• 대한화장품학회지
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• 제48권1호
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• pp.25-32
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• 2022

본 연구에서는 20 대 ~ 40 대 한국 여성을 대상으로 피부 수분량, 피부 멜라닌, 피부 붉은기, 피부 비틀림 탄력을 측정하여 기초 피부 특성 데이터를 수집하고, 이를 나이와 상관성 분석을 진행하여 피부 지수를 만들고 이에 기반 하여 4 개의 군집으로 분류하여 그 특성을 확인하였다. 그 후 시제품 2 종을 2 주간 사용하여 피부 수분량, 피부 붉은기, 피부 각질량 감소에 대한 개선 효과를 확인한 후, 해당 시험자 중 피부 특성시험에 참여했던 피험자들을 대상으로 어느 군집에서 어떤 제품이 더 효과적이었는지 분석하였다. 이를 통해 피부 지수와 군집분석결과를 제품 효능평가에 반영하여 맞춤형 화장품 시장에 대비할 수 있는 가능성을 확인하였다.

• 동의생리병리학회지
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• 제25권2호
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• pp.212-216
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• 2011

In traditional medicines, Dansam-samul-tang and Samwhang-sasim-tang extracts were known to effects of antioxidant and antimicrobial activity. To investigate the safety evaluation of skin, these extracts were measured to skin safety testing such as primary skin irritation test, eye irritation test and skin sensitization test. The results of the primary skin irritation test and eye irritation test in vitro showed that these extracts included in the nonirritating area. Skin sensitization test results by Guinea Pig Maximization (GPMA) indicated that there was no allergy reaction. Therefore, Dansam-samul-tang and Samwhang-sasim-tang extracts were very safe in every safety test of skin. These results suggests that Dansam-samul-tang and Samwhang- sasim-tang extracts in 1 % concentration can be useful cosmetic ingredients.

• 대한의사협회지
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• 제61권11호
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• pp.649-654
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• 2018

Although the dermoscopy had very long history since its introduction in 17th century, only recently it has been possible to see the widespread application of dermoscopy in the dermatology clinic. One of the most promising areas where the dermoscopy can be applied is the diagnosis of skin cancer, especially malignant melanoma. Due to its inherent limitation to obtain in-depth information-literally, from more than skin-deep and more importantly, from microscopic structures-of skin cancers, dermoscopy cannot replace the present gold-standard 'biopsy' in the diagnosis of skin cancer. However, several advantages of dermoscopy over biopsy merit further considerations. For example, as a non-invasive tool, dermoscopy is best suited for the follow-up of suspicious skin lesions, and as an all-at-a-glance tool, dermoscopy can aid the selection of the best biopsy-site to obtain the most meaningful pathological information from the minimal tissue specimen. There goes a saying that 'it takes two to tango,' similarly, we might need the two (biopsy and dermoscopy) to cope rhythmically with the varying tempos of everprogressing skin tumorigenesis and to reveal the true face of skin cancers usually hidden in various disguises.

• 대한본초학회지
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• 제37권2호
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• pp.23-31
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• 2022

Objectives : The purpose of this research was to find out the efficacy of Castanea crenata Inner Shell (CCIS) on the skin by comparing the difference effect between only MTS (microneedle therapy system) and the CCIS essence application after MTS treatment. Methods : The present author performed once a week and total 3 times of MTS treatment. The treatment time took about 5 ~ 10 minutes and the depth of the needle was adjusted according to the participant's skin condition. In the control group, essence base was applied after MTS and in the experimental group, CCIS powder dissolved essence was applied. One week after each treatment, the change of skin condition was measured. Two weeks after the end of the clinical trial, the skin condition was checked again. Results : In the case of the test group and the control group, there was a significant decrease in thermography temperature and there was a significant increase in skin tone. In the case of pores and pigmentation, there was no significant difference on both group. In the case of moisture, there was a significant increase only in the test group. Conclusion : The MTS treatment itself showed good effects on thermography temperature and skin tone. But in the case of the moisture effect, it was much better when the CCIS essence was applied to the skin after MTS treatment. This study suggests that CCIS essence increases the efficacy of MTS on the point of moisture.

• 한국식품영양과학회지
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• 제24권5호
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• pp.690-694
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• 1995

광범위한 천연항균제로 그 활용이 고려되고 있는 grapefruit 종자추출의 안전성을 검토하기 위하여 급성 경구독성, 피부자극 및 급성 안점막 자극시험을 수행하였다. 실험 흰쥐에 대한 급성 $LD_{50}$값은 3.75g/kg이었으며, 피부에 대한 독성은 약한 편으로 부종 등의병변이 거의 생기지 않았으나 눈에 대한 자극성이 있는 것으로 나타났다.

• 대한두개안면성형외과학회지
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• 제20권2호
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• pp.94-100
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• 2019

Background: Skin defects of head and neck need reconstruction using various local flaps. In some cases, surgeons should consider skin graft for large skin defect. It is important to heal skin graft and donor sites. The authors investigated wound healing mechanisms at the donor sites with split-thick-ness skin graft (STSG). In this study, the authors compared two types of immediate regraft including sheets and islands for the donor site after facial skin graft using remnant skin. Methods: The author reviewed 10 patients who underwent STSG, from March 2015 to May 2017, for skin defects in the craniofacial area. The donor site was immediately covered with the two types using remnant skin after harvesting skin onto the recipient site. Depending on the size of the remnant skin, we conducted regraft with the single sheet (n= 5) and island types (n= 5). Results: On postoperative day 1 and 3 months, the scar formation was evaluated using the Patient and Observer Scar Assessment Scale (POSAS) and Vancouver Scar Scale (VSS). Total POSAS and VSS scores for the island type were lower than in single sheet group after 3 months postoperatively. There was significant difference in specific categories of POSAS and VSS. Conclusion: This study showed a reduction in scar formation following immediate regrafting of the remnant skin at the donor site after STSG surgery. Particularly, the island type is useful for clinical application to facilitate healing of donor sites with STSG.

