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An Experimental Study on the Effect of Hydrogen Peroxide in the Treatment of Carbon Monoxide Poisoning (일산화탄소중독(一酸化炭素中毒)의 약물치료효과에 관(關)한 실험적(實驗的) 연구(硏究) -과산화수소(過酸化水素) 관장법(灌腸法)을 중심(中心)으로-)

  • Choi, D.W.;Yoo, K.Y.;Park, H.B.
    • Journal of Preventive Medicine and Public Health
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    • v.13 no.1
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    • pp.13-18
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    • 1980
  • The ultimate goal of treatment of carton monoxide poisoning is to promote dissociation of carboxyhemoglobin and to maintain arterial $PO_2$ above 50mmHg throughout the course of treatment to protect vital organs from damage caused by hypoxia. The hyperbaric chamber designed and manufactured for this purpose has obviousely made an enormous contribution and yet has several handicaps to be overcome by any means. These handicaps are: the financial impact to purchase the chamber (especially in a small, remote community), an extra manpower requirement to operate the device, limitation in the capacity of the chamber (one man type), and the possible hazard of oxygen intoxication and dysbarism. The primary objective of this study is to develope a new therapeutic measure as an alternative to the hyperbaric chamber when it is not available or contraindicated. The effect of intestinal perfusion with hydrogen peroxide has been studied by many investigators and was known to be an excellent way of extrapulmonary oxygen supply. the advantage of this method will include; 1) much more amount of oxygen is delivered to the tissue than one would expect from 100% saturation with oxygen at 1 ata, 2) the procedure is simple and most economical, 3) neither sophisticated equipment nor extra manpower is required. As a study preliminary to the clinical application, authors conducted a series of experiment to observe the effect of hydrogen peroxide enema on dissociation of carboxyhemoglobin in intoxicated rabbit blood. Using an animal gas chamber, 20 rabbits were exposed to CO gas of 6,000 ppm for 60 minutes. Ten rabbits of control group were given 10cc of warmed normal saline solution by reactal perfusion and for the other 10 of the experimental group, the same amount of 1% $H_{2}O_{2}$ solution was given by the same way. Two blood specimens were drawn from each rabbit: the first one immediately following the exposure and the second one after rectal perfusion, about 30 minutes after the first sampling. The result was as follows; 1) The decrease in carboxyhemoglobin concentration during the first 30 minutes in the control and experimental group were $18.18{\pm}4.49%\;and\;23.03{\pm}4.13%$ respectively shelving the significant difference (p<0.05) between the two groups. 2) Hemoglobin and hematocrit value showed no significant difference between two groups and not altered significantly by intestinal perfusion with $H_{2}O_{2}$.

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A Study on the Predictability of Hospital's Future Cash Flow Information (병원의 미래 현금흐름 정보예측)

  • Moon, Young-Jeon;Yang, Dong-Hyun
    • Korea Journal of Hospital Management
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    • v.11 no.3
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    • pp.19-41
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    • 2006
  • The Objective of this study was to design the model which predict the future cash flow of hospitals and on the basis of designed model to support sound hospital management by the prediction of future cash flow. The five cash flow measurement variables discussed in financial accrual part were used as variables and these variables were defined as NI, NIDPR, CFO, CFAI, CC. To measure the cash flow B/S related variables, P/L related variables and financial ratio related variables were utilized in this study. To measure cash flow models were designed and to estimate the prediction ability of five cash flow models, the martingale model and the market model were utilized. To estimate relative prediction outcome of cash flow prediction model and simple market model, MAE and MER were used to compare and analyze relative prediction ability of the cash flow model and the market model and to prove superiority of the model of the cash flow prediction model, 32 Regional Public Hospital's cross-section data and 4 year time series data were combined and pooled cross-sectional time series regression model was used for GLS-analysis. To analyze this data, Firstly, each cash flow prediction model, martingale model and market model were made and MAE and MER were estimated. Secondly difference-test was conducted to find the difference between MAE and MER of cash flow prediction model. Thirdly after ranking by size the prediction of cash flow model, martingale model and market model, Friedman-test was evaluated to find prediction ability. The results of this study were as follows: when t-test was conducted to find prediction ability among each model, the error of prediction of cash flow model was smaller than that of martingale and market model, and the difference of prediction error cash flow was significant, so cash flow model was analyzed as excellent compare with other models. This research results can be considered conductive in that present the suitable prediction model of future cash flow to the hospital. This research can provide valuable information in policy-making of hospital's policy decision. This research provide effects as follows; (1) the research is useful to estimate the benefit of hospital, solvency and capital supply ability for substitution of fixed equipment. (2) the research is useful to estimate hospital's liqudity, solvency and financial ability. (3) the research is useful to estimate evaluation ability in hospital management. Furthermore, the research should be continued by sampling all hospitals and constructed advanced cash flow model in dimension, established type and continued by studying unified model which is related each cash flow model.

