• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.49-56
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• 2005

The negative skin friction on piles, which are installed in currently consolidating soft deposits, creates significant problems on the stability of pile foundations. This study investigated whether or not the pile foundation designs were appropriate in soft deposits with large amount of consolidation settlement. The final settlements of the grounds along the pile depth were estimated by the soil parameters obtained from the laboratory tests and by the field-measured settlement curves, if they were available. The displacement of the piles along the pile depth was estimated by both the load transfer method and the numerical method. Both methods gave similar locations of neutral points and magnitudes of the maximum axial forces. The movements of the ground and the piles were compared to calculate the down drag acting on piles. For the piles whose bearing capacities were less than the design loads including the down drag, slip layer coatings and/or incrementing of the penetration depth into the bearing stratum were proposed to improve the piles capacities.

• Journal of the Korea Society of Computer and Information
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• v.17 no.3
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• pp.105-111
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• 2012

Photoplethysmogram is widely used to measure heart rate and arterial blood oxygen saturation in human. This paper describes implementation a photoplethysmography monitoring system that uses 780nm and 940nm length infrared light in radial artery. That system used combinations of 8 LEDs and 2 photoelectricities. When recorded on the skin over radial artery, the radial pulse wave was inverted. The mechanism of inverted pulse wave skin, which was reduced during systolic period and increase during diastolic period of the cardiac cycle. Through this system, we discovered optimal environments and combinations of sensors in both penetration type and reflection type. These results suggest that radial arterial wall way reflect infrared ray.

• Geotechnical Engineering
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• v.8 no.3
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• pp.13-22
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• 1992

Model pile tests using calibration chamber are performed in !his paper in order to clarify the effect of the fundamental differences between the newly developed SPLT(Simple Pile Loading Test)and the conventional pile loading test on the pile bearing capacity. They are : (1) the direction of the applied load to mobilize the skin friction ; and (2) the use of reduced sifted sliding core. The conclusions obtained from the model pile tests are as follows : (1) The skin friction in tension loading is found to be somewhat smaller than that in compression loading. The average ration is 0.73 with the coefficient of variation (COV) of 0.18. (2) The ratio of the tip resistance rosin연 the reduced sized sliding core to that using the whole shoe shows wide scattering ; its average is 0.99 and the COV is 0.28. The aver - age of 0.99 means that there is no considerable difference in the tip resistance whether the reduced sized sliding core or the whole shoe is used, on condition that penetration depth ratio is larger than 4 : if the boundary effect of the chamber test is considered, the resistance of the whole shoe might be even larger.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.644-648
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• 2003

To investigate the feasibility of developing a new ondansetron transdermal system, the effects of vehicles and penetration enhancers on the in vitro permeation of ondansetron hydrochloride (OS) from a pressure-sensitive adhesive (PSA) matrices across dorsal hairless mouse skin were studied. Vehicles employed in this study consisted of various ratios of propylene glycol monocaprylate (PGMC)-diethylene glycol monoethyl ether (DGME) co-solvents and PGMC-propylene glycol (PG) co-solvents with 3% oleic acid. $Duro-Tak^\circledR$ 87-2100 and $Duro-Tak^\circledR$ 87-2196 were used as PSAs. The concentration of DGME in PGMC-DGME co-solvent system affected the release rate; as the concentration of DGME increased, the release rate decreased. The cumulative release amount of OS increased as the ratio of PSA to drug solution decreased. The permeation flux was also primarily affected by the amount of PSAs; as the amount decreased, the permeation flux increased. The overall fluxes from matrix formulations were significantly lower when compared to those obtained from solution formulations. The ratio of PG to PGMC did not affect permeation flux, while the lag time decreased significantly from $5.14\pm3.31 to 0.31\pm0.12$ h as the PG increased from 40% to 60%.

• Korean journal of dermatology
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• v.56 no.10
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• pp.624-627
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• 2018

Allergic contact dermatitis is an inflammatory condition associated with periorbital erythema, edema, and pruritus. The periorbital skin is relatively thin compared with the skin over other facial areas; therefore, it is vulnerable to allergen penetration and may show a variety of cutaneous manifestations. Recently, vision enhancement surgery is a widely performed procedure, and the prevalence of senile cataract and glaucoma is increasing. The prevalence of periocular allergic contact dermatitis is increasing secondary to the growing use of topical ophthalmic medications. Several studies in Korea have reported periocular allergic contact dermatitis secondary to the use of topical ophthalmic medications including latanoprost ($Latano^{(R)}$), fluorometholone ($Tolon^{(R)}$), polymyxin B ($Terramycin^{(R)}$), atropine sulfate ($Atropine^{(R)}$), neomycin sulfate ($Cambison^{(R)}$), and befunolol hydrochloride ($Bentos^{(R)}$), among others. However, ofloxacin ($Effexin^{(R)})$-induced allergic contact dermatitis has not been reported in the domestic and/or foreign literature. We report a case of periocular allergic contact dermatitis secondary to the use of ofloxacin ophthalmic ointment.

