• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.7
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• pp.535-540
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• 2019

The coupling between different models for MDO (Multi-disciplinary Optimization) greatly increases the complexity of the computational framework, while at the same time increasing CPU time and memory usage. To overcome these difficulties, POD (Proper Orthogonal Decomposition) and RBF (Radial Basis Function) are used to solve the optimization problem of determining the thickness of composites and sandwich cores when composite sandwich structures are used as aircraft wing skin materials. POD and RBF are used to construct surrogate models for the wing shape and the load data. Optimization is performed using the objective function and constraint function values which are obtained from the surrogate models.

• Journal of Ginseng Research
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• v.45 no.4
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• pp.498-509
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• 2021

Background: A wide range of environmental factors, such as diseases, nutritional deficiencies, ageing, hormonal imbalances, stress, and ultraviolet (UV) radiation, may affect the structure and function of the skin that covers the entire surface of the human body. In this study, we investigated roles of red ginseng oil (RGO) in enhancing skin functions, including hair growth and skin protection, using mouse models. Methods: For hair growth experiment, shaved dorsal skins of C57BL/6 mice were topically applied with vehicle, RGO, RGO's major compounds, or minoxidil for consecutive 21 days and skin tissues were examined the hair growth promoting capacity. For skin protection experiment, SKH-1 hairless mice were topically applied with vehicle or RGO twice a day for three days prior to exposure to UVC radiation at 20 kJ/cm². Skin tissues were collected to evaluate skin protective effects of RGO. Results: Topical application of RGO to C57BL/6 mice effectively promoted hair regeneration by inducing early telogen-to-anagen transition and significantly increasing the density and bulb diameter of hair follicles. Major compounds, including linoleic acids and β-sitosterol, contributed to RGO-promoted hair growth. Treatment with RGO as well as its major components upregulated expression of hair growth-related proteins. Furthermore, in SKH-1 hairless mice, RGO had a protective effect against UVC-induced skin damage by inhibiting inflammation and apoptosis, as well as inducing cytoprotective systems. Conclusion: These data suggest that RGO may be a potent agent for improving skin health and thereby preventing and/or treating hair loss and protecting skin against UV radiation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.189-194
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• 2017

Skin has a strong barrier function to protect the body from external harmful factors. This strong barrier function of the skin makes for any effective substance difficult to permeate through the skin. The purpose of this study was to evaluate skin permeability of the reduced particle size by non-invasive method. The particles were prepared by high-pressure emulsification. The niacinamide prepared in a high-pressure emulsification was absorbed 1.56 times higher than the control sample. In addition, it was found from the sixth layer of keratin that was removed by tape-stripping method. This was significantly deeper penetration. The whitening efficacy of the sample containing niacinamide was evaluated before and after 6 weeks of use. The skin color was significantly improved in both pigmented area and non-pigmented area. Through this study, it was possible to visually and quantitatively confirm the permeability confirm the permeability of the reduced particle sample into skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.73-80
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• 2020

Psychological stress can affect the physiological condition of the skin and cause various cutaneous disorders. The stress hormone cortisol is secreted by various skin cells such as fibroblasts, keratinocytes, and melanocytes. Tight junctions (TJs) are cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. TJs can also affect other skin barriers and are affected by chemical, microbial, or immunological barriers. Stress can cause damage to the skin barrier. Interestingly, to our knowledge, there has not been any research demonstrating the involvement of TJs in this process. In this study, cortisol was used to treat keratinocytes to determine its role in regulating TJs. We found that cortisol damaged skin barrier function by regulating the gene expression and structure of TJ components. Cortisol also inhibited the development of the granular layer in a skin equivalent model. These results suggest that cortisol affects the skin barrier function by the regulation of TJs.