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A Study on Curriculum of Dental Hygienists (치과위생사 교육과정 연구)

  • Park, II-Soon
    • Journal of Korean society of Dental Hygiene
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    • v.4 no.2
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    • pp.193-207
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    • 2004
  • The aims of the study are as following : First, define and clarify the role and function of the dental hygienist. Second, based on thai definition, present an improved dental hygienist curriculum, improving their special competence. This study seeks to present a way for promoting role of dental hygienists as independent specialists, rather than as auxiliaries, contributing to better dental service in the process. The research was pursued by surveying by questionnaire those directly related to dental hygiene. They are 58 professors of dental hygiene, 164 dentists, 253 dental hygienists and 496 dental hygiene students, selected by the method of simple random sampling. Due to the small size of the sample, professors' group was analysed only through frequency and probabilities. For groups with larger samples(dentists, dental hygienists, dental hygiene students), methods of chi square(${\chi}^2$) tests, frequency analysis and one-way ANOVA were used in their analysis. Conclusions of the study are as following : First, role and function of the dental hygienist was defined and clarified. According to the analysis of the survey, main role of the dental hygienists as perceived by 62.9% of dentists was supporting treatments and managing patients and facility. This perception by dentists differs significantly to perception of other groups, which saw main role of dental hygienists as preventive dental treatment and dental hygiene education. Also, only 20.2% of dental hygienists perceived patients and facility management as their main role. This divergence of perception between groups weakens speciality competence of dental hygienists. To strengthen dental hygienists' speciality competence, preventive dental treatment and dental hygiene education must be defined as main role of dental hygienists. Furthermore, role of dental hygienists can be categorized into cooperative and auxiliary role. Second, in order to strengthen speciality competence of dental hygienists, their education must be augmented with curriculum emphasizing cooperative role. Specifically, courses on preventive dental treatment, dental hygiene education and dental X-ray photography must become compulsory, as well as becoming more comprehensive and organized. Also, training in schools and hospitals must be focused on those subjects. In addition, courses concerning auxiliary role must be incorporated into optional courses and more pedagogical courses are needed to widen students' career choices. Third, practical relevance of national dental hygienist certification examination must be heightened. In the survey, all groups gave negative response to questions concerning practical relevance of national dental hygienist certification test. Specifically, contents of the tests must be changed to test participants' competence in the cooperative area. Also, the test itself must be strengthened by adding practical examination to the certification scheme, as well as having more difficult examinations.

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Integrating UAV Remote Sensing with GIS for Predicting Rice Grain Protein

