• 제목/요약/키워드: Slow and rapid methods

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N-Acetyltransferase 2와 glutathione S-transferase mu 및 theta 다형성이 방광암 발생에 미치는 영향에 대한 환자-대조군 연구 (A case-control study on the effects of the genetic polymorphisms of N-acetyltransferase 2 and glutathione S-transferase mu and theta on the risk of bladder cancer)

  • 김헌;김원재;이형래;이무송;김철환;김로사;남홍매
    • Journal of Preventive Medicine and Public Health
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    • 제31권2호
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    • pp.275-284
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    • 1998
  • 1996년 3월부터 1996년 12월까지 충북대학교병원 비뇨기과에 입원하여 치료를 받은 방광암 환자 67명과 암 아닌 다른 질환을 가진 대조군 67명을 대상으로 흡연, 음주, 직업력 등을 포함한 생활 습관과 NAT2와 GSTM1, 그리고 GSTT1 유전자 다형성 양상을 조사하여 다음과 같은 결론을 얻었다. 1. NAT2 다형성 분포는, 환자군이 slow, intermediate, rapid acetylator가 각각 3.0%, 38.8%, 58.2%, 그리고 대조군이 7.6%, 40.9%, 51.5%였으며, NAT2의 활성과 방광암 위험도 사이의 관련성은 유의하지 않았다($\chi^2_{trend}=1.18$, P-value>0.05). 2. GSTM1 결손은 환자군의 68.7%, 대조군의 49.3%에서 확인되었으며, OR(95% 신뢰구간)이 2.23(1.12-4.56)으로, 방광암 발생의 위험인자로 나타났다. 3. GSTT1은 환자군의 26.9%,그리고 대조군의 43.3%에서 결손이 있는 것으로 나타나서, GSTT1 결손은 방광암에 대하여 보호효과가 있는 것으로 관찰되었다(OR: 0.48, 95% 신뢰구간: 0.23-0.99). 4. 흡연 여부는 방광암의 발생에 유의한 영향을 미치지 않는 것으로 나타났는데(OR=1.85, 95% CI: 0.85-4.03), 이는 환자군과 대조군의 흡연률이 모두 높기 때문으로 판단된다. 5. 그 외, 음주력, 직업력, 수혈 여부, 그리고 피임시술의 과거력 등의 요인들은 방광암 발생과 유의한 관련성이 없는 것으로 나타났다.

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제대혈 유래 중간엽 줄기 세포를 이용한 피부 창상 치료시 세포 투여 방법에 따른 창상치유 효과의 비교 (Effective Delivering Method of Umbilical Cord Blood Stem Cells in Cutaneous Wound Healing)

  • 박상은;한승범;나동균;유대현
    • Archives of Plastic Surgery
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    • 제36권5호
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    • pp.519-524
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    • 2009
  • Purpose: This study was conducted to establish the most effective method of cell therapy by comparing and analyzing the level of wound healing after various cell delivery methods. Methods: Human mesenchymal stem cells were administered using 5 different methods on full thickness skin defects which were deliberately created on the back of 4 - week old mice using a 8 mm punch. Different modes of administration, cell suspension, local injection, collagen GAG matrix seeding, fibrin, and hydrogel mix methods were used. In each experiment group, $4{\times}105$ mesenchymal stem cells were administered according to 5 deferent methods, and were not for the corresponding control group. Results: The wound healing rate was fastest in the local injection group. The wound healing rate was relatively slow in the collagen matrix group, however, the number of blood vessels or VEGF increased most in this group. Conclusion: For rapid wound healing through wound contraction, it is advantageous to administer MSC by the local injection method. For the healing process of a wide area, such as a burn, the seeding of cells to collagen matrix is thought to be effective.

