• Radiation Oncology Journal
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• 제31권3호
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• pp.171-174
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• 2013

Sorafenib is a multi-targeted kinase inhibitor, which is the current standard treatment for advanced hepatocellular carcinoma (HCC). Only one case of radiation recall dermatitis (RRD) associated with sorafenib has been reported so far. Our patient with recurrent HCC was treated with palliative radiotherapy (RT) for the chest wall mass. Sorafenib at 400 mg twice daily was begun on the day following RT. On the 14th day post-RT, an erythematous patch was observed on right chest wall which matched area previously irradiated. It was consistent with RRD. Ten days later, a disseminated exanthematous rash and severe pruritus occurred. Sorafenib was stopped and an oral antihistamine was prescribed to relieve symptoms. At the 1-week follow-up after the cessation of sorafenib, all symptoms were resolved. Physicians should be alert to this recall phenomenon as it can occur both in the skin and elsewhere and the occurrence of RRD may be unpredictable.

• Journal of Pharmaceutical Investigation
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• 제29권4호
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• pp.337-341
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• 1999

We have studied the stability and transdennal flux of prostaglandin $E_1\;(PGE_1)$ from various donor solutions through hairless mouse skin. Stability in HEPES buffer or in propylene glycol (PG) solution where enhancer (oleic acid (OA), propylene glycol monolaurate (PGML), transcutol (TC), ethanol (EtOH))s dissolved was investigated. $$PGE_1 was not stable in HEPES buffer. The concentration of $$PGE_1 decreased continuously for 7 days, and the degradation rate constant was $0.0028\;h^{-1}$, assuming first order reaction. The effect of current or penetration enhancer on the degradation was minimal. Percutaneous transport from HEPES buffer by passive or iontophoretic delivery without enhancer was close to nil. When OA or PGML was used together with PG, both passive and iontophoretic flux increased. PGML showed better enhancing effect than OA. Flux by cathodal delivery was about 2 times larger than that by passive delivery. Flux by anodal delivery was lower than that by passive delivery. TC and EtOH also increased the transdermal flux, but the effect was not as good as that observed when OA or PGML was used. These stability and flux data provide important information on how to formulate the patch, which will be the next step of this work, and on the polarity of current to use during iontophoresis.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.193-199
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• 2004

The decreasing effect of wrinkle on the pressure sensitive adhesive hydrogel patches containing ulmi cortex extract and sorbitol as the drug for anti-wrinkle were investigated. In this study, hydrogels were prepared by the crosslinking reaction of acrylic polymers and aluminum ions produced by L(+)-tartaric acid hydrolysis of the dihydroxy aluminum aminoacetates. The inhibition concentration of ulmi cortex extract on the collagenase exhibited at 0.01%. Furthermore, the moisturizing effect of hydrogel patches formulated with sorbitol was higher than that without it. In vivo animal test in hairless mouse showed that the ulmi cortex-loaded hydrogel patches had about 31.2% of anti-wrinkle effect compared to blank (before attaching the patches). Human test showed that only 33% of subjects showed the decreasing of wrinkle during 8 weeks. In conclusion, the model pressure sensitive adhesive hydrogel patches in this study would be pharmaceutically applicable for the wrinkle treatment on the facial skin.

• 대한두개안면성형외과학회지
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• 제22권1호
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• pp.52-55
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• 2021

Complete surgical excision within a margin of normal healthy bone is the treatment of choice for intraosseous hemangioma. A 56-year-old man visited with complaints of a firm, mildly tender, immovable, and palpable mass on the right forehead (size: 1.5×1.5 cm). Non-contrast brain computed tomography performed preoperatively revealed a 1.5 cm heterogenous osteolytic lesion with suspected internal trabeculation in the right frontal bone. Under general anesthesia, a 2 cm transverse incision was made on the forehead skin rather than bicoronal incision. Full-thickness en bloc resection of the frontal bone including the mass was performed. The frontal bone was removed with care taken not to damage the frontal sinus mucosa. The frontal sinus was sealed with a collagen patch (Tachocomb) and a cranioplasty was performed using bone cement. At 6 months postoperative, a clean wound was confirmed without any complications, and there was no local recurrence. Surgical excision of intraosseous hemangioma in the frontal sinus bone can be performed via direct incision or the bicoronal approach. In this case, the direct incision approach was used to achieve smaller scars and faster recovery than the bicoronal approach.