  • Sarkar, Tapash Kumar;Ryu, Chan-Seok;Kang, Ye-Seong;Kim, Seong-Heon;Jeon, Sae-Rom;Jang, Si-Hyeong;Park, Jun-Woo;Kim, Suk-Gu;Kim, Hyun-Jin
    • Journal of Biosystems Engineering
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    • v.43 no.2
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    • pp.148-159
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    • 2018
  • Purpose: Unmanned air vehicle (UAV) remote sensing was applied to test various vegetation indices and make prediction models of protein content of rice for monitoring grain quality and proper management practice. Methods: Image acquisition was carried out by using NIR (Green, Red, NIR), RGB and RE (Blue, Green, Red-edge) camera mounted on UAV. Sampling was done synchronously at the geo-referenced points and GPS locations were recorded. Paddy samples were air-dried to 15% moisture content, and then dehulled and milled to 92% milling yield and measured the protein content by near-infrared spectroscopy. Results: Artificial neural network showed the better performance with $R^2$ (coefficient of determination) of 0.740, NSE (Nash-Sutcliffe model efficiency coefficient) of 0.733 and RMSE (root mean square error) of 0.187% considering all 54 samples than the models developed by PR (polynomial regression), SLR (simple linear regression), and PLSR (partial least square regression). PLSR calibration models showed almost similar result with PR as 0.663 ($R^2$) and 0.169% (RMSE) for cloud-free samples and 0.491 ($R^2$) and 0.217% (RMSE) for cloud-shadowed samples. However, the validation models performed poorly. This study revealed that there is a highly significant correlation between NDVI (normalized difference vegetation index) and protein content in rice. For the cloud-free samples, the SLR models showed $R^2=0.553$ and RMSE = 0.210%, and for cloud-shadowed samples showed 0.479 as $R^2$ and 0.225% as RMSE respectively. Conclusion: There is a significant correlation between spectral bands and grain protein content. Artificial neural networks have the strong advantages to fit the nonlinear problem when a sigmoid activation function is used in the hidden layer. Quantitatively, the neural network model obtained a higher precision result with a mean absolute relative error (MARE) of 2.18% and root mean square error (RMSE) of 0.187%.

Modeling Methodology for Cold Tolerance Assessment of Pittosporum tobira (돈나무의 내한성 평가 모델링)

  • Kim, Inhea;Huh, Keun Young;Jung, Hyun Jong;Choi, Su Min;Park, Jae Hyoen
    • Horticultural Science & Technology
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    • v.32 no.2
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    • pp.241-251
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    • 2014
  • This study was carried out to develop a simple, rapid and reliable assessment model to predict cold tolerance in Pittosporum tobira, a broad-leaved evergreen commonly used in the southern region of South Korea, which can minimize the possible experimental errors appeared in a electrolyte leakage test for cold tolerance assessment. The modeling procedure comprised of regrowth test and a electrolyte leakage test on the plants exposed to low temperature treatments. The lethal temperatures estimated from the methodological combinations of a electrolyte leakage test including tissue sampling, temperature treatment for potential electrical conductivity, and statistical analysis were compared to the results of the regrowth test. The highest temperature showing the survival rate lower than 50% obtained from the regrowth test was $-10^{\circ}C$ and the lethal was $-10^{\circ}C{\sim}-5^{\circ}C$. Based on the results of the regrowth test, several methodological combinations of electrolyte leakage tests were evaluated and the electrolyte leakage lethal temperatures estimated using leaf sample tissue and freeze-killing method were closest to the regrowth lethal temperature. Evaluating statistical analysis models, linear interpolation had a higher tendency to overestimate the cold tolerance than non-linear regression. Consequently, the optimal model for cold tolerance assessment of P. tobira is composed of evaluating electrolyte leakage from leaf sample tissue applying freeze-killing method for potential electrical conductivity and predicting lethal temperature through non-linear regression analysis.

An Analytical Review of the Methods Computing Age at First Marriage (평균초혼연령 측정방법에 관한 소고)

  • 김남일;이지현
    • Korea journal of population studies
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    • v.18 no.2
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    • pp.1-22
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    • 1995
  • In this paper, the methods to measure the mean age at first marriage is examined, and by analysing data of Korean women for the period 1970-1990, the differences that each methods make on measurements of the mean age at first marriage are presented. The main findings were : The Hajnal's SMAM, the most used index in studies of the pattern of marriage in Korea, was not a measure based on the marriages for a specific period. The resulting biases, in cases of 1970-1990 Korean women, were below 0.3 year in age, which can be considered small, if the changes in the pattern of marriage in these periods took into account. But the possibility of bringing larger bias cannot be excluded. Also the direction of biases was toward raising the mean age when marriage was in upward tendency. Considering the availability of data in Korea, the utilization of the simple mean or the measure from Agarwala method according to the purpose is recommendable. The mean age at first marriage by Agarwala(ASMAM) meets with the one computed from a gross nuptiality table based on the cohort's marriage rates for a specific period. The time series of the proportion single by age groups obtained from the population censuses showed high consistency. However when they were compaired with those computed from sample surveys at a same point of time, significant differences(at $\alpha$=0.05) were found in some major age groups. It was also pointed out that these differences were not caused by the problems related with the sampling frame for surveys or the survey questions.

