• Archives of Plastic Surgery
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• 제36권4호
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• pp.507-511
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• 2009

Purpose: Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm derived from the salivary glands. In some cases, ACC may arise in other primary sites, such as skin. We report a case of adenoid cystic carcinoma arising the scalp skin of 69 - year - old woman. Methods: A 69 - year - old woman presented with a tender scalp nodule. A local wide excision was performed. Histopathologic examination was revealed the adenoid cystic carcinoma with basaloid cells in a cribriform pattern. The resection margins were free of tumor. Two years later a tumor recurred in the scarred area. The lesion was removed surgically and the histopathological diagnosis of adenoid cystic carcinoma was again established. After two years, tumor recurred again and diatant metastasis of the lung was diagnosed. A surgical wide excision was done and the close regular follow - up for recurrence was done. Two years later, third recurrence of the scalp was observed. We also performed the wide local excision with tumor free margin. Results: We experience the recurrent adenoid cystic carcinoma of the scalp with pulmonary metastasis. We have performed the wide local excision for three times. The patient has been followed up for 10 years with regular work - up for recurrence and metastasis Conclusion: primary cutaneous adenoid cystic carcinoma is a rare skin neoplasm with a high potential for recurrence after local excision. The standard treatment of ACC is wide local excision with tumor - free margins established by permanent section.

• Archives of Reconstructive Microsurgery
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• 제19권2호
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• pp.81-87
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• 2010

In surgical treatment of the malignant melanoma, radical resection and a sentinel lymph node biopsy are essential procedures to eradicate the tumor and to minimize the risk of local recurrence. For the reconstruction of skin defect after tumor resection, a skin graft has been generally performed procedure. However, if tendon or bone is exposed after tumor resection, simple skin graft is not enough for the coverage of the defect and additional procedure is mandatory. In this study, we reviewed the clinical results of 16 patients, who had been diagnosed with malignant melanoma of the limb and underwent surgical resection and reconstruction of the defect with various methods. The sentinel lymph node dissection was performed in all patients combined with radical excision of the tumor. In 11 cases of positive sentinel lymph nodes, further elective lymph node dissections were performed. The mean tumor invasion depth was 4.54 mm (2~10 mm), and AJCC stage II was most common (9 cases). The pedicled flaps were performed in 10 cases for the reconstruction of defects. All flaps were successfully survived without significant complications until the last follow up. In conclusion, a pedicled flap coverage is very useful reconstruction strategy for the soft tissue defects after radical resection of malignant melanoma.

• 한국식품영양과학회지
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• 제41권4호
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• pp.462-470
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• 2012

본 연구의 결과, TPA 종양촉진 시작과 함께 실험식이를 급여하였을 때, 장뇌삼은 대조군과 인삼군보다 낮은 피부종양발생수를 나타내었으며 종양발생률에서도 대조군과 인삼군에 비해 장뇌삼군에서 종양의 발생이 지연되는 것으로 나타났다. 반면, DMBA 종양개시 한 달 전부터 실험 종료 시까지 실험식이를 급여하였을 때는 대조군과 장뇌삼군에 비해 인삼군의 종양발생수가 감소된 것으로 나타나 인삼은 암 예방효능이 장뇌삼보다 더 높은 것으로 나타났다. 장뇌삼과 인삼은 마우스 피부암이 아닌 다른 상피세포성 암에 대해서도 각각 이러한 효능을 보일 것인지에 대해서 후속연구가 요구되며 또한 앞으로 인삼과 장뇌삼의 유효성분을 발굴하고 이를 더욱 효과적으로 섭취할 수 있는 방법이 개발되어야 할 것으로 생각된다. 아울러 질적으로 우수한 우리나라 장뇌삼과 인삼이 건강기능식품으로서 뿐만 아니라 암 예방과 암치료에 사용될 수 있는 대체의약품으로 개발되기 위해서는 실질적인 임상치료 연구와 더불어 보다 구체적인 과학적 기능 규명연구가 필요하다고 생각된다.

• 대한두개안면성형외과학회지
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• 제21권5호
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• pp.323-325
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• 2020

Sclerotic fibroma is a rare fibrous tumor of the skin associated with Cowden's disease. In 1989, Rapini described sclerotic fibroma without Cowden's disease as solitary sclerotic fibroma of the skin. It is a solid, well-circumscribed, slow-growing nodular tumor and it looks similar to a keloid scar. Consequently, it is extremely difficult to make a differential diagnosis of solitary sclerotic fibroma with keloid scar based on clinical findings only. The authors report a case of solitary sclerotic fibroma arising at the left lateral thigh of a 25-year-old man.

