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http://dx.doi.org/10.3746/jkfn.2012.41.4.462

Differential Anti-Carcinogenic Effect of Mountain Cultivated Ginseng and Ginseng on Mouse Skin Carcinogenesis  

Lee, Min-Hee (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Choi, Sang-Won (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Kim, Eun-Jung (Dept. of Food Science and Nutrition, Catholic University of Daegu)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.41, no.4, 2012 , pp. 462-470 More about this Journal
Abstract
Mountain cultivated ginseng (MCG) is a type of Panax ginseng C. A. Mayer, grown in the mountains by artificial seeding. In general, it has been known that the biophysical activities of MCG is greater than that of ginseng. However, the in vivo efficacy of MCG on cancer has not been studied. In this study, we investigated the anti-carcinogenic effect of MCG and ginseng using the 7,12-dimethylbenz[a]anthracene (DMBA)-12-O-tetradecanoylphorbol- 13-acetate (TPA) two stage mouse skin carcinogenesis model. Six weeks of female ICR mice were divided into control, MCG, and ginseng diet groups and were subjected into two different experimental protocols. In the first study, each experimental diet was fed with TPA promotion for 24 weeks. The result showed that supplementation of MCG reduced tumor incidence, tumor multiplicity, and tumor size compared to those of the control and ginseng groups. In the second study, 3 groups of mice were supplied with each diet 4 weeks before DMBA tumor initiation, until the end of experiment. The result showed that tumor incidence, tumor multiplicity, and tumor size were reduced in the ginseng diet group compared to those of the control and MCG groups. TPA-induced BrdU incorporation was also significantly reduced in the ginseng diet group. Taken together, these results suggest that MCG is chemotherapeutic, whereas ginseng has a chemopreventative effect on mouse skin cancer.
Keywords
ginseng; mountain cultivated ginseng; mouse skin cancer;
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