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Gene Expression Biodosimetry: Quantitative Assessment of Radiation Dose with Total Body Exposure of Rats

  • Saberi, Alihossein;Khodamoradi, Ehsan;Birgani, Mohammad Javad Tahmasebi;Makvandi, Manoochehr
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.18
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    • pp.8553-8557
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    • 2016
  • Background: Accurate dose assessment and correct identification of irradiated from non-irradiated people are goals of biological dosimetry in radiation accidents. Objectives: Changes in the FDXR and the RAD51 gene expression (GE) levels were here analyzed in response to total body exposure (TBE) to a 6 MV x-ray beam in rats. We determined the accuracy for absolute quantification of GE to predict the dose at 24 hours. Materials and Methods: For this in vivo experimental study, using simple randomized sampling, peripheral blood samples were collected from a total of 20 Wistar rats at 24 hours following exposure of total body to 6 MV X-ray beam energy with doses (0.2, 0.5, 2 and 4 Gy) for TBE in Linac Varian 2100C/D (Varian, USA) in Golestan Hospital, in Ahvaz, Iran. Also, 9 rats was irradiated with a 6MV X-ray beam at doses of 1, 2, 3 Gy in 6MV energy as a validation group. A sham group was also included. After RNA extraction and DNA synthesis, GE changes were measured by the QRT-PCR technique and an absolute quantification strategy by taqman methodology in peripheral blood from rats. ROC analysis was used to distinguish irradiated from non-irradiated samples (qualitative dose assessment) at a dose of 2 Gy. Results: The best fits for mean of responses were polynomial equations with a R2 of 0.98 and 0.90 (for FDXR and RAD51 dose response curves, respectively). Dose response of the FDXR gene produced a better mean dose estimation of irradiated "validation" samples compared to the RAD51 gene at doses of 1, 2 and 3 Gy. FDXR gene expression separated the irradiated rats from controls with a sensitivity, specificity and accuracy of 87.5%, 83.5% and 81.3%, respectively, 24 hours after dose of 2 Gy. These values were significantly (p<0.05) higher than the 75%, 75% and 75%, respectively, obtained using gene expression of RAD51 analysis at a dose of 2 Gy. Conclusions: Collectively, these data suggest that absolute quantification by gel purified quantitative RT-PCR can be used to measure the mRNA copies for GE biodosimetry studies at comparable accuracy to similar methods. In the case of TBE with 6MV energy, FDXR gene expression analysis is more precise than that with RAD51 for quantitative and qualitative dose assessment.

A study of the Impact of Fourism Attractions and Images on the Destination Development Patterns (관광 매력성과 이미지가 관광지 개발유형에 미치는 영향 연구)

