP lenses were cleaned with normal saline, multipurpose solution for RGP lens and a combination of saline and multipurpose solution were 2.5%, 70%, and 27.5%, respectively, indicating that relatively many opticians followed the lens cleaning regimen. In local optical shops, the cleaning trial cosmetic lens was mainly conducted at every 10 days or a month and the washing cycle of cosmetic lens case was in a month or 2~3 months. The cleaning interval of trial RGP lens was primarily in a month or 2~3 months. For those lens cases, more than 75% of opticians washed them with a surfactant and then rinsed with cold water. The storing periods of lens care products were primarily in a week for saline and in a month and 2~3 months indicating that storing period of lens care products was relatively well-kept in local optical shops. Conclusions: It is thought that the concern about any microbial infection is not that high since trial contact lenses and lens care products were generally well-managed by opticians in local optical shops from the results above. However, better public eye health and better public confidence in opticians may be possible if further strengthen in avoidance of lens cleaning with saline, keep of cleaning cycles within 2 weeks and rinsing of lens cases with hot water happens.

• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.178-185
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• 2016

Tear is a promising biological fluid for non-invasive health monitoring. It has been studied in the past to be a possible candidate for the diagnosis of certain systemic diseases, such as breast cancer, multiple sclerosis, prostate cancer, and diabetes. However, currently existing methods for collecting and extracting tear from the human eye causes inconsistencies in the biomolecule concentrations of the tear sample due to the irritating nature of the process. In response, we designed and fabricated a microfluidic system embedded soft contact-lens for the purpose of tear sampling. The lens was then tested with artificial tear for its tear sampling capability, and found to be able to find concentration equilibrium within 50 minutes. Additionally, simulation was carried out to further optimize the design so that tear sampling rate matched the natural tear turn-over rate of 1 microliter per minute.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.133-140
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• 2015

Purpose: It was investigated whether two different stabilization designs of toric contact lenses changed the rotational axis and degree of toric lenses according to body posture and gaze direction in the present study. Methods: Toric soft contact lenses with Lo-Torque$^{TM}$ design and ASD design (accelerated stabilized design) were fitted on 52 eyes aged in 20s-30s. Then, rotational degree was measured at the five gaze directions including front gaze and the lying position. Results: When gazing the front and vertical directions in the upright posture, lens was much rotated to nasal side for the Lo-Torque$^{TM}$ design and temporal side for the ASD design. When gazing horizontal direction, both design lenses were rotated against to the gaze direction. Rotation degree was the smallest at superior direction gaze and the largest at nasal gaze. In case of the rotation degree less than $5^{\circ}$, Lo-Torque$^{TM}$ design was more frequent when gazing front and vertical directions, and ASD design was more frequent when gazing horizontal direction. In addition, the lens with Lo-Torque$^{TM}$ design was lesser rotation degree than with ASD design immediately after lying. On the other hand, the lens with ASD design was lesser rotation degree than with Lo-Torque$^{TM}$ design 1 minute later after lying. Conclusions: This study confirmed that axis rotation of the lens induced by gaze direction and posture was different according to axis stabilization design during wearing toric soft contact lens.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.455-462
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• 2015

Purpose: To develop more accurate wet measuring system combining the wet cell, automatic lensmeter and the related software for hydrophilic contact lenses and to verify the accuracy of those measuring holder system already available in the market. Methods: Refractive power measurement were done in both a conventional method which has been commonly used in optical shops and a new method which is recently developed in korea. Hydrophilic contact lens of korean brand was chosen as a test material and was tested by water content ratio and by spherical refractive power. Results: When spherical power of -3.00 D contact lens is measured in the newly developed wet cell measurement holder with automatic lensmeter, it reads -3.01 D at water content ratio of 38%. -3.00 D at 45% and -2.98 D at 58%. The same experiment with the Poster soft contact lens wet cell measurement holder maintaining other conditions same resulted in -3.60 D at the water content ratio of 38%, -3.06 D at 45% and -2.46 D at 58%. Conclusions: At the higher water content, the refractive power values measured by both of the wet cell measuring holders are shown lower, and additionally, the new method using the wet cell holder and new software program in a automatic lensmeter showed more accurate readings than conventional Poster soft contact lens wet cell measuring system.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.301-312
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• 2004

This study was performed to compare the relationship between contact lens wearer and dry-eye patient. In this study, TBUT, SIT, TTT, Rose bengal staining and McMonnies dry eye symptom questionnaire were performed as a baseline. With the base data, the subjects were classified to 3 groups : 3S patients who have dry eye signs and symptoms, 38 patients who are wearing soft contact tenses, 35 subjects who have health eyes and never worn on a contact lenses as control subjects. Contact lens wearers were divided into 3 groups according to the duration of contact lens wear. There were no significant differences in TBUT, STT, TTT, Rose-bengal staining and McMonnies dry eye symptom questionnaire result between contact lens wearer group and dry eye patients group. We suggest that there are similarities in tear function tests between the dry-eye patient and the contact lens wearer.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.19-25
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• 2013