층층나무와 신갈나무 폐바이오매스를 활용한 수용액 중 납 제거 효율 및 기작 (Efficiency and Mechanism of Pb(II) Removal from Aqueous Solutions Using Cornus controversa and Quercus mongolica Biomass Waste)

  • 최시영;정석순;양재의;김혁수;조준형
    • 한국환경농학회지
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    • 제40권4호
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    • pp.239-247
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    • 2021
  • BACKGROUND: Enormous amounts of the wood biomass wastes have been produced through various wood processing. This study characterizes the surface characteristics of biomass powders of Cornus controversa (CC) and Quercus mongolica (QM) and investigates their removal efficiency and mechanism for Pb (II) in aqueous solution on which to base potential recycling alternative of the wood biomass. METHODS AND RESULTS: Batch experiments were conducted under different conditions of Pb concentrations, temperatures, time and solid/solution ratios. Adsorption isotherm of Pb by CC and QM biomass was explained significantly by the Langmuir model, indicating Pb was likely adsorbed on the monolayer of the surfaces. The adsorption kinetics were fitted significantly to the double first-order model consisting of rapid and slow steps. The respective rate constants (k1) of CC and QM for the rapid adsorption kinetic steps were 0.051 and 0.177 min-1, and most of the sorption reactions proceeded rapidly within 6-20 minutes. The maximum adsorption quantities (qmax) of Pb were 17.25 and 23.47 mg/g for CC and QM, respectively. Thermodynamic parameters revealed that adsorption of Pb on the biomass of CC and QM was a spontaneous endothermic reaction. CONCLUSION(S): Results demonstrate that biomass wastes of CC and QM can be used as Pb adsorbents judging from adsorption isotherm, kinetics, and thermodynamic parameters.

Use of Near Infrared Spectroscopy in the Meat Industry

  • Akselsen, Thorvald M.
    • 한국축산식품학회:학술대회논문집
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    • 한국축산식품학회 2000년도 국제심포지엄 및 제26차 추계학술발표회
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    • pp.1-14
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    • 2000
  • The Near Infrared region of the energy spectrum was first discovered by Hershel in the year 1800. The principles of NIR is based on light absorption of specific organic chemical bonds. The absorption at each wavelength is measured and a spectre is obtained. The spectre is then treated mathematically and with the absorption data is converted to absolute units via a calibration. In the last two decades it has developed dramatically. With the invention of computers and the ability to treat a large amount of data in a very short time the use of NIR for many different purposes has developed very fast. During the last decade with the aid of very powerful PC's the application of NIR technology has become even more widespread. Now or days development of very robust calibrations can be done in a relatively short time with a minimum of resources. The use of Near Infrared Spectroscopy (NIR) in the Meat industry is relatively new. The first installations were taken into operation in the 80ties. The Meat Industry in often referred to as rather conservative and slow to embrace new technologies, they stay with the old and proven methods. The first NIR instruments used by the Meat Industry, and most other industries, were multipurpose build, which means that the sample presentation was not well suited to this particular application, or many other applications for that sake. As the Meat Industry grows and develops to meet the demands of the modern markets, they realise the need for better control of processes and final products. From the early 90 ties and onward the demand for 'rear time' rapid results starts growing, and some suppliers of NIR instruments (and instruments based on other technologies, like X-ray) start to develop and manufacture instrumentation dedicated to the particular needs of the Meat Industry. Today it is estimated that there are approximately 2000 rapid instruments placed in the Meat industry world-wide. By far most of these are used as at-line or laboratory installations, but the trend and need is moving towards real on-line or in-line solutions. NIR is the most cost effective and reproducible analytical procedure available for the twenty first century.

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Maxillary expansion with the memory screw: a preliminary investigation

