• 산업식품공학
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• 제13권2호
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• pp.92-98
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• 2009

추출방법에 따른 기능성 성분을 분석한 결과 양파 착즙액의 경우 100$^{\circ}C$에서 열수 추출한 시료에서 총 phenol, flavonoid, quercetin의 함량이 가장 높게 검출되었으며, 에탄올 추출 시 100$^{\circ}C$에서 추출한 시료와 거의 유사한 농도의 기능성 성분이 검출되었다. 양파 추출액의 quercetin 함량은 총 flavonoid의 80-90%로 quercetin이 flavonoid의 대부분을 구성하는 것으로 확인되었다. 양파분말의 경우 착즙액과 비교하여 추출된 flavonoid와 quercetin 함량이 약간 높았지만, thiosulfinate는 약 40% 낮은 농도를 나타내어 동결건조 과정이 황화합물의 손실을 초래하는 것으로 나타났다. 양파 껍질은 육질에 비하여 60배 이상 높은 quercetin을 함유하고 있는 것으로 나타났으나, thiosulfinate는 껍질에서 검출되지 않았다. 양파 추출액의 살균조건에 따른 기능성 성분을 분석한 결과 60, 80, 105, 121$^{\circ}C$의 열처리는 살균 전과 비교하여 기능성 성분의 함량에 영향을 미치지 않았다. 양파 추출액의 저장동안 총 phenol, flavonoid, quercetin 함량은 저장기간과 온도에 상관없이 안정적으로 유지되었으나, thiosulfinate는 저장 기간이 길어질수록 감소하였고 25$^{\circ}C$에 저장한 경우 4$^{\circ}C$에서 보다 급격히 감소하는 경향을 나타냈다.

• 대한본초학회지
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• 제32권3호
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• pp.63-69
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• 2017

Objectives : Advanced glycation end product (AGEs) is combine formation of glucose and protein. AGEs and reactive oxygen species are potential therapeutic targets for the various disease such as diabetic complications, renal injury, skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from 40 Korean medicines and 5 heating-processed Korean medicines. Methods: AGEs formation inhibitory activities of Korean medicines measured using bovine serum albumin (BSA), glucose, and fructose. Then, five effective Korean medicines were selected and heated with 30% ethanol. The AGEs inhibitory activities of heated Korean medicine were measured compared with not-heated Korean medicines. The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. Furthermore, we examined total phenol and flavonoids contents. Results: Scutellariae Radix, Corni Fructus, Persimmon Fruit, Paeoniae Radix, Mori Folium respectively reduced AGEs production. Morever, heating-processed Scutellariae Radix has AGEs inhibitory activities better than not-processed Scutellariae Radix. Heating- processed Scutellariae Radix scavenged DPPH and ABTS effectively and $IC_{50}$ of DPPH and ABTS radical scavenging activity of Heat processed Scutellariae Radix were $15.47{\pm}0.26{\mu}g/m{\ell}$ and $12.07{\pm}1.23{\mu}g/m{\ell}$. It caused heat processing methods of Scutellariae Radix up regulated total phenol and flavonoids contents ($26.68{\pm}0.01$ to $46.15{\pm}0.10$, $20.30{\pm}0.38$ to $64.20{\pm}0.52$). Conclusion: It has AGEs inhibitory activities that 20 kind of medicinal plants of 40 medicinal plants. Especially, heat processed Scutellariae Radix has excellent AGEs inhibitory activities and antioxidant effect.

• 혜화의학회지
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• 제20권1호
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• pp.11-23
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• 2011

Systemic Lupus Erythematosus(SLE) is an autoimmune disease invading the skin, joint, kidney, intestinal membrane, neurosystem and other organs. SLE is an autoimmune disease characterized by immune dysregulation resulting in the production of antinuclear antibodies(ANA), generation of circulating immune complexes, and activation of the complement system. In Korean medicine, lupus can be classified as acute arthritis, reddish butterfly erythema, asthenic disease, edema and so on. The cause and procedure of the diseases are flourishing noxious heat, excessive fire due to deficiency of yin, blood stasis due to stagnation of qi, internal movement of the liver-wind, congenital deficiency, exhausted vital-qi, which are treated by clearing away heat and cooling the blood, nourshing yin and extinguishing fire, treating flatulence and activating blood circulation, nourishing the blood to expel wind, invigorating the liver and kidney, invigorating qi and replenishing the blood. To experimentally examine the influence of Insam-Buja-Tang (Ginseng & Aconiti Extract, IBT) on the outbreak and development of lupus, lupus induce MRL/MpJ-Faslpr lupus-prone mice model was used. As IBT was orally administrated to a lupus model mouse, various tests such as the weight, urine protein, renal function, Lymph cell test of the spleen, Cytokine expression, histopathological analysis of kideny were performed to see the influence on the kidney and whether it work effectively on the immune function. The main purpose of this study is to evaluate the effect of IBT on MRL/MpJ-Faslpr lupus-prone mice model. The effect of IBT on MRL/MpJ-Faslpr lupus-prone mice that can have autoimmune disease similar to SLE in human was evaluated after IBT per oral in the present study.

