• 대한예방한의학회지
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• 제21권2호
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• 동의생리병리학회지
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• 제18권3호
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• pp.724-728
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• 2004

Several studies have shown that a low frequency stimulation can depress blood pressure in hypertension. We had developed a new auriculoelectrostimulator as an electronic blood pressure regulator for simple and easy stimulation. The new auriculoelectrostimulator was employed in hypertensive rat model induced by immobilization stress, diabetic and essential hypertensive rat models. Rats were stimulated by auriculoelectrostimulator at ear acupoint (Ear point for hypertension) bilaterally. Ear stimulation by auriculoelectrostimulator significantly decreased blood pressure in all hypertensive rat models and inhibited the increase of heart rates in stressed and spontaneous hypertensive rats. The results showed that auriculoelectrostimulator had depressive effects on hypertension in rat hypertensive models, suggesting that it is useful in treatment of hypertension.

• 대한한방체열의학회지
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• 제6권1호
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• pp.39-48
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• 2008

Purpose: The purpose of this study is to report the effect of TKM to Rhumatitis Arthritis after parturition and show the importance of recuperation after parturation. Methods: The patient was a 33-year-old woman who complains arthralgia, edema and sense of coldness after her third parturation. The patient was treated by Herb medicine, Acupuncture treatment, Moxa treatment and Physical Treatment. And the progress of symtoms was evaluated by cheking the change of VAS, and inspecting the DITI. Results: The Pain and edema have declined. After discharge, she got definite diagnosis as Rhumatitis Arthritis. But We already estimated it from the results of serum test. So we had treated the patience with TKM and we could explain the prognosis. We regulated the pain and edema successfully at the acute phase. And the patient could take care of herself, she didn't play her disease down as a simple symptoms of parturation. Conclusion: TKM is expected to have positive effect on Rheumatic arthritis with quick onset after parturation.

• 한방비만학회지
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• 제10권1호
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• pp.17-28
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• 2010

Objectives It is significant to determine the validation of a self-administered somatotype drawing for the simple assessment of childhood obesity in elementary school and clinical practice. Methods The subjects were 202 children(112 boys and 90 girls) who answered a questionnaire for somatotype drawing and weremeasured for body components with bioelectrical impedance. The somatotype drawing of children was analysed according to the three criteria of childhood obesity - BMI percentile, obesity index and percent body fat, respectively. Results BMI, waist-hip ratio, skeletal musclemass and proteinmass had significant differences(p<.05) between boys and girls. Somatotype drawing had the highest correlation with BMI in both boys and girls, and also showed a high correlation with BMI percentile, obesity index and percent body fat.According to these criteria of childhood obesity, the somatotype drawing was the best consistent with the obesity index, next turn was the percent body fat and then the BMI percentile. Conclusions The validation of somatotype drawing for the assessment of childhood obesity was analysed according to BMI percentile, obesity index and percent body fat, and the somatotype drawing was the best consistent with obesity index in both boys and girls.

• 대한한의학회지
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• 제35권1호
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• pp.99-113
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• 2014

Objectives: To provide theoretical basis for the classification of medicinal moxibustion(藥灸劑) in Health Insurance Medical Benefit in Korea through investigating trend of judicial precedents on indirect moxibustion and usage of medicinal moxibustion in "Donguibogam". Methods: We analyzed statistical data of moxibustion from Health Insurance Review & Assessment Service and National Health Insurance Statistical Yearbook. We investigated major judicial precedents on indirect moxibustion to find out some trend and we searched the usages of medicinal moxibustion in "ZhenJiuDaCheng" and "Donguibogam". Results: According to recent judicial precedents, indirect moxibustion with equipment is no loner regarded as Korean Medical Procedure. In composition of 'Oriental Health Treatment', amount for acupuncture has gradually decreased instead, amount for moxibustion has increased steadily for 5 years. Medicinal moxibustion(藥灸劑) is often used as a form of indirect medicinal moxibustion with moxa in "Donguibogam". Argyi Folium, Moschus, Natrii Chloridium, Radix Preparata, Realgar and Olibanum are most frequently used for medicinal moxibustion in "Donguibogam". Medicinal moxibustions are composed of simple prescription or herb-pair or multiple prescription in "Donguibogam". Conclusions: In Health Insurance Medical Benefit in Korea, under the division of moxibustion, direct medicinal moxibustion and indirect medicinal moxibustion should be classified in addition.

