• The Korean Journal of Pain
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• v.24 no.2
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• pp.74-80
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• 2011

Background: Lidocaine patch (L5P) has demonstrated short-term efficacy in treating both acute surgical pain and chronic neuropathic pain with tolerable side effects. Percutaneous endoscopic lumbar discectomy (PELD) is the mainstay of minimally invasive spine surgery (MISS). Sufficient analgesia during PELD surgery makes the patient consider it real MISS. This study was performed to evaluate the efficacy and adverse effects of lidocaine patch in patients who underwent PELD under local anesthesia. Methods: L5P (L group) or placebo (P group) was randomly applied on the skin of the back covering the anticipated path of the working channel before 1 hour of surgery in 100 patients who underwent a single level PELD at L4-L5. Efficacy of the lidocaine patch was assessed by patient's numeric rating scale (NRS) of pain at each stage during the surgery and by a 5-scale grading of the satisfaction with the anesthesia of the operator and patients after surgery. Results: Mean NRS scores at the stages of needle insertion, skin incision, serial dilation and insertion of working channel, and subcutaneous suture were significantly lower in the L group than the P group. Postoperative operator's and patients' satisfaction scores were also significantly higher in L group than in the P group. There were subtle adverse effects in both groups. Conclusions: L5P provided better pain relief during PELD, especially at the stage of needle insertion, skin incision, serial dilation and insertion of working channel, and subcutaneous suture. It also provided higher patient and operator postoperative satisfaction, with only subtle adverse effects.

• The Plant Pathology Journal
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• v.25 no.3
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• pp.291-293
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• 2009

The low virus titer in woody plant tissues and the presence of inhibitor compounds such as polyphenols, tannins and polysaccharides are common difficulties that compromise purification of plant viroids from their woody hosts. A simple, reliable method of RNA isolation using CF11 cellulose column on a microcentrifuge tube scale for detecting Apple scar skin viroid (ASSVd) in apple was developed. Total RNA extracted from leaf, woody bark and the fruit skin was used for reverse transcription. RT-PCR products could be detected from RNA prepared from dormant woody bark, fruit skin and fresh leaves with both the CF11 cellulose column method and NucliSens extractor in February, August and November. Meanwhile, with the RNeasy kit RT-PCR, products were detected only in leaves and not from bark or fruit skin. The PCR product, about 330 base pairs, was analyzed by agarose gel electrophoresis. The CF11 cellulose column method was effective for detecting ASSVd. The method enabled the processing of a large numbers of samples of dormant woody bark, leaf and fruit skin of apple.

• Korean Journal of Ichthyology
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• v.12 no.1
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• pp.25-32
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• 2000

The structure of skin was studied in Iksookimia longicorpus based on the micro-anatomical investigation of skin fragments taken from four regions. The epidermis was distinguished by two types of skin glands, a small mucous cell and a large club cell. The mucous cell was acid sulfomucins (some sialomueins) but the club cell did not give any histochemical tests for mucosubstances. The presence of a well defined lymphatic system with small lymphocytes was established in the stratum germinativum layer of the epidermis. A large number of blood capillaries run very close to each other just below the basement membrane, and a definite area giving AB and PAS positive was present between the basement membrane and scale.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.2
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• pp.27-40
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• 2010

Background and Objective : Increasing interest in anti-aging and anti-wrinkling agents for the skin has triggered the recent outflow of researches and studies in this field. This study was designed to investigate the effects of bee venom on skin wrinkling and skin aging by testing the skin wrinkling, skin elasticity, trans-epidermal water loss (TEWL), free radical level, anti-oxidative agent level, and skin tissue after infusion of bee venom on hairless mouse. Materials and Methods : Fifteen hairless mice aged between 36~40 weeks were divided randomly into 3 Group; the Bee Venom Syringe Group, the Bee Venom Needle Group, and the control group. The Bee Venom Syringe Group were injected subcutaneously with bee venom (0.1cc in total) using an insulin syringe on three spots in the lumbar spine (one spot on the center and two spots 1~2cm to the side bilaterally). The Bee Venom Needle Group were pricked with bee venom-smeared acupuncture needles on three longitudinal spots in the lumbar spine each 1cm apart, after which the needles were removed 10 minutes later. The Control Group did not receive any form of intervention. All procedures took place thrice a week for four weeks, during which the mice were allowed free access to water and fodder. The mice were measured and compared in the weight, skin wrinkling scale, skin elasticity, and TEWL before and after the experiment. After the experiment, blood samples were taken to measure the free radical and anti-oxidative agent level, and the skin tissue was sliced for examination. Data was analyzed using the SPSS program (ver 12.0). The ANOVA analysis was used to compare and contrast the three groups, and t-test for paired samples was used to evaluate skin-wrinkling before and after experiment. The cut-off p-value of significance was set at p<0.05. Results : 1. Administration of bee venom did not cause serious weight loss or gain. 2. Compared to the control group, the Bee Venom Syringe Group and the Bee Venom Needle Group both showed a decrease in skin wrinkling scale after intervention. Especially, the Bee Venom Syringe Group showed a significant decrease (p<0.05). 3. Compared to the control group, the Bee Venom Syringe Group and the Bee Venom Needle Group both showed an increase in skin elasticity. Especially, the Bee Venom Syringe Group showed a significant increase (p<0.05). 4. No significant change in TEWL was found in the mice in all the three groups before and after experiment. 5. Free radical level was normal in all 15 mice in all the three groups, and anti-oxidative agent was not significantly different across the three groups. 6. The Bee Venom Syringe Group, the Bee Venom Needle Group, and the control group did not show any significant difference in the thickness of epidermis and dermis, infiltration of inflammatory cells, and skin wrinkling. The epidermis layer was relatively better preserved in the Bee Venom Syringe Group as compared to the Bee Venom Needle Group and the control group. Conclusion : Direct injection of bee venom on the hairless mouse using a syringe was found to improve wrinkling of the skin and increase skin elasticity but did not show effectiveness on skin dryness due to water loss. The bee venom appears to have suppressive effects on skin wrinkling, one of the symptoms of skin aging, through a process independent of suppression of free radicals or increase of anti-oxidative agent.