• 문화기술의 융합
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• 제9권6호
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• pp.273-280
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• 2023

본 연구의 목적은 세라비다 회복 물질의 기능성 침구가 수면 전·후 경추의 근육 피로, 뇌파 및 온열에 미치는 영향을 규명하는 것이다. 연구대상자는 수면 장애와 경추 통증으로 인한 불면증을 호소한 D광역시 소재 50대 이상의 여성 12명으로 하였다. 본 연구의 결과는 첫째 기능성 침구가 근긴장도를 낮추는 결과를 보였다. 둘째 피부 온도는 기능성 침구와 일반 침구 모두 통계적으로 유의하게 증가하였다. 셋째, 뇌파에서(알파, 베타. 세타, 델타) 기능성 침구에서 통계적으로 유의한 차이를 보였다. 이러한 결과를 통해 세라비다 회복 물질의 기능성 침구가 수면 회복 기술의 충분한 효과가 있다고 사료된다.

• 전기학회논문지P
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• 제67권2호
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• pp.106-111
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• 2018

Recently, due to the effect of global warming, the high temperature phenomenon continues, and the time for workers exposed to high temperature, cold and infrared is increasing and then safety is threatened. Due to the nature of on-site work, the work is being carried out in an unreasonable manner due to the process, which is exposed to disasters due to high temperature and cold. Even though the injured skin may be damaged, the worker may not be aware of it and may be injured. By understanding the working environment of the worker and calculating the risk index and expressing it on the helmet, the surrounding colleagues inform the worker of the risk and take appropriate measures so that the accident can be prevented in advance. This study was conducted to investigate the effect of exposure duration on the workers' by measuring the exposure time, the risk index is displayed in the form of a traffic light to the helm, informing neighboring workers and managers, and transmitting to the workers by voice.

• 혜화의학회지
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• 제9권2호
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• pp.197-209
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• 2001

In the Literal Study on the Effect of Acupuncture and Moxibustion Treatment on the Bungru, the results were as follows. 1. The Bungru means an abnormal bleeding of femail genetalia. and is devided to Bungjung and Bungha. 2. The etiological factors of Bungru are heat of blood, asthenic coldness. asthenia of chong and ren channels. deficiency of blood, deficiency of vital energy, stagnated blood. and asthenia of spleen & stomach. 3. In the frequency of practical use in Acupuncture treatment, the order was Ren channel, Bladder meridian. Liver meridian, Spleen meridian and Kidney meridian. 4. In the frequency of practical use in Moxibustion treatment, the order was Extra Points, Ren channel, Bladder meridian, Spleen meridian, Liver meridian and Kidney meridian. 5. The most using points of Acupuncture and Moxibustion Treatment on the Bungru were Samumgyo(Sp6), Taechung(Liv3), Hyoihae(Sp10), Umgok(B10), Kihae(CV6), Chung-guk(CV3), Kwanwon(CV4), Unbaek(Spl) and etc. 6. The charicteristics of the most used points were nourishing the spleen, regulating the middle warmer, cleaning the blood, promoting blood circulation, activating blood circulation, promoting the vital energy, regulating the obstruction of vital energy, nourishing the kidney and so on. 7. In the new Acupuncture therapy, Ear-acupuncture, Head-acupuncture, Foot-acupuncture and Skin-acupuncture were used.

• KSBB Journal
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• 제28권5호
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• pp.287-294
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• 2013

염색 및 탈색된 헤어는 일상생활 중의 자외선, 열기구 사용수세 (샴푸)에 의해 재손상되며, 이의 해결을 위해 최근 피부와 두피에 안전한 각종 천연물질의 연구가 활발하다. 이 연구는 녹차씨 오일의 광퇴색 방지와 모발 트리트먼트 효과를 확인하고자 수행되었다. 그러나 녹차의 기능은 이미 많이 알려져 있으나 녹차씨 오일을 이용한 모발 트리트먼트 및 퇴색 방지의 연구는 미비하다. 염색 및 탈색된 헤어에 녹차씨 오일을 이용한 전처리 트리트먼트 효과를 알아보기 위해 인장 강도 및 신장율을 측정하고 모발표면을 SEM으로 분석하였으며 색차계를 이용한 모발 광퇴색을 비교하였다. 실험결과 모발의 인장강도와 신장율의 측정에서 녹차씨 오일 전처리 시료는 버진헤어, 염색헤어, 탈색헤어에서 모두 증가하였고 신장율은 염색헤어와 탈색헤어에서 낮아져 염색헤어와 탈색헤어에서 트리트먼트 효과가 있었다. 모발표면을 촬영한 결과 모든 군에서 전처리된 모발 큐티클의 문리가 더 선명하고 코팅효과가 확인되었다. 모발의 광퇴색 값은 열과 수세의 반복 실험에서 전처리된 각 시료 모두 $L^*$, $a^*$, $b^*$값이 감소하였고 자외선 조사 실험에서는 염색과 탈색헤어에서 $L^*$, $a^*$, $b^*$값이 각각 감소하였다. 위의 실험결과에 의해 녹차씨 오일은 염색 및 탈색모발의 재손상 방지와 열과 자외선에 의한 색상의 퇴색방지 효과를 확인하였으며 앞으로 미용 실무현장에서 고객의 피부와 두피에 적합한 천연화장품 오일로 사용이 가능하리라 사료된다.

