Browse > Article
http://dx.doi.org/10.6116/kjh.2014.29.6.7.

Synergistic combination effect of anti-obesity in the extracts of Phyllostachys pubescence Mael and Scutellaria baicalensis Georgi  

Kang, Young Min (erbal Medicine Resources Group, Korea Institute of Oriental Medicine)
Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Lee, Young-Cheol (Department of Herbology, College of Korean Medicine, Sangji University)
Kim, Ho Kyoung (erbal Medicine Resources Group, Korea Institute of Oriental Medicine)
Kim, Dong-Seon (erbal Medicine Resources Group, Korea Institute of Oriental Medicine)
Publication Information
The Korea Journal of Herbology / v.29, no.6, 2014 , pp. 7-13 More about this Journal
Abstract
Objectives : Anti-obesity drugs that have been developed so far have limited efficacies and considerable adverse effects affecting tolerability and safety. Therefore, most anti-obesity durgs have been withdrawn. We tried to develop anti-obesity agent by combinations from herbs that are used in food ingredients as well as in traditional medicines. Methods : The 80% (v/v) ethanol extracts from Bamboo (Phyllostachys pubescence) leaf (BL) and Scutellaria baicalensis (SB) and their 1:1 combination (BLSB) was evaluated on high fat diet induced obese mice compared to Omega-3 as a positive control. The mice were divided into six groups (n=5), one group fed a normal diet (ND), and the others fed a high fat diets for eight weeks. Two weeks after starting feeding the diets, the high fat diet groups were orally administered vehicle and Omega-3, BL, SB, and BLSB at dosage of 200 mg/kg/day for six weeks. All groups were assayed for body weights, food efficiency ratio, blood biochemistry parameters, and organic tissue weights. Results : BLSB group showed significant reductions in body weight gain and fat weights of liver and epididymal adipose tissue compared to BL or SB alone as well as control. Total-cholesterol and LDL-cholesterol levels significantly decreased, and HDL-cholesterol level increased. In liver tissue, macrovesicular steaotisis was remarkably improved and its fat cell size was also significantly decreased. Conclusions : These results suggested that a combination preparation of bamboo leaf and S. baicalensis has anti-obesity effect and have synergistic effect compared to bamboo leaf or S. baicalesis.
Keywords
Anti-obesity; Herbal combination; Phyllostachys pubescence; Scutellaria baicalensis; Synergistic effect;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 Chun JM, Kim DS, Choi G, Sung YY, Park SH, Kim SH, Kim HK. Ainti-obesity effect of five formulas which can be used to treat hypertension in high fat diet induced obese mice. Kor J Pathol. 2013 ; 27(5) : 637-43.   과학기술학회마을
2 Cho E, Kim S, Na I, Kim DC, In MJ, Chae HJ. Antioxidant and anticoagulant activities of water and enthanol extracts of Phyllostachys pubescence leaf produced in Geoje. J Appl Biol Chem. 2010 ; 53(3) : 170-3.   DOI   ScienceOn
3 In MJ, Park MK, Kim SY, Chae HJ, Chae MW, Sone J, Ji HS, Han KS, Kim DC. Composition analysis and antioxidative activity of maengjong-juk (Phyllostachys pubescence) leaves tea. J Appl Biol Chem. 2010 ; 53(2) : 116-9.   DOI   ScienceOn
4 Yoon HJ, Park YS. Effects of Scutellaria baicalensis water extract on lipid metabolism and antioxidant defense system in rats fed gigh fat diet. J Korean Soc Food Sci Nutr. 2010 ; 39(2) : 219-26.   DOI   ScienceOn
5 Kim SC, Ahn KS, Park CK, Jeon BS, Lee JT, Park WJ. Isolation of antioxidative compound from Scutellaria baicalensis G. Korean J Med Crop Sci. 2006 ; 14(4): 212-6.   과학기술학회마을
6 Chun JM, Choi G, Kim DS, Sung YY, Nho KJ, Kim SH, Kim HK. The anti-obesity effect of 5 herbal formulas in high fat diet induced obese mice. Herbal Formula Sci. 2013 ; 21(2) : 44-52.   DOI   ScienceOn
7 Kurukulasuriya LR, Stas S, Lastra G, Manrique C, Sowers JR. Hypertension in obesity. Med Clin North Am. 2011 ; 95(5) : 903-17.   DOI   ScienceOn
8 Jin WY, Kim SH, Kim HK, Kang YM, Jang DG, Nam JB, Hwang BY, Kim DS. Antiplatelet and antithrombotic effect of Phyllostachys pubescens leaves and Mume Fructus combination. Integr Med Res. 2013 ; 2(2) : 70-5.   DOI
9 Wright SM, Salter AM. Effects of soy protein on plasma cholesterol and bile acid excretion in hamsters. Comp Biochem Physiol B Biochem Mol Biol. 1998 : 119(2) : 247-54.   DOI   ScienceOn
10 Lee HJ, Yang SJ. Effects of resveratrol on hepatic autophagy in high fat diet-induced obese mice. J Nutr Health. 2013 ; 46(4) : 307-14.   DOI   ScienceOn
11 Plaa GL, Charonneau M. Detection and evaluation of chemically induced liver injury. In Principles and methods of toxicology. New York : Hayes At Raven Press. 1994 : 839-70.
12 Kang YH, Park YH, Ha TY, Moon KD. Effects of pine needle extracts on serum and liver lipid contents in rats fed high fat diet. J Korean Soc Food Nutr. 1996 : 25 : 367-73.   과학기술학회마을
13 Song KH, Lee SH, Kim BY, Park AY, Kim JY. Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db mice. Phytother Res. 2013 ; 27(2) : 244-50.   DOI   ScienceOn
14 Kim EY, Jung EY, Lim HS, Heo YR. The effects of the Sasa borealis leaves extract on plasma adiponectin, resistin, C-Reactive protein and homycysteine levels in high fat diet-induced obese C57/BL6J mice. Kor Nutri Soc. 2007 ; 40(4) : 303-11.
15 Lee DS, Ko W, Kim KS, Kim DC, Yoon CS, Cho K, Cui X, Oh H, Kim YC. The comparison between hot-water extracts and microwave extracts of Scutellaria radix for antioxidant for antioxidant and neuroprotective effects. Kor J Pharmacogn. 2014 ; 45(1) : 55-61.   과학기술학회마을
16 Blackburn P, Cote M, Lamarche B, Couillard C, Pascot A, Tremblay A, Bergeron J, Lemieux I, Despres JP. Impact of postprandial variation in triglyceridemia on low-density lipoprotein particle size. Metabolism. 2003 ; 52(11) : 1379-86.   DOI   ScienceOn
17 Arai T, Kim HJ, Chiba H, Matsumoto A. Anti-obesity effect of fish oil and fish oil-fenofibrate combination in female KK mice. J Atheroscler Thromb. 2009 ; 16(5) : 674-83.   DOI   ScienceOn
18 Dietschy JM, Wilson JD. Regulation of cholesterol metabolism. New Engl J Med. 1970 ; 282(20) : 1128-38.   DOI   ScienceOn
19 Wout ZG, Pec EA, Maggiore JA, Willians RH, Palicharla P, Johnston TP. Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats. J Parenter Sci Technol. 1992 ; 46(6) : 192-200.
20 Afifi FU, Al-Khalidi B, Khalil E. Studies on the in vivo hypoglycemic activities of two medicinal plant used in the treatment of diabetes in Jordanian traditional medicine following intranasal administration. J Ethnopharmacol. 2005 ; 100(3) : 314-8.   DOI   ScienceOn