• Title/Summary/Keyword: Skin penetration

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Preparation and Characteristics of Multilayer Lamellar Vesicle Using Phosphate Ester Surfactant (Phosphate ester 계면활성제를 이용한 다중층 라멜라 베시클의 제조 및 특성)

  • Kim, Young-Ho;Lee, Sang-Gil;Jung, Eun-Ji;Lee, Dong-Won;Pyo, Hyeong-Bae;Lee, Dong-Kyu
    • Journal of the Korean Applied Science and Technology
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    • v.30 no.2
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    • pp.280-289
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    • 2013
  • Various vehicles have been studied in order to protect skin ageing and sustain constantly moisturization. Recently, in relation to maintain of moisture, absorption and penetration of active materials, there has been introducing many preparing methods such as liposome, liquid crystal and multilamellar emulsion. We developed multilayer lamellar vesicle using cetearyl alcohol/ceteth-20 phosphate/dicetyl phosphate as analogy of phospholipid according to variation of shear rate and pH. These multilayer lamellar vesicles were confirmed by cross polarizing microscope. As results, morphologies of lamellar vesicle were not uniformed at low shear rate and pH. Also, stabilities for encapsulation of retinol were observed at $42^{\circ}C$ during two months. As a result, quantitative content of retinol decreased at low pH. Multilayer lamellar vesicle decreased 14% of transepidermal water loss compared with O/W emulsion. We compared multilayer lamellar sun cream to O/W sun cream using in vitro SPF test of water resistance and concluded that multilayer lamellar sun cream is similar to O/W sun cream in water resistance.

흉총창에 의한 심방파열 치험 2례

  • Lee, Doo-Yun;Kwack, Sang-Ryong
    • Journal of Chest Surgery
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    • v.13 no.1
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    • pp.60-65
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    • 1980
  • We have experienced 2 cases of the hunshot wound sof the chest involving cardiac injuries at department of the thoracic surgery, Capital Armed Forces General Hospital during I year from April I 1979 to Jan. 1980. In one case of two patients , he was a 22 years old man who was transported to this emergency room 4 hour 10 minutes after having gunshot wound of the left chest by helicopter. Physical examination showed small inlet in left 3rd ICS and left parasternal border, large outlet in left 8th ICS and left scapular line, no breath sound on left side and distant heart sound. chest roentgenography demonstrated marked pleural effusion in left side and mediastinum shifted to right. As soon as chest X-ray was taken, the bleeding through penetrating wound became profuse and cardiac arrest ensued. Closed chest cardiac massage was started and vigorous transfusion continued, but no effective cardiac activity could not be obtained. The patient was pronounced dead due to exsanguinating hemorrhage from wuwpected cardiac wounds. In this critically injured patient with evidence of intrathoracic hemorrhage and suspected cardiac penetration, only emergency thoracic exploration and immediate surgical control of bleeding points might offer the maximum possibility of survival. The other case was a 23 years old man who was transferred to the emergency room 4 hours 50 minutes after having kmultiple communicated fractures of sternum and linear fracture of right mandible by a missile. Examination revealed about 30% skin loss of the anterior chest wall, weak pulse of 96 beats/min., distant heart sound and decreased breath sounds bilaterally. finding on the chest X-ray films showed multiple sternal fractures, marked pericardial effusion indicating hemopericardium. So, the patient was moved immediately to the operation room where, after endotracheal tube inserted, a median sternotomy was performced. A hemorrhagic congestion of the right upper lobe and marked bulging pericardium were disclosed. The pericardium was opened anterior to right phrenic nerve and exsanguinating hemorrhage ensued from the 0.5cm lacerated wound in the auricle of right atrium. The rupture site of right atrium was occluded with non-crushing vascular clamps and then was over sewn with interrupted sutures. It was thought to be highly possible that he was alive long enough to have cardiorrhaphy because of cardiac tamponade, which prevented exsanguinating hemorrhage. He was taken closed reduction for linear fracture of right mandible 2 weeks after repair of ruptured right auricle in dental clinic. This patient's post-operative course was not eventful.

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Study on Corydalis Tuber for iontophoresis (현호색의 이온삼투요법 활용에 관한 연구)

  • Kim, Sung-Won;Keum, Dong-ho;Lee, Myung-Jong
    • The Journal of Dong Guk Oriental Medicine
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    • v.8 no.2
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    • pp.69-81
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    • 2000
  • OBJECTIVE Iontophoresis is a kind of medical treatment of penetration of several ion into a body through skin by dirrect current. In oriental medicine for iontophoresis, it has little standard and method to extract the efficient element from herbal medicine. So we studied the quantitative analyzation of extracted Corydalis Tuber. METHODS AND MATERIALS Materials are Corydaline standard and extracted Corydalis Tuber, and the measurement methods of variation by time and pH are HPLC/UV, CG/MS. RESULTS 1. The chromatography and spectrometer of HPLC/UV on extracted Corydalis Tuber has no corydaline. 2. The CG/MS on extracted Corydalis Tuber has no corydaline. CONCLUSION According to the above results, when we extract herbal medicine for iontophoresis, we should consider special nature of the object herbal medicine to take the efficient element. And it needs more syudy on possibility of another element effect with the exception of Corydaline.

