• 제목/요약/키워드: Skin Type

검색결과 1,421건 처리시간 0.034초

Concordant Surgical Treatment: Non-melanocytic Skin Cancer of the Head and Neck

  • Ryu, Wan Cheol;Koh, In Chang;Lee, Yong Hae;Cha, Jong Hyun;Kim, Sang Il;Kim, Chang Gyun
    • 대한두개안면성형외과학회지
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    • 제18권1호
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    • pp.37-43
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    • 2017
  • Background: Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. Methods: The medical records of 176 patients with head and neck non-melanocytic skin cancer (NMSC) who were treated by a single surgeon at our institution between January 2010 and May 2016 were retrospectively reviewed, and their data (age, sex, pathological type, tumor location/size, treatment modality) were analyzed. Patients with cutaneous squamous cell carcinoma (cSCC) who were classified as a high-risk group for nodal metastasis underwent sentinel node mapping according to the National Comprehensive Cancer Network guidelines. Results: Among the patients with NMSC who were treated during this period, basal cell carcinoma (BCC; n=102, 57.9%) was the most common pathological type, followed by cSCC (n=66, 37.5%). Most lesions were treated by complete excision, with tumor-free surgical margins determined via frozen section pathology. Thirty-one patients with high-metastasis-risk cSCC underwent sentinel node mapping, and 17 (54.8%) exhibited radiologically positive sentinel nodes. Although these nodes were pathologically negative for metastasis, 2 patients (6.5%) later developed lymph node metastases. Conclusion: In our experience, BCC treatment should comprise wide excision with tumor-free surgical margins and proper reconstruction. In contrast, patients with cSCC should undergo lymphoscintigraphy, as nodal metastases are a possibility. Proper diagnosis and treatment could reduce the undesirably high morbidity and mortality rates.

콜라겐과 무세포진피를 이용한 혼합형 인공피부 개발 및 쥐 모델에서 창상치료 적용 (Application of a Composite Skin Equivalent using Collagen and Acellular Dermal Matrix as the Scaffold in a Mouse Model of Full-thickness Wound)

  • 이동혁;윤진철;이정희;김인섭
    • KSBB Journal
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    • 제29권1호
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    • pp.42-49
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    • 2014
  • The aim of this study was to develop a composite human skin equivalent for wound healing. Collagen type1 and acellular dermal matrix powder were utilized as the scaffold with dermal fibroblasts and keratinocytes for the development of a composite human skin equivalent. Fibroblast maintained the volume of composite skin equivalent and also induced keratinocytes to attach and proliferate on the surface of composite skin equivalent. The composite human skin equivalent had a structure and curvature similar to those of real skin. Balb-C nu/nu mice were used for the evaluation of full-thickness wound healing effect of the composite human skin equivalent. Graft of composite skin equivalent on full-thickness wound promoted re-epithelialization and granulation tissue formation at 9 days. Given the average wound-healing time (14 days), the wound in the developed composite skin equivalent healed quickly. The overall results indicated that this three-dimensional composite human skin equivalent can be used to effectively enhance wound healing.

인삼 재배지의 토양 화학성에 따른 생리장해 유형 분석 (Analysis of Occurrence Type of Physiological Disorder to Soil Chemical Components in Ginseng Cultivated Field)

  • 현동윤;연병열;이성우;강승원;현근수;김영철;이광원;김성민
    • 한국약용작물학회지
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    • 제17권6호
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    • pp.439-444
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    • 2009
  • This study was to set the guidelines of soil chemical components in order to assure the safety and quality of the panax ginseng from physiological disorder. The disorder symptoms appeared on the leaf with yellow spot, atrophy, yellow-brown spot, also showed red skin and rough skin of the root. Occurrence type of physiological disorder in cultivated field divided into two types : type I 'such as, yellow spot' consist of single disorder symptom; type II 'such as, yellow spot and yellow-brown spot' consist of two or more different disorder symptoms. The individual contribution of soil properties to the occurrence type was as follows ; The yellow spot was affected by Na > $NO_3$-N > salinity (EC) in soil. The same results was observed in red skin. Atrophy was affected by $NO_3$-N > salinity (EC) > Ca > Mg. Rough skin was affected by $P_2O_5$>pH>Organic material > K. It showed positive associated to $P_2O_5$, pH and K, but negative associated to organic matter. Simultaneous occurrence of two different disorder, including cases which yellow spot and yellow-brown spot, those were affected by $NO_3$-N > salinity (EC) > Na > Mg. In the case of atrophy plus yellow-brown spot, those also were affected by in the order : $NO_3$-N > salinity (EC) > Ca > Mg > Na. Red-rough skin was affected in the order : salinity (EC) > $NO_3$-N > K > Na. Soil chemical components appear to be related to occurrence of physiological disorder, particularly in salinity (EC) and $NO_3$-N. The salinity (EC) and $NO_3$-N were negative related to plant growth. In addition, exchangeable cation capacity play critical roles in attributing to complex occurrence of physiological disorder.

