• Journal of the Optical Society of Korea
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• v.17 no.2
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• pp.205-212
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• 2013

Pain is one of the quite common symptoms in clinics and many treatment methods have been applied to relieve pain. Among the treatments, high-intensity light therapy for pain has been introduced, but this therapy has not been fully supported by confirmed efficacy due to the absence of quantitative assessments and treatment feedback data in real time. In this study, the evaluation of light distribution in tissue was performed with current high-intensity light sources quantitatively using light-tissue interaction simulations. The diffuse reflectance in tissue was generated using Monte Carlo simulation that traces photons as they undergo multiple scattering and absorption within each tissue layer (skin, fat, and muscle) and within multi-layered tissue. The results showed that the highest diffuse reflectance and the deepest penetration of tissue were achieved at ${\lambda}$=830 nm when compared with other wavelengths like ${\lambda}$=650 nm, 980 nm and 1064 nm.

• Proceedings of the Korean Geotechical Society Conference
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• 1997.10a
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• pp.19-36
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• 1997

This paper discusses the reduction and subsequent recovery and increase of shear strength of clay in the vicinity of soil-cement column. Laboratory and field tests were conducted to investigate the effects on surrounding clay during and after soil-cement column installation in soft Ariake clay. Discussions were made on the mechanism of strength changes of clay by considering the thixotropic recovery, reconsolidation effect, penetration of cement slurry and diffusion of exchangeable cations. On the basis of field and laboratory observations, 10 days after column installation, the decreased shear strength of surrounding clay during mixing was recovered and 30 days later, shear strength of surrounding clay increased 30% by average. Therefore, it is recommended that the increase of shear strength of clay can be taken into consideration in the bearing capacity and stability analysis of the composite ground.

• Korean Journal of Veterinary Research
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• v.43 no.3
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• pp.457-461
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• 2003

A diagnosis of iodine-deficient goiter was confirmed in newborn piglets that were born hairless edematous, and with markedly enlarged thyroid gland. Clinically, most of the piglets were born dead, extreme weakness or dying within a few hours of birth. Gestation periods were prolonged for 3-7 days. Histopathologically, hair follicles were scarce and reduced in size, contained slender hairs, and revealed a shallow penetration into the hypodermis that showed severe diffuse edema. Thyroid glands had severely hyperplastic follicles and poorly staining colloid. The follicles were irregular in size and shape depending on varying amounts of lightly eosinophilic and granular colloid in the lumen. The iodine content of the diet fed to the sows and plasma total thyroxine and triiodothyronine concentration of sows were very low. This is a first report for iodine-deficient goiter in newborn piglets in Korea.

• The Korean Journal of Pain
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• v.14 no.2
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• pp.207-210
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• 2001

Backgroud: Caudal blocks have been used for pain management in outpatient clinics. It is important to estimate the proper depth and angle in order to increase the success rate of the procedure. Methods: Data was collected from 60 patients who visited our pain clinic. We measured the depth of the needle's penetration and the angle of the needle at the insertion point when a caudal approach was confirmed by air flow method. We recorded age, sex, body weight and height, and calculated the ponderal index. Results: The depth from the skin to the caudal epidural space was a mean 2-4 cm ($3{\pm}0.4\;cm$). The angle at the needle insertion point was a mean 15-50 degree ($34.9{\pm}6.8$ degree). Conclusions: If we use the mean depth and angle as a guide, complications during the caudal epidural procedure can be avoided.

• Journal of fish pathology
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• v.19 no.1
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• pp.83-86
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• 2006

Effect of iron on the extracellular proteolytic activity of live Uronema marium was determined by fluorescence polarization (FP) method. Supplementation of 0.5 and 5.0 μM iron significantly increased caseinolytic activity of live U. marinum. In contrast, supplementation of 50 μM iron showed no significant differences in FP values compared to the control. The present result suggests that iron in cultured water or skin tissue of olive flounder may influence on the penetration and establishment of U. marinum, correlating with modulation of extracellular protease activity of the ciliates.