• Korean Institute of Interior Design Journal
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• v.23 no.6
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• pp.22-32
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• 2014

Development of digital technology, which is individualizing and differentiating the world, makes time and space facilitate multi-layering in the contemporary society. It gives a large influence on the contemporary architecture that inducing the visual and spatial experience. Also, It generates new images through the skin of architecture, which implies the contingent and fluid characteristics. These phenomenon show that various parameters are working on the architectural skin simultaneously. Such complexity make the structure of open space and diversity that are homogenized and synchronized. Like this, the architectural skin implies 'multiplicity': qualitative difference which is enable to change and create new images. This characteristic generates instant images changing variously and semantics constantly by the function of skin as a filter. Also, the architectural skin integrates or relocates of relationships between the various information and elements appearing in contemporary society in order to escape the customary relationship between internal and external. Furthermore, the inside and outside of the mixture as a collection of sense has been recognized as one image. This image of mixture consists of one unified continuous integration and extend the meaning of a fluid interface not just surface of the building. The skin of the contemporary architecture is very technical, so its meaning and role is expanded as a complex that exchange interaction. This means that the skin itself has functional elements of the integrated multiple skin to assist. Also it can form a multi-layered relationship and act as a wide range of interfaces depending on the perception of the observer. Therefore the multiplicity of the architectural skin indicates the importance as a boundary that generate images of new life through the sensory perception and implicit force. And it shows potential as the intermediary to try to communicate.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.226-230
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• 2008

Monoolein-based cubic liquid crystalline systems were formulated for the local delivery of oregonin and hirsutanonol for the treatment of atopic dermatitis. The liquid crystalline phase and its nanodispersion containing drugs were prepared. The skin permeation and deposition properties of the drugs were examined in normal and delipidized rat skin. The proportion of oregonin (%) deposited in normal skin after topical administration of the drugs in the form of aqueous solution, cubic phase or cubic nanodispersions were $1.53\;{\pm}\;0.46$, $3.62\;{\pm}\;0.17$ and $5.13\;{\pm}\;0.73$, and those of hirsutanonol were $2.46\;{\pm}\;0.02$, $5.44\;{\pm}\;0.27$ and $17.28\;{\pm}\;2.19$, respectively. The greater lipophilicity and thus greater skin affinity of hirsutanonol than oregonin contributed the greater amount of skin deposition. The monoolein-based liquid crystalline phases significantly increased the amount of both drugs permeated and deposited. Approximately 3.2, 2.1 and 3.0 times greater amount of oregonin, and 3.4, 2.1 and 2.2 times greater amount of hirsutanonol were deposited in delipidized skin after administration of each drug in the form of aqueous solution, cubic phase and cubic nanodispersions system, respectively, because of lowered barrier function of the delipidized skin. In this study, the effects of drug property, vehicles type and skin condition on skin deposition and permeation properties of drug were examined and concluded that monoolein-based liquid crystalline systems would be a promising formulation for the local delivery of drugs.

• Journal of Veterinary Clinics
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• v.18 no.3
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• pp.206-210
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• 2001

Various commercial shampoos were frequently prescribed for dermatologic therapy in small animal practice. Skim hydration affected by the shampoos, however, was not evaluated routinely. In order to evaluate the skin hydration for the exact prescription of shampoos method to measure skin hydration of shampoos are needed. This study was undertaken to evaluate the skin hydration effect of shampoo on canine skin using Corneometer. Five healthy dogs were applied with 7 commercial shampoos: Humilac, Sebocalm, Sebolytics, Etiderm, Benzoyl peroxide, HyLyt and Zn-7 Derm. Skin hydrations were evaluated by measurement of electrical capacitance by Corneometer. A statistically significant increase in skim hydration was found 17(p<0.05) and 77 minutes(p<0.01) after application of Humilac indicating a humidifying effect of this product. A statistically significant decrease in skin hydration was found for the Benzoyl peroxide after 77 minutes(p<0.05). No statistically significant differences between the other shampoos were found. None of the products tested had any negative effect on the skin barrier function. The Corneometer was found useful for detecting skin hydration to shampoos and considered as a simple and useful tool for prescription of various shampoos routine practice.