• Composites Research
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• 제22권3호
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• pp.55-59
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• 2009

마이크로스트림 안테나는 가볍고 부피가 작을 뿐만 아니라 집적화가 가능하고, 표면 부착력이 탁월하여 많은 통신 시스템 안테나로 응용되고 있다. 안테나의 구조는 12.5GHz의 중심주파수를 갖는 사각 패치 마이크로 스트립 안테나로 설계하였고 곡률 방향으로 패치를 확장시켜 총 4개의 패치를 배열시켰다. 양쪽의 복합재료 사이에 허니컴을 삽입한 샌드위치 구조물이 되도록 설계한 다음 충격 실험을 실시하였다. 충격실험 후 안테나 성능변화를 측정한 결과 영향을 받지 않는다는 것을 확인하였다.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.36-43
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• 2020

항산화력이 있는 비자, 초두구의 추출물에 대해 향장소재로서의 특성을 시험하고 마스크 팩 제형에 적용하여 향장특성을 연구하였다. 비자, 초두구의 열수 및 에탄올 추출물의 DPPH 항산화 시험으로 에탄올 추출물이 열수추출물에 비해 우수한 항산화 효능이 있는 것을 확인하였다. 비자와 초두구의 마스크 팩 원료로서 최적 혼합비율은 DPPH 항산화 시험결과 3:7임을 확인하였다. 세포독성 시험결과 무처리군 대비 0.5 ug/mL에서 103.30%, 1 ug/mL에서 104.25%, 5 ug/mL에서 102.56%, 10 ug/mL에서 99.17%의 세포생존율을 각각 나타내어 세포생존율이 양호하였다. 비자, 초두구 추출물을 사용한 시트마스크 팩 제형에서의 패치테스트 결과, 피부 첩포 일차자극 인체적용시험에서 피부 자극 지수 0.02로 비자극 제품으로 판정되었다. 피부 보습성 평가에서는 시료 적응 전에 비하여 시료적응 후 19.178%의 유의한 증가율을 보였다. 시트마스크 팩 제형에서 경시변화 평가는 저온(4℃), 상온(25℃), 고온(45℃)에서 12주간 점도 및 pH변화가 없는 제형안정성을 확인하였다.

• 대한화장품학회지
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• 제33권3호
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• pp.189-196
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• 2007

이온교환수지를 이용하여 말단기에 이중결합 생성이나 고리열림반응 없이 저분자 히알루론산(oligo HA)을 제조하였다. 제조된 oligo HA의 화장품소재로서의 활용 가능성 및 그 효능을 평가하기 위하여 fibroblast, keratinocyte 및 SIRC cell을 이용하여 독성을 평가하였고, Caco-2 cell과 인공피부를 이용하여 피부 투과도를 평가하였다. Oligo HA는 fibroblast와 keratinocyte cell에서 각각 300 ${\mu}g/mL$ 및 1,000 ${\mu}g/mL$까지의 농도에서 독성이 없었으며 in vitro ocular test에서도 2,000 ${\mu}g/mL$의 높은 농도에서까지 자극에 의한 세포독성이 관찰되지 않았다. Caco-2 cell을 이용한 세포 투과실험에서는 HA는 거의 투과되지 않는 것에 비해 oligo HA은 16.0 %까지 투과되었고, 인공피부를 이용한 세포투과 실험에서도 약 90 %의 상당히 높은 투과도를 보였다. 사람 피부에서 보습효과를 확인하기 위하여 oligo HA를 함유한 제형을 피부에 도포한 후 피부 수분량과 경피수분 손실량을 측정한 결과 HA와 비슷하게 우수한 보습 효과를 확인할 수 있었다. 인체 피부 누적 첩포 실험 결과, 특별한 피부 자극이 확인되지 않았다. Oligo HA는 HA의 우수한 보습력을 유지하면서 높은 피부 투과도를 갖는 보습소재로써 화장품에 유용하게 활용될 수 있음을 확인하였다.

• 대한화장품학회지
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• 제44권4호
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• pp.437-445
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• 2018

본 연구는 새로운 항산화 및 미백 기능성 화장품 성분을 개발하기 위해 기존의 항산화와 미백 기능성 성분으로 알려진 두 가지 성분을 혼합한 새로운 조성을 개발하고, 이를 이용해 항산화 및 미백효과를 알아보고자 하였다. 두 가지 성분은 항산화와 멜라닌 생성억제 기능이 알려진 sulforaphane과 멜라닌 생성 억제 효과가 알려진 PF-3758309이다. 각 성분 및 혼합 조성에 대한 세포독성을 조사하여 세포독성이 나타나지 않는 농도를 결정하였다. 단독 처리 시 sulforaphane는 $10{\mu}M$까지, PF-3758309는 100 nM까지 세포독성이 없다는 것을 확인하였다. 두 화합물 $10{\mu}M$ sulforaphane과 1 nM PF-3758309를 병합 처리 시 세포독성은 없었다. LPS 자극에 의해 생성된 일산화질소는 sulforaphane과 PF-3758309의 병합 처리시 현저히 감소되었다. ${\alpha}$-MSH에 의한 멜라닌 생성 역시 병합 처리에 의해 억제되었다. 화장품 소재로 사용 가능성을 확인하기 위해 혼합 조성시료에 대한 인체적용시험을 실시하였다. 혼합조성 시료는 피부첩포에 의한 안전성 평가는 무자극으로 판정되었고, 피부밝기 증가효과와 피부 멜라닌 침착을 억제함을 확인하였다. 이러한 결과들로 혼합 조성물이 항산화와 미백 기능이 있는 새로운 기능성 화장품 조성으로 개발될 가능성을 확인할 수 있었다.