• Archives of Plastic Surgery
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• 제32권1호
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• pp.139-142
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• 2005

Atypical fibroxanthoma(AFX) is a tumor that occurs as a solitary and ulcerative nodule on actinically damaged or radiation damaged skin of the head and neck in the elderly. AFX is a pleomorphic spindle cell neoplasm of the dermis, which is a clinically benign reactive lesion despite of apparently malignant histologic features. We report a case of AFX which developed on the nasal root area of a 23-year-old man. This case is very unusual in terms of site(less sun-damaged area), overlying skin feature(grossly normal skin) and age(too young). This tumor was completely removed with surgical excision and remained free of recurrence for a period of about 1 year follow-up.

• 대한세포병리학회지
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• 제16권2호
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• pp.98-101
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• 2005

Eccrine spiradenoma is a rare adnexal tumor of the skin and its cytomorphology has seldom been described in literature. To evaluate the cytologic features and diagnostic pitfalls of eccrine spiradenoma, we report a case of 33-year-old male whose clinical presentation was a painful subcutaneous mass at the right preauricular area. Fine needle aspirates revealed tight clusters of multilayered, uniform, cuboidal cells arranged around hyalinized perivascular spaces. Some epithelial cells showed tubules or rosette formations. The background showed scattered, naked nuclei. The histologic findings confirmed the eccrine spiradenoma. The recognition of peculiar cytologic features and clinical correlation could be helpful in the diagnosis of skin adnexal tumors.

• 대한전기학회논문지:시스템및제어부문D
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• 제52권11호
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• pp.634-643
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• 2003

This paper presents a method for detecting skin tumors on chicken carcasses using hyperspectral images. It utilizes both fluorescence and reflectance image information in hyperspectral images. A detection system that is built on this concept can increase detection rate and reduce processing time, because the procedure for detection can be simplified. Chicken carcasses are examined first using band ratio FCM information of fluorescence image and it results in candidate regions for skin tumor. Next classifier selects the real tumor spots using PCA components information of reflectance image from the candidate regions. For the real world application, real-time processing is a key issue in implementation and the proposed method can accommodate the requirement by using a limited number of features to maintain the low computational complexity. Nevertheless, it shows favorable results and, in addition, uncovers meaningful spectral bands for detecting tumors using hyperspectral image. The method and findings can be employed in implementing customized chicken tumor detection systems.

• 한국임상수의학회지
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• 제19권4호
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• pp.440-442
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• 2002

A fourteen-year-old mongrel female dog that was 22 kg and had two large mammary tumor lesions was admitted to the Animal Teaching Hospital of Chonbuk National University. Two large mammary tumor lesions were observed in the right caudal thoracic and the left inguinal mammary glands, which were sized 6 cm and 5 cm in diameter, respectively. These tumor lesions were removed by block mastectomy, then large skin defect of 7 cm diameter in caudal abdominal wall were recoverd by classic Z-plasty in both medial thigh. Classic Z-plasty was designed with 60 in angle and, with 6 cm in length of central limb in right medial thigh and 4 cm in left, respectively. This patient had been recoverd to normal gait and behavior at 20 days after the plastic operation.

• 대한수의학회지
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• 제54권1호
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• pp.63-66
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• 2014

The pathological features of a mass in the back skin region of an 8-year-old castrated male dog are described herein. The cut section of the tumor was white to tan with a soft multilobulated mass containing hemorrhagic and necrotic foci and a mucinous-like composition. Microscopically, the tumor was composed of a mixture of lipocytes, lipoblasts, spindle cells and stellate cells and had a myxoid background. Oil red O staining revealed that the cytoplasm of neoplastic cells contained large numbers of lipid droplets. Immunohistochemically, tumor cells were positive for vimentin and S-100 protein. The skin mass was diagnosed as myxoid liposarcoma.

• Archives of Plastic Surgery
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• 제43권6호
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• pp.538-543
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• 2016

Background Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC. Methods Twenty-six cases were collected for this prospective study. Frozen biopsies were examined after complete resection of the tumor, followed by histological confirmation by pathological examination. The major and minor axis lengths of the tumor, the invasion depth, and the level of invasion were measured. Recurrence or metastasis was recorded through regular follow-up. Results The Pearson correlation coefficient was used for statistical analysis. Significant results were observed for the relationship between the major and minor axis lengths and the invasion depth of the tumor (0.747, 0.773). No cases of recurrence or metastasis were observed. Conclusions In head and neck cutaneous SCC, the invasion depth of the tumor is closely related to the major and minor axis lengths of the tumor. Therefore, the invasion depth of the tumor can be estimated by measuring the size of the tumor, and a standard vertical safety margin for head and neck cutaneous SCC can be established, which could be helpful in the development of a preoperative reconstruction plan.