• Journal of the Korean Ceramic Society
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• v.40 no.8
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• pp.730-734
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• 2003

This research examined the effect, which it follows in particle size distribution change of CaHPO$_4$ㆍ2$H_{2}O$ (DCPD). We used two kinds of compositions; tetracalcium phosphate (TTCP)/dicalcium phosphate dihydrate (DCPD) composition and $\alpha$-tricalcium phosphate ($\alpha$-TCP)TTCP/DCPD composition. As the result, the mean particle size of the DCPD decreased, the setting tine shortened at all compositions. The reference powder (DR), which did not milling, showed about 2 times strength value compared with other milling sample. Especially, the compressive strength of 60 : 20 : 20 sample (DR(do$_{0.5}$)=12.08 $\mu\textrm{m}$) after curing 7 days in simulated body fluid solution was 40$\pm$0.5 MPa, which was the highest. This resulted from the packing density at $\alpha$-TCP/TTCP/DCPD combination.

• Journal of electromagnetic engineering and science
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• v.2 no.1
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• pp.50-55
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• 2002

In this paper, Ive propose a bow-tie-shaped meander slot antenna find by a microstrip line to achieve compact size as well as wideband characteristic. While conventional bow-tie slot antennas exhibit wide band characteristic, they have relatively large size. On the other hand, the meander slot antennas are very small, but they reveal quite narrow bandwidth (typically less than 1 %). To realize miniaturized antennas balling large bandwidth, combination of the bow-tie slot and the meander slot geometries is proposed in this paper. Theoretical results show that the proposed antenna with uniform slot width is 65.5 % smaller than that of the conventional bow-tie antenna in size, while the bandwidth is 3 times larger than that of the meander slot antenna. Moreover, the non-uniform slot width antenna shows 60 % smaller in size and about 3.5 times wider in bandwidth than the previous antennas. Measured antenna performance reveals excellent agreement with the predicted values.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2000.04a
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• pp.373-378
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• 2000

The heat resistant material, in service, may experience static loading, cyclic loading, or a combination of two. An experimental study of crack growth behavior of STS 316L austenitic stainless steel under fatigue, and creep-fatigue loading conditions were carried out on compact tension specimens at various tensile hold times. In the crack growth experiments under hold times. In the crack growth experiments under hold time loading conditions, tensile hold times were ranged from 5 seconds to 100 seconds and its behavior was characterized using the $\Delta$K parameter. The crack growth rates generally increase with increasing hold times. However in this material, the trend of crack growth rates decreases with increasing hold times for short hold time range relatively. It is attributed to a decline in the cyclic crack growth rate as a result of blunting at the crack tip by creep deformation. The effect of grain size on the creep behavior of STS 316L was investigated. Specimens with grain size of 30, 65 and 125${\mu}{\textrm}{m}$ were prepared through various heat treatments and they were tested under various test conditions. The fracture mode of 316L changed from transgranular to intergranular with increasing grain size.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2016.10a
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• pp.128-129
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• 2016

This study is to categorize the loading of multiple persons on a vertical building elements into three types to test the size of crowd pressure under each loading patterns. The loading patterns is divided under the combination of loading method and loading persons. The loading method is categorized into the method of instantaneous loading of hand on a force plate and the method of continuous loading. The loading persons has been composed of 1~5 persons under the loading patterns. The loading patterns is also divided into lateral loading, longitudinal loading, and agglomeration loading. The subject group has been composed of 12 males in 20s. The load measurement device(size 1800×600×36mm, capacity 20kN, rigidity 28kN/cm) has been designed and manufactured directly. To eliminate the difference of individual, the size of crowd pressure has been converted into the strength to weight ratio (maximum load/weight) for computation. The strength to weight ratio in lateral loading was about 0.91 under instantaneous loading and about 0.47 under continuous loading. The strength to weight ratio in longitudinal loading was about 0.65 under instantaneous loading and about 0.36 under continuous loading. The strength to weight ratio in agglomeration loading was about 0.65 under instantaneous loading and about 0.36 under continuous loading.