• Journal of Aerospace System Engineering
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• v.1 no.1
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• pp.36-44
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• 2007

This study was performed on preliminary structural design of a small scale WIG craft which has been developed as a next generation high speed maritime transportation system in Korea. A composite structure design using the foam-sandwich for main wing and tail fins and the honeycomb sandwich and skin-stringer-ring frame for fuselage was applied for weight reduction as well as structural stability. A commercial FEM code, NASTRAN for was utilized to confirm the structural safety for the reiterate design modifications to meet design requirements including the target weight. Each main wing was jointed with the fuselage by eight high strength insert bolts for easy assembling and disassembling as well as for assuring the required 20 years service life. For control surface structural design, the channel type spar, the foam sandwich skin and the lug joint were adopted.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.240-248
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• 2016

Objectives: The purpose of this study is to report the effectiveness of Sihochunggan-tang gagambang in two patients with erythema multiforme which ocurred repeatedly in stress condition.Methods: This case study was conducted in two erythema multiforme(EM) patients who have visited Korean Medicine Clinic. All two patients were treated with Sihochunggan-tang gagambang and acupuncture. VAS(Visual Analogue Scale) score was used to check the subjective change of skin symptoms and itching sense.Results & Conclusions: The VAS score were decreased compared to the initial visit in all two patients in our study. And most skin symptoms and itching sense of two patients were improved. As a result of examining VAS scores and photographs, Sihochunggan-tang gagambang can be effective on EM in two cases in our study.

• Advanced Composite Materials
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• v.17 no.4
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• pp.343-358
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• 2008

This present study provides the structural design and analysis of main wing, horizontal tail and control surface of a small scale WIG (Wing-in-Ground Effect) craft which has been developed as a future high speed maritime transportation system of Korea. Weight saving as well as structural stability could be achieved by using the skin.spar.foam sandwich and carbon/epoxy composite material. Through sequential design modifications and numerical structural analysis using commercial FEM code PATRAN/NASTRAN, the final design structural features to meet the final design goal such as the system target weight, structural safety and stability were obtained. In addition, joint structures such as insert bolts for joining the wing with the fuselage and lugs for joining the control surface to the wing were designed by considering easy assembling as well as more than 20 years service life.

• International Journal of Aerospace System Engineering
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• v.10 no.2
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• pp.1-4
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• 2023

Even though the recent development trend of wind turbine systems has been focused on larger MW Classes, the small-scale wind turbine system has been continuously developed because it has some advantages due to easy personnel establishment and use with low cost and energy saving effect. This work is to propose a specific structural design and analysis procedure for development of a low noise 500W class small wind turbine system which will be applicable to relatively low wind speed region like Korea. The proposed structural feature has a skin-spar-foam sandwich composite structure with the E-glass/Epoxy face sheets and the Urethane foam core for lightness, structural stability, low manufacturing cost and easy manufacturing process. Moreover this type of structure has good behaviors for reduction of vibration and noise. Structural analysis including load cases, stress, deformation, buckling and vibration was performed using the Finite Element Method. In order to evaluate the designed blade structure the structural tests were done, and their test results were compared with the estimated results.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.10
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• pp.851-856
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• 2016

Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.

• Journal of the Korean Geotechnical Society
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• v.33 no.1
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• pp.5-15
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• 2017

Skin friction may be one of the most critical factors in designing the prebored and precast pile. Special attention was given to the interface behavior of cement milk-surrounding soil during the installation of prebored and precast pile. Small-scale field model pile test was conducted for the case of single pile. The size and geometry of the small-scale field model piles were designed with pile length 1.3m, boring diameter 0.067 m. Quick maintain-load test was conducted for the cases of boring diameter 150, 125, 90, 86, 74 mm and water-cement ratio 90, 70, 60%. It was shown that the bearing capacity of the pile increased as the cement-water ratio and cement milk thickness increased. Considering the scale effect between the small-scale model test and the actual construction site, it was found that cement milk thickness of 0.1~0.4D (50~200 mm) was reasonable for the stability of the structure. Also, the proper cement paste water / cement ratio was about 70% when considering the results of this study and quality control.