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Methodology for Quantitative Monitoring of Agricultural Worker Exposure to Pesticides (농작업자에 대한 농약 노출의 정량적 측정 방법)

  • Kim, Eun-Hye;Lee, Hye-Ri;Choi, Hoon;Moon, Joon-Kwan;Hong, Soon-Sung;Jeong, Mi-Hye;Park, Kyung-Hun;Lee, Hyo-Min;Kim, Jeong-Han
    • The Korean Journal of Pesticide Science
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    • v.15 no.4
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    • pp.507-528
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    • 2011
  • Agricultural workers who mix/loads and spray pesticide in fields expose to pesticide through dermal and inhalation routes. In such situation, exposed amount should be measured quantitatively for reasonable risk assessment. Patch, gloves, socks and mask will be good materials for monitoring for dermal exposure while personal air monitor equipped with solid adsorbent and air pump will be a tool for inhalation exposure. For extrapolation of absorbed amount in dermal exposure matrices and of trapped amount in solid sorbent to total deraml or inhalation exposure, Korean standard body surface area and respiration rate were proposed in substitution of EPA data. Important exposure factors such as clothing and skin penetration ratio of dermal and inhalation exposure were suggested based on Spraying time for exposure monitoring must be long enough that the amount of pesticide to get absorbed/trapped in exposure matrices results in reasonable analytical value. In domestic case for the both of speed sprayer and power spray machine, spraying time of 20~40 minutes (0.1~0.2 ha) will be reasonable per single replicate before extrapolating to 4 hours a day with triplicates experiment.

Embryo-Fetal Developmental Toxicity Study of Methoxycinnamidopropyl Polysilsesquioxane (Methoxycinnamidopropyl Polysilsesquioxane의 랫드를 이용한 배.태자 발생독성 연구)

  • Hong, Jeong-Sup;Lim, Jeong-Hyeon;Kim, Kang-Hyun;Park, Myeong-Kyu;Jo, Ki-Yeon;Park, Gil-Jong;Jung, Taek-Kyu;Kim, Ja-Young;Yoon, Kyung-Sup
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.37 no.3
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    • pp.247-256
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    • 2011
  • Existing organic UV protection materials seem to be problematic due to their penetration and irritation to skin. Inorganic UV protection materials are also at issue for safety of their nano-type transformation. Therefore, the recent studies of UV protection materials have been focused not only on the effectiveness but also on their safety. One of the UV protection materials in study which have higher safety is the organic-inorganic conjugation type UV protection material. Previously, we have reported the manufacturing process, physical property and UV protection efficiency of methoxychinnamidoprophy poloysilsesquixan as a new cross-linked polymer type UV protection material. In this study, we have evaluated the effect of the methoxychinnamidoprophy poloysilsesquixan on embryo-fetal development in SD rats. This study is expected to show some definite information related to the effect on pregnancy or embryo-fetal abnormality in case of the clinical exposure of the methoxychinnamidoprophy poloysilsesquixan.

Study on Encapsulation Efficiency and Preparation of SLN Using Conjugated New Whitening Agent(LA-PEG) and Its Cosmetic Application (새로운 미백물질을 함유하는 SLN의 제조와 봉입효율에 관한 연구)

  • Kang, Ki-Choon;Pyo, Hyeong-Bae;Lee, Cheong-Hee;Kim, Tae-Hoon;Ma, Sang-Chol;Im, Won-Cheol;Jeong, Noh-Hee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.34 no.1
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    • pp.15-23
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    • 2008
  • This study is on encapsulation of a new whitening agent, LA-PEG using solid lipid nanoparticle(SLN) method, one of nanoparticle preparation method. Classical method has high capsulation efficiency for hydrophobic compounds but has demerit of low capsulation efficiency($2{\sim}3%$) for hydrophilic compounds. Purpose of this study is preparation of SLN that has higher skin penetration effect compared with general liposome, and also has higher encapsulation efficiency of hydrophilic compounds. For SLN preparation, coconut oil, macadamia oil, and jojoba oil were used. As a result, SLN preparation using coconut oil(include LA-PEG) has the most high encapsulation efficiency and also has the smallest average particle size(270 nm). SLN prepared with macadamia oil and 1% of Tween 60 has the largest particle size. Base made with coconut oil and 2% of Tween 60 showed the fastest release and base made with macadamia oil and 2% of Tween 20 showed the latest release.

