• Journal of Korean Society on Water Environment
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• v.31 no.6
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• pp.610-618
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• 2015

This study was conducted to find out the influence of sample size (accumulated survey areas) on the seven biological indices of benthic macroinvertebrates. BMI, the index similar to Zeilika-Marvan’s saprobic index, tended to be independent on the variations of sample size. The other indices (Shannon-Weaver’s diversity, Margalef’s richness, Menhinick’s richness, Pielou’s evenness, and Lenat’s EPT index) showed the considerable variations along with the increase of sample size and environmental conditions. To get the appropriate index values, it should be sampled at least 6 replicates more based on 30×30cm Surber sampler. In addition, the habitat heterogeneity index of benthic macroinvertebrates suggested in this study, it will be able to be used for evaluating the heterogeneity of habitats.

• Genomics & Informatics
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• v.20 no.4
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• pp.49.1-49.7
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• 2022

Many packages for a meta-analysis of genome-wide association studies (GWAS) have been developed to discover genetic variants. Although variations across studies must be considered, there are not many currently-accessible packages that estimate between-study heterogeneity. Thus, we propose a python based application called Beta-Meta which can easily process a meta-analysis by automatically selecting between a fixed effects and a random effects model based on heterogeneity. Beta-Meta implements flexible input data manipulation to allow multiple meta-analyses of different genotype-phenotype associations in a single process. It provides a step-by-step meta-analysis of GWAS for each association in the following order: heterogeneity test, two different calculations of an effect size and a p-value based on heterogeneity, and the Benjamini-Hochberg p-value adjustment. These methods enable users to validate the results of individual studies with greater statistical power and better estimation precision. We elaborate on these and illustrate them with examples from several studies of infertility-related disorders.

• Journal of KIISE:Information Networking
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• v.31 no.3
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• pp.305-313
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• 2004

The use of a cache for a storing and processing of Web object is becoming larger. Also, many studies for efficient management of storing scope on cache are performed actively. Web caching technique have many differences with traditional techniques. Particularly, a heterogeneity of Web object which is a processing unit of Web caching and a variation of Web object reference characteristic with time are the important causes to decrease performance of existing techniques. In this study, We proposed the ACASH which was new web caching technique. As ACASH divided and managed Web object and a cache scope with a heterogeneity, It can reduced a heterogeneity variation of an object. Also, it is reflecting a variation of object reference characteristics with time adaptively. In the experiment, We verified that the performance of ACASH was improved than existing techniques on the two experiment model which considered a heterogeneity of an object.

• East Asian Economic Review
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• v.16 no.4
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• pp.315-331
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• 2012

Previous studies of location choice have focused on country-level data more than firm-level data and been more concerned with host countries' distinctive features than with firm heterogeneity. Therefore, they do not answer the question of who will go where in terms of location choice. To analyze the role of firm heterogeneity in determining location choice, we develop a theoretical model and analyze data on 3,644 Korean manufacturing multinationals operating in 87 countries between 1982 and 2006. The results of our conditional logit analysis indicate that not only host country characteristics but also firm heterogeneous factors such as productivity, labor intensity, and size have considerable influence on the decision of where to locate FDI.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.4
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• pp.1866-1888
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• 2017

Efficient energy consumption in WSN is one of the key design issues for improving network stability period. In this paper, we propose a new Heterogeneity-aware Energy-efficient Clustering (HEC) technique which considers two types of heterogeneity - network lifetime and of sensor nodes. Selection of cluster head nodes is done based on the three network lifetime phases: only advanced nodes are allowed to become cluster heads in the initial phase; in the second active phase all nodes are allowed to participate in cluster head selection process with equal probability, and in the last dying out phase, clustering is relaxed by allowing direct transmission. Simulation-based performance analysis of the proposed technique as compared to other relevant techniques shows that HEC achieves longer stable region, improved throughput, and better energy dissipation owing to judicious consumption of additional energy of advanced nodes. On an average, the improvement observed for stability period over LEACH, SEP, FAIR and HEC- with SEP protocols is around 65%, 30%, 15% and 17% respectively. Further, the scalability of proposed technique is tested by varying the field size and number of sensing nodes. The results obtained are found to be quite optimistic. The impact of energy heterogeneity has also been assessed and it is found to improve the stability period though only upto a certain extent.

