• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.905-906
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• 2013

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.166.1-166.1
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• 2000

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.2
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• pp.119-128
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• 2016

In a performance-based design, the structural safety is estimated from pre-defined damage states and corresponding damage indices. Both damage states and damage indices are well defined for above-ground structures, but very limited studies have been performed on underground structures. In this study, we define the damage states and damage indices of a cut-and-cover box tunnel which is one of typical structures used in metro systems, under a seismic excitation from a series of inelastic frame analyses. Three damage states are defined in terms of the number of plastic hinges that develop within the structure. The damage index is defined as the ratio of the elastic moment to the yield moment. Through use of the proposed index, the inelastic behavior and failure mechanism of box tunnels can be simulated and predicted through elastic analysis. In addition, the damage indices are linked to free-field shear strains. Because the free-field shear strain can be easily calculated from a 1D site response analysis, the proposed method can be readily used in practice. Further studies are needed to determine the range of shear strains and associated uncertainties for various types of tunnels and site profiles. However, the inter-linked platform of damage state - damage index - shear wave velocity - shear strain provides a novel approach for estimating the inelastic response of tunnels, and can be widely used in practice for seismic designs.

• Journal of the Korean Society of Safety
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• v.35 no.3
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• pp.86-95
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• 2020

This paper describes the work and the results of the final Probabilistic Safety Assessment (PSA) for the Jordan Research and Training Reactor (JRTR). This final PSA was undertaken to assess the level of safety for the design of a research reactor and to evaluate whether it is probabilistically safe to operate and reliable to use. The scope of the PSA described here is a Level 1 PSA, which addresses the risks associated with core damage. After reviewing the documents and its conceptual design, nine typical initiating events were selected regarding internal events during the normal operation of the reactor. AIMS-PSA (Version 1.2c) was used for the accident quantification, and FTREX was used as the quantification engine. 1.0E-15/yr of the cutoff value was used to deliminate the non-effective Minimal Cut Sets (MCSs) when quantifying the JRTR PSA model. As a result, the final result indicates a point estimate of 2.02E-07/yr for the overall Core Damage Frequency (CDF) attributable to internal initiating events in the core damage state for the JRTR. A Loss of Primary Cooling System Flow (LOPCS) is the dominant contributor to the total CDF by a single initiating event (9.96E-08/yr), and provides 49.4% of the CDF. General Transients (GTRNs) are the second largest contributor, and provide 32.9% (6.65E-08/yr) of the CDF.

• Biomolecules & Therapeutics
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• v.11 no.2
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• pp.139-144
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• 2003

Ganoderma lucidum is commonly known as medically potent mushroom, which has been widely used in China and other oriental countries for the treatment of various diseases, including cancer. In this report, we investigated the anti-oxidant and protective effect of Ganodema lucidum extract (GLE) against the DNA damage induced by free radical and U.V. In the assay of cell growth inhibition, the inhibitory cell growth rate induced by hydroxyl radical was dose-dependently decreased by GLE. This results support that GLE has a detoxifying activity against cytotoxicity of hydroxyl radical in E. coli cell. GLE also protected ColE1 plasmid DNA damage in the concentration of 200$\mu\textrm{g}$ per reaction on the DNA fragmentation assay. The nuclear tailing by hydrogen peroxide in single cell gel electrophoresis(SCGE) was decreased by GLE in the concentration of 50$\mu\textrm{g}$/ml. These data indicate that Ganoderma lucidum has an anti-oxidative activity to hydrogen peroxide. The mutation rate after irradiation of U.V. was reduced by 50$\mu\textrm{g}$/ml GLE and total number of Rif (Rifampicin) resistant mutants was decreased in a concentration dependent manner when added the GLE exogenously in a culture media. According to the results, it is likely that GLE has not only an anti-oxidative activity to hydroxyl radical but also an anti-mutagenic activity to U.V. mutagenesis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2563-2569
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• 2012

Oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage in a variety of liver disorders. Hence there is a great demand for the development of agents with potent antioxidant effect. The aim of the present investigation is to evaluate the efficacy of Moringa oleifera as a hepatoprotective and an antioxidant against 7, 12-dimethylbenz[a]anthracene induced hepatocellular damage. Single oral administration of DMBA (15 mg/kg) to mice resulted in significantly (p<0.001) depleted levels of xenobiotic enzymes like, cytochrome P450 and b5. DMBA induced oxidative stress was confirmed by decreased levels of reduced glutathione (GSH) and glutathione-S-transferase (GST) in the liver tissue. The status of hepatic aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) which is indicative of hepatocellular damage were also found to be decreased in DMBA administered mice. Pretreatment with the Moringa oleifera (200 and 400 mg/kg) orally for 14 days significantly reversed the DMBA induced alterations in the liver tissue and offered almost complete protection. The results from the present study indicate that Moringa oleifera exhibits good hepatoprotective and antioxidant potential against DMBA induced hepatocellular damage in mice that might be due to decreased free radical generation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.27 no.1
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• pp.73-81
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• 2001