• 한국산학기술학회논문지
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• 제13권6호
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• pp.2648-2654
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• 2012

본 연구는 피부미용실에서 많이 적용하고 있는 다양한 도구를 이용한 등마사지의 효과를 알아보고자 하였으며 마사지 전후의 체열변화를 비교분석함으로 가장 효과적인 방법을 제시하여 등관리 프로그램을 개발하는 기초자료를 제공하고자 하였다. 수기와 초음파기, 석션기를 이용하여 각각의 도구에 5명씩의 35세에서 45세 사이의 전남 광주시에 거주하는 여성들에게 2011년 7월 3일부터 7월 10일까지 시행하였다. 마사지전과 20분간의 마사지 시행후 각각 체열변화를 체열진단기 DITI IRIS-XP로 측정하였다. 수집된 자료는 SPSS 18.0 program을 이용하여 t-test를 실시하였다. 그 결과는 수기마사지전 $30.82{\pm}0.52$에서 수기마사지후 $35.06{\pm}0.36$로 체온상승이 유의하게 나타났고(p<.001), 초음파 마사지전 $30.66{\pm}0.53$에서 초음파 마사지후 $35.14{\pm}0.39$로 체온상승이 유의하게 나타났으며(p<.001),석션마사지전 $30.93{\pm}0.47$에서 석션마사지후 $39.25{\pm}0.19$로 체온상승이 유의하게 나타났다(p<.001). 수기와 초음파기, 석션기는 마사지도구로서 체온상승에 모두 효과적이며 특히 석션기를 이용한 마사지가 체온상승에 가장 효과가 높은 것으로 나타났다. 따라서 석션기는 등관리 프로그램을 개발하여 활용하는 가장 효과적인 도구인 것으로 분석되었다.

• 한방안이비인후피부과학회지
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• 제28권1호
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• pp.11-22
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• 2015

Objective : Siegesbeckia Herba can treat various skin disease by expelling wind and removing dampness and clearing away heat and toxic material effects. This study was designed to investigate effects of Siegesbeckia Herba Extracts(SHE) on skin elasticity and whitening using B16F10 cell lines. Method : In this experiment, We observed effect of SHE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. SHE treated group showed decreased cell viability rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. 2. SHE significantly showed tyrosinase inhibitory activity in vitro, SHE increased tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, and tyrosinase inhibitory activity in vitro. 3. Tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, tyrosinase inhibitory activity in vitro were not accepted statistical significance compared with non-treated group. 4. SHE treated group showed increased SOD-like activity rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. Conclusion : These results suggest that SHE can inhibit melanin synthesis and tyrosinase inhibtory activity. So, We suggest that SHE can be maintained skin whitening.

• 동의생리병리학회지
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• 제30권2호
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• pp.109-115
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• 2016

Hataedock is a Korean medical treatment that administers herbal extracts orally to newborn infants. This method is used for alleviating harmful heat and excreting fetal wastes by meconium. The purpose of this study was to evaluate anti-inflammatory effect of Hataedock method with Douchi on 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD). The 3-week-old NC/Nga mice were divided into 3 groups: the control group (Ctrl), the AD-induced group (AE), and the Hataedock-treated group (GT). Only the GT group was treated with Hataedock at the 3rd week. After 28 days from Hataedock treatment, we induced AD-like dermatitis to the AE and GT group by DNFB. The effects of Hataedock were evaluated by immunohistochemical method. In the epithelium, PKC-positive reaction of the GT group was decreased by 57%. In the dermal papillae, IL-4-positive reaction was decreased by 34%. In the dermis, the distribution of degranulated mast cells was decreased and substance P-positive reaction was decreased by 49%. In the skin tissue, edema was decreased and MMP-9-positive reaction was decreased by 71%. Tissue damage such as epithelial cell hyperplasia, infiltration of granulocyte and lymphocyte, and capillary distribution were also decreased. The Hataedock method with Douchi maintained skin barrier and inhibited skin-damaging factors via regulating Th2 differentiation. In conclusion, Hataedock has a potential for preventative treatment of AD. Further studies are necessary to investigate the immune-regulating mechanism and verify the safety and efficacy of the Hataedock method.