• 대한지역사회작업치료학회지
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• 제7권1호
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• pp.9-16
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• 2017

목적 : 본 연구는 수면장애 동물모델 쥐에게 환경변화를 적용하였을 때, 혈 중 멜라토닌의 변화를 통하여 수면장애 개선 효과를 확인하는데 그 목적이 있다. 연구방법 : 본 연구는 경북 소재의 동물실험실에서 실험을 진행하였고 수면장애 모델의 흰쥐 26마리에게 적용하였다. 3일간 환경변화를 적용한 실험군과 일반 케이지에서 환경변화를 적용받지 못한 대조군의 수면장애 모델 쥐 각각 13마리의 혈 중 멜라토닌의 농도를 확인하였다. 결과 : 수면장애 모델 쥐에게 환경변화를 적용한 결과, 환경 적용 후 실험군에서는 3일간 일별 멜라토닌 농도의 변화는 유의하게 증가하였고(p=.000), 대조군은 3일간 일별 멜라토닌 농도의 변화는 약간의 증가는 있었지만 유의한 변화는 없었다(p=.212). 환경 적용 전, 후 멜라토닌 농도의 변화는 실험군, 대조군 모두 유의한 차이를 보였지만 실험군에서는 멜라토닌 농도의 유의미한 증가가 있었고, 대조군에서는 멜라토닌 농도의 유의미한 감소가 있었다. 결론 : 수면장애 환자가 증가하고 있는 현대사회에서 환자들에게 적용되어지는 환경적용이 수면장애에 어떠한 영향을 주는지 확인하기 위해 동물모델을 제작하였고 인간의 환경변화와 유사한 환경변화를 적용하였으며 이를 통해 수면장애의 개선효과를 확인할 수 있었다.

• 대한한방내과학회지
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• 제40권5호
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• pp.785-796
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• 2019

Objective: Facial nerve palsy causes both facial muscle malfunction and mental illness. Because a facial nerve palsy lesion shows on the face, it can have serious effects on social relationships and mental health. Many facial nerve palsy patients undergo anxiety, depression, and social phobia. In this study, a facial nerve palsy patient with sleep disorder was admitted to the Korean medicine hospital for treatment. Methods: The patient with facial nerve palsy and sleep disorder was treated with herbal medicines, acupuncture, herbal acupuncture therapy, and physical therapy. We used the House Brackmann grading system and Yanagihara's Unweighted Grading System to assess changes in facial nerve palsy symptoms and the Korean Modified Leeds Sleep Evaluation Questionnaire to assess the sleep disorder. Results: The patient was hospitalized for 18 days and showed a recovery from both facial nerve palsy and sleep disorder symptoms without any adverse events. We conclude that patients with facial nerve palsy should be treated from both the physical and mental health perspectives.

• 턱관절균형의학회지
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• 제7권1호
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• pp.1-10
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• 2017

In order to establish a relationship between sleep related breathing disorder (SBD) and temporomandibular disorders (TMDs), a literature review was performed. A researching was performed based on PubMed, including english languages. Any clinical study identified relationship between SBD and TMD were selected in this review. 13 studies were analyzed in this review. According to SBD diagnosis, articles were grouped as follows: polysomnographic diagnosis (n=7), clinical diagnosis (n=2) and survey/self-report (n=4). 12 articles established a positive relation between SBD and TMD and 1 did not. SBD would be associated with protrusion/retrusion degree, myofascial pain, muscular and joint pathology, and other orofacial findings. It was analyzed that the retrusion of the mandible had the significant influence on the severity of the SBD.

• 수면정신생리
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• 제18권2호
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• pp.67-71
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• 2011

Schizophrenia is a chronic, currently incurable, and devastating syndrome. Although sleep disturbances are not primary symptoms of schizophrenia, they are important aspects of schizophrenia. Difficulties initiating or maintaining sleep are frequently encountered in patients with schizophrenia. Many schizophrenics report low subjective sleep quality. Measured by polysomnography, increased sleep latency as well as reduced total sleep time, sleep efficiency, slow wave sleep, and rapid eye movement sleep latency (REM latency), are found in most patients with schizophrenia and appear to be an important aspect of the pathophysiology of this disorder. Some literatures suggest that worsening sleep quality precedes schizophrenic exacerbations. Co-morbid sleep disorders such as obstructive sleep apnea (OSA) and restless legs syndrome (RLS), and sleep-disrupting behaviors associated with schizophrenia may lead to sleep disturbances. Clinicians should screen the patient with sleep complaints for primary sleep disorders like OSA and RLS, and carefully evaluate sleep hygiene behaviors of all patients with schizophrenia who complain of sleep disturbances.

• 수면정신생리
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• 제24권1호
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• pp.19-23
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• 2017

Obstructive sleep apnea is a common disorder in which respiratory flow decreases or disappears despite respiratory effort due to occlusion of the upper respiratory tract during sleep. Oxidative stress and systemic inflammatory reaction induced by the obstruction cause complications such as hypertension, coronary artery disease, and diabetes and increase cancer incidence. Furthermore, in patients with interstitial lung disease, obstructive sleep apnea has a very high prevalence and is thought to have a close pathophysiological and clinical correlation. In other words, obstructive sleep apnea could be the cause or a complication of interstitial lung disease ; when these two afflictions coexist, the prognosis of the patient is worse. In patients with interstitial lung disease with obstructive sleep apnea, CPAP treatment significantly improved sleep and quality of life, as well as improved morbidity and mortality in a recent study. Therefore, early diagnosis and treatment of obstructive sleep apnea in patients with interstitial lung disease are very important, and additional studies designed to include patients with idiopathic pulmonary fibrosis as well as patients with advanced interstitial lung disease should be performed.