  • Halicioglu, Koray;Kiki, Ali;Yavuz, Ibrahim
    • 대한치과교정학회지
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    • 제42권2호
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    • pp.73-79
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    • 2012
  • Objective: The purpose of this study was to investigate the effects of a newly developed rapid maxillary expansion screw-the memory screw-over 6 months. Methods: Five subjects, aged between 11.7 and 13.75 years, were enrolled in this study. All subjects underwent placement of a maxillary expansion appliance containing superelastic nickel-titanium open-coil springs in its screw bed. The parents of the patients and/or the patients themselves were instructed to activate the expansion screw by 2 quarter-turns 3 times a day (morning, midday, and evening; 6 quarter-turns a day). The mean expansion period was $7.52{\pm}1.04$ days. Dentoskeletal effects of the procedure, including dentoalveolar inclination, were evaluated. Measurements of all the parameters were repeated after 6 months of retention in order to check for relapse. Results: Sella-Nasion-A point (SNA) and Sella-Nasion/Gonion-Menton angles increased, and Sella-Nasion-B point (SNB) angle decreased in all the subjects during the expansion phase. However, they approximated to the initial values at the end of 6 months. On the other hand, the increments in maxillary apical base (Mxr-Mxl) and intermolar widths was quite stable. As expected, some amount of dentoalveolar tipping was observed. Conclusions: The newly developed memory expansion screw offers advantages of both rapid and slow expansion procedures. It widens the midpalatal suture and expands the maxilla with relatively lighter forces and within a short time. In addition, the resultant increments in the maxillary apical base and intermolar width remained quite stable even aft er 6 months of retention.

Multi-classification Sensitive Image Detection Method Based on Lightweight Convolutional Neural Network

  • Yueheng Mao;Bin Song;Zhiyong Zhang;Wenhou Yang;Yu Lan
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제17권5호
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    • pp.1433-1449
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    • 2023
  • In recent years, the rapid development of social networks has led to a rapid increase in the amount of information available on the Internet, which contains a large amount of sensitive information related to pornography, politics, and terrorism. In the aspect of sensitive image detection, the existing machine learning algorithms are confronted with problems such as large model size, long training time, and slow detection speed when auditing and supervising. In order to detect sensitive images more accurately and quickly, this paper proposes a multiclassification sensitive image detection method based on lightweight Convolutional Neural Network. On the basis of the EfficientNet model, this method combines the Ghost Module idea of the GhostNet model and adds the SE channel attention mechanism in the Ghost Module for feature extraction training. The experimental results on the sensitive image data set constructed in this paper show that the accuracy of the proposed method in sensitive information detection is 94.46% higher than that of the similar methods. Then, the model is pruned through an ablation experiment, and the activation function is replaced by Hard-Swish, which reduces the parameters of the original model by 54.67%. Under the condition of ensuring accuracy, the detection time of a single image is reduced from 8.88ms to 6.37ms. The results of the experiment demonstrate that the method put forward has successfully enhanced the precision of identifying multi-class sensitive images, significantly decreased the number of parameters in the model, and achieved higher accuracy than comparable algorithms while using a more lightweight model design.

A Study on the Seaborne Collision Avoidance System Using the Airborne CAS

  • KANG, Jeong-gu;PARK, Jin-Soo;PARK, Young-Soo
    • 한국항해항만학회지
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    • 제44권2호
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    • pp.65-72
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    • 2020
  • Mankind has been using ships for more than 5,000 years and has developed a range of related technologies. However, despite such a long history, compared to aircraft with a history of approximately one century, the pace of progress has been markedly slow. Even though technological progress of ships or the installation of various navigation equipment have been achieved, seaborne collisions have occurred quite frequently. This study analyzed the TCAS( Traffic Collision Avoidance System) that has contributed to the prevention of collisions with other transport methods including aircraft to suggest a collision avoidance system that can be deployed for ships. To apply the technologies applied to aircraft that move in 3D to ships that move in 2D, the difference in the operational environment between the two modes was analyzed to identify elements that need to be applied to ships. The suggested display of data on the collision prevention system is one that manipulates the augmented reality display device used in automobiles that over the past few years has undergone rapid development. Based on the presentation of technological elements that need to be considered when adopting the SCAS or the Seaborne Collision Avoidance System as suggested in this study, the authors hope to contribute to the prevention of collisions.

