• Journal of Ginseng Research
• /
• v.46 no.3
• /
• pp.435-443
• /
• 2022

Background: Post-traumatic stress disorder (PTSD) is a psychiatric disease that develops following exposure to a traumatic event and is a stress-associated mental disorder characterized by an imbalance of neuroinflammation. Korean Red Ginseng (KRG) is the herbal supplement that is known to be involved in a variety of pharmacological activities. We aimed to investigate the effects of KRG on neuroinflammation as a potential mechanism involved in single prolonged stress (SPS) that negatively influences memory formation and consolidation and leads to cognitive and spatial impairment by regulating BDNF signaling, synaptic proteins, and the activation of NF-κB. Methods: We analyzed the cognitive and spatial memory, and inflammatory cytokine levels during the SPS procedure. SPS model rats were injected intraperitoneally with 20, 50, or 100 mg/kg/day KRG for 14 days. Results: KRG administration significantly attenuated the cognitive and spatial memory deficits, as well as the inflammatory reaction in the hippocampus associated with activation of NF-κB in the hippocampus induced by SPS. Moreover, the effects of KRG were equivalent to those exerted by paroxetine. In addition, KRG improved the expression of BDNF mRNA and the synaptic protein PSD-95 in the hippocampus. Taken together, these findings demonstrate that KRG exerts memory-improving actions by regulating anti-inflammatory activities and the NF-κB and neurotrophic pathway. Conclusion: Our findings suggest that KRG is a potential functional ingredient for protecting against memory deficits in mental diseases, such as PTSD.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.18 no.3
• /
• pp.19-25
• /
• 2010

The purpose of this study is to gain a better understanding of the effects of fuel stratification on reducing the pressure-rise rate at high load in HCCI combustion. It was found that fuel stratification offers good potential to achieve a staged combustion event and reduced pressure-rise rates. The engine is fueled with Di-Methyl Ether (DME) which has unique 2-stage heat release. Numerical analysis is conducted with single and multi-zones model and detailed chemical reaction scheme is done by chemkin and senkin. Calculation result shows that proper fuel stratification prolongs combustion duration and reduce pressure rise rate. Besides IMEP, combustion efficiency and indicated thermal efficiency keep constant. However, too wide fuel stratification increases pressure rise rate and CO and NOx emissions in exhaust gas.

• Journal of Astronomy and Space Sciences
• /
• v.13 no.1
• /
• pp.40-47
• /
• 1996

One of the important effects of the space environment on the satellites and spacecrafts is the single event upsets (SEUs) which are caused by the high energy particles in space. A SEU occurs when an ionizing radiation produces a burst of electron-hole pairs in a digital microelectronic circuit and causes the charge state to change. We have developed and integrated a software package which can estimate the SEU rates for any specified locations or altitudes under various geophysical conditions. We report in this paper the algorithm of the software and the results for some devices with known parameters. We also compare the results with actual observations made by Akebono.

• 제어로봇시스템학회:학술대회논문집
• /
• 2003.10a
• /
• pp.2295-2297
• /
• 2003

The major problem encountered in satellite design is EMI (Electro-Magnetic Interference) and EMC (Electro-Magnetic Compatibility). Here, our focus is on the effects of protons on the electronic system. The SEU (Single Event Upset) results from the level change of stored information due to photon radiation and temperature in the space and the nuclear power plant environment. The impact of SEU on PLD (Programmable Logic Devices) technology is most apparent in ROM/SRAM/DRAM devices wherein the state of storage cell can be upset. In this paper, a simple and powerful test techniques is suggested, and the results are presented for the analysis and future reference. The test results are compared with that of JPL test report. In our experiment, the proton radiation facility available at KIRAMS (Korea Institute of Radiological Medical Sciences) has been applied on a commercially available SRAM manufactured by Hynix Semiconductor Company.

• Bulletin of the Korean Chemical Society
• /
• v.33 no.3
• /
• pp.963-970
• /
• 2012

We review novel chemical kinetics proposed for quantitative description of fluctuations in reaction times and in the number of product molecules in a heterogeneous biological system, and discuss quantitative interpretation of randomness parameter data in enzymatic turnover times of ${\beta}$-galactosidase. We discuss generalization of renewal theory for description of chemical fluctuation in product level in a multistep biopolymer reaction occurring in a dynamically heterogeneous environment. New stochastic simulation results are presented for the chemical fluctuation of a dynamically heterogeneous reaction system, which clearly show the effects of the initial state distribution on the chemical fluctuation. Our stochastic simulation results are found to be in good agreement with predictions of the analytic results obtained from the generalized master equation.