• Toxicological Research
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• v.31 no.2
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• pp.105-136
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• 2015

Polyethylene glycols (PEGs) are products of condensed ethylene oxide and water that can have various derivatives and functions. Since many PEG types are hydrophilic, they are favorably used as penetration enhancers, especially in topical dermatological preparations. PEGs, together with their typically nonionic derivatives, are broadly utilized in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners. The compounds studied in this review include PEG/PPG-17/6 copolymer, PEG-20 glyceryl triisostearate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil. Overall, much of the data available in this review are on PEGylated oils (PEG-40 and PEG-60 hydrogenated castor oils), which were recommended as safe for use in cosmetics up to 100% concentration. Currently, PEG-20 glyceryl triisostearate and PEGylated oils are considered safe for cosmetic use according to the results of relevant studies. Additionally, PEG/PPG-17/6 copolymer should be further studied to ensure its safety as a cosmetic ingredient.

• Current Optics and Photonics
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• v.2 no.4
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• pp.378-382
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• 2018

In most previous investigations of plasmonic and metamaterial applications, the metallic film has been regarded as a perfect electrical conductor. Here we demonstrate the resonance characteristics of THz metamaterials fabricated from metal film that has a finite dielectric constant, using finite-difference time-domain simulations. We found strong redshift and spectral broadening of the resonance as we decrease the metal's plasma frequency in the Drude free-electron model. The frequency shift can be attributed to the effective thinning of the metal film, originating from the increase in penetration depth as the plasma frequency decreases. On the contrary, only peak broadening occurs with an increase in the scattering rate. The metal-thickness dependence confirms that the redshift and spectral broadening occur when the effective metal thickness drops below the skin-depth limit. The electromagnetic field distribution illustrates the reduced field enhancement and reduced funneling effects near the gap area in the case of low plasma frequency, which is associated with reduced charge density in the metal film.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.293.1-293.1
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• 2003

Electroosmotic flux during iontophoresis originates due to the net negative charge of the current passing channels (pores) in skin at physiological pH (pH 7.4). Thus, the channels are permselective to cations, and this causes the convective solvent flow from anode to cathodal direction. This solvent flow facilitates the flux of cations (from anode), inhibits that of anions (from cathode), and enables theenhanced transport of neutral, polar solutes. (omitted)

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.34 no.1
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• pp.44-49
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• 2021

Recently, infrared (IR) and near-infrared (NIR) light-emitting diodes (LEDs) were widely used for home medical applications owing to its low output power and wide exposed area for curing. For deep penetration of the light under the skin, multiple LEDs with wavelengths of 700~10,000 nm were located on a flexible printed circuit board. When multiple wavelengths of LEDs were soldered on a circuit board, the lifetime of LED module highly depends on LEDs with a short lifetime. The mean time to failure (MTTF) was able to calculate with the experimental results under high temperature and the Arrhenius model. The results of this study could help companies to approve the warranty of LED modules and its product.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.1
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• pp.77-85
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• 2022

Retinaldehyde (RA), vitamin A derivative, is an intermediate between retinol and retinoic acid and has an excellent wrinkle improving effect. In this study, Drug-in-cyclodextrin-in-liposome (DCL) was used to enhance the stability and skin penetration of RA. The complex of RA and hydroxypropyl-beta-cyclodextrin (HP-β-CD) was prepared by the freeze-drying method, and the presence or absence of inclusion of retinal was confirmed by UV-Vis spectrometer, FT-IR and SEM images. RA was captured in HP-β-CD about 95.6% on 1 : 15 (w/w). The retinal-HP-β-CD complex was encapsulated in liposomes using a homomixer and microfluidizer, with an average particle size of 215 ± 4.2 nm and a zeta potential of -31.2 ± 0.5 mv. In the evaluation of the degradation stability of RA, degradation rate of RA-HP-β-CD-liposomes in water was 1.8% higher than RA-liposome (5.8%), RA-HP-β-CD complex (9.7%) and RA alone (37.6%). RA cream (0.05% RA) including RA-HP-β-CD-liposomes was prepared for clinical test with wrinkle-improving efficacy and skin dermis denseness evaluated for 2 or 4 weeks. RA cream showed a significant wrinkle improving effect without skin irritation. In conclusion, it was confirmed that the double stabilization technology using the DCL system contribu tes to the effect of improving skin wrinkles by increasing the stabilization of retinal.