Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Inhibitory Effects of Ginsenoside Rb1 on Atopic Dermatitis-Like Skin Lesions in Mice

  • Park, Hye-Jin (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy) ;
  • Byeon, Hye-Eun (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy) ;
  • Choi, Ko-Woon (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy) ;
  • Rhee, Dong-Kwon (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy) ;
  • Lee, Kang-Ro (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy) ;
  • Pyo, Suhk-Neung (Division of Immunopharmacology, Sungkyunkwan University School of Pharmacy)
  • Received : 2010.09.30
  • Accepted : 2010.10.15
  • Published : 2010.12.29
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Abstract

Allergies are immediate hypersensitive responses to antigens and interleukin (IL)-4 is involved in the initiation and development of allergic responses. $Rb_1$ has been known to have a variety of biological activities including anti-inflammatory activity, but the effect of $Rb_1$ on allergic responses is not known yet. The present study was undertaken to examine whether $Rb_1$ has an inhibitory effect on allergic response in mouse model. In allergic mouse model, our results showed that topical application of $Rb_1$ on atopic dermatitis (AD)-like skin lesions improved skin condition and inhibited starching behaviors. In addition, $Rb_1$ application not only suppressed mRNA expression of IL-4 and IL-10, but also prevented the nuclear factor of activated T cells 1 transcription. Moreover, $Rb_1$ application suppressed IL-4's secretion. Taken together, these results suggest that $Rb_1$ has a potent inhibitory effect in AD-related T cell cytokine production and may be a candidate for therapeutic agent in allergy.

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References

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