Cutaneous asthenia associated with Ehlers-Danlos syndrome in a Yorkshire terrier

  • Cho, Sung-Jin;Kim, Okjin
    • 대한수의학회지
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    • 제47권1호
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    • pp.91-94
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    • 2007
  • tisue disease of dog and cat, resembling Ehlers-Danlos syndrome (EDS) in man. EDS is characterizedby loose, hyperextensible and, fragile skin, it is attributed to mutations in connective tisue gene. Thesemutations cause defects in type I or II collagen synthesis and as a result lack of strength or elasticityto skin, joint, ligament and vessels. EDS-affected animals often experience subcutaneous hematomas thathave long bleeding times. The 4-years old male Yorkshire terrier was evaluated because of subcutaneoushematoma after stifle surgery. Clinical examination revealed a thin and hyperextensible skin and jointlaxity. The degree of skin extensibility index was 23.4%, marked skin stretchy. Clinical diagnosis wasconfirmed by histophathological examination of a skin biopsy revealing reduced packing density ofcollagen fiber of skin.

멜라닌생성억제제인 코직산 모노스테아레이트의 가수분해와 피부투과성 및 in vivo 미백효과 (Hydrolysis , Skin Permeation and In Vivo Whitening Effect of Kojic Acid Monostearate as an Antimelanogenic Agent)

  • 하용호;유성운;김동섭;임세진;최영욱
    • 약학회지
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    • 제42권1호
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    • pp.39-45
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    • 1998
  • Kojic acid, antimelanogenic agent, has been widely used in cosmetics to lighten the skin color. However, it has skin irritancy and instability against pH, temperature and light. To overcome these problems and optimize the molecular structure of kojic acid (KA), a prodrug, kojic acid monostearate(KMS), has been synthesized to modify the topical drug delivery in the point of sustained release of the parent drug via enzymatic hydrolysis during skin absorption. The prodrug was tested for enzymatic hydrolysis with cytosolic fraction of hairless mouse, skin. From the in vitro skin permeation study through hairless mouse skin, we found that KMS was retained in the skin and generated KA continuously by the skin esterase cleavage. In addition, topical formulations of o/w type creams and polyolprepolymer-containing cream were further tested for whitening effects using in vivo yellow skin guinea pig model.

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전산유체 해석을 통한 슬림형 이중외피 창호의 태양열 취득량 분석 - 높은 태양고도 및 하절기 냉방조건에서의 자연환기구 적용 및 창문 조절 방식별 비교 - (Numerical analysis of solar heat gain on slim-type double-skin window systems - Heat transfer phenomena with opening of windows and vent slot in summer condition -)

  • 박지호;오은주;조동우;조경주;유정연
    • KIEAE Journal
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    • 제17권1호
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    • pp.69-75
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    • 2017
  • Purpose: Heat transfer analysis of recently developed 'slim type double-skin system window' were presented. This window system is designed for curtain wall type façade that main energy loss factor of recent elegant buildings. And the double skin system is the dual window system integrated with inner shading component, enclosed gap space made by two windows when both windows were closed and shading component effectively reflect and terminate solar radiation from outdoor. Usually double-skin system requires much more space than normal window systems but this development has limited by 270mm, facilitated for curtain wall façade buildings. In this study, we estimated thermophysical phenomena of our double-skin curtain wall system window with solar load conditions at the summer season. Method: A fully 3-Dimentional analysis adopted for flow and convective and radiative heat transfer. The commercial CFD package were used to model the surface to surface radiation for opaque solid region of windows' frame, transparent glass, fluid region at inside of double-skin and indoor/outdoor environments. Result: Steep angle of solar incident occur at solar summer conditions. And this steep solar ray cause direct heat absorption from outside of frame surface rather than transmitted through the glass. Moreover, reflection effect of shading unit inside at the double-skin window system was nearly disappeared because of solar incident angle. With this circumstances, double-skin window system effectively cuts the heat transfer from outdoor to indoor due to separation of air space between outdoor and indoor with inner space of double-skin window system.

Evaluation of the in vivo skin moisturizing effects and underlying mechanisms of pomegranate concentrate solution and dried pomegranate concentrate powder

  • Kang, Su-Jin;Choi, Beom-Rak;Kim, Seung-Hee;Yi, Hae-Yeon;Park, Hye-Rim;Sung, Mi-Sun;Song, Chang-Hyun;Cho, Il-Je;Lee, Young-Joon;Ku, Sae-Kwang
    • 대한한의학회지
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    • 제37권2호
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    • pp.12-22
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    • 2016
  • Objectives: The aim of this study was to confirm the dose-dependent skin moisturizing effects of dried pomegranate concentrate powder (PCP) and pomegranate concentrate solution (PCS) in ICR mice. Materials and methods: To observe the in vivo skin moisturizing effects and possible underlying mechanisms of PCP and PCS, oral PCP (100, 200, and 400 mg/kg) and PCS (1, 2, and 4 mL/kg) were administered to normal ICR mice. Changes in body weight, skin water content, and skin type I collagen and hyaluronan contents were measured. Additionally, the mRNA expression levels of hyaluronan synthase (Has) 1, 2, and 3, and collagen type I alpha (COL1A) 1 and 2 were determined in the dorsal skin of mice by real-time reverse transcription polymerase chain reaction (RT-PCR). Results: Significant and dose-dependent increases in dorsal skin water content and type I collagen and hyaluronan contents were seen in PCP and PCS-treated mice. Moreover, the mRNA levels of Has 1, 2, and 3, involved in hyaluronan synthesis, and of COL1A1 and COL1A2, involved in collagen synthesis, were significantly and dose-dependently upregulated in PCS- and PCP-treated mice. Conclusions: In this study, PCP and PCS led to favorable skin moisturizing effects as indicated by increased skin water content and the upregulation of hyaluronan and collagen synthesis enzymes in mice treated with PCS (4 mL/kg) and PCP (200 mg/kg).