• IMMUNE NETWORK
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• v.4 no.4
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• pp.250-254
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• 2004

Background: It is necessary for human beings to uptake vitamin C through diet or supplements. It is also well-known that vitamin C plays an important role in the prevention of scurvy, enhancement of collagen synthesis and anti-tumor immune response. In addition, there are several recent reports regarding the effective role of vitamin C on the regulation of allergic responses, such as atopic dermatitis and asthma. However, the effective therapeutic and preventive measures using vitamin C are not established yet, since vitamin C is seriously unstable in aqueous solution. Therefore, we have investigated the best way to maintain the stability of vitamin C. Methods: After we making a mixture of polyphenol (0.001, 0.01, 0.1%) and vitamin C (1 mM), the mixtures were placed at room temperature both with/without light protection. And then the concentration of ascorbic acid was measured with HPLC. To analyze the in vivo effect of vitamin C on the regulation of skin allergic reaction, polyphenol (0.1%)-vitamin C (1 mM) mixture was applied to the skin and the production of histamine from mast cell was analyzed by Evans blue dye staining. Results: We have found that the polyphenol has preventive power of oxidation of vitamin C. In addition, the production of histamine was suppressed by the polyphenol (0.1%)-vitamin C (1 mM) mixture. Conclusion: We have reached the conclusion that our study suggests the research guideline for the therapy of atopic dermatitis through vitamin C.

• Journal of Biomedical Engineering Research
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• v.31 no.5
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• pp.401-406
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• 2010

Recently, many implantable medical devices have been developed and manufactured in many countries. In these devices, generally, energy is supplied by a transcutaneous method to avoid the skin penetration due to the power wires. As the most transcutaneous power transmission methods, the electromagnetic coupling between two coils and resonance at a specific frequency has been used widely. However, in case of a transcutaneous power transmitter with a fixed switching frequency to drive an electromagnetic coil, inefficient power transmission and thermal damage by the undesirable current variation may occur, because the electromagnetic coupling state between a primary coil and a secondary coil is very sensitive to skin thickness of each applied position and by person. In order to overcome these defects, a transcutaneous power transmitter of which operating frequency can be automatically tracked into the resonance frequency at each environment has been designed and implemented. Through the results of experiments for different coil surroundings, we have been demonstrated that the implemented transcutaneous power transmitter can track automatically into a varied resonance frequency according to arbitrary skin thickness change.

• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.111-115
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• 1999

We have studied the transdermal flux of prostaglandin $E_1$ $(PGE_1)$ from a hydrogel patch through hairless mouse skin, to test the possibility of developing a transdermal delivery system. Karaya gum patch containing $PGE_1$ was prepared by casting method. $PGE_1$ was stable in the patch for 10 weeks. The effect of current application, enhancer (propylene glycol monolaurate : PGML), adhesive and patch thickness on the flux was studied using side-by-side diffusion cell. Passive flux of $PGE_1$ was negligible. Cathodal delivery increased the flux about 20 fold. As the concentrations of PGML increased, flux increased. When 5% PGML was used as the enhancer, maximum flux by cathodal iontophoresis was $55\;{\mu}g/cm^2\;hr$. It increased about 2 folds to $100\;{\mu}g/cm^2\;hr$, when the amount of PGML used was 9%. Large increase in flux and the decrease in time to reach maximum flux were observed when the skin was pretreated with neat PGML (maximum flux obtained was about $200\;{\mu}g/cm^2\;hr$). Use of adhesive decreased the flux significantly. To the contrary of our expectation, increase in current density decreased the flux. These flux data together with the stability data indicate that, though the onset of sufficient delivery occur after 1-2 hours of application, therapeutic amount of $PGE_1$ can be delivered through skin using iontophoresis and penetration enhancer.

• Journal of the Korean Geotechnical Society
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• v.21 no.5
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• pp.65-74
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• 2005

The negative skin friction on piles, which are installed in currently consolidating soft deposits, creates significant problems on the stability of pile foundations. This study investigated whether or not the pile foundation designs were appropriate in soft deposits with large amount of consolidation settlement. The final settlements of the grounds along the pile depth were estimated by the soil parameters obtained from the laboratory tests and by the field-measured settlement curves, if they were available. The displacement of the piles along the pile depth was estimated by both the load transfer method and the numerical method. Both methods gave similar locations of neutral planes and magnitudes of the maximum axial forces on the piles. The movements of the ground and the piles were compared to calculate the down drag acting on piles. For the piles whose bearing capacities were less than the design loads including the down drag, slip layer coatings and/or incrementing of the pile penetration depth into the bearing stratum were proposed to improve the pile capacities.

• Journal of the Korean Geotechnical Society
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• v.35 no.6
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• pp.27-38
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• 2019

Bearing capacity of a pile in homogeneous soil is the sum of end bearing and skin resistance, and the skin resistance is more prominent in sandy soil. Bearing capacity of a pile in pile groups especially in sandy ground should be designed under the consideration of the influence by the adjacent piles. In this study, the end bearing capacity of a pile in pile groups was experimentally investigated. For this purpose, piles were installed in sandy ground in a circular test box, and end bearing - settlement behavior of the pile was measured while the pile was loaded. As the results, end bearing - settlement relation curves of the piles showed a distinct limit value. Limit value of the end bearing was little affected by skin friction and pile diameter, and it became a constant value as pile penetrates deeper. End bearing was not affected by the adjacent piles in a group of piles, when their clearance was larger than the pile diameter.