• 약학회지
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• 제42권1호
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• pp.25-30
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• 1998

This study was designed to compare the absorption fraction and extent of ketoprofen gels and a matrix typed ketoprofen plaster patch. 3g (90mg as ketoprofen) of the two gels whi ch has oleohydrogel or hydrogel as a base, respectively, and 3 pieces of plaster patches (90mg as ketoprofen) were, applied in the area of 210$cm^2$ on forearm in 12 volunteers by cross over design. Blood samples were collected serially up to 24 hours and the plasma concentrations of ketoprofen were analyzed by HPLC using flurbiprofen as an internal standard. The detection limit of the assay was 1ng/ml of ketoprofen in plasma. The pharmacokinetic parameters (e.g. $AUC_{24hr}$, $AUMC_{24hr}$, MRT, Fraction Absorbed) were calculated from the plasma concentrations time data of each volunteer. The oleo-hydrogel showed significantly higher absorption fraction and extent of ketoprofen than the current hydrogel. The mean plasma concentrations of the oleo-hydrogel were increased to 98.46${\pm}$23.15ng/ml by 6 hour after application, and increased futher to 100.61${\pm}$18.65ng/ml at 24 hour. On the other hand, those of the hydrogel were increased 17.61${\pm}$18.65ng/ml at 5 hour to 34.68${\pm}$9.65ng/ml at 24 hour gradually. Therefore the plasma concentrations of oleo-hydrogel at each measured time were 3~7 times greater than those of the hydrogel with statistical significance. The $AUC_{24hr}$ (1797.26${\pm}$52.09ng.h/ml) of the oleo-hydrogel was 3.5 times greater (P<0.05) than that (516.17${\pm}$104.52ng.h/ml) of the hydrogel. The plaster patches showed higher bioavailability ($AUC_{24hr}$ 2877.37${\pm}$578.27ng.h/ml) than the olea-hydrogel ($AUC_{24hr}$ 1797.26${\pm}$52.09ng.h/ml) without statistical significance. But the absorption fraction of the oleo-hydrogel was rather higher than that of the plaster patches during the first 6 hours after administration. These results suggest that newly developed ketoprofen gel which is used oleo-hydrogel as a base would show excellent skin permeation on topical application for the corresponding clinical indications and could be absorbed as well as plaster patches.

• Asian-Australasian Journal of Animal Sciences
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• 제20권11호
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• pp.1761-1769
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• 2007

This experiment was conducted to determine the extent to which susceptibility to cortisol-induced follicle shutdown is influenced by fleece phentotype. Twenty Finewool (10 sheep low fibre diameter, low coefficient of fibre diameter-LL and 10 low fibre diameter, high coefficient of variation of fibre diameter-LH) and twenty Strongwool (10 low fibre diameter, low coefficient of variation of fibre diameter-HL and 10 high fibre diameter and high coefficient of variation of fibre diameter-HH) sheep of 9 months of age were individually penned in an animal house and were injected intramuscularly with an aqueous suspension of hydrocortisone acetate at a rate of 1.42 mg/kg body weight for a period of two weeks. Fibre diameter was measured from clipped tattooed patch wool samples. Follicle activity was measured by histological changes in skin biopsies taken weekly. Blood samples were collected at two-week intervals and plasma cortisol measured. Increased plasma cortisol concentration significantly (p<0.05) reduced clean wool production and mean fibre diameter dropped to its lowest level four weeks after commencement and two weeks after the cessation of cortisol injection. Elevation of plasma cortisol concentration significantly (p<0.0001) increased the percentage of inactive follicles two weeks after injection started. High fibre diameter groups (Strongwool sheep; i.e. HL+HH) had significantly (p<0.0001) higher percentage of follicle shutdown than low fibre diameter groups (Finewool sheep; i.e. LL+LH). Average percentage of shutdown follicles for Finewool (LL+LH) and Strongwool (HL+HH) Merino sheep was $9.8{\pm}0.9$ and $13.5{\pm}0.9$ respectively. Shutdown of primary follicles was more pronounced in Finewool than Strongwool sheep. There was no significant effect of coefficient of variation of fibre diameter on propensity to follicle shutdown induced by exogenous cortisol. It is concluded that elevation in plasma cortisol concentration is inhibitory to the normal activity of follicles in Strongwool sheep but that variation in fibre diameter has little or no effect.