For an attempt to develop safe materials protecting UV-induced skin damage, plant extracts were evaluated for their antioxidative and free radical scavenging activities. From the results of these screening procedures, the ethanol extract of the flowers of Prunus persica was selected for further study. It was found that Prunus persica (50-200 $\mu\textrm{g}$/㎖) inhibited UVB-induced DNA damage measured by tail moment in the Single Cell Gel Electrophoresis(COMET assay) and inhibited UV-induced lipid peroxidation, expecially against UVB-induced peroxidation at higher than 10 $\mu\textrm{g}$/㎖. Also P.persica(100∼1,000 $\mu\textrm{g}$/㎖) inhibited the amount of $\^$14/C-arachidonic acid metabolites release from UVB-irradiated keratinocytes and it possessed the protective activity against UV-induced cytotoxicity of keratinocytes. All these results indicate that the flowers of P. persica extract may be beneficial for protection UV-induced skin damage when topically applied.

• Journal of Forest and Environmental Science
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• v.24 no.3
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• pp.143-149
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• 2008

We conduct economic analysis of the snow damage on sugi (Cryptomeria japonica) forest stands in Toyama Prefecture, Japan. We utilize a single tree and distant independent growth simulator called "Silv-Forest." With this growth simulator, we developed an optimization model by dynamic programming, called DP-Silv (Dynamic Programming Silv-Forest). The MS-PATH (multiple stage projection alternative technique) algorithm was embedded as a searching algorithm of dynamic programming. The height / DBH ratio was used to constrain the thinning regime for snow damage protection. The optimal rotation age turned out to be 65 years for the non-restricted case, while it was 50 years for the restricted case. The difference in NPV of these two cases as the induced costs ranged from 179,867 to 1,910,713yen/ha over the rotation age of 20 to 75 years. Under the optimal rotation of 65 years, the cost became 914,226 yen/ha. The estimated annual payment based on the difference in NPV, was from 9,869 yen/ha/yr to 85,900 yen/ha/yr. All in all, 10,000 yen/ha/yr to 20,000 yen/ha/yr seems to cover the payment from the rotation age of 35 to 75 years.

• Korean Journal of Environmental Agriculture
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• v.34 no.4
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• pp.350-354
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• 2015

BACKGROUND: Botanical insecticides, especially Azadirachta Indica extract (AIE) and Sophorae radix extract (SRE) are widely used in Agriculture field. In our previous studies on genotoxicity test of AIE and SRE samples, a suspicious clastogenic properties was shown. Herein, we investigated the DNA damage effect of these botanical insecticide samples through the in vitro comet assay. METHODS AND RESULTS: Chinese hamster lung (CHL) fibroblast cell line was used, and methyl methanesulphonate was as positive control. Respective two samples of AIE and SRE were evaluated using Single Cell Gel Electrophoresis (Comet) assay and measured as the Olive tail moment (OTM). Results from this study indicated that all tested AIE and SRE samples did not show DNA damage in comet assay using CHL cells, compared with control. CONCLUSION: AIE and SRE samples used in this study were not cause genetic toxicity and are suitable for use as organic materials.

• Earthquakes and Structures
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• v.10 no.6
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• pp.1315-1330
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• 2016

This study investigates ground motion parameters and their damage potential for building type structures. It focuses on low and mid-rise reinforced concrete buildings that are important portion of the existing building stock under seismic risk in many countries. Correlations of 19 parameters of 466 earthquake records with nonlinear displacement demands of 1056 Single Degree of Freedom (SDOF) systems are investigated. Properties of SDOF systems are established to represent RC building construction practice. The correlation of damage and ground motion characteristics is examined with respect to number of story and site classes. Equations for average nonlinear displacement demands of considered RC buildings are given for some of the ground motion parameters. Velocity related parameters are generally found to have better results than the acceleration, displacement and frequency related ones. Correlation of the parameters may be expected to decrease with increasing intensity of seismic event. Velocity Spectrum Intensity and Peak Ground Velocity have been found to have the highest correlation values for almost all site classes and number of story groups. Common parameter of Peak Ground Acceleration has lower correlation with damage when compared to them and some other parameters like Effective Design Acceleration and Characteristic Intensity.