• Korean Journal of Microbiology
• /
• v.48 no.2
• /
• pp.93-101
• /
• 2012

We analyzed mupirocin resistance rates among staphylococcal isolates collected from a Korean hospital in 2003 (100 isolates), 2005 (195 isolates), 2006 (151 isolates), and 2009 (112 isolates). In Staphylococcus aureus, rates of high-level mupirocin resistance (MIC, minimal inhibitory concentration ${\geq}512{\mu}g/ml$) decreased and did not appear since 2005. In contrast, low-level mupirocin resistance (MIC $8-256{\mu}g/ml$) was not detected in 2003 and 2005 but its rates later increased to 6.9% in 2009. Total resistance rates of coagulase-negative staphylococci (CNS) were significantly higher than those of S. aureus. The rates of high-level resistance of CNS increased from 16.0% in 2003 to 31.5% in 2009. The rate of low-level resistance of CNS was 8.0% in 2003 and around 11% later. In all high-level resistant isolates, the ileS-2 gene was detected. All low-level resistant isolates contained the known V588F mutation in ileS gene. Previously unknown mutations such as V458G in S. aureus and D172A, Y490H and I750V in CNS were identified additionally. One S. aureus isolate with high-level resistance was resistant to oxacillin and several topical antibiotics commonly used for the treatment of skin infection. Ten S. aureus isolates with low-level resistance were also resistant to all of these antibiotics except fusidic acid. CNS isolates with high-level (61 isolates) and low-level resistance (27 isolates) exhibited significantly higher resistance rates to these antibiotics than mupirocin-susceptible CNS isolates (167 isolates). In conclusion, prevention of the emergence of mupirocin resistance is necessary for the effective treatment of skin infection by staphylococci.

• The Korea Journal of Herbology
• /
• v.20 no.4
• /
• pp.1-10
• /
• 2005

Objectives : We investigated the anti-aging effect on skin with the extract of the needles of red pine, Pinus densiflora. Methods : We measured various effects related to skin such as the anti-oxidant effect, the protection against ultraviolet (UV) irradiation, the inhibition of reactive oxygen species (ROS) generation, the induction of heat shock protein 70 (HSP70), the reduction of matrix metalloproteinase-2 (MMP-2) synthesis and senescent cell. Results : The results were as follows : The extract of the needles of red pine (RP) had the potent anti-oxidant effect and the ROS scavenging effect. Also RP preserved the systemic anti-oxidant enzyme system (superoxide dismutase and catalase) from UVB irradiation. RP protected the cell membrane from the damages induced by UVB irradiation. RP induced HSP70, a mediator of resistance to UVB irradiation. RP reduced the synthesis of MMP-2 induced by UVB irradiation. And RP inhibited the amount of senescent-associated (SA) ${\beta}-galactosidase$ staining, as a marker of replicative senescence. Conclusions : The results of our study indicate that the extract of the needles of red pine, Pinus densiflora, has anti-aging effects on skin.

• Korean Journal of Human Ecology
• /
• v.12 no.5
• /
• pp.747-754
• /
• 2003

The actual clothing conditions were surveyed to diagnose clothing condition of Korean female in the view point of the adaptation to the thermal environment according to seasonal changes. Then, clothing microclimate, physiological responses, and subjective sensation were investigated through wearing trials on human body in climatic chamber based on the results from the survey. Factors to evaluate validity of clothing condition were clothing weight, clothing microclimate, physiological response of human body, and subjective sensation. The results were as follows: 1. Clothing weight per body surface area of the season was $856g/m^{2}$, $439g/m^{2}$ in summer, $630g/m^{2}$ in fall, and $1184g/m^{2}$ in winter. Cold - resistance of Korean female in office was superior to Japanese, inferior to residents of rural areas of Korea, and similar to male in office. However, in heat - resistance, female in office was inferior to residents of rural areas of Korea. 2. In spring, fall, winter, clothing microclimate temperature was a little higher than that in summer. Therefore, it was not a desirable wearing condition even though the clothing microclimate was comfortable zone. 3. Mean skin temperature of female in office was including within the range of Winslow's comfortable zone, but the range of comfortable zone in mean skin temperature of female was more narrow than Winslow's. Thus, it has problem for female to adaptation to thermal environment.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.31 no.3
• /
• pp.481-485
• /
• 2004

Rabson-Mendenhall syndrome(RMS) is first characterized in 1955 by Rabson and Mendenhall. RMS is a rare autosomal recessive variant with insulin resistance. This is due to insulin receptor mutations or other target-cell defects in insulin action. General findings include acanthosis nigricans, hypertrichosis, onychauxis, growth retardation, precocious puberty, genital enlargement, protuberant abdomen and xerotic skin. Characteristic oral and maxillofacial findings include dental dysplasia, coarse facial skin, prognathic jaw and fissured tongue. In this case report, dental characteristics of a 4-year old boy with Rabson-Mendenhall syndrome are described.