Purpose: The degree of the pupil covered with tinted region of circle soft contact lens was determined according to the illuminant conditions in everyday life and the change of visual acuity by its covering was further investigated. Methods: The circle contact lens having the non-tinted area of 6.2 mm in the center of the lens was applied on 82 eyes in their 20s and their minimum separable visual acuity and minimum legible visual acuity were determined under the luminances of 50 and 370 lux. Results: The covering of pupil was not found when wearing circle contact lens under 370 lux, however, some pupil covering ranged from 0.40 to 1.70 mm was observed in all subjects under 50 lux. The minimum separable visual acuity and minimum legible visual acuity were significantly decreased by the wearing of circle contact lens under 50 lux and the correlation between the larger pupil size of subjects and more decrease of visual acuity was observed. Furthermore, the decrease of minimum separable visual acuity was larger than the case of minimum legible visual acuity indicating that minimum separable visual acuity was largely affected by the covering of pupil. Conclusions: The consideration is necessary for the lens wearers and the manufacturers since the wearing circle contact lens in low-light indoor or nighttime activities may affect directly visual acuity.

• Polymer(Korea)
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• v.36 no.3
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• pp.338-343
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• 2012

Interfacial properties of commercially available soft contact lens hydrogels were studied to understand thermodynamic phenomena of protein adsorption. Hydrogel particles ($1{\times}1mm^2$) with varying water wettability were exposed to bovine serum albumin solutions for an hour. The remained albumin solutions were analyzed with Bradford assay method. The amount of protein adsorbed to hydrogels increased with protein solution concentrations following Langmuir isotherm. The partition coefficient ($P$) and Gibbs free energy cost of dehydrating the surface region by protein displacement upon adsorption increased with increasing hydrophilicity of contact lens. Understanding of physical chemistry in protein adsorption to contact lens materials enabled elucidating relationships between surface energy and albumin adsorption capacity.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.441-447
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• 2013

Purpose: The present study was conducted to investigate the axial rotations of toric soft lens during the change of lens wearer's posture, and the relationship between its rotation and corneal astigmatism. Methods: The amount, direction, and speed of toric soft contact lens rotation were measured for 42 eyes (aged 20s) with the rule astigmatism in the straight and lying postures, and it compared between their changes according to corneal astigmatism. Results: There was no significant difference in the axial rotation of lens for the astigmatism prescription between the straight and lying postures. However, the rotation angle was significantly different according to the posture of lens wearer. Rotating directions in straight posture were nasal direction for 20 eyes and temporal direction for 22 eyes. In lying posture, lenses of most wearers were rotated to a direction of lying posture, and the initial rotating speed was very fast in initial wearing for -0.75 D toric lenses, but consistency for -1.25 D toric lenses. The rotation angle in lying posture showed significantly different according to the amount of corneal astigmatism, the lens speed was also significantly different according to the wearing time but not the amount of corneal astigmatism. Conclusions: The axial rotation of toric soft lens was different by the lens wearer's posture and its amount was the greater with the higher degree of corneal astigmatism. Thus, these factors should be considered for the development of toric lens design.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.4
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• pp.365-372
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• 2012

Purpose: To investigate ocular higher order aberrations (HOA) and spherical aberration changes caused by an aspheric soft contact lens designed to reduce spherical aberration (SA) of the eye. Methods: Fifty subjects who have successfully experienced soft contact lenses were refitted with aspheric design (Soflens Daily Disposable: SDD, Bausch+Lomb) soft contact lens. Ocular higher order aberrations (HOA) and stand alone SA were measured and analyzed for a 4-mm pupil size using Wave-Scan Wavefront$^{TM}$ aberrometer (VISX, Santa Clara, CA, USA). High and low contrast log MAR visual acuity and contrast sensitivity function (CSF) were also measured under photopic and mesopic conditions (OPTEC 6500 Vision Tester$^{(R)}$). All measurements were conducted monocularly with an undilated pupil. Results: The RMS mean values for total HOA with SDD contact lenses were significantly lower than those at with unaided eyes (p<0.001) and a reduction for SA in the SDD was close to the baseline SA (zero ${\mu}m$) (p<0.001). For the SDD lens, there was a statistically significant correlation between the changes in the total HOA and the contact lens power (r=0.237, p=0.018) as well as between the changes in SA and the lens power (r=0.324, p=0.001). High contrast visual acuity (HCVA) and low contrast visual acuity (LCVA) with SDD lenses were $-0.063{\pm}0.062$ and $0.119{\pm}0.060$, respectively under photopic and $-0.003{\pm}0.063$ and $0.198{\pm}0.067$, respectively under mesopic condition. Contrast Sensitivity Function (CSF) with SDD lenses under both photopic and mesopic conditions was $3.095{\pm}0.068$ and $3.087{\pm}0.074$, respectively. Conclusions: The SDD contact lens designed to control SA reduced the total ocular HOA and SA of the eye, resulting in compensating for positive SA of the eyes. Thus, the optical benefits of the lens with SA control would be adopted for improving the quality of vision.