• Journal of Korean Society of Forest Science
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• v.97 no.2
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• pp.165-170
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• 2008

Litterfall has been recognized an important part of the forest ecosystem production, playing a major pathway in energy flow and nutrient cycling through the ecosystem. This study was carried out to examine the quantity and components, temporal variation, and spatial heterogeneity of the litterfall in the mixed broadleaved-Korean pine forest. The data were collected from the 9ha permanent experimental plot, of which on the center area, i.e. $150m{\times}150m$, the total number of 319 circular litterfall traps with the size of $0.5m^2$ were established to collect falling litterfall. The results showed that the annual amount of litterfall was totalized 3,033.7 kg/ha, occupying broad-leaves of 39.3%, conifer-leaves of 29.5%, others of 18.5%, branches of 10.4%, and seeds of 2.3%. The peak point of the litterfall production was made at the end of September, proportionating 32.2% of total amount. The analysis of semivariogram revealed the existence of high spatial heterogeneity, calculated the scale of spatial heterogeneity ranged from 11.6 m to 29.1 m. The result of proportion (C/[Co+C]) showed that spatial heterogeneity of autocorrelation in total spatial heterogeneity were from 97.0% to 100%. The relatively heavy branches and others had significant differences in litterfall production between the areas of canopy gap and closed canopy in the 95% probability level, but the other components did not show statistical differences.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.29-39
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• 2020

The purpose of this study is to investigate the determinants of blockholder presence in the Korean stock market. This study examines previous theories and studies, points that previous studies did not examine, and proposes two hypotheses. To verify two hypotheses, fundamental data were collected from firms listed on Korea Exchange from 2005 to 2017. As explanatory variables, we use the factors and characteristics of the firms used in the previous studies. Logistic regression analysis was conducted to test the determinants of blockholder presence. We find that firm size is the most distinctive factor determining the presence of blockholder, and firm idiosyncratic risk is the most similar factor determining the existence of each blockholder. Tobin Q shows significant value in family and government, and R&D intensity appears to be a negative related to the presence of blockholder in financial institutions. We also find that the determinant of blockholder presence differs from the mechanisms that govern each individual blockholder type when all blockholders grouped together. This suggests that there is blockholder heterogeneity within Korea listing firms. Our findings contribute to investors and policy makers who interested in the determinants of the presence of blockholder and blockhoder heterogeneity in Korea stock market.

• BMB Reports
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• v.28 no.1
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• pp.46-50
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• 1995

Three kinds of mouse tumor necrosis factor (TNF), which have molecular weights of 35 kDa, 45 kDa, and 18 kDa on SDS-PAGE, were partially purified from serum-free culture supernatants of mouse peritoneal macrophages induced with lipopolysaccharide. Analysis of the native molecular weights by gel filtration indicated that the 18 kDa and 45 kDa TNFs aggregate into 50 kDa and 100 kDa molecules, respectively, while the 35 kDa TNF is contained in high molecular weight aggregates of approximately 200 kDa. The three kinds of cytotoxic factors all elicited tumor reducing responses.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3691-3698
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• 2014

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A (RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis was here performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to November 2013 on the association between RASSF1A Ala133Ser polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Bothfixed-effect and random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) by using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 10 studies including 4,572 cancer cases and 4,320 controls were included in the meta-analysis. Overall, significantly increased cancer risk was associated with the variant Ser133 when all studies were pooled (Ser vs Ala: OR=1.51, 95% CI=1.08-2.12, $P_{heterogeneity}{\leq}0.001$; Ser/Ser+Ala/Ser vs Ala/Ala: OR=1.55, 95% CI=1.08-2.22, $P_{heterogeneity}{\leq}0.001$). Moreover, in subgroup analyses by cancer types, a significant association between RASSF1A Ala133Ser polymorphism and lung cancer risk was found (Ser vs Ala: OR=2.27, 95% CI=1.29-4.02, $P_{heterogeneity}$=0.61; Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.42, 95% CI=1.33-4.42, $P_{heterogeneity}=0.75$). In addition, in subgroup analyses by ethnicity, it was found that the RASSF1A Ala133Ser polymorphism was associated with overall cancer risk in Asians (Ser vs Ala: OR=1.37, 95% CI=1.06-1.77, $P_{heterogeneity}=0.06$) and Caucasians (Ser/Ser+Ala/Ser vs Ala/Ala: OR=2.21, 95% CI=1.01-4.82, $P_{heterogeneity}{\leq}0.001$). Conclusions: This meta-analysis suggests, for the first time, that RASSF1A Ala133Ser polymorphism may contribute to cancer susceptibility, especially for lung cancer. Besides, additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• Journal of Digital Convergence
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• v.16 no.2
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• pp.151-156
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• 2018

The purpose of this study is to conduct a meta-analysis of 18 papers that can be verified among the papers on the subject of TPM. Five hypotheses were set for the analysis and meta - analysis was carried out with CMA as presented in each research paper. As a result of analysis, I-square value is more than 75% in four hypotheses. Therefore, the null hypothesis that the size of the population effect is the same for all studies was rejected. The reason for the heterogeneity is that the research characteristics such as the distribution of the respondents, the study conditions, the study period, and the study area are different. In this case, a summary statistic of the individual studies that can be classified according to the characteristics of the research is needed to analyze the effect size difference. However, individual studies do not provide a summary statistic that can classify the effect differences, so it is not possible to analyze the causes of heterogeneity.