• Steel and Composite Structures
• /
• v.33 no.6
• /
• pp.877-889
• /
• 2019

The developments of double skin composite (DSC) walls with novel enhanced C-channel connectors (DSCW-EC) were reported. Followed axial compression tests on prototype walls were carried to evaluate structural performances of this novel DSC composite structures. The testing program consists of five specimens and focused on the layout of the novel enhanced C-channel (EC) connectors, which include the web direction of C-channels, steel-faceplate thickness, vertical and horizontal spacing of C-channels. Crushing in concrete core and buckling of steel faceplate were two main observed failed modes from the compression tests. However, elastic or plastic buckling of the steel faceplate varies with designed parameters in different specimens. The influences of those investigated parameters on axial compressive behaviors of DSCW-ECs were analyzed and discussed. Recommendations on the layout of novel EC connectors were then given based on these test results and discussions. This paper also developed analytical models for predictions on ultimate compressive resistance of DSCW-ECs. Validation against the reported test results show that the developed theoretical models predict well the ultimate compressive resistance of DSCW-ECs.

• Steel and Composite Structures
• /
• v.26 no.6
• /
• pp.759-769
• /
• 2018

This paper studies shear and tensile behaviors of headed stud connectors in double skin composite (DSC) structure. Firstly, 11 push-out tests and 11 tensile tests were performed to investigate the ultimate shear and tensile behaviors of headed stud in DSC shear wall, respectively. The main parameters investigated in this test program were height and layout of headed stud connectors. The test results reported the representative failure modes of headed studs in DSC structures subjected to shear and tension. The shear-slip and tension-elongation behaviors of headed studs in DSC structures were also reported. Influences of different parameters on these shear-slip and tension-elongation behaviors of headed studs were discussed and analyzed. Analytical models were also developed to predict the ultimate shear and tensile resistances of headed stud connectors in DSC shear walls. The developed analytical model incorporated the influence of the dense layout of headed studs in DSC shear walls. The validations of analytical predictions against 22 test results confirmed the accuracy of developed analytical models.

• Steel and Composite Structures
• /
• v.37 no.5
• /
• pp.533-549
• /
• 2020

Recently, Concrete-filled double skin steel tubular (CFDST) columns have proven an exceptional structural resistance in terms of strength, stiffness, and ductility. However, the resistance of these column members can be severely affected by the type of loading in which bending stresses increase in direct proportion with axial load and eccentricity value. This paper presents a non-linear finite element based modeling approach that studies the behavior of slender CFDST columns under biaxial loading. Finite element models were calibrated based on the outcomes of experimental work done by other researchers. Results from simulations of slender CFDST columns under axial loading eccentric in one direction showed good agreement with the experimental response. The calibrated models are expanded to a total of thirty models that studies the behavior of slender CFDST columns under combined compression and biaxial bending. The influences of parameters that are usually found in practice are taken into consideration in this paper, namely, eccentricity-to-diameter (e/D) ratios, slenderness ratios, diameter-to-thickness (D/t) ratios, and steel contribution ratios. Finally, an analytical study based on current code provisions is conducted. It is concluded that South African national standards (2011) provided the most accurate results contrasted with the Eurocode 4 (2004) and American Institute of Steel Construction (2016) that are found to be conservative. Accordingly, correction factors are proposed to the current design guidelines to provide more satisfactory results.

• Geotechnical Engineering
• /
• v.14 no.5
• /
• pp.163-172
• /
• 1998

To study the carrying capacity behavior of pile, dynamic pile testis and static load tests were carried out on two instrumented piles during and some time after pile driving. Cone Penetration Test( CPT) and Standard Penetration Test(SPT) were also performed at the test site before pile tests to investigate the relationship between unit skin friction of piles and cone tip resistance values and SPT N values. Total static capacity of pile reached the ultimate stage at the pile head settlement of about 0.055D (D : Pile diameter), at which skin friction of Pile already Passed the maximum value, but the end bearing was still increasing with the pile head settlement. The carrying capacity of pile increased in the form of natural logarithmic function with the time after pile driving. The increase in skin friction with time was very substantial the increase in skin friction 40 days after pile driving was 4.6 times of that determined during pile driving. The contribution of skin friction to the total capacity twas insignificant in the beginning, but became substantial 40 days after pile driving. This implies that the tested pile initially responded as an end bearing pile and later behaved as a friction pile. It was also noted that unit skin friction of pile might be ielated to cone tip resistance values(q.) and SPT N values, though the coefficient of this relationship might differ from one soil group to another and was somewhat greater than the value used in the design practice of Korea.

• Proceedings of the IEEK Conference
• /
• 2003.07c
• /
• pp.2903-2906
• /
• 2003

In this paper, we developed a multichannel acupuncture point balance measurement system that measures skin resistances at various acupuncture points to evaluate the balancing state of the meridian. The system consists of 16 channel resistance-voltage converter, signal processing part for signal amplification and filtering, A/D conversion part, micro-controller part, and data processing part. Compared to the previously developed 1 channel or 4 channel systems, it is found that the 16 channel system can measure the skin resistances of 16 acupuncture points, simultaneously, providing various clinical information such as balance and variation of the resistance value.

• Geotechnical Engineering
• /
• v.12 no.4
• /
• pp.87-100
• /
• 1996

The pull -out test has been used to investigate the friction properties between soil and grid type geosynthetics which is useful to measure the passive bearing resistance as well as the skin friction. In this paper, the friction properties between geogrid and a weathered granite soil are investigated by performing various pull-out tests. From the test results, a rational pull out test equipment and test method is suggested by evaluating the effects of major factors (such as geogrid width, location of soil box facing, vertical loads and pulll -out displacement rate, etc.) on pull -out test results.