  • 김계섭;김선영
    • Journal of Applied Tourism Food and Beverage Management and Research
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    • v.12 no.1
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    • pp.79-110
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    • 2001
  • Tourist Destination is based on tourism attractions. Components of Tourism attraction are included tourism resources, entertainment facilities, transportation, accommodation, infrastructure, assistance facilities & service, hospitality, information facilities & service, and retailing & service. Tourism resources of them is the key to determine destination development pattern, because tourism attraction that attract tourists is based on tourism resources. Therefore, there are need to study what is tourism attraction of destination at the view of tourists and what is destination development pattern based on it to develop tourism attraction that is able appeal tourists. The purpose of this study is to examine what effect of tourism attraction affects destination development pattern. This study defined Haeundae, Kwanganri, Songjung, Taejongdae in Pusan, Korea as research areas. Research data were collected from 300 respondents by a simple random sampling method. A final 284 usable questionaries were used for empirical analysis after data purification process. Reliability and validity of the scale on the tourism attraction, destination image, and facility needs have been evaluated using Cronbach $\alpha$, item-total correlations. This study analyzed the factors of the tourism attraction and destination images. The result obtained that tourism attraction is divided relaxation attraction, local activity attraction, culture . nature attraction and touring circuit attraction, and destination image is divided culture . urban attractiveness, touring attractiveness, local . stay attractiveness, convenience of travel and relativeness for destination investigated. ANOVA and regression (stepwise) were used to test hypotheses. Based on the results of hypotheses testing, major findings of the empirical research are as follow : 1. The tourism attraction and destination image are significantly different, but facility needs are not significantly by destinations (e. g. Haeundae, Kwanganri, Songjung, Taejongdae) . 2. Destination development pattern is a(fact by the tourism attraction in partial. In case of Haeundea, relaxation attraction take effect partially spa, history and marine/spa tourism. 3. The destination development pattern is influenced by the destination image in partial. In case of Kwanganri, the natural . activity attractiveness and urban tourism images have been found as influential factors that affect marine tourism. 4. The destination images are influenced the physical attributes in literature review, but the destination image are taken effect partially the tourism attraction in this study. 5. Destination development pattern are influenced by the tourism attraction and the destination image partially. This research has provided a variety of practical suggestions. Especially, it was suggested that the destination have appeal to tourists by strengthening attraction and improving weakness. Also, we need to specialize destination in same destination development pattern.

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Propensity Adjustment Weighting of the Internet Survey by Volunteer Panel (자원자 패널에 의한 인터넷 조사의 성향조정 가중화)

  • Huh, Myung-Hoe;Cho, Sung-Kyum
    • Survey Research
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    • v.11 no.2
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    • pp.1-28
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    • 2010
  • This paper reports the results of the 2009 Internet volunteer panel version of the social survey conducted by Statistics Korea (Korea National Statistical Office). Authors identify socio-psychological characteristics of Internet survey volunteers and present quantitative evaluation of the propensity adjustment weighting method intended to remove Internet sample bias. The nine criteria used for propensity adjustment were regions, urban/rural, gender, age, education, consumer satisfaction, views on income distribution, newspaper access and Internet news access. Propensity adjustment weighting based on the logit model and rim weights were applied to the online survey of 2,903 respondents using the face-to-face area sample data of 37,049 respondents as reference. A total of 106 items were used for evaluating the propensity adjustment weighting methods. The results showed that in 80% of survey items the propensity adjustment weighting yielded better estimates compared to simple demographic weighting. This suggests that Internet surveys by volunteer panels are useful for conducting the general social study in Korea. The reference survey data for this study contains several items on social-psychological behaviors and attitudes, is large in size and obtained by probability sampling. Thus it may be utilized in propensity adjustment of other Internet surveys.

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Determination of the Origin of Particulate Organic Matter at the Estuary of Youngsan River using Stable Isotope Ratios (${\delta}^{13}C$, ${\delta}^{15}N$) (탄소 및 질소 안정동위원소 비를 이용한 영산강하구역 유기물 기원 추정 연구)

  • Lee, Yeon-Jung;Jeong, Byung-Kwan;Shin, Yong-Sik;Kim, Sung-Hwan;Shin, Kyung-Hoon
    • Korean Journal of Ecology and Environment
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    • v.46 no.2
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    • pp.175-184
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    • 2013
  • Organic carbon and total nitrogen stable isotope ratios of suspended materials were determined at 3 stations (from Mongtan Bridge to Youngsan river estuary barrage) (n=6, each) from November 2008 to August 2009, in order to understand the origin of particulate organic matter at the Estuary of Youngsan River. Allochthonous organic matter, ammonia-N and silicate were increased after heavy rain (in August). Carbon isotope ratios were significantly different between stations in November and August, and it was possible to determine the origin of organic matter. The heavier nitrogen isotope ratios, as well as higher phosphate concentrations, were found in November than other sampling times. Livestock wastewater and farmland input was likely the main causes of these high values. In addition, YS3 station, the nearest site to estuary barrage, appears to be affected by a substantial amount of livestock wastewater and farmland input, considering that nitrogen isotope ratios were heavier than those at the upper sites. These results suggest that the analysis of stable isotope ratios is a simple but useful tool for the determination of organic matter origin in aquatic environments.