• 한국자원식물학회지
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• 제17권2호
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• pp.116-121
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• 2004

고려 인삼중 폐포와 4등급 이하를 유발시키는 90％이상이 적변삼이라고 불리는 인삼의 표피 색택이 붉은 삼이 그 원인이다. 이러한 적변삼은 미국삼보다는 고려 인삼에 서 다량 발견되는 바, 적변은 유전적 요인이 있다고 사료된다. 그러므로 이 연구의 목적은 RT-PCR을 이용하여 인삼적병에 내성을 가지는 유전자를 탐색하기 위하여 실시되었다. 고려인삼 3년근 1개체 중에서 적변이 발생된 부위와 건전 부위의 RNA를 추출하여 형성된 cDNA를 여러개의 random primer를 사용하여 PCR 증폭을 한 결과 정상 부위의 cDNA에서 발견되지 않는 band가 적변삼의 부위에서 발견되었다. 따라서 band가 형성된 부위의 유전자가 적변과 관련될 가능성이 있는 것으로 사료되고 이러한 유전자는 향후 염기서열을 분석하여 어떠한 유전자인지 판명을 하여야 하며 적변관련 유전자이면 선발마커로서 사용되고 또한 형질전환을 통한 적변내성 인삼계통을 육성할 수 있으며, 만약 적변과 관련이 없는 유전자로 판명된다면 더 많은 primer를 사용하여 적변관련 유전자를 탐색해야 할 것이다.

• 한방안이비인후피부과학회지
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• 제25권1호
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• pp.55-74
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• 2012

Objective : The purpose of this study is to investigate the skin disease in Sanghanron"傷寒論" and Geumgweyoryak"金匱要略". Methods : We conducted a study on the original text paragraphs of Sanghanron and Geumgweyoryak containing the skin disease and analysis of Woo, Oh, Sung, Zhang, etc. We drew a parallel between skin disease from Sanghanron and Geumgweyoryak and matching diagnoses from western medicine. Results : The results were as follows. 1. In Sanghanron and Geumgweyoryak pruritus was related to psychogenic pruritus and similar to skin disease caused by decrease of sweating, dry skin in cholinergic urticaria, atopic dermatitis and eczema, etc. in western medicine. 2. In Geumgweyoryak ichthyosis was caused by woman's disease, after menopause, chronic disease and malnutrition and related to winter itch and xerotic eczema in western medicine. 3. In Sanghanron Goose bumps, keratosis follicularis, acute and chronic urticaria and cold urticaria were occurred because of poorly managed fever care and side effect of antibiotic. 4. In Geumgweyoryak red face was similar to face flushing and side effects, which is after drug and laser treatment on face, in western medicine. 5. In Geumgweyoryak urticaria was, in a broad sense, skin disease with pruritus and secondary infection resulted from scratch. Skin diseases with pruritus are similar to urticaria, dermatitis herpetiformis, lichen planus, atopic dermatitis, contact dermatitis, psoriasis, nummular eczema, lichen simplex chronicus, prurigo nodularis, neurodermatitis and internal disease with pruritus in western medicine. 6. In Geumgweyoryak spots in the skin were caused by fever and similar to allergic purpura and SLE symptom in western medicine. 7. In Geumgweyoryak bullous disease with yellowish discharge was similar to eczema, pustule, atopic eczema, etc. in western medicine. 8. In Geumgweyoryak repeated inflammation of oral cavity, genitals, eyes and skin was similar to Behcet's disease in western medicine. 9. In Sanghanron and Geumgweyoryak boil was similar to abscess and acute lymphadenitis in western medicine caused by oily foods and infections. 10. In Geumgweyoryak swelling and boil were occurred in a poor health. Damage from metalic material could cause a convulsion and was similar to tetanus in western medicine. Conclusion : We analyzed the original text paragraphs of Sanghanron and Geumgweyoryak and explanations about skin disease. As a results, we found out etiology, pathogenesis, treatments of the skin disease in Sanghanron and Geumgweyoryak. Further we compared with western medicine to develop better understanding of the skin disease.