• 대한한의학회지
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• 제39권2호
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• pp.80-91
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• 2018

Objectives: The purpose of this study was to investigate stress and health recognition in Korean medical student by gender. Methods: 393 Korean medical student participated in this study. They were surveyed demographic characteristics(gender, age, drinking, morning diet, health recognition and etc), medical stress scale, Maslachh burnout inventory, Korea acceptance and action, and Ego Resilience Scale. For statistical analysis, chi-square test, Student t-test, correlation analysis, and simple regression analysis has been used. Results: In Medical stress scale and ego resilience, it is not significant difference by gender. Female students were significantly higher than male students in Maslach burnout inventory(P=0.015). Male students were significantly higher than female students in Korea Acceptance and Action(P=0.002). Health recognition have negative correlation between medical stress and academic exhaustion, and positive correlation between psychological flexibility and ego resilience. Conclusions: Through these results, we need to further study and develop strategies to reduce stress according to gender in Korean medical college.

• 대한한방내과학회지
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• 제37권1호
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• pp.135-142
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• 2016

Objectives: To introduce the effect of traditional Korean medicine (TKM) treatment with Injinoryeong-san on alcoholic liver cirrhosis (ALC).Methods: A 37-year-old man with a history of alcohol ingestion for the past five years was diagnosed with ALC based upon his clinical symptoms, sonogram results, and laboratory studies. The patient received TKM treatment with acupuncture, moxibustion, and Injinoryeong-san in parallel to Western medicine for two weeks. The clinical assessment was monitored based upon changes in the Child-Pugh score and ultrasonography, body weight, and abdominal circumference for measuring the amount of ascites.Results: The patient’s clinical symptoms improved with decreases in abdominal circumference and body weight. Ultrasound revealed a regression of the amount of ascites in the abdominal cavity. Laboratory results also improved significantly, and the Child-Pugh score increased from class B to A.Conclusions: This case report showed a significant improvement of ALC with relatively simple treatment for only a short period and therefore supported the potential of TKM treatment in ALC.

• 동의생리병리학회지
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• 제22권2호
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• pp.459-463
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• 2008

Postural balance of temporomandibular joint (TMJ) reflects the neuromuscular balance. TMJ posture treatment for meridian yinyang balance has been asserted to have an impact upon cervical spine alignment with an episodic good clinical result for refractory torticollis cases. A retrospective study with one-group pretest-posttest design was conducted to review cervical spine imaging data and clinical symptom changes in cervical dystonia cases to explore the effect of TMJ balance treatment. Review of clinical symptoms and cervical spine imaging data including computed tomography and simple x-ray of 9 cervical dystonia cases revealed significant improvement of cervical spine alignment and clinical symptoms. Improvement of cervical spine alignment may be an underlying mechanism of TMJ balance treatment, as a way of balancing the whole-body meridian system.

• 대한한방부인과학회지
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• 제20권3호
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• pp.246-258
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• 2007

Purpose: The purpose of this study is to report the effect of TKM to Rhumatitis Arthritis after parturition and show the importance of recuperation after parturition. Methods: The patient was a 33-year-old woman who complains arthralgia, edema and sense of coldness after her third parturition. The patient was treated by Herb medicine, Acupuncture treatment, Moxa treatment and Physical Treatment. And the progress of symptoms was evaluated by cheking the change of VAS, and inspecting the DITI. Results: The Pain and edema have declined. After discharge, she got definite diagnosis as Rhumatitis Arthritis. But We already estimated it from the results of serum test. So we had treated the patience with TKM and we could explain the prognosis. We regulated the pain and edema successfully at the acute phase. And the patient could take care of herself, she didn't play her disease down as a simple symptoms of parturition. Conclusion: TKM is expected to have positive effects on Rheumatic arthritis with quick onset after parturition.

• 대한한방내과학회지
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• 제40권4호
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• pp.697-708
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• 2019

Objective: The aim of this study was to introduce gastric dysmotility as a common cause in patients with concurrent functional dyspepsia and chronic atrophic gastritis. Method: Dyspeptic symptoms, the Rydoraku score, gastric motility (electrogastrography, bowel sound analysis), gastric mucosa (gastroendoscopy), and blood and blood chemistry were all evaluated. For the treatment method, Pyengwi-san (solution) and Banwhasashim-tang (extract) were used as herbal drugs. Both ST36 electrical stimulation and simple immersion stimulation of CV11, 12, and 13 in the abdomen were applied. Results: Dyspeptic symptoms including indigestion, headache, and insomnia were all relieved. Gastric myoelectrical activity and gastric pyloric function were additionally improved. The condition of the gastric mucosa was changed from atrophic to erosive. Other side-effects of the treatment were not noted. Conclusion: The traditional Korean treatment showed effectiveness in the relief of dyspeptic symptoms and mucosal improvement of chronic atrophic gastritis. Gastric dysmotility is a common cause of the condition being concurrent with both functional dyspepsia and chronic atrophic gastritis without Helicobacter pylori infection.