• Environmental Analysis Health and Toxicology
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• v.23 no.2
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• pp.67-77
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• 2008

It has been observed that the linear relationship between the logarithm of bioconcentration factor (log BCF) of highly hydrophobic chemicals and their log $K_{ow}$ breaks when log $K_{ow}$ becomes greater than 6.0. Consequently, super hydrophobic chemicals were not thought to cause baseline toxicity as a single compound. Researchers often call this phenomenon as "hydrophobicity cutoff" meaning that bioconcentration or corresponding baseline toxicity has a certain cutoff at high log $K_{ow}$ value of hydrophobic organic pollutants. The underlying assumption is that the increased molecular size with increasing hydrophobicity prohibits highly hydrophobic compounds from crossing biological membranes. However, there are debates among scientists about mechanisms and at which log $K_{ow}$ this phenomenon occurs. This paper reviews three hypotheses to explain observed "cutoff": steric effects, kinetic or physiological limitations, and chemical activity cutoff. Although the critical molecular size that makes biological membranes not permeable to hydrophobic organic chemicals is uncertain, size effects in combination with kinetic limitation would explain observed non-linearity between log BCF and log $K_{ow}$. Chemical activity of hydrophobic chemicals generally decreases with increasing melting point at their aqueous solubility. Thus, there may be a chemical activity cutoff of baseline toxicity if there is a critical chemical activity over which baseline effects can be observed.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.2 s.179
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• pp.73-80
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• 2006

High speed machining(HSM) technique is widely used in the appliance, automobile part and mold industries, because it has many advantages such as good quality, low cost and rapid machining time. But it also has problems such as tool breakage, smooth tool path, and so on. In particular, small size end mill is easy to break, so it must be changed before interrupting operation. Generally, the tool life of small size end mill is affected by the milling conditions whose selected parameters are spindle speed, feedrate, and width of cut. The experiments were carried out by full factorial design of experiments using an orthogonal array. This paper shows optimal combination and mathematical model for tool life, Therefore, the analysis of variance(ANOVA) is employed to analyze the main effects and the interactions of these milling parameters and the second-order polynomial regression model with three independent variables is estimated to predict tool life by multiple regression analysis.

• Bulletin of the Korean Chemical Society
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• v.23 no.6
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• pp.872-879
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• 2002

One of the improtant characteristics of core-shell type nanoparticles is the long-term storage and reuse as an aqueous injection solution when required. For this reason, reconstruction of lyophilized core-shell type nanoparticles is considered to be essential . BAB type triblock copolymers differ from AB type diblock copolymers, which contain the A block as a hydrophilic part and the B block as a hydrophobic part. by not being easily redistributed into phosphate-buffered saline (PBS, pH 7.4, 0.1 M). Therefore, lyophilized core-shell type nanoparticles of CEC triblock copolymer were reconstituted using a somication process with a bar-type sonicator in combination with a freezing-thawing process. Soncation for 30s only resuspended CEC nanoparticles in PBS; their particle size distribution showed a monomodal pattern with narrow size distribution. The bimodal size distribution pattern and the aggregates were reduced by further sonication for 120 s but these nanoparticles showed a wide size distribution. The initial burst of drug release was increased by reconstitution process. The reconstitution of CEC core-shell type nanoparticles by freezing-thawing resulted in trimodal distribution pattern and formed aggregates, although freezing-thawing process was easier than sonication . Drug release form CEC nanoparticles prepared by freezing-thawing was slower than from the original dialysis solution. Although core-shell typenanoparticles of CEC triblock copolymers were not easily performed. Cytotoxicity testing of core-shell type nanoparticles of CEC-2 triblock copolymers containing clonazepam (CNZ) was performed using L929 cells. Cytotoxicity of CNZ was decreased by incorporation into nanoparticles.