한방미용제제(자음미단)의 Hairless Mouse Model에서의 피부광노화 억제 및 섬유아세포의 UVB손상 저해효과 (Protective Effects of Jaummi-dan (Ciyinmei-dan) against Skin Photoaging in Hairless Mouse Model and UVB-induced Damage in Human Fibroblasts)

  • 김선영;안덕균;박성규;이진영;김완기;심영철;이상준
    • 대한한의학회지
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    • 제23권3호
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    • pp.43-53
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    • 2002
  • Objectives : To investigate the photoprotective effects and efficacy of Jaummi-dan (Ciyinmei-dan) on UV damage to animal skin/fibroblast cultures. Methods and Results : Hairless mice were orally administered Jaummi-dan (Ciyinmei-dan) extract and irradiated with UV for four weeks. In the Jaummi-dan (Ciyinmei-dan) treated group, a better skin appearance and less wrinkles were observed when compared to the control group. In addition, immunostaining for type 1 pN collagen showed that the amount of collagen deposition was higher in the Jaummi-dan (Ciyinmei-dan) treated group. The interstitial collagenase was measured in the cultured medium of fibroblasts after UVB irradiation using ELISA for MMP-l. Jaummi-dan (Ciyinmei-dan) treatment resulted in a significant decrease in MMP-1 secretion compared to the UVB-irradiated, untreated group. Conclusions : The results of our study indicate that orally administered Jaummi-dan (Ciyinmei-dan) seems to have photoprotective effects on UV damaged hairless mouse skin partly due to an inhibitory effect on collagen breakdown.

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백작약(白芍藥)이 피부 미백 및 주름에 미치는 영향 (Effects of Paeoniae radix alba(PRA) on Skin whitening and Elasticity using Melanoma cells)

  • 이종철;박수연;최정화;김종한
    • 한방안이비인후피부과학회지
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    • 제25권1호
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    • pp.1-11
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    • 2012
  • Objective : Paeoniae radix alba(PRA) can enrich the blood and regulate menstruation, astringe yin and arrest sweating, calm the liver and arrest pain. This study was designed to investigate effects of PRA on skin whitening and elasticity using melanoma cells. Methods : In this experiment, effect of PRA on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. More than $1,000\;{\mu}g/ml$ of PRA treated group showed lowered proliferation rates significantly compared to non-treated control group. 2. All of treated groups were lower levels of melanin synthesis respectively. 3. PRA did not show inhibitory effect on tyrosinase activities in vitro. But, PRA suppressed tyrosinase activities in B16F10 cells significantly. 4. PRA suppressed elastse type 1 activities in dose-dependent manner in vitro. But, PRA slightly suppressed elastase type 4 activities in vitro, and PRA also slightly suppressed elastase activities in vivo. Conclusion : These results suggest that PRA can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin whitening or elasticity.

Proteomic analysis of differentially expressed skin proteins in iRhom2Uncv mice

  • Liu, Bing;Xu, Yuan;Li, Wen-Long;Zeng, Lin
    • BMB Reports
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    • 제48권1호
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    • pp.19-24
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    • 2015
  • A mouse homozygous for the spontaneous mutation uncovered (Uncv) has a hairless phenotype. A 309-bp non-frameshift deletion mutation in the N-terminal cytoplasmic domain of iRhom2 was identified in Uncv mice ($iRhom2^{Uncv}$) using target region sequencing. The detailed molecular basis for how the iRhom2 mutation causes the hairless phenotype observed in the homozygous $iRhom2^{Uncv}$ mouse remains unknown. To identify differentially expressed proteins in the skin of wild-type and homozygous $iRhom2^{Uncv}$ littermates at postnatal day 5, proteomic approaches, including two-dimensional gel electrophoresis and mass spectrometry were used. Twelve proteins were differentially expressed in the skin in a comparison between wild-type and homozygous $iRhom2^{Uncv}$ mice. A selection of the proteomic results were tested and verified using qRT-PCR, western blot and immunohistochemistry. These data indicate that differentially expressed proteins, especially KRT73, MEMO1 and Coro-1, might participate in the mechanism by which iRhom2 regulates the development of murine skin.