• Korean Journal of Acupuncture
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• 제19권1호
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• pp.145-151
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• 2002

Medical concept of the skin disease is a symptom like itchs. It outbreakes by immunologic and nonimmunologic mechanisms. The most common case is hypersensitive reaction intermediated by IgE. Other case of immunologic mechanism includes activation of the complement system. Autoimmune antibodies for histamine-secreting mast cell IgE receptors are found in some patients suffer from chronic skin paroxysm. Most common causes of acute skin paroxysm are foods, viruses, parasite infections and drugs. Causes of chronic skin paroxysm are undiscovered. Air pollution, simplification of eating habits, habitual eating of convenience food; drug abuse in present days made skin disease more common. Now many methods of acupunctural treatments are being used clinically. So this report presents some views about acupunctural treatments for the Skin disease.

• IMMUNE NETWORK
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• 제11권5호
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• 한방안이비인후피부과학회지
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• 제19권3호통권31호
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• pp.180-188
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• 2006

Objectives : The purpose of this study is to investigate the differences of skin disease, particularly Acne between the rotating shift work nurses and the nurses on a fixed day schedule. Methods : Questionnaries were distributed to 30 rotating shift work nurses(the rotating group) and 34 nurses on a fixed day schedule(the daytime group). The questionnaris included questions on general health concepts, insomnia skin disease(particularly Acne), gastroenteric trouble, menstrual irregularity. Result : 1. There was significant difference on skin disease(particularly Acne) between two groups. 2. There was no significant relation between Gastroenteric trouble and Acne. But, in particular, there was significant relation between Constipation, Gastritis and Acne. 3. There was no significant relation between menstrual irregularity and Acne. 4. In Acne group, more than 70% felt the necessity of treatment, but only 2.5% used Korean Oriental Medical therapy. Conclusion : Disorder of circadian rhythm affects the skin disease(particularly Acne) more than Gastroenteric trouble and menstrual irregularity. But in this study, the total number of the nurse is not enough. So we need more accurate study about the aspects of skin disease. And about the Acne, publicity of Korean Oriental Medical therapy is required.

• Journal of Preventive Medicine and Public Health
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• 제32권2호
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• pp.130-140
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• 1999

Objectives: This study was carried out to estimate the magnitude of skin disease related to occupation and to find out the characteristics of it. Methods: We collected and analyzed the cases of occupational skin disease reported by surveillance system composed of doctors and nurses in 150 enterprises with dispensary or attacked hospital and physicians in 92 specific health examination institutes and 150 dermatologists from May to November, 1998. Results: Among members of surveillance system, 66 enterprises and 47 specific health examination institutes and 55 dermatologists reported 571 cases of occupational skin disease in 512 workers. Excepting 81 cases reported by dermatologists, We analyzed 490 cases reported by enterprises and specific health examination institutes. Among 490 cases, contact dermatitis was most common(368 cases, 75.1%) and the second was hyper or hypopigmentation(36 cases, 7.3%). When we analyzed the characteristics of workers with occupational contact dermatitis, male workers were 281 (79.2%) and female were 74(20.8%). 165 workers(64.5%) had chronic skin disease with repeated cure and relapse. 245 workers(72.5%) answered positively that their coworkers had similar skin disease. 27 workers(8.7%) experienced absence due to contact dermatitis related to occupation. To analyze the type of industries of workers with occupational contact dermatitis, automobile and trailer manufacturing industry was most common(105 cases, 29.6%) and the second was manufacturing industry for image, sound and communication equipment(55 cases, 15.5%). Organic solvent(183 cases, 46.7%) was the most common treating material of workers with contact dermatitis and the second was various kinds of chemicals(59cases, 15.1%). Conclusions: This is the first study using nationwide surveillance system to collect data of occupational skin disease. We found that many workers had skin disease related to occupation and characteristics of occupational skin disease were chronic and clustering. Therefore, we had to establish counterplan to manage occupational skin disease and to operate surveillance system to identify trends of occupational skin disease, continuously.