• 셀메드
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• 제13권9호
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• pp.34.1-34.5
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• 2023

Objective: A case report on the improvement of sleep disorders using Ortho-Cellular Nutrition Therapy (OCNT) Methods: The study subject is a Korean woman in her 40s who is very sensitive to caffeine and suffers from sleep disorders. Results: She no longer complained of discomfort due to sleep disorders after undergoing OCNT. Conclusion: OCNT can be helpful in the treatment of patients with sleep disorders.

• 수면정신생리
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• 제28권2호
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• pp.53-69
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• 2021

Sleep disorders, increasingly prevalent in the general population, induce impairment in daytime functioning and other clinical problems. As changes in cortical excitability have been reported as potential pathophysiological mechanisms underlying sleep disorders, multiple studies have explored clinical effects of modulating cortical excitability through non-invasive brain stimulation in treating sleep disorders. In this study, we critically reviewed clinical studies using non-invasive brain stimulation, particularly transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), for treatment of sleep disorders. Previous studies have reported inconsistent therapeutic effects of TMS and tDCS for various kinds of sleep disorders. Specifically, low-frequency repetitive TMS (rTMS) and cathodal tDCS, both of which exert an inhibitory effect on cortical excitability, have shown inconsistent therapeutic effects for insomnia. On the other hand, high-frequency rTMS and anodal tDCS, both of which facilitate cortical excitability, have improved the symptoms of hypersomnia. In studies of restless legs syndrome, high-frequency rTMS and anodal tDCS induced inconsistent therapeutic effects. Single TMS and rTMS have shown differential therapeutic effects for obstructive sleep apnea. These inconsistent findings indicate that the distinctive characteristics of each non-invasive brain stimulation method and specific pathophysiological mechanisms underlying particular sleep disorders should be considered in an integrated manner for treatment of various sleep disorders. Future studies are needed to provide optimized TMS and tDCS protocols for each sleep disorder, considering distinctive effects of non-invasive brain stimulation and pathophysiology of each sleep disorder.

• 수면정신생리
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• 제12권2호
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• pp.87-92
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• 2005

Cytokines are the main regulatory molecules of not only immune system but also sleep system. Research on the role of cytokines on sleep has greatly been expanding since the first report of sleep-promoting effects of interleukin-1, the first cytokine molecule. Interleukin-1 and tumor necrosis factor are most widely studied among various cytokines. Studies over about twenty years demonstrate that most cytokines promote sleep but several cytokines inhibit sleep. Slow wave sleep is the main part that cytokines have effects on. Besides normal sleep physiology, cytokines have more major roles on pathophysiology of various sleep disorders. Obstructive sleep apnea is the representative sleep disorder that shows how deeply cytokines are involved in their pathophysiologic mechanisms of sleep disorders. Though there are many controversial issues on this topic, more mysterious part of normal sleep physiology and sleep disorders will be revealed in near future through thorough studies on sleep and cytokine.

• 근관절건강학회지
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• 제14권1호
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• pp.61-69
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• 2007

Purpose: The purpose of the study is to investigate the degree of fatigue and its related factors in women with rheumatoid arthritis. Method: The subjects were 143 patients with rheumatoid arthritis. Data were collected by questionnaires including Multi-Dimensional Assessment of Fatigue(Tack, 1991), Korean Health Assessment Questionnaire(Bae et al., 1991), numeric scale of pain(Lee & Song, 1987), Center for Epidemiologic StudiesDepression, and Korean Sleep Scale(Oh, et al., 1998). The data were analyzed by SPSS WIN 12.0 program using descriptive statistics, Pearson Correlation, and Stepwise Multiple Regression. Result: The result were as follows. 1. The scores of fatigue of subjects averaged $4.95{\pm}1.83$, degree of fatigue was $5.85{\pm}1.98$, and influence of fatigue was $4.04{\pm}2.09$. 2. The mean score of the degree of physical dysfunction, pain, sleep disorder, and depression were $1.42{\pm}0.38,\;8.15{\pm}3.58,\;1.86{\pm}0.67,\;and\;1.85{\pm}0.46$ points respectively. 3. The subject's total fatigue score, physical dysfunction, pain, sleep disorder, and depression was correlated positively(r=.44, r=.28, r=.29, r=.27, p< .01). 4. The main influencing factors on the fatigue were physical dysfunction and sleep disorder. These two main variables made it possible to explain 23.0% of the variance in fatigue. Conclusion: Therefore, nursing interventions for fatigue experienced women with rheumatoid arthritis would be focused to decrease physical dysfunction and sleep disorder.

• 대한한의학회지
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• 제33권1호
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• pp.169-176
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• 2012

Objectives: Obstructive sleep apnea (OSA) is prevalent disorder, particularly among the middle-aged. In this study, we report a new approach to improve OSA using oriental medicine and acupuncture. Methods: Three men diagnosed with OSA were enrolled in this study. They took oriental medicine 3 times a day and were given acupuncture twice a week for about 4 months. Results: We analyzed apnea-hypopnea index (AHI), oxygen desaturation index (ODI), average saturation (AS) and lowest saturation (LS) before and after treatment. AHI highly decreased in all patients and ODI also decreased in two of the three patients. Conclusions: These results indicate that oriental medicine and acupuncture therapy was effective in the improvement of OSA. Further study in a larger group with severity grades is recommended.