A Study on Consumer's Perception and Preference for Providing Information of Fashion Products by Using QR Code (QR 코드를 이용한 패션제품의 정보제공에 대한 20대 소비자의 인식과 선호조사 연구)

  • Yoon, Jiwon;Yoo, Shinjung
    • Science of Emotion and Sensibility
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    • v.22 no.2
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    • pp.59-69
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    • 2019
  • The present study explored consumer's perception and preference on providing information of fashion products by using QR code and suggested the possibility for consumer-to-consumer and consumer-to-company connection. A survey was conducted on males and females in their 20s-a population among whom the rate of smart phone penetration is higher than in any other age group and who tend to exchange information online. The results showed that consumers are dissatisfied with the amount of information, terms of instructions, and ambiguous washing symbols currently provided. Therefore, the study identified the need for better methods of providing information and found that QR code, which is able to deliver high-quality information on fashion products, can be an efficient alternative. Moreover, respondents felt the need for detailed washing instructions, information on handling, and functionality of material on high-involvement fashion products such as outdoor, padding, suit, and underwear worn next to the skin. They also desire styling tips or purchasing information such as SNS OOTD (Outfit Of The Day) utilizing the product, other products that may go well with the one purchased, and similar products on casual wear and coat used on a daily basis. Therefore, QR code used as a link to information web pages or a social network can help consumers to satisfy information needs and to use the products effectively.

Critical Review and Alternatives to the Decriminalization of Tattooing (문신시술의 비범죄화에 대한 비판적 검토와 대안)

  • Shim, YoungJoo;Lee, Sang-Han
    • The Korean Society of Law and Medicine
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    • v.23 no.1
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    • pp.149-176
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    • 2022
  • South Korean law strictly prohibits engagement in medical activities by non-medical practitioners. In the country, tattooing is classified as a medical practice, and non-medical practitioners who engage in it are penalized because they are unauthorized to carry out this procedure. In reality, however, people rarely seek tattooing services from medical personnel. Arguing that their freedom of job selection is violated, non-medical personnel who make a living as tattoo artists reject the characterization of the procedure as a form of medical treatment and demand the decriminalization of tattooing by non-medical practitioners. Nevertheless, tattooing can cause health- and hygiene-related dangers when it is not performed by medical professionals because it involves penetration into the skin using needles. Hence, stringent management is necessary for infection prevention. The gap between reality and the law gives rise to the need for proactive thinking about the institutionalization of tattoo practice by non-medical personnel. Policymakers should reflect on the fact that only minimal tattooing services are currently performed by medical staff while also accounting for health and safety. On this basis, this study examined tattoo-related legislation in South Korea to determine whether the procedure corresponds to medical practice and identify ways to solve problems that occur from the perspective of health care. As a response that promotes safety and reflects reality, this research proposed a three-phase approach.

Characteristics of Dynamic Shear Behavior of Pile-Soil Interface Considering pH Conditions of Groundwater (지하수 pH조건을 고려한 말뚝-지반 접촉면의 동적 전단거동 특성)

  • Kwak, Chang-Won
    • Journal of the Korean Geotechnical Society
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    • v.38 no.5
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    • pp.5-17
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    • 2022
  • A pile is a type of medium for constructing superstructures in weak geotechnical conditions. A pretensioned spun high-strength concrete (PHC) pile is composed of high-strength concrete with a specified strength greater than 80 MPa. Therefore, it has advantages in resistance to axial and bending moments and quality control and management since it is manufactured in a factory. However, the skin friction of a pile, which accounts for a large portion of the pile bearing capacity, is only approximated using empirical equations or standard penetration test (SPT) N-values. Particularly, there are some poor research results on the pile-soil interface under the seismic loads in Korea. Additionally, some studies do not consider geoenvironmental elements, such as groundwater pH values. This study performs sets of cyclic simple shear tests using submerged concrete specimens for 1 month to consider pH values of groundwater and clay specimens composed of kaolinite to generate a pile-soil interface. 0.2 and 0.4 MPa of normal stress conditions are considered in the case of pH values. The disturbed state concept is employed to express the dynamic behavior of the interface, and the disturbed function parameters are newly suggested. Consequently, the largest disturbance increase under basic conditions is observed, and an early approach to the failure under low normal stress conditions is presented. The disturbance function parameters are also suggested to express this disposition quantitatively.

Inorganic-organic nano-hybrid; Preparation of Nano-sized TiO$_2$ Paste Trapped OMC Nano-emulsion and it's Application for Cosmetics (OMC Nano-emulsion을 포집하고 있는 Nano-TiO$_2$-Paste의 합성과 화장품의 응용)

  • Byung Gyu, Park;Jong Heon, Kim;Jin Hee, Im;Kyoung Chul, Lee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.2
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    • pp.181-187
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    • 2004
  • Preparations of mesoporous materials using various templates and their applicability have been intensively investigated for many years. We studied on synthesizing mesoporous Ti02 with pores in which sensitive compounds having weak physico-chemical properties such as thermal or UV irradiation and low solubility in solvent are trapped. Prior to trapping OMC in the pores of mesoporous titania, OMC was nano-emulsified in O/W system using Lecithin. Thereafter the OMC was trapped in the pores of mesoporous titania using sol-gel method. Main focus of this work is to prepare OMC-trapped mesoporous titania and to trace the stability and solubility of nano-emulsified OMC in the pores of mesoporous titania, and compared with that of mesoporous silica. OMC-trapped mesoporous Inorganic-Organic hybrid titania showed higher factors in sun protecting and a skin penetration phenomenon was reduced.