• Journal of Microbiology and Biotechnology
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• v.17 no.4
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• pp.579-585
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• 2007

Formation of inclusion bodies is usually observed when foreign proteins are overexpressed in E. coli. The formation of inclusion bodies might be prevented by lowering the rate of protein synthesis, and appropriate regulation of the protein expression rate may lead to the soluble expression. In this study, human growth hormone (rhGH) was expressed in a soluble form by slowing down the protein synthesis rate, which was controlled in the transcriptional and translational levels. The transcriptional level was controlled by the regulation of the amount of RNA polymerase specific to the promoter in front of the rhGH gene. For lowering the rate of translation, the T7 transcription terminator-deleted vector was used to synthesize the longer mRNA of the target gene because the longer mRNA is expected to reduce the availability of tree ribosomes. In both methods, the percentage of soluble expression increased when the expression rate slowed down, and more than 93% of rhGH expressed was a soluble form in the T7 transcription terminator-deleted expression system.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2010.10a
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• pp.229-230
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• 2010

• Nuclear Engineering and Technology
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• v.45 no.7
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• pp.921-928
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• 2013

A future nuclear energy system is being developed at Korea Atomic Energy Research Institute (KAERI), the system involves a Sodium Fast Reactor (SFR) linked with the pyro-process. The pyro-process produces a source material to fabricate a SFR fuel rod. Therefore, an isotopic fissile content assay is very important for fuel rod safety and SFR economics. A new technology for an analysis of isotopic fissile content has been proposed using a lead slowing down spectrometer (LSDS). The new technology has several features for a fissile analysis from spent fuel: direct isotopic fissile assay, no background interference, and no requirement from burnup history information. Several calculations were done on the designed spectrometer geometry: detection sensitivity, neutron energy spectrum analysis, neutron fission characteristics, self shielding analysis, and neutron production mechanism. The spectrum was well organized even at low neutron energy and the threshold fission chamber was a proper choice to get prompt fast fission neutrons. The characteristic fission signature was obtained in slowing down neutron energy from each fissile isotope. Another application of LSDS is for an optimum design of the spent fuel storage, maximization of the burnup credit and provision of the burnup code correction factor. Additionally, an isotopic fissile content assay will contribute to an increase in transparency and credibility for the utilization of spent fuel nuclear material, as internationally demanded.

• Journal of Korean Clinical Health Science
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• v.8 no.1
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• pp.1386-1397
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• 2020

Purpose: To examine the effectiveness of various treatments; bifocal spectacles, orthokeratology, atropine, and time spent in outdoors; in slowing down the myopia progression for Asian adolescents (6-18age). Methods: The research focused on examining the most effective treatment in controlling myopia based on the literature sources that have been published. Through meta-analysis of various research papers that already has been done in this field, a lot of data was collected. For each treatment, the difference in axial length and spherical equivalent over time was measured and recorded. To quantitatively record the difference, both axial length and spherical equivalent was determined by value of control group value of treatment group. The paper compared the effectiveness of each treatment based on the data that was measured. Results: Adolescents who chose to spend time outdoors in order to slow down myopia progression had axial length difference of 0.03 mm and spherical equivalent difference of 0.17 D. Adolescents that used atropine had axial length difference of 0.36 mm and spherical equivalent difference of 0.92 D. Bifocal spectacle resulted in axial length difference of 0.21 mm and spherical equivalent difference of 0.59 D, and for orthokeratology 0.23 mm and 0.04 D, respectively. Axial length wise, myopia was most controlled by the atropine since there was a greatest difference between the group that got the treatment and the group that did not have the treatment. According to the spherical equivalent difference data, myopia was most controlled by atropine. Conclusion: Atropine showed the most effective result in controlling myopia among the four treatment. Again, compared to other three treatment, using atropine appeared to have greatest ability in slowing down myopia progression since adolescents who were treated with atropine had greatest difference from adolescents in the control group that had the same condition but didn't get the treatment. However, every treatment was only used for 2 or 3 years which is quite short time period to measure the long term effect of the four treatments. Also, since atropine is a pharmaceutical method to control myopia, it may harm adolescents' eyes compared to optical or environmental treatment.

