Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use

  • Received : 2015.06.10
  • Accepted : 2015.06.29
  • Published : 2015.06.30
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Abstract

Polyethylene glycols (PEGs) are products of condensed ethylene oxide and water that can have various derivatives and functions. Since many PEG types are hydrophilic, they are favorably used as penetration enhancers, especially in topical dermatological preparations. PEGs, together with their typically nonionic derivatives, are broadly utilized in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners. The compounds studied in this review include PEG/PPG-17/6 copolymer, PEG-20 glyceryl triisostearate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil. Overall, much of the data available in this review are on PEGylated oils (PEG-40 and PEG-60 hydrogenated castor oils), which were recommended as safe for use in cosmetics up to 100% concentration. Currently, PEG-20 glyceryl triisostearate and PEGylated oils are considered safe for cosmetic use according to the results of relevant studies. Additionally, PEG/PPG-17/6 copolymer should be further studied to ensure its safety as a cosmetic ingredient.

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References

  1. Polyethylene glycol: chemical product info at CHEMINDUSTRY.RU. Available from http://chemindustry.ru/Polyethylene_Glycol.php.
  2. CIR Expert Panel. (2010) PEGs. Cosmetic Ingredient Review.
  3. Fruijtier-Polloth, C. (2005) Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology, 214, 1-38. https://doi.org/10.1016/j.tox.2005.06.001
  4. European Parliament And Council Directive No 95/2/EC of 20 February 1995 on food additives other than colours and sweeteners. Available from Available from https://www.fsai.ie/uploadedFiles/95_2_EC.pdf.
  5. Lanigan, R.S., Yamarik, T.A. and Cosmetic Ingredient Review Expert Panel. (2001) Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax. Int. J. Toxicol., 20 Suppl 4, 27-38. https://doi.org/10.1080/10915810152902565
  6. CIR Expert Panel. (2004) Final report of the amended safety assessment of PEG-5, -10, -16, -25, -30, and -40 soy sterol. Int. J. Toxicol., 23 Suppl 2, 23-47. https://doi.org/10.1080/10915810490499046
  7. EWG (Environmental Working Group). Available from http://www.ewg.org/skindeep/ingredient/704702/PEG%3B%3B_PPG-17%3B%3B_6_COPOLYMER/.
  8. CIR Expert Panel. (2013) Safety assessment of alkyl PEGPPG ethers as used in cosmetics. Cosmetic Ingredient Review, Washington D.C., pp. 1-28.
  9. SCCNFP. (1999) Opinion concerning Corrections in entries of poloxamers, meroxapols and poloxamines, and respective nomenclature conventions adopted by the plenary session of the SCCNFP on 17 February 1999. European Commission.
  10. Singh-Joy, S.D. and McLain, V.C. (2008) Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics. Int. J. Toxicol., 27 Suppl 2, 93-128. https://doi.org/10.1080/10915810802244595
  11. Schmolka, I.R. (1994) Physical basis for poloxamer interactions. Ann. N. Y. Acad. Sci., 720, 92-97. https://doi.org/10.1111/j.1749-6632.1994.tb30437.x
  12. PEG/PPG-17/6 COPOLYMER Cosmetic Ingredient (INCI). Available from http://cosmetics.specialchem.com/inci/peg-ppg17-6-copolymer?id=9667.
  13. PEG/PPG-17/6 copolymer-Cosmetic Ingredient Dictionary: Cosmetics Cop Expert Advice. Available from http://www.paulaschoice.com/cosmetic-ingredient-dictionary/definition/pegppg-176- copolymer.
  14. NICNAS (National Industrial Chemicals Notification And Assessment Scheme). (2010) FULL PUBLIC REPORT-PEG-20 Glyceryl Triisostearate. NICNAS, pp. 1-7.