• Proceedings of the Zoological Society Korea Conference
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• 1997.10a
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• pp.42-57
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• 1997

The multicriterion matrix technique (MM-technique) was proposed for a method of monitoring and assessment about vegetation naturalness. Four criteria and 10 subcriteria were selected and two evaluation indices such as VN-value and VN-class were used. The criteria were characterized by syntaxonomical informations of hemeroby concept and potential natural vegetation, hierarchical system between criteria, and ordinal scale of VN-values. VN-values were classified into 11 ordinal levels and condensed to five VN-classes for facilitating practical use. A vegetation map of naturalness described by combination o( two indices was proposed as an alternative resolution of the DGN map. We also discuss the organization of the map content which is a matter of grid size (unit-area). In the case study, a grid size proper to show a full account of real information of actual vegetation is less 250-grid (250 $\times$ 250 $m^2$) in a medium size of city area containing relatively fragmented ecosystems. In conclusion, it was recognized that this new assessment technique was useful and vegetation assessment was accomplished with the smaller grid size in Korea.

• Journal of Animal Science and Technology
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• v.66 no.5
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• pp.1021-1033
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• 2024

Exosomes have been extensively studied as disease biomarker in humans, given their role in transporting bioactive molecules. However, despite the great potential of exosomes as noninvasive diagnostic markers and therapeutic nanocarriers for bovine diseases, few studies have been conducted on bovine exosome. Thus, this study aimed to quantitatively and qualitatively compare three isolation methods to identify a suitable method for bovine serum. Exosomes were isolated using ultracentrifugation alone (UC), a combination of ultracentrifugation and size exclusion chromatography (US), or membrane affinity-based exoEasy kit (EE). Isolated particles were evaluated using a range of complementary techniques. Transmission electron microscopy showed that all three isolation methods resulted in particles with a cup-shaped morphology. The particle concentration measured by nanoparticle trafficking analyzer of US was lower compared to those of UC and EE method. As a result of immunoblotting, exosome markers including TSG101, CD81, and HSP70 were detected in US particles, while in UC and EE, only TSG101 expression was confirmed. Particles isolated from UC and EE showed a contamination with the blood protein albumin, whereas particles from US did not show albumin contamination. In addition, to evaluate the possibility of using exosomes as biomarkers, the profiles of the small RNA in the exosomes were compared using the bioanalyzer 2100. As a result, in the EE method, the band of small RNA (25-200 nt) was most prominent, and in the US methods, a distinct band was observed in the small RNA range. Collectively, the purity of exosomes without non-exosomal contamination was highest in the US method. However, for the detection of small RNA, the EE method was found to be the most suitable. Therefore, the results suggest that the optimal isolation method varies depending on the specific purpose of exosome isolation.

• The Korea Journal of Herbology
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• v.29 no.6
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• pp.7-13
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• 2014

Objectives : Anti-obesity drugs that have been developed so far have limited efficacies and considerable adverse effects affecting tolerability and safety. Therefore, most anti-obesity durgs have been withdrawn. We tried to develop anti-obesity agent by combinations from herbs that are used in food ingredients as well as in traditional medicines. Methods : The 80% (v/v) ethanol extracts from Bamboo (Phyllostachys pubescence) leaf (BL) and Scutellaria baicalensis (SB) and their 1:1 combination (BLSB) was evaluated on high fat diet induced obese mice compared to Omega-3 as a positive control. The mice were divided into six groups (n=5), one group fed a normal diet (ND), and the others fed a high fat diets for eight weeks. Two weeks after starting feeding the diets, the high fat diet groups were orally administered vehicle and Omega-3, BL, SB, and BLSB at dosage of 200 mg/kg/day for six weeks. All groups were assayed for body weights, food efficiency ratio, blood biochemistry parameters, and organic tissue weights. Results : BLSB group showed significant reductions in body weight gain and fat weights of liver and epididymal adipose tissue compared to BL or SB alone as well as control. Total-cholesterol and LDL-cholesterol levels significantly decreased, and HDL-cholesterol level increased. In liver tissue, macrovesicular steaotisis was remarkably improved and its fat cell size was also significantly decreased. Conclusions : These results suggested that a combination preparation of bamboo leaf and S. baicalensis has anti-obesity effect and have synergistic effect compared to bamboo leaf or S. baicalesis.