Joo Hyung Lee;Yoon Su Lee;Jin Yoo;Seoyeon Won;Taehwan Lim
Journal of Industrial Technology
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v.43
no.1
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pp.25-31
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2023
Stretchable and flexible electronics that comply with dynamic movements and micromotion of the human tissues can enable real-time monitoring of physiologic signals onto the human skin and in the brain, respectively. Especially, gallium based liquid metal stretchable electronics can offer human-interactive biosensors to monitor various physiologic parameters. However, the liquid-like nature, surface oxidation and contamination by organic materials, and low biostability of the liquid metals have still limited the long-term use as bioelectronics. Here we introduced electrochemical deposition without oxidation pathways to overcome these practical challenges in liquid metal bioelectronics. CNT/PDDA composite with reduction way and PEDOT:BF4 with oxidation way under organic solvent are suggested as rationally designed material engineering approaches. We confirmed that the structures with the soft, flexible, and stretchable liquid metal platform can successfully detect dopamine with a high sensitivity and selectivity, record neural signals including action potentials without scar formation, and monitor physiologic signals such as EMG and ECG.
V. Michael Holers;Francisco G. La Rosa;Nirmal K. Banda
IMMUNE NETWORK
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v.21
no.6
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pp.45.1-45.13
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2021
Many mouse models of rheumatoid arthritis have been identified, but only a limited number are present for axial spondyloarthritis (AxSpA). Collagen Ab-induced arthritis (CAIA) is one of the most widely used mouse models of arthritis, and it is complement-dependent. We found that mice developing CAIA also developed spinal lesions similar to those found in AxSpA. To induce CAIA, mice were injected intraperitoneally at day 0 with anti-collagen Abs, followed by LPS injection at day 3. CAIA mice demonstrated a significant kyphosis through the spine, as well as hypertrophic cartilage and osseous damage of the intravertebral joints. Immunohistochemical staining of the kyphotic area revealed increased complement C3 deposition and macrophage infiltration, with localization to the intravertebral joint margins. Near Infrared (NIR) in vivo imaging showed that anti-collagen Abs conjugated with IRDye® 800CW not only localized to cartilage surface in the joints but also to the spine in arthritic mice. We report here a novel preclinical mouse model in which, associated with the induction of CAIA, mice also exhibited salient features of AxSpA; this new experimental model of AxSpA may allow investigators to shed light on the local causal mechanisms of AxSpA bone and soft tissue changes as well as treatment.
Novel platform technology has been developed to replace the photolithography used currently for manufacturing semiconductors and display devices. As a substrate, plastics, especially polycarbonates, have been considered for future application such as flexible display. Other plastics, i.e. polyimide, polyetheretherketon, and polyethersulfone developed for the substrate at this moment, are available for photolithography due to their high glass transition temperature, instead of high price. After thin polystyrene film was coated on the polycarbonate substrate, microstructure of the film was formed with polydimethylsiloxane template over the glass transition temperature of the polystyrene. The surface of the structure was treated with potassium permanganate and octadecyltrimethoxysilane so that the surface became hydrophobic. After this surface treatment, the nanoparticles dispersed in aqueous solution were aligned in the structure followed by evaporation of the DI water. Without the treatment, the nanoparticles were placed on the undesired region of the structure. Therefore, the interfacial interaction was also utilized for the nanoparticle alignment. The surface was analyzed using X-ray photoelectron spectrometer. The evaporation of the solvent occurred after several drops of the solution where the hydrophilic nanoparticles were dispersed. During the evaporation, the alignment was precisely guided by the physical structure and the interfacial interaction. The alignment was applied to the electric device.
Chuncheon National Museum currently own a bronze Buddhist gong that was discovered in 1987 at the Sudasa Temple site of in Suhangri, Pyeongchang. Significantly, showing many casting defects and areas where was repaired, the Gong offered crucial information about the casting technique. To better understand the production technique, scientific analysis was conducted on various aspects of the gong, including its materials, moulds, chaplets, and defects. Composition analysis revealed that the gong was composed primarily of copper 71.6wt%, tin 18.2wt%, and lead 7.2wt%, along with about 1wt% of both arsenic and antimony. The lead content of the chaplets was higher than that of the gong, and the lead content was the highest in the solder, which was used to fill holes after casting. Surface analysis, based on the parting line, indicated that the gong was most likely produced with the sand casting process. Radiography and close examination of the surface disclosed various casting defects e.g., Cold Shut, Surface Folds, Misrun, and Blowholes Adjacent to Chaplets and their possible causes. The casting defects of a few holes were filled with soft solder.