• 식물병연구
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• 제15권3호
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• pp.230-235
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• 2009

배 저장 중 신고에서 발생되는 과피얼룩 및 부패증상의 발생억제를 위해 2년간 시험한 결과 수확 후 약제 또는 생물제제 살포로 발병을 억제할 수 있었으며, 살포시기가 늦어질수록 발병가능성은 높은 것으로 나타났다. 한편, 처리시기와 관련하여 과실 수확 후 6주 또는 그 이후 처리는 상처부위의 부패 발생 억제효과가 낮았다. 그러나 TBZ를 수확 3~6주에 처리시 저장중 과피얼룩 및 부패과 발생은 현저히 억제되었다. 또한, TBZ, Fludioxonil과 Pyrimethanil 처리에 의한 과피얼룩 및 부패과 발생은 상처접종 처리에서 최대 14일까지 발병이 억제되었다. 그리고 수확시 TBZ 및 3주 후 Fludioxonil 처리는 수확시 TBZ 단용처리보다 발병억제력이 높았다. 한편, 2종의 생물제제(EXTN-1, Bio-Save 110)는 C. tenuissimum 접종처리에서 저장 14일까지 발병을 억제하여 저장 유통중 발생하는 상처부위 발병 억제가 가능 할 것으로 판단되었다. 결론적으로 저장 중 과피얼룩 및 부패방제를 위해 서로 다른 약제조합을 수확 후 저장 전에 처리할 때 가장 높은 방제효과를 얻을 수 있었다.

• 혜화의학회지
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• 제24권2호
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• pp.25-34
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• 2016

Objectives : Historical study on application of Kyungohkgo, one of the most popular tonic medicine, and suggestion of modernistic method through it Methods : Investigated effect and its range of Kyungohkgo in original texts of Korean medicine, and researched studies on medical action and treatment effect of Kyungohkgo nowaday. Results : Kyungohkgo has "replenish essence and marrow(補精益髓)" as a major effect, and various original text suggested that Kyungohkgo can be used as antioxidant tonic medicine, treatment of respiratory disease like tuberculosis and medicine for bone disease controling hormone. Several research about these subjects has been progressed recently. However, the most of these researches is not an in-depth study about virtues in original texts, but deduced from effects of Kyungohkgo, and there are some studies experimented with Kyungohkgo that has not followed its own formula. Conclusions : It is required to discuss new application based on understanding effect and is range of Kyungohkgo. It could be thought that using for skin disease based on t theory of "lung presides skin and hair", chronic pulmonary disease based on treatment of cough(咳嗽), and disease of uterine and bone based on "replenish essence and marrow(補精益髓)".

• Journal of Ginseng Research
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• 제34권4호
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• pp.363-368
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• 2010

Allergies are immediate hypersensitive responses to antigens and interleukin (IL)-4 is involved in the initiation and development of allergic responses. $Rb_1$ has been known to have a variety of biological activities including anti-inflammatory activity, but the effect of $Rb_1$ on allergic responses is not known yet. The present study was undertaken to examine whether $Rb_1$ has an inhibitory effect on allergic response in mouse model. In allergic mouse model, our results showed that topical application of $Rb_1$ on atopic dermatitis (AD)-like skin lesions improved skin condition and inhibited starching behaviors. In addition, $Rb_1$ application not only suppressed mRNA expression of IL-4 and IL-10, but also prevented the nuclear factor of activated T cells 1 transcription. Moreover, $Rb_1$ application suppressed IL-4's secretion. Taken together, these results suggest that $Rb_1$ has a potent inhibitory effect in AD-related T cell cytokine production and may be a candidate for therapeutic agent in allergy.

• 대한한방소아과학회지
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• 제29권2호
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• pp.1-15
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• 2015

Objectives In the theory of Korean Medicine, Cicadae Periostracum (CP) has been used to treat skin diseases such as inflammatory dermatitis, tetanus and pruritus. CP can reduce heat and disperse wind. In prior studies, anti-allergic effect and anti-inflammatory effect of CP were reported. However, there has been no report regarding the correlation of CP and allergic contact dermatitis (ACD). This study was performed to show the effects of CP in ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods In this experiment, the effects of CP on biological changes were measured, such as changes in ear and spleen weight, ear and dorsum skin thickness, clinical aspect on the dorsum skin and histological changes. The effect of proliferation rate of splenocytes was also investigated in vitro and vivo study. Results In results, CP application (CPA) group and CP application and administration (CPAA) group were significantly restrained in ear weight gain and increase in ear and dorsum skin thickness compared to the control group. In addition, CPA and CPAA group showed diminished erythema, desquamation, bloodstain, and marks. Also, the histological assessment showed that CP treatement diminished thickness of epidermis, hyperkeratosis, pigmentation and parakeratosis. Conclusions In conclusion, these data suggest that CP can decrease symptoms of ACD.