• The Journal of Korean Medicine
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• v.29 no.1
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• pp.117-133
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• 2008

Objectives : Since ancient times, Koreans have applied medicinal spabaths for treatment of various diseases. The objective of this study was to investigate the effect of strontium, one of the common ingredients of such baths, experimentally on acute skin barrier damage. Materials and Methods : Male hairless mice, average weight 20g, were divided into six groups. Each group consisted of five mice. The first was the normal, non-treated group. The second was the control group with acute skin barrier damage intentionally induced by TS. The third was the Ba-Sr1 group bathed in 1mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fourth was the Ba-Sr7 group bathed in 7mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fifth was the Sr1 group bathed in 1mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. The sixth was the Sr7 group bathed in 7mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. External changes of skin, skin erythema level, transepidermal water loss level, and GOT and GPT level of each group were checked immediately before and after TS, 3 hrs, 5 hrs and 24 hrs after inducing acute skin barrier damage. Then, tissue samples were made and examined for damage to epithelial cells, stratum corneum, change of mucous polysaccharide in dermis and amount of mast cells. Statistical analysis was performed by one way-ANOVA, Scheffe and Duncan for a post hoc test and pairwise comparison for comparing for difference between each time. Statistical significance was achieved if the probability was less than 5% (p<0.05) Results : 1. From skin erythema and TEWL level indicating the function of the skin barrier, we can know that it is helpful to the skin barrier to bathe in a water solution including a low concentration of strontium. 2. In the control group with acute skin barrier damage induced by TS, skin barrier damage persisted until 3-5 hrs and recovered after 5-24 hrs. Differently from the control group, in the case of taking a bath in a water solution including strontium, skin barrier damage recovered after only 3-5 hrs. Therefore, the bath with a water solution including strontium can promote recovery of the skin barrier. 3. Bathing in water solution including a higher concentration of strontium was more beneficial to recovery of skin barrier damage. 4. There was no influence on serum GOT and GPT from bathing in a water solution including strontium. Conclusions : The strontium was effective for recovery and mitigation of acute skin barrier damage induced by tape stripping. I suggest that strontium (Sr) can be used as an external treatment medicine, addedinto bath water to treat acute skin barrier damage.

• Archives of Craniofacial Surgery
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• v.21 no.1
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• pp.49-52
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• 2020

The specialized structure of the upper eyelid ensures complete closure of the eye and eyeball sealing. An upper eyelid injury can cause various symptoms associated with eyeball trauma, not just scar formation or eyelid deformity. In this report, we describe a case of lagophthalmos observed after wound repair in a patient with a crushing injury caused by a grinder. Several surgical techniques are used to treat lagophthalmos or scar contracture. In most cases, a releasing procedure is performed after 6 months of initial repair. However, if the patient has severe symptoms that are not relieved by conservative care, early revision is inevitable. We describe a case of early lagophthalmos successfully resolved with pentagonal wedge resection, fat redistribution, and full-thickness skin grafting. After the revisional surgery, we observed that the patient regained the ability to completely close the injured eyelid, with restoration of function and favorable cosmetic outcomes. Pentagonal wedge resection to release a retracted structure, fat redistribution to prevent readhesion, and full-thickness skin grafting for enough amount of skin to regain upper eyelid function is useful for scar release and lagophthalmos following crushing injuries of the upper eyelid.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.2
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• pp.346-349
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• 2008

To investigate whether aqueous extract from Aconitum koreanum (AEAK) effects in the process of melanin synthesis, the expression of tyrosinase-related proteins (TRPs) by immunohistochemical methods were performed in ultraviolet B (UVB) irradiated skin of guinea pig. The irradiation of UVB (60 mJ/day) was performed for 3 days and treated with AEAK for 15 days. About the color evaluation, the visual scores of UV B irradiated guinea pig with AEAK treatment were slightly lower than those in the UV B alone irradiated ones. At day 15 after UVB exposure, immunohistochemical analysis for TRPs expression were performed. The intensive expression of tyrosinase was mainly observed over epidermis with skin appendage and in the cells of dermis. Slight increase of these reaction was induced in response to UVB in the spinous and granular layer of epidermis, but similar expression in the AEAK treated guinea pig as normal one. The TRP-1 and TRP-2 expression were not detected in the skin of normal guinea pig. But intensive expression for TRP-1 and TRP-2, especially TRP-2, induced by UV B irradiation in the cells of dermis. These expressions were decreased in the AEAK treated guniea pig. Collectively, these results suggest that AEAK has a potential to inhibit synthesis through regulation of TRPs expression in the skin of guinea pig, but better understanding the function of AEAK, more research should be done in the effects of AEAK on the function of TRPs in melanogesis.