Kim, Kiseok;Oh, Ju-Young;Lee, Hyobum;Choi, Hangseok
Journal of Korean Tunnelling and Underground Space Association
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v.20
no.2
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pp.433-452
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2018
The shield tunneling method can minimize surface settlements by preventing the deformation of tunnel face and tunnel intrados due to tunnel excavation. For this purpose, it is very important to control the operating conditions of shield TBM. The face pressure and backfill pressure for tail void grouting should be the most important and immediate measure not only to restrain surface settlement, but also to influence the effective stress and pore water pressure around the circumstance of tunnel during excavation. The reaction of the ground to the application of face pressure and backfill pressure relies on the stiffness and permeability of ground. Especially, the reaction of saturated clayey ground formations, which shows the time-dependent deformation, is different from the permeable ground. Hence, in this paper it was investigated how the TBM operating conditions, ground stiffness, and permeability impact on the surface settlement of saturated clayey ground. For this purpose, a series of parametric studies were carried out by means of the stress-pore water pressure coupled FE analysis. The results show that the settlement of soft clayey ground is divided into the immediate settlement and consolidation settlement. Especially, the consolidation settlement depends on the ground stiffness and permeability. In addition, the existence of critical face pressure and backfill pressure was identified. The face pressure and backfill pressure above the critical value may cause an unexpected increase in the ground settlement.
Objectives : This study was designed to establish a characteristic discrimination of internal and external morphological standard of original plants and herbal states in Polygoni Multiflori and Cynanchi Wilfordii Radix. Methods : In this studies, the external-internal morphological standards were determined by using stereoscope and butanol series. Results: 1. The external characteristics of original plants: Polygonum Multiflorum has alternate leaves, and its flower with white color blooms at the shoot apex or leaf axil. In the other hand, Cynanchum wilfordii has opposite leaves, and its flower with yellowish green color blooms at the leaf axil. 2. The physical characteristics of herbal slates: Polygoni Multiflori Radix is red-brown in outer surface pink-brown in section. In the other hand, Cynanchi Wilfordii Radix is earthly-brown in outer surface greyish white in section. 3. The physical characteristics according to the place of production: Demonstrable difference according to the place of production is not seen. Polygoni Multiflori Radix is brown or dark brown in outer surface, soft $Yellow{\sim}dark$ brown in section. In the other hand, Cynanchi Wilfordii Radix is white in outer surface, $white{\sim}weak$ red in section, and has power type. 4. The internal characteristics: Polygonum multiflorum has hetero-vascular bundle and lignification of cork layer is progressive. In the other hand, Cynanchum wilfordii has not hetero-vascular bundle, and lignification of cork layer is weak. Conclusion: In the future, many fundamental study such as how to discriminate between Polygoni Multiflori Radix and Cynanchi Wilfordii Radix in origin and efficacy will be necessary. Also the standard of discrimination must be specific and distinct in that several kinds of fo-ti has been traded. It is considered the results of this study will be furnish κ I the basis Lo succeeding studies and it is needed to extensive comparative study for the same genus-degree of relatedness.
Proceedings of the Korean Vacuum Society Conference
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2014.02a
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pp.413-413
/
2014
In this paper, we present a fabrication method of functionalized gold nanostructures on flexible substrate that can be implemented for plasmonic sensing application. For biomolecular sensing, many researchers exploit unconventional lithography method like nanoimprint lithography (NIP), contact transfer lithography, soft lithography, colloidal transfer printing due to its usability and easy to functionalization. In particular, nanoimprint and contact transfer lithography need to have anti-adhesion layer for distinctive metallic properties on the flexible substrates. However, when metallic thin film was deposited on the anti-adhesion layer coated substrates, we discover much aggravation of the mold by repetitive use. Thus it would be impossible to get a high quality of metal nanostructure on the transferred substrate for developing flexible electronics based transfer printing. Here we demonstrate a method for nano-pillar mold and transfer the controllable nanoparticle array on the flexible substrates without an anti-adhesion layer. Also functionalization of gold was investigated by the different length of thiol applied for effectively localized surface plasmonic resonance sensing. First, a focused ion beam (FIB) and ICP-RIE are used to fabricate the nanoscale pillar array. Then gold metal layer is deposited onto the patterned nanostructure. The metallic 130 nm and 250 nm nanodisk pattern are transferred onto flexible polymer substrate by bi-layer functionalized contact imprinting which can be tunable surface energy interfaces. Different thiol reagents such as Thioglycolic acid (98%), 3-Mercaptopropionic acid (99%), 11-Mercaptoundecanoic acid (95%) and 16-Mercaptohexadecanoic acid (90%) are used. Overcoming the repeatedly usage of the anti-adhesion layer mold which has less uniformity and not washable interface, contact printing method using bi-layer gold array are not only expedient access to fabrication but also have distinctive properties including anti-adhesion layer free, functionalized bottom of the gold nano disk, repeatedly replicate the pattern on the flexible substrate. As a result we demonstrate the feasibility of flexible plasmonic sensing interface and anticipate that the method can be extended to variable application including the portable bio sensor via mass production of stable nanostructure array and other nanophotonic application.