치주인대세포(齒周靭帶細胞)의 생화학적(生化學的) 특이성(特異性)에 대(對)한 연구(硏究) (BIOCHEMICAL CHARACTERISTICS OF HUMAN PERIODONTAL LIGAMENT CELLS IN VITRO)

  • 조성욱;차경석
    • 대한치과교정학회지
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    • 제22권1호
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    • pp.273-283
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    • 1992
  • To find out the differences between periodontal ligament cells (PDL cells) and gingival fibroblast cells (GFB cells), alkaline phosphatase, a marker enzyme for osteoblast, was used to measure the activities and $^{45}CaCl_2$ isotope was used to find out cellular and release of $^{45}Ca$, a requisite for bone formation,. PDL cells and GFB cells from 1 to 5 passages were also measured in alkaline phosphatase activity assay. By the use of above methods, followings were concluded that the PDL cells and the GFB cells have characteristics that are different from each other. In that PDL cells showed large amount of calcium uptake and large amount of calcium release in initial stage, they seem to possess characteristics which are similar to osteoblast-like cells. 1. The PDL cells, in contrast to the gingival fibroblast, showed exceedingly high alkaline phosphatase activity which was highest at the second passage, decreasing thereon. But gingival fibroblasts cells showed no distinct differences in alkaline phosphatase activity as the passage were elapsed. 2. For both PDL cells and GF cells, the $^{45}Ca$ uptake was greatest at 2 hours period. The PDL cells showed higher measuring than GFB cells through out the whole time period. 3. Whereas the GFB cells showed slow increase of $^{45}Ca$ release as time relapsed, the PDL cells showed rapid increase of $^{45}Ca$ release.

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수면 의존성 운동 학습에 대한 고찰 (A Review of Sleep-Dependent Motor Learning)

  • 이명희;이상열;박민철;배성수
    • PNF and Movement
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    • 제6권3호
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    • pp.19-28
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    • 2008
  • Purpose : The objective of this study was to determine efficacy of sleep-dependent motor learning. Methods : This is a literature study with books and internet. We searched the PubMed, Science Direct, KISS and DBpia. Key words were Sleep-dependent, motor learning, RAM and LTP. Results : Procedural memory, like declarative memory, undergoes a slow, time-dependent period of consolidation. A process has recently been described wherein performance on some procedural task improves with the mere passage of time and has been termed "enhancement". Some studies have reported that the consolidation/enhancement of perceptual and motor skill is dependent on sleep. Specially, rapid-eye-movement(REM) sleep seems to benefit procedural aspects of memory. Conclusion : Motor learning is very important for CNS injury patients. And also distribution of practice sessions is important because REM sleep is to benefit procedural aspects of memory consolidation.

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입자분리효율을 높이기 위한 새로운 기술 (New Technologies for Enhancing Particles Separation Efficiency in Coagulation and Filtration)

  • Kunio, Ebie;Jang, Il-Hun
    • 상하수도학회지
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    • 제18권2호
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    • pp.254-269
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    • 2004
  • Polysilicato-iron coagulant (PSI) is receiving attention in Japan as a substitute for aluminum-based coagulants. In the first part of this article, coagulation, sedimentation and filtration experiments were carried out using kaolin clay particles as the turbidizing material and four types of PSI with various molar ratios of polysilicic acid to ferric chloride (Si/Fe ratio). Results demonstrate that use of a PSI with a high Si/Fe ratio can cause a more dramatic decrease in treated water turbidity but a higher suction time ratio (STR) than when PACl is used. However, optimization by increasing the rapid agitation strength GR is found to greatly improve the STR. In addition, the series of filtration experiments verified that optimization of GR is greatly effective in controlling rapid increases in filter head loss, and also formation of a thin aging layer in the upper part of the filter bed by slow-start filtration is effective in improving filtered water turbidity over the entire filtration process. The second part of this article describes two innovative filtration techniques to increase the particle separation efficiency; (1) coagulant-coated filter medium by enhancing the electrical potential of the surface of the filter medium, and (2) coagulant dosing in influent by controlling the electrical potential of particles entering the filter layer. From the results of the various filtration experiments using a pilot plant, these two techniques were found to be very effective to reduce the effluent water turbidity from the start to the end of a filter run. Moreover, in the filtration experiments using these two methods simultaneously, higher removal efficiency of approximately 3-log (99.7%) was realized, resulting that the finished water turbidity was accordingly reduced to 0.004mg/L.