• Electronics and Telecommunications Trends
• /
• v.37 no.2
• /
• pp.21-29
• /
• 2022

Cosmic radiation environments having extremely high-energy particles and photons cause severe malfunctions of electrical components in space and terrestrial regions. In this study, we revisit basic knowledge on radiation effects in ICT electrical devices, such as single event effect, total ionizing dose, and displacement damage. To avoid such soft errors and system failures, we introduce essential technical approaches from the perspectives of materials, layouts, circuits, and systems, including current research trends. By considering several techniques and Space EEE part standards, we suggest possible directions that can invoke New Space Era technology.

• Journal of Mechanical Science and Technology
• /
• v.20 no.9
• /
• pp.1436-1448
• /
• 2006

This paper describes the effects of injection rate shaping on the combustion, fuel consumption and emission of $NO_x$ and soot of a medium duty diesel engine. The focus is on the influence of four different injection rate shapes, square type 1, square type 2, boot and ramp, with a variation of maximum injection pressure and start of injection (SOI). The experiments were carried out on a 1 liter single cylinder research diesel engine equipped with an amplifier-piston common rail injection system, allowing the adjustment of the injection pressure during the injection event and thus injection rate as desired. Two strategies to maintain the injected fuel mass constant were followed. One where rate shaping is applied at constant injection duration with different peak injection pressure and one strategy where rate shaping is applied at a constant peak injection pressure, but with variable injection duration. Injection rate shaping was found to have a large effect on the premixed and diffusion combustion, a significant influence on $NO_x$ emissions and depending on the followed strategy, moderate or no influence on soot emission. Only small effects on indicated fuel consumption were found.

• Proceedings of the Korean Information Science Society Conference
• /
• 2011.06b
• /
• pp.313-316
• /
• 2011

SRAM-based FPGAs are very sensitive to single event upset(SEU) induced by space irradiation. To mitigate SEU effects, space applications employ some mitigation schemes. The triple modular redundancy(TMR) is a well-known mitigation scheme. It uses one or three voters as well as three identical blocks performing the same work. The voters can mask out one error in the outputs from the three replicated blocks. One SEU error in TMRed circuits can be masked but it needs to be detected for some reasons such as to analyze the SEU effects in the satellite or to recover the circuits from the error before additional error occur. In this paper, we developed a fault detection circuit and reporting system to detect a fault on the TMRed circuits. To verify our error detection circuit and reporting circuit, we performed an irradiation test at MC-50 Cyclotron. Experimental results showed that error detection circuit can detect a fault on the TMRed test circuit in radiation environment.

• The Bulletin of The Korean Astronomical Society
• /
• v.42 no.1
• /
• pp.44.1-44.1
• /
• 2017

The single lens event OGLE-2015-BLG-1482 has been simultaneously observed from two ground-based surveys and from Spitzer. The Spitzer data exhibit finite-source effects due to the passage of the lens close to or directly over the surface of the source star as seen from Spitzer. Thanks to measurements of the microns parallax and the finite-source effect, we find that the lens of OGLE-2015-BLG-1482 is a very low-mass star with the mass $0.10{\pm}0.02M{\odot}$ or a brown dwarf with the mass $55{\pm}9MJ$, which are respectively located at $DLS=0.80{\pm}0.19kpc$ and $DLS=0.54{\pm}0.08kpc$, and thus it is the first isolated low-mass microlens that has been located in the Galactic bulge. The degeneracy between the two solutions is severe. The fundamental reason for the degeneracy is that the finite-source effect is seen only in a single data point from Spitzer and this single data point gives rise to two ${\rho}$ solutions.

• Journal of Korean Medicine Rehabilitation
• /
• v.30 no.2
• /
• pp.153-164
• /
• 2020

Objectives This study is designed to evaluate the safety of Soshihotang soft extract in healthy male volunteers. Methods 12 healthy male volunteers were recruited and this study was carried out by a single center. Laboratory test results, vital signs of the volunteers were collected to evaluate safety. According to registration order, the 12 subjects were allocated by serial number. To evaluate safety, blood samples were taken and vital signs were checked 4 times-screening, pre administration, post administration and follow up-during the whole trial. The incidence of all adverse effects are shown in percentage. The mean and standard deviation were used to to describe and summarize continuous data. To evalate the effectiveness of the intervention, data of blood tests was analyzed by Wilcoxon signed rank test or paired T-test (p<0.05). Results In the case of red blood cell, hemoglobin, hematocrit, neutrophils, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase values, the normality test result of the variable for the difference value before and after the dosing has a significance level <0.05. But most of values did not deviate from the normal range, and the deviation from the normal range could not be regarded as the significance associated with this clinical trial. And adverse event wasn't observed associated with the clinical trial drug. Conclusions Soshihotang soft extract were considered to be safe for healthy male volunteers.