  15. CIR Expert Panel. (2000) Final Report on the Safety Assessment of PEG-20 Sorbitan Cocoate; PEG-40 Sorbitan Diisostearate; PEG-2, -5, -20 Sorbitan Isostearate; PEG-40 and -75 Sorbitan Lanolate; PEG-10, -40, -44, -75, and -80 Sorbitan Laurate; PEG-3 and -6 Sorbitan Oleate; PEG-80 Sorbitan Palmitate; PEG-40 Sorbitan Perisostearate; PEG-40 Sorbitan Peroleate; PEG-3, -6, -40, and -60 Sorbitan Stearate, PEG-20, -30, -40, and -60 Sorbitan Tetraoleate; PEG-60 Sorbitan Tetrastearate; PEG-20 and -160 Sorbitan Triisostearate; PEG-18 Sorbitan Trioleate; PEG-40 and -50 Sorbitol Hexaoleate; PEG-30 Sorbitol Tetraoleate Laurate; PEG-60 Sorbitol Tetrastearate - Addendum to the Final Report on the Safety Assessment of Polysorbates. J. Am. Coll. Toxicol., IJT 19 Suppl. 2.
  16. Johnson, W. Jr. and Cosmetic Ingredient Review Expert Panel. (2001) Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate and glyceryl stearate diacetate. Int.J. Toxicol., 20 Suppl 4, 61-94. https://doi.org/10.1080/10915810152902592
  17. Lanigan, R.S., Yamarik, T.A. and Cosmetic Ingredient Review Expert Panel. (2002) Final report on the safety assessment of sorbitan caprylate, sorbitan cocoate, sorbitan diisostearate, sorbitan dioleate, sorbitan sesquiisostearate, sorbitan sesquistearate, and sorbitan triisostearate. Int. J. Toxicol., Suppl. 1, 93-112.
  18. CIR Expert Panel. (2013) Final amended report, Amended Safety Assessment of PEGylated Oils as Used in Cosmetics. Cosmetic Ingredient Review.
  19. BASF SE - Care Chemicals Division - Personal Care Ingredients. (2010) Cremohpor RH Grades.
  20. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1981) Clinical evaluation report: Human patch test of roll-on deodorant 20851-34 containing 0.25% PEG-40 Hydrogenated Castor Oil.
  21. Hill Top Research. (1976) The study of cumulative irritant properties of a series of test materials, 12G/66171-04, containing 3.0% PEG-60 Hydrogenated Castor Oil (0547).
  22. Hisatomi, A., Kimura, M., Maeda, M., Matsumoto, M., Ohara, K. and Noguchi, H. (1993) Toxicity of polyoxyethylene hydrogenated castor oil 60 (HCO-60) in experimental animals. J. Toxicol. Sci., 18 Suppl 3, 1-9.
  23. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1982) Acute oral toxicity of 2.5% PEG-40 Hydrogenated Castor Oil (RI 0538). No. 34-054.
  24. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1984) 13 week subchronic dermal toxicity study of formula 20851-34 containing 0.25% PEG-40 Hydrogenated Castor Oil (RI 0538). CTFA, pp. 1-19.
  25. Hua, L., Weisan, P., Jiayu, L. and Hongfei, L. (2004) Preparation and evaluation of microemulsion of vinpocetine for transdermal delivery. Pharmazie, 59, 274-278.
  26. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1976) Acute oral toxicity of 3.0% PEG-60 Hydrogenated Castor Oil (RI 0538). CTFA.
  27. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1976) Allergic contact sensitization test of 12(3/66171-04 containing 3.0% PEG-60 Hydrogenated Castor Oil. CTFA, pp. 1-9.
  28. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1976) Eye irritation of 3.0% PEG-60 Hydrogenated Castor Oil RI 05471. No. 28-035.
  29. CTFA (Cosmetic, Toiletry, and Fragrance Association). (1977) Thirteen week subacute dermal toxicity study in female ChR-CD rats, night cream containing 3.0% PEG-60 Hydrogenated Castor Oil. CTFA, 1-9.
  30. Hirai, O., Miyamae, Y., Zaizen, K., Miyamoto, A., Takashima, M., Hattori, Y., Ohara, K. and Mine, Y. (1994) Mutagenicity tests of polyoxyethylene hydrogenated castor oil 60 (HCO-60). J. Toxicol. Sci., 19, 89-96. https://doi.org/10.2131/jts.19.2_89
  31. Soliman, S.M., Abdel Malak, N.S., El-Gazayerly, O.N. and Abdel Rehim, A.A. (2010) Formulation of microemulsion gel systems for transdermal delivery of celecoxib: In vitro permeation, anti-inflammatory activity and skin irritation tests. Drug Discoveries Ther., 4, 459-471.

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