It has been held that excessive mechanical forces to the osseous and soft tissues of the TMJ result in joint dysfunction. Understanding the stress pattern on TMJ is very important in TMJ research. But, it is very difficult to measure directly the biomechanical stress distribution in the TMJ when the mandible is loaded. Therefore, stress distribution in the TMJ during functional movement was studied through animal experiment or mathematical model. It was observed and compared the stress distribution occuring in the working and balancing condyle when lower right canine, lower right first molar and lower right second molar were clenched by the three dimensional finite element analysis. Also, stress distribution in the working and balancing condyles were observed and compared when $20^{\circ}$ forward and buccal bite forces were applied to the first molar. The results were as follows : 1. Stress distribution in the condyles during unilateral clenching of the first molar, second molar, canine showed no difference. In the working condyle, tensile force was concentrated on the lateral aspect of the condylar articular surface and condylar neck. And compressive force was concentrated on the anteromedial and lateral aspect of condyle. In the balancing condyle, tensile and compressive forces were concentrated on the lateral aspect of the condylar articular surface and stress transmission to the temporal bone was not observed. 2. When lateral forces were applied to the first molar, tensile forces were concentrated on the medial aspect of the condylar neck and condylar posterior surface in working and balancing condyle. Compressive force was concentrated on the anteromedial and lateral surface of the condyle and stress transmission to the temporal bone was not observed. 3. During unilateral clenching, stress in the working condyle decreased as the occlusal load moved posteriorly while the stress in the balancing condyle increased. when lateral force was applied to first molar, the incremental amount of stress was greater than vertical load. 4. During unilateral clenching, the average balancing/working condyle stress ratio was 2.52. There was a greater concentration of stress in the balancing condyle. The ratio increased as the occlusal load moved posteriorly and decreased considerably when lateral forces were applied to the first molar.
For the success of complete denture, three essential requirements such as retention, stability and support are needed. Moreover, due to the absorption of residual ridge and scarring due to the surgery, when making a complete denture, which is difficult to form the mandibular lingual margins, various considerations such as the arrangement of the Non-anatomical dl non-anatomical teeth, the polished surface impression, the internally weighted metal framework and the use of the denture adhesive cream are necessary. In this case report, the patient has a severely resorbed edentulous ridge from severe periodontitis and has some soft tissue problems after the glossectomy due to tongue cancer. To obtain additional retention and stability, some trials such as polished surface impression taking, internally weighted metal insertion and minimal pressure impression were done for the better result. Moreover To make a metal framework that precisely shapes the desired three-dimensional shape and reduces the complicated process, minimal pressure impression method and direct metal laser sintering technique were used.
In seven species of Korean Asarum, 44 qualitative and 28 quantitative characters were reviewed taxonomically. Among 44 qualitative characters observed in vegetative and reproductive organs, the states of 27 characters were common in all the seven species. Among 28 quantitative characters, five characters have the same values in all the seven species; the number of cataphyll (2-4), leaf (2), calyx lobe (5), stamen (12) and pistil (6). White spots on adaxial surface of leaf (effectively) distinguished A. maculatum and A. versicolor from the other species. Many long soft hairs on abaxial surface of leaf distinguished A. mandshuricum from other species with short hairs. The glandular hairs on inner surface of calyx tube were divided into 2 types, reflecting the taxonomic relationships between the species: Type 1 has non-stalked glandular hairs (A. maculatum, A. sieboldii and A. sp.), and Type 2 has stalked glandular hairs (A. patens, A. versicolor, A. mandshuricum and A. misandrum). The length, shape, colour of calyx lobe and the extent to which the calyx lobe recurves, as well as the diameter and colour of calyx tube throat, were confirmed to be taxonomically valuable. In the case of glandular hair density on the surface of calyx lobe, A. patens with low density and A. sp. with high density were clearly distinct from all the other species with intermediate hair density. Meanwhile, the stylar protuberance length of A. patens (2.9-3.3 mm) was strikingly different from other species (1.4-2.5 mm). Additionally, further examination of the identities of A. yeonbyeonense and A. yeonbyeonense var. viridiluteolum is required.
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