• 대한한의학회지
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• 제26권3호
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• pp.43-54
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• 2005

Backgrounds : Many people think that ski disease has littel influence on the quality of life in patient, but various studios show that skin disease may produce a range of impacts on QOL. Nevertheless, there is much to be learned about the association between the duality of life and skin disease in the area of Oriental dermatology. Objectives : This study was conducted fe investigate the impact of the various skin diseases on QOL and explore prognostic factors that influence outcomes. Methods : 103 patients were recruited who filled out more than $90\%$ of the skindex-29 questionnaire. The function of sum scores and three domain scores with each skin disease were investigated, as well as the correlation of each domain scores. Results : The disease with the lowest qualify of life was atopic dermatitis. followed by eczematous dermatitis, seborrheic dermatitis and acne vulgaris in order. The sum scales showed significant correlation with three domain scores in atopic dermatitis, urticaria, allergodermia, acne vulgaris, psoriasis and seborrheic dermatitis, The correlation of all three domain scores was significant in atopic dermatitis, urticaria, allergodermia, and psoriasis. Conclusions : Tn this study, skin disease affects the quality of life in physical, social, and psychological factors- Thus, we must consider the quality of life as well as clinical severity inpatients with skin disease.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.172-201
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• 2010

Objective : The purpose of this study is to investigate kings' skin diseases of The Annals of the Choson Dynasty. Methods : We conducted a study on the text paragraphs of The Annals of the Choson Dynasty containing kings' skin diseases. Results : The results were as follows. 1. The successive kings in the Choson Dynasty are total 27, and 19 kings of them are suffered from skin disease. 2. The most frequent skin disease that the kings of the Choson Dynasty suffered from is Abscess. 3. According to the Annals of the Choson Dynasty, King Moonjong, King Hyeonjong, King Sukjong mainly suffered from skin disease. 4. According to the Annals of the Choson Dynasty, King Moonjong, King Sungjong, King Hyojong, King Chungjo, King Soonjo died of skin disease. Conclusion : We expect this study could be helpful for understanding past state of oriental medicine, re-evaluating present state, and singposting future state.

• Journal of Preventive Medicine and Public Health
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• 제32권2호
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• pp.206-214
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• 1999

Objectives: This study was carried out to identify relation of health care utilization due to skin disease(ICD-10, L00-L99) and characteristics(sex, age, exposure status, type of industry, size of enterprise) of workers. Methods: We made new database composed of 30,536 workers' health examination results in one specific health examination institute in Inchon and data of medical insurance utilization due to skin disease in 4 medical insurance associations for enterprise from January, 1995 to December, 1997 And we analyzed determinants of health care utilization due to skin disease of workers. Results: Among 30,536 study subjects, 8,837(28.9%) workers and 4,181 (13.7%) workers utilized medical insurance due to total skin disease(ICD-10, L00-L99) and contact dermatitis(ICD-10, L23-L25), respectively. Female workers(p<.001), workers exposed to organic solvents(p<.05), workers if manufacturing industries(p<.05, p<.01, respectively) and in large scale enterprises(p<.001) utilized more medical insurance due to total skin disease and contact dermatitis than male workers, workers not exposed to organic solvents, workers in non-manufacturing industries and small scale enterprises. With multiple logistic regression analysis, significant explanatory variables affecting workers' medical utilization due to total skin disease and dermatitis and eczema(ICD-10, L20-L30) in total workers were sex, age, specific chemicals and size of enterprises. And age, type of industries, organic solvents, specific chemicals and size of enterprises were significant explanatory variables related to medical insurance utilization due to dermatitis and eczema and contact dermatitis in male workers. Conclusion: From the above results, we found that workers exposed to organic solvents utilized more medical insurance due to skin disease than workers not exposed to. And, comparing to workers in large scale enterprises, workers in small scale enterprises may have unmet medical care utilization due to skin disease. Therefore we have to establish counterplan to manage occupational skin disease of high risk group(organic solvent exposure group) and to satisfy unmet medical care utilization of workers in small scale enterprises.

• The Journal of Korean Physical Therapy
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• 제4권1호
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• pp.7-11
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• 1992

This study was to consider the effect of PUVA treatment on patients with skin disease. The result can be summarized as follows : 1) PUVA treatment may effect directly on lymphocytes to be permeable locally in Skin disease. 2) PUVA treatment may effect on abnormal immune reacton in skin disease. The significance on the effect of PUVA treatment is still unknown. So, we will study continuously for PUVA treatment on patients with skin disease.