• Proceedings of the Korean Society of Coastal and Ocean Engineers Conference
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• 1996.10a
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• pp.137-139
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• 1996

It is known that under storm waves, beach will respond by eroding material from the beach Ace and the formation of longshore bar(s) in the vicinity of breaking point. This breakpoint bar is believed to have the effect of slowing down beach erosion by dissipating incoming wave energy and retarding offshore sediment transport. Recently, artificial bin are being proposed as beach protective measures based on this reasoning. (omitted)

• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.3
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• pp.18-27
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• 1998

Molecular dynamicsinvestigations of ion implantation considering point defect generation were performed with ion energies in the range of ~1keV, Simulation starts perfect diamond cubic lattice site. Stillinger-Weber potential and ZBL potential were used to calculate forces between atoms. We have simulated slowing-down of ion velocity, ion trajectory and coupled-coing between ion and silicon. We also discussed distribution of point defect using rdial distribution function. We found that interstitial produced by ion bombardment mainly formed interstitial cluster.

• Journal of electromagnetic engineering and science
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• v.4 no.2
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• pp.93-96
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• 2004

In this paper we introduce a new escalator(ESC) structure-based adaptation algorithm. The proposed algorithm is independent of eigenvalues spread ratio(ESR) of channel and has faster convergence speed than that of the conventional ESC algorithms. This algorithm combines the fast adaptation ability of least square methods and the orthogonalization property of the ESC structure. From the simulation results the proposed algorithm shows superior convergence speed and no slowing down of convergence speed when we increase the ESR of the channel.

• Journal of Radiation Protection and Research
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• v.8 no.1
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• pp.26-32
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• 1983

A somewhat detailed energy spectra in terms of the track length resulting from coupled electron-photon slowing down are calculated throughout the ICRU standard tissue with uniformly distributed gamma sources of $^{60}Co\;and\;^{137}Cs$, respectively. The calculation was accomplished by utilizing the latest available cross-section data as input to a carefully optimized computer code. In this report, the calculational method is described in detail. Furthermore, results of calculations are given in graphical form. The results show that the energy spectrum defined in terms of differential track length has about same shape although the energies of gamma source are different. The discontinuity in the energy spectrum appears at the energy of $T=(1/T_0+2/m_0c^2)^{-1}$, because a primary photon can not be degrade to a point below this energy.

• Phonetics and Speech Sciences
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• v.6 no.4
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• pp.3-15
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• 2014

An articulatory study (using an Electromagnetic Articulography, EMA) was conducted to explore effects of prosodic boundary strength (Intonational Phrase/IP versus Word/Wd), and focus (Focused/accented, Neutral, Unfocused/unaccented) on the kinematic realization of /m/ in the coda (${\ldots}$am#i${\ldots}$) and the onset (${\ldots}$a#mi${\ldots}$) conditions in Korean. (Here # refers to a prosodic boundary such as an IP or a Wd boundary). Several important points have emerged. First, the boundary effect on /m/s was most robustly observed in the temporal dimension in both the coda (IP-final) and the onset (IP-initial) conditions, generally in line with cross-linguistically observable boundary-related lengthening patterns. Crucially, however, in contrast with boundary-related slowing-down effects that have been observed in English, both the IP-final and IP-initial temporal expansions of Korean /m/s were not accompanied by an articulatory slowing down. They were, if anything, associated with a faster movement in the lip opening (release) phase (into the vowel). This suggests that the mechanisms underlying boundary-related temporal expansions may differ between languages. Second, observed boundary-induced strengthening effects (both spatial and temporal expansions, especially on the IP-initial /m/s) were remarkably similar to prominence (focus)-induced strengthening effects, which is again counter to phrase-initial strengthening patterns observed in English in which boundary effects are dissociated from prominent effects. This suggests that initial syllables in Korean may be a common focus for both boundary and prominence marking. These results, taken together, imply that the boundary-induced strengthening in Korean is different in nature from that in English, each being modulated by the individual language's prosodic system. Third, the coda and the onset /m/s were found to be produced in a subtly but significantly different way even in a Wd boundary condition, a potentially neutralizing (resyllabification) context. This suggests that although the coda may be phonologically 'resyllabified' into the following syllable in a phrase-medial position, its underlying syllable affiliation is kinematically distinguished from the onset.

• Journal of Radiation Protection and Research
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• v.35 no.3
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• pp.124-134
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• 2010

The Geant4 simulation toolkit provides improved or renewed physics model according to the version. The latest Geant4.9.3 which has been recoded by developers applies inserted Livermore data and renewed physics model to the low energy electromagnetic physics model. And also, Geant4.9.3 improved the physics factors by modified code. In this study, the stopping power and CSDA(Continuously Slowing Down Approximation) range data of electron or particles were acquired in various material and then, these data were compared with NIST(National Institute of Standards and Technology) data. Through comparison between data of Geant4 simulation and NIST, the improvement of physics model on low energy electromagnetic of Geant4.9.3 was